2023
Sex, Genotype, and Liver Volume Progression as Risk of Hospitalization Determinants in Autosomal Dominant Polycystic Liver Disease
Schönauer R, Sierks D, Boerrigter M, Jawaid T, Caroff L, Audrezet M, Friedrich A, Shaw M, Degenhardt J, Forberger M, de Fallois J, Bläker H, Bergmann C, Gödiker J, Schindler P, Schlevogt B, Müller R, Berg T, Patterson I, Griffiths W, Sayer J, Consortium G, Ambrose J, Arumugam P, Bevers R, Bleda M, Boardman-Pretty F, Boustred C, Brittain H, Caulfield M, Chan G, Elgar G, Fowler T, Giess A, Hamblin A, Henderson S, Hubbard T, Jackson R, Jones L, Kasperaviciute D, Kayikci M, Kousathanas A, Lahnstein L, Leigh S, Leong I, Lopez J, Maleady-Crowe F, McEntagart M, Minneci F, Moutsianas L, Mueller M, Murugaesu N, Need A, O’Donovan P, Odhams C, Patch C, Pereira M, Perez-Gil D, Pullinger J, Rahim T, Rendon A, Rogers T, Savage K, Sawant K, Scott R, Siddiq A, Sieghart A, Smith S, Sosinsky A, Stuckey A, Tanguy M, Tavares A, Thomas E, Thompson S, Tucci A, Welland M, Williams E, Witkowska K, Wood S, Popp B, Torres V, Hogan M, Somlo S, Watnick T, Nevens F, Besse W, Gall E, Harris P, Drenth J, Halbritter J. Sex, Genotype, and Liver Volume Progression as Risk of Hospitalization Determinants in Autosomal Dominant Polycystic Liver Disease. Gastroenterology 2023, 166: 902-914. PMID: 38101549, DOI: 10.1053/j.gastro.2023.12.007.Peer-Reviewed Original ResearchAutosomal dominant polycystic liver diseasePolycystic liver diseaseDisease-related hospitalizationsLiver diseaseLiver eventsPathogenic variantsPrimary clinical end pointCombination of female sexCohort of patientsClinical end pointsInternational multicenter cohortPrediction of disease progressionGenotype-phenotype correlationPrimary clinical endpointTotal liver volumeUnderlying genetic defectSymptomatic hepatomegalyDesign of randomized controlled trialsRandomized Controlled TrialsFemale patientsIndependent of sexMulticenter cohortFemale preponderanceRare conditionSymptomatic disease
2022
Prevalence and gender distribution of trichotillomania: A systematic review and meta-analysis
Thomson HA, Farhat LC, Olfson E, Levine JLS, Bloch MH. Prevalence and gender distribution of trichotillomania: A systematic review and meta-analysis. Journal Of Psychiatric Research 2022, 153: 73-81. PMID: 35802953, DOI: 10.1016/j.jpsychires.2022.06.058.Peer-Reviewed Original ResearchConceptsHair-pulling behaviorMeta-analysesPrevalence estimatesOdds ratioSystematic reviewRandom-effects meta-analysesHair-pullingMeta-analysisSignificant public health impactPublic health impactGender distributionPrevalence dataHair lossEpidemiological studiesHealth impactsIncreased riskEpidemiological samplePrevalenceDatabase searchTrichotillomaniaFemale preponderance
2019
The challenges of primary biliary cholangitis: What is new and what needs to be done
Terziroli Beretta-Piccoli B, Mieli-Vergani G, Vergani D, Vierling JM, Adams D, Alpini G, Banales JM, Beuers U, Björnsson E, Bowlus C, Carbone M, Chazouillères O, Dalekos G, De Gottardi A, Harada K, Hirschfield G, Invernizzi P, Jones D, Krawitt E, Lanzavecchia A, Lian ZX, Ma X, Manns M, Mavilio D, Quigley EM, Sallusto F, Shimoda S, Strazzabosco M, Swain M, Tanaka A, Trauner M, Tsuneyama K, Zigmond E, Gershwin ME. The challenges of primary biliary cholangitis: What is new and what needs to be done. Journal Of Autoimmunity 2019, 