2025
TAVR vs. SAVR for severe aortic stenosis in the low and intermediate surgical risk population: An updated meta-analysis, meta-regression, and trial sequential analysis
Krishna M, Joseph M, Ezenna C, Pereira V, Rossi R, Akman Z, Rubens M, Mahadevan V, Nanna M, Goldsweig A. TAVR vs. SAVR for severe aortic stenosis in the low and intermediate surgical risk population: An updated meta-analysis, meta-regression, and trial sequential analysis. Cardiovascular Revascularization Medicine 2025 PMID: 40425422, DOI: 10.1016/j.carrev.2025.05.021.Peer-Reviewed Original ResearchSurgical aortic valve replacementTranscatheter aortic valve replacementPatient-prosthesis mismatchIntermediate surgical riskSevere patient-prosthesis mismatchAcute kidney injuryAortic valve replacementPermanent pacemaker implantationRandomized Controlled TrialsSurgical riskParavalvular leakFollow-upValve replacementPacemaker implantationAtrial fibrillationClinical outcomes of transcatheter aortic valve replacementOutcomes of transcatheter aortic valve replacementRate of permanent pacemaker implantationSafety of transcatheter aortic valve replacementBenefits of transcatheter aortic valve replacementNew-onset atrial fibrillationRates of all-cause deathAortic valve reinterventionNew-onset AFSevere aortic stenosisUnderstanding Surgical Management and Outcomes in Mitral Valve Endocarditis
Dzilic E, Niedermayer S, Burri M, Amabile A, Krane M, Vitanova K. Understanding Surgical Management and Outcomes in Mitral Valve Endocarditis. Journal Of Clinical Medicine 2025, 14: 2712. PMID: 40283542, PMCID: PMC12027858, DOI: 10.3390/jcm14082712.Peer-Reviewed Original ResearchMitral valve endocarditisMitral valve repairValve endocarditisValve repairPropensity score matchingValve replacementScore matchingNative mitral valve endocarditisMitral valve replacementRetrospective cohort studyLong-term survivalConsecutive patientsSurgical outcomesValve reconstructionAbscess formationSingle-centerSurgical managementEndocarditisSurgical patientsFollow-upCohort studyPatientsTreatment assignment biasMortality rateSurvivalANTITHROMBOTIC THERAPY AND OUTCOMES AFTER TRANSCATHETER AORTIC VALVE REPLACEMENT: AN UPDATED SYSTEMATIC REVIEW AND NETWORK META-ANALYSIS
Siami S, Maleki S, Kazemian S, ebrahimi E, Ebrahimzade M, Jodeiri F, Hajiqasemi M, Ebrahimi S, Mehdizadeh M, Aghaei M, Bastan M, Sabet M, Nazari R, Ebrahimi P, Rana J, Nanna M, Giri J, Kolte D, Alkhouli M, Hosseini K. ANTITHROMBOTIC THERAPY AND OUTCOMES AFTER TRANSCATHETER AORTIC VALVE REPLACEMENT: AN UPDATED SYSTEMATIC REVIEW AND NETWORK META-ANALYSIS. Journal Of The American College Of Cardiology 2025, 85: 888. DOI: 10.1016/s0735-1097(25)01372-5.Peer-Reviewed Original ResearchPost-Transcatheter Aortic Valve Replacement Antithrombotic Treatment in Nonindicated Patients Updated Systematic Review and Network Meta-Analysis
Siami S, Kazemian S, Maleki S, Ebrahimi E, Jodeiri F, Ebrahimzade M, Hajiqasemi M, Ebrahimi S, Mehdizadeh M, Aghaei M, Bastan M, Sabet M, Nazari R, Ebrahimi P, Rana J, Nanna M, Giri J, Kolte D, Biering-Sørensen T, Alkhouli M, Hosseini K. Post-Transcatheter Aortic Valve Replacement Antithrombotic Treatment in Nonindicated Patients Updated Systematic Review and Network Meta-Analysis. JACC Advances 2025, 4: 101719. PMID: 40286375, PMCID: PMC12049831, DOI: 10.1016/j.jacadv.2025.101719.Peer-Reviewed Original ResearchTranscatheter aortic valve replacementDual antiplatelet therapyOral anticoagulantsAntithrombotic regimensNetwork Meta-AnalysisAntiplatelet therapyCardiovascular mortalityMyocardial infarctionRisk of all-cause mortalityChronic oral anticoagulationAortic valve replacementMeta-analysisOptimal antithrombotic strategyIncreased risk of mortalityFrequentist network meta-analysisRisk of cardiovascular mortalityChronic obstructive pulmonary diseaseAll-Cause MortalityRisk of mortalityObstructive pulmonary diseaseBleeding riskValve replacementAntithrombotic treatmentNo significant differenceAntithrombotic strategies5-Year Outcomes After Transcatheter or Surgical Aortic Valve Replacement in Low-Risk Patients With Aortic Stenosis
Forrest J, Yakubov S, Deeb G, Gada H, Mumtaz M, Ramlawi B, Bajwa T, Crouch J, Merhi W, Sang S, Kleiman N, Petrossian G, Robinson N, Sorajja P, Iskander A, Berthoumieu P, Tchétché D, Feindel C, Horlick E, Saito S, Oh J, Jung Y, Reardon M, Investigators L. 5-Year Outcomes After Transcatheter or Surgical Aortic Valve Replacement in Low-Risk Patients With Aortic Stenosis. Journal Of The American College Of Cardiology 2025, 85: 1523-1532. PMID: 40158212, DOI: 10.1016/j.jacc.2025.03.004.Peer-Reviewed Original ResearchConceptsTranscatheter aortic valve replacementTranscatheter aortic valve replacement groupEvolut Low Risk trialEndpoint of all-cause mortalityAll-Cause MortalityNoninferior to surgeryLow-risk patientsAortic valve replacementSevere aortic stenosisSurgery groupKaplan-Meier estimatesLow-risk trialsAortic stenosisDisabling strokeValve replacementRisk trialsSurgical aortic valve replacementLost to follow-upRates of all-cause mortalityKansas City Cardiomyopathy Questionnaire summary scoreLow surgical riskQuestionnaire summary scoreQuality-of-life outcomesAttempted implantReintervention rateSevere Mitral Regurgitation in Paradoxical Low-Flow, Low-Gradient Severe Aortic Stenosis
Dahan S, Dal-Bianco J, Plakht Y, Namasivayam M, Capoulade R, Zeng X, Passeri J, Yucel E, Picard M, Levine R, Hung J. Severe Mitral Regurgitation in Paradoxical Low-Flow, Low-Gradient Severe Aortic Stenosis. Circulation Cardiovascular Imaging 2025, 18: e017598. PMID: 40116009, DOI: 10.1161/circimaging.124.017598.Peer-Reviewed Original ResearchConceptsLow-gradient severe aortic stenosisParadoxical low-flowSevere aortic stenosisAortic valve replacementPRESERVED LEFT VENTRICULAR EJECTION FRACTIONSevere mitral regurgitationSevere MRVentricular ejection fractionAortic stenosisMitral regurgitationAll-Cause MortalityValve replacementMR degreeEjection fractionComposite outcomeAortic valve replacement ratesAssociated with adverse outcomesComplexity to diagnosisIncreased left ventricular dimensionsLow transaortic gradientNon-severe MRSevere MR groupHeart failure hospitalizationPropensity-adjusted modelLeft ventricular remodelingEarly Aortic Valve Replacement Versus Conservative Management: A Meta-Analysis of Randomized Controlled Trials
Shah T, Shah Y, Lansky A, Giri J, Fanaroff A, Nathan A. Early Aortic Valve Replacement Versus Conservative Management: A Meta-Analysis of Randomized Controlled Trials. Structural Heart 2025, 9: 100461. PMCID: PMC12207225, DOI: 10.1016/j.shj.2025.100461.Peer-Reviewed Original ResearchRacial and ethnic disparities in aortic stenosis within a universal healthcare system characterized by natural language processing for targeted intervention
Biswas D, Wu J, Brown S, Bharucha A, Fairhurst N, Kaye G, Jones K, Copeland F, O’Donnell B, Kyle D, Searle T, Pareek N, Dworakowski R, Papachristidis A, Melikian N, Wendler O, Deshpande R, Baghai M, Galloway J, Teo J, Dobson R, Byrne J, MacCarthy P, Shah A, Eskandari M, O’Gallagher K. Racial and ethnic disparities in aortic stenosis within a universal healthcare system characterized by natural language processing for targeted intervention. European Heart Journal - Digital Health 2025, 6: 392-403. PMID: 40395418, PMCID: PMC12088714, DOI: 10.1093/ehjdh/ztaf018.Peer-Reviewed Original ResearchSurgical aortic valve