105: 102328. PMID: 31548157, DOI: 10.1016/j.jaut.2019.102328.Peer-Reviewed Original ResearchConceptsPrimary biliary cholangitisAnti-mitochondrial autoantibodiesBiochemical cholestasisBiliary cholangitisBiliary epitheliumUrsodeoxycholic acidPBC-specific anti-nuclear antibodiesBile acidsToxic hydrophobic bile acidsAutoimmune liver diseaseSecond-line treatmentFirst-line treatmentAnti-nuclear antibodiesReliable disease markersEarly disease stagesCholestatic biochemical profileNew therapeutic approachesHydrophobic bile acidsAutoimmune originSeronegative casesLiver histologyAutoimmune attackFemale preponderanceHistologic confirmationImmunologic pathways
2018
Rapid‐Onset Obesity with Hypoventilation, Hypothalamic, Autonomic Dysregulation, and Neuroendocrine Tumors (ROHHADNET) Syndrome: A Systematic Review
Lee J, Shin J, Kim S, Gee H, Lee J, Cha H, Rim J, Park S, Kim J, Uçar A, Kronbichler A, Lee K, Shin J. Rapid‐Onset Obesity with Hypoventilation, Hypothalamic, Autonomic Dysregulation, and Neuroendocrine Tumors (ROHHADNET) Syndrome: A Systematic Review. BioMed Research International 2018, 2018: 1250721. PMID: 30584530, PMCID: PMC6280256, DOI: 10.1155/2018/1250721.Peer-Reviewed Original ResearchConceptsWhole-exome sequencingNeuroendocrine tumorsCopy number variationsEarly recognitionExamining copy number variationGenetic causeRapid-onset obesitySystematic reviewIndividual patient dataPatient dataAggregate patient dataHypothalamic symptomsMedian agePrompt diagnosisCase seriesFemale preponderanceCase reportClinical manifestationsReduce morbidityAutonomic dysregulationGrave outcomeRare diseaseExome sequencingPatientsElectronic databases
2004
Utility of age, gender, ANA titer and pattern as predictors of anti-ENA and -dsDNA antibodies
Kang I, Siperstein R, Quan T, Breitenstein ML. Utility of age, gender, ANA titer and pattern as predictors of anti-ENA and -dsDNA antibodies. Clinical Rheumatology 2004, 23: 509-515. PMID: 15801070, DOI: 10.1007/s10067-004-0937-0.Peer-Reviewed Original ResearchConceptsAnti-dsDNA AbsLow titer ANAsANA titersDsDNA AbsImmunofluorescence patternDsDNA antibodiesAnti-extractable nuclear antigensLow titersHigh titer ANAHomogeneous patternUtility of ageANA test resultsFemale preponderanceANA patternsDecreased frequencyLogistic regressionTitersNuclear antigenROC curveCurve areaPatientsAntibodiesAgeANAAssociation
2002
Toward validation of atypical depression in the community: results of the Zurich cohort study
Angst J, Gamma A, Sellaro R, Zhang H, Merikangas K. Toward validation of atypical depression in the community: results of the Zurich cohort study. Journal Of Affective Disorders 2002, 72: 125-138. PMID: 12200203, DOI: 10.1016/s0165-0327(02)00169-6.Peer-Reviewed Original ResearchConceptsZurich cohort studyAtypical depressionCohort studyAtypical subtypeAtypical major depressive episodeCommunity-based longitudinal cohort studyDSM-IV atypical depressionAtypical depressive subtypesSignificant female preponderanceSex differencesAtypical depressive symptomsPopulation-based cohortMajor depressive episodeLongitudinal cohort studyHigh population prevalenceMood reactivitySymptom Checklist-90Marked sex differenceFemale preponderanceTreatment patternsAtypical syndromesClinical correlatesDepressive episodeDepressive subtypesClinical severity
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