replacementTranscatheter aortic valve implantationAortic stenosisBlack patientsWhite patientsSevere ASEthnic disparitiesSurgical aortic valve replacement proceduresAS managementAortic valve replacementRetrospective cohort studySocioeconomic statusAll-Cause MortalityAortic valve implantationHealthcare systemAS severityValve replacementUniversal healthcare systemValvular interventionsSelf-reported raceCohort studyValve implantationSymptomatic casesMultivariate analysisPrimary outcomeCurrent Practices for Cohort Reporting and Statistical Adjustment in Studies From The Society of Thoracic Surgeons Adult Cardiac Surgery Database
Mantaj P, Hameed I, Hirofuji A, Dell'Aquila M, Rahouma M, Abdalla S, Kennedy M, Gregg A, Rossi C, Soletti G, Falco G, Charlson M, Sandner S, Schwann T, Gaudino M. Current Practices for Cohort Reporting and Statistical Adjustment in Studies From The Society of Thoracic Surgeons Adult Cardiac Surgery Database. The Annals Of Thoracic Surgery 2025, 119: 1317-1324. PMID: 40049382, DOI: 10.1016/j.athoracsur.2025.02.011.Peer-Reviewed Original ResearchAdult Cardiac Surgery DatabaseCardiac Surgery DatabaseParticipant User FileSTS ACSDValve surgerySurgery DatabaseThe Society of Thoracic Surgeons Adult Cardiac Surgery DatabaseSociety of Thoracic Surgeons Adult Cardiac Surgery DatabaseSTS Adult Cardiac Surgery DatabaseSurgical aortic valve replacementMitral valve surgeryTricuspid valve surgeryCoronary Artery Bypass GraftingAortic valve replacementArtery Bypass GraftingStatistical adjustmentAortic surgeryValve replacementBaseline characteristicsBypass GraftingCohort reportSurgerySenior authorMultivariate regressionPublished studiesTranscatheter vs Surgical Aortic Valve Replacement in Lower-Risk Patients An Updated Meta-Analysis of Randomized Controlled Trials
Reddy R, Howard J, Mack M, Reardon M, Jørgensen T, Hørsted Thyregod H, Toff W, Van Mieghem N, Vora A, Makkar R, Kapadia S, Forrest J, Leon M, Ahmad Y. Transcatheter vs Surgical Aortic Valve Replacement in Lower-Risk Patients An Updated Meta-Analysis of Randomized Controlled Trials. Journal Of The American College Of Cardiology 2025, 85: 926-940. PMID: 40044297, DOI: 10.1016/j.jacc.2024.12.031.Peer-Reviewed Original ResearchConceptsSurgical aortic valve replacementTranscatheter aortic valve replacementLower-risk patientsAortic valve replacementPooled survival analysisValve replacementIndividual participant dataPairwise meta-analysesFollow-upMeta-analysis of randomized controlled trialsLonger-term clinical outcomesReduced hazard of deathSevere aortic stenosisFixed effect assumptionsComposite of deathLonger-term follow-upAll-cause deathMean survival time modelsMeta-analysesHazard of deathRate of strokeRandomized Controlled TrialsSurvival time modelFrailty termProportional odds modelThe Impact of Aortic Arch Morphology on Periprocedural Stroke in Transcatheter Aortic Valve Replacement
Voss S, Rusa K, Campanella C, Georgescu T, Vitanova K, Ruge H, Amabile A, Sideris K, Krane M, Burri M. The Impact of Aortic Arch Morphology on Periprocedural Stroke in Transcatheter Aortic Valve Replacement. Journal Of Clinical Medicine 2025, 14: 1045. PMID: 40004577, PMCID: PMC11856225, DOI: 10.3390/jcm14041045.Peer-Reviewed Original ResearchTranscatheter aortic valve replacementMulti-Slice Computed TomographyAortic valve replacementAortic arch morphologyArch anatomyValve replacementPeriprocedural strokeLeft common carotid arteryTransfemoral transcatheter aortic valve replacementEpi-aortic vesselsIschemic strokeArch morphologyPeriprocedural ischemic strokePropensity-matched case-control studyScore-matched studyCase-control studyCommon carotid arteryOccurrence of ischemic strokeAortic arch geometryEuroSCORE IIPropensity score matchingAortic archComparing PatientsCatheter manipulationCarotid arteryConcurrent aortic valve replacement and splenectomy for Q-fever endocarditis with massive splenomegaly and pancytopenia
Weininger G, Pedroza A, Shou B, Forrester J, Lin Y. Concurrent aortic valve replacement and splenectomy for Q-fever endocarditis with massive splenomegaly and pancytopenia. JTCVS Techniques 2025, 30: 73-76. PMID: 40242106, PMCID: PMC11998301, DOI: 10.1016/j.xjtc.2025.01.021.Peer-Reviewed Original ResearchTranscatheter Aortic Valve Replacement in Hypertrophic Cardiomyopathy: A Systematic Review and Meta‐Analysis
Ahmed A, Kaddoura R, Aggarwal A, Zinyandu T, Webber F, Davila C, Zarich S. Transcatheter Aortic Valve Replacement in Hypertrophic Cardiomyopathy: A Systematic Review and Meta‐Analysis. Catheterization And Cardiovascular Interventions 2025, 105: 754-760. PMID: 39748537, DOI: 10.1002/ccd.31367.Peer-Reviewed Original ResearchConceptsTranscatheter aortic valve replacementOutcomes of transcatheter aortic valve replacementAortic valve replacementHypertrophic cardiomyopathyAortic stenosisRenal impairmentValve replacementAortic dissectionVascular complicationsCardiogenic shockOdds ratioTranscatheter Aortic Valve Replacement OutcomesSevere aortic stenosisPermanent pacemaker implantationComplete heart blockAssociated with higher ratesObservational cohort studyGold standard managementConfidence intervalsRandom-effects modelSignificantly higher occurrenceSurgical riskPacemaker implantationHeart blockSurgical intervention
2024
Inflow-to-Outflow Stent Frame Expansion, Ellipticity, and Decoupling in Evolut TAVR: Implications for Mid-term Hemodynamic Performance
Puri R, Spencer J, Tchétché D, Van Mieghem N, Forrest J, Reardon M, Sanchez J, Caballero A, Blanke P, Leipsic J, Sorajja P, Deeb G, Fukuhara S, Lucas L, Oyekunle T, Tang G. Inflow-to-Outflow Stent Frame Expansion, Ellipticity, and Decoupling in Evolut TAVR: Implications for Mid-term Hemodynamic Performance. Journal Of The Society For Cardiovascular Angiography & Interventions 2024, 4: 102448. PMID: 40061419, PMCID: PMC11887556, DOI: 10.1016/j.jscai.2024.102448.Peer-Reviewed Original ResearchTranscatheter aortic valve replacementTranscatheter aortic valveFrame deformationHypoattenuated leaflet thickeningEffective orifice areaFrame expansionHemodynamic performanceLeaflet thickeningSelf-expanding transcatheter aortic valve replacementLeaflet regionsOrifice areaDays post-TAVRAortic valve replacementNative aortic annulusInflow geometriesEllipticity ratioVariable ellipticityComputed tomography imagesAortic annulusValve replacementParavalvular regurgitationAnnular levelPost-TAVRAortic valveMechanisms of Repair Failure After Mitral Valve Repair Using Chordal Replacement
Lang M, Feirer N, Voss B, Geirsson A, Amabile A, Krane M, Vitanova K. Mechanisms of Repair Failure After Mitral Valve Repair Using Chordal Replacement. The Annals Of Thoracic Surgery 2024, 119: 362-369. PMID: 39603581, DOI: 10.1016/j.athoracsur.2024.10.029.Peer-Reviewed Original ResearchMechanisms of repair failureMitral valve repairMitral valve replacementMitral valve sclerosisDegenerative mitral regurgitationChordal replacementValve repairMitral regurgitationRe-repairRepair failureTechnical failureIsolated mitral valve repairCases of mitral valve replacementTranscatheter edge-to-edge repairCases of technical failureEdge-to-edge repairMitral valve reoperationGerman Heart Center MunichRetrospective observational studyValve reoperationValve replacementRe-reoperationMitral valveReoperationFollow-upTranscatheter or surgical aortic valve replacement in pregnant women? A comprehensive review of the current literature.
Kuchibhatla A, Soghrati N, Saleh Y, Rushing G, Halim M, Pelletier M, Baeza C, El-Diasty M. Transcatheter or surgical aortic valve replacement in pregnant women? A comprehensive review of the current literature. Journal Of Invasive Cardiology 2024, 37 PMID: 39453868, DOI: 10.25270/jic/24.00065.Peer-Reviewed Original ResearchCerebrovascular Events in Patients Undergoing Transcatheter Aortic Valve Replacement: A Review
Patel K, Rathod K, Lansky A, Prendergast B, Kharbanda R, Mathur A, Perry R, Baumbach A. Cerebrovascular Events in Patients Undergoing Transcatheter Aortic Valve Replacement: A Review. Stroke 2024, 55: 2754-2764. PMID: 39371005, DOI: 10.1161/strokeaha.124.047149.Peer-Reviewed Original ResearchTranscatheter aortic valve replacementAortic valve replacementCerebrovascular eventsValve replacementAtrial fibrillationLow operative risk patientsAdvent of transcatheter aortic valve replacementNew-onset atrial fibrillationComplication of transcatheter aortic valve replacementIncreased risk of bleedingHigher risk of cerebrovascular eventsAssociated with significant mortalityTranscatheter aortic valve replacement procedureRisk of cerebrovascular eventsOperative risk patientsResults of embolizationRisk of bleedingRisk of thromboembolismHypoattenuated leaflet thickeningImprove risk stratificationCerebral lesion volumeAssociated with cerebrovascular eventsTherapy to patientsOverall stroke rateSeverity of comorbiditiesTCT-826 A Validated Risk Model for Acute Kidney Injury Prediction in Patients Undergoing Transcatheter Aortic Valve Replacement: Insights From the STS/ACC National Cardiovascular Data Registry–Transcatheter Valve Therapy Registry
Julien H, Mutaawe S, Siaw-Asamoah A, Vemulapalli S, Uzendu A, Vora A, Kaneko T, Wang T, Secemsky E, Pai A, Shah B, Giri J. TCT-826 A Validated Risk Model for Acute Kidney Injury Prediction in Patients Undergoing Transcatheter Aortic Valve Replacement: Insights From the STS/ACC National Cardiovascular Data Registry–Transcatheter Valve Therapy Registry. Journal Of The American College Of Cardiology 2024, 84: b334-b335. DOI: 10.1016/j.jacc.2024.09.977.Peer-Reviewed Original ResearchFour-year outcomes after transcatheter or contemporary surgical aortic valve replacement from the Evolut Low Risk trial
Ramlawi B, Deeb G, Mumtaz M, Bajwa T, Rovin J, Yakubov S, Jung Y, Reardon M, Forrest J. Four-year outcomes after transcatheter or contemporary surgical aortic valve replacement from the Evolut Low Risk trial. Journal Of Thoracic And Cardiovascular Surgery 2024, 170: e16-e26. PMID: 39181441, DOI: 10.1016/j.jtcvs.2024.08.023.Peer-Reviewed Original ResearchCurrent Role of Cardiac Magnetic Resonance for the Clinical Decision-Making Process in Transcatheter Aortic Valve Replacement
Dallan L, Feroze R, Jarrett C, Yoon S, Rajagopalan V, Walker J, Baeza C, Pelletier M, Al-Kindi S, Ukaigwe A, Filby S, Rajagopalan S, Attizzani G, Rashid I. Current Role of Cardiac Magnetic Resonance for the Clinical Decision-Making Process in Transcatheter Aortic Valve Replacement. Cardiovascular Revascularization Medicine 2024, 65: 58. DOI: 10.1016/j.carrev.2024.04.130.Peer-Reviewed Original Research
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