2025
Impact of Preoperative LDL Level on Lower Extremity Revascularization Outcomes
Carter W, Alappan U, Chetty A, Wells N, Alameddine D, Slade M, Possick S, Ochoa Chaar C. Impact of Preoperative LDL Level on Lower Extremity Revascularization Outcomes. Annals Of Vascular Surgery 2025, 122: 239-247. PMID: 40651525, DOI: 10.1016/j.avsg.2025.07.016.Peer-Reviewed Original ResearchLower extremity revascularizationPeripheral arterial diseaseRetrospective chart reviewProportion of patientsRetrospective chart review of patientsChart review of patientsLDL testingReview of patientsCox regression analysisAdverse cardiovascular eventsChronic limb-threatening ischemiaHybrid lower extremity revascularizationBurden of comorbiditiesAssociated with outcomeLimb-threatening ischemiaOld white maleBaseline LDLTertiary centerStatin useLipid testingCardiovascular eventsFollow-upLDL levelsLower LDLRevascularization outcomesUsing vascular biomarkers to assess heart failure event risk in hospitalized patients with and without AKI
Shi A, Andrawis A, Biswas A, Wilson F, Obeid W, Philbrook H, Go A, Ikizler T, Siew E, Chinchilli V, Hsu C, Garg A, Reeves W, Prince D, Bhatraju P, Coca S, Liu K, Kimmel P, Kaufman J, Wurfel M, Himmelfarb J, Parikh C, Mansour S. Using vascular biomarkers to assess heart failure event risk in hospitalized patients with and without AKI. BMC Nephrology 2025, 26: 271. PMID: 40457292, PMCID: PMC12131712, DOI: 10.1186/s12882-025-04169-1.Peer-Reviewed Original ResearchConceptsArea under the curveRisk of HF eventsHeart failureHF eventsHospitalized patientsPrediction of HFVascular biomarkersClinical modelHigher risk of HF eventsPrediction of HF eventsLevels of injury markersRates of heart failureDormant phenotypeAssociated with higher riskCox regression analysisHeart failure eventsCardiovascular disease risk factorsPost-hospitalizationDisease risk factorsSerum creatinineAKI patientsStratify patientsInjury markersLung diseaseClinical centersFeasibility of machine learning–based modeling and prediction to assess osteosarcoma outcomes
Zhao Q, Hu W, Xia Y, Dai S, Wu X, Chen J, Yuan X, Zhong T, Xi X, Wang Q. Feasibility of machine learning–based modeling and prediction to assess osteosarcoma outcomes. Scientific Reports 2025, 15: 17386. PMID: 40389469, PMCID: PMC12089500, DOI: 10.1038/s41598-025-00179-z.Peer-Reviewed Original ResearchConceptsGene signatureLow-risk score groupIncreased metastasis riskLow-risk patientsSensitive to immunotherapyUnivariate Cox regression analysisReduced immune infiltrationCox regression analysisPersonalized therapeutic strategiesAggressive bone malignancyOsteosarcoma outcomesPersonalized treatment strategiesHigh-risk scoreOverall survivalHigher mortality rateProlonged survivalMetastasis riskMulticenter cohortImmune infiltrationPoor prognosisRisk stratificationC-indexDrug sensitivityClinical managementPrognostic toolProphylactic anticoagulant therapy is associated with improved survival in ICU patients with non-COVID-19 pneumonia: a retrospective cohort study
Hu H, Zhu Y, Hu R, Zhao L, Zeng X, Wu X, Qiu R, Nie Y, Sharma L, Chang D. Prophylactic anticoagulant therapy is associated with improved survival in ICU patients with non-COVID-19 pneumonia: a retrospective cohort study. Frontiers In Pharmacology 2025, 16: 1597885. PMID: 40406481, PMCID: PMC12095157, DOI: 10.3389/fphar.2025.1597885.Peer-Reviewed Original ResearchProphylactic anticoagulant therapyShort-term mortalityKaplan-Meier survival analysisAnticoagulant therapyICU patientsPropensity score matchingPulmonary infectionImproved survivalNon-COVID-19Subgroup analysisNon-COVID-19 pneumoniaDuration of anticoagulant therapyAssociated with improved survivalMultivariate Cox regression modelSurvival analysisEffect of anticoagulant therapyMedical Information Mart for Intensive Care IV databaseCox regression analysisRetrospective cohort studyAssociated with reduced short-term mortalityOptimal administration strategiesCox regression modelsPrognostic factorsAnticoagulation groupCoagulation disordersValidation of the WIfI Classification in the Vascular Quality Initiative database
Alameddine D, Satam K, Slade M, Cardella J, Aboian E, Guzman R, Mills J, Chaar C. Validation of the WIfI Classification in the Vascular Quality Initiative database. Journal Of Vascular Surgery 2025 PMID: 40056961, DOI: 10.1016/j.jvs.2025.03.001.Peer-Reviewed Original ResearchChronic limb-threatening ischemiaWIfI stageWIfI scoreWIfI classificationLower extremity revascularizationPeripheral vascular interventionsMajor amputationAssociated with major amputationWIfI clinical stagePredicting major amputationPeripheral vascular interventional proceduresAssociated with increased riskVascular Quality InitiativeRegression analysisAmputation groupAmputation resultsCox regression analysisLimb-threatening ischemiaCharacteristics of patientsAfrican AmericansQuality InitiativeAmputationRisk factorsExtremity revascularizationFoot Infection classificationRed blood cell casts on kidney biopsy and progression of IgA nephropathy
Yao Y, Tang C, Shi S, Chen P, Zhou X, Lv J, Liu L, Zhang H. Red blood cell casts on kidney biopsy and progression of IgA nephropathy. Nephrology Dialysis Transplantation 2025, gfaf023. PMID: 39909472, DOI: 10.1093/ndt/gfaf023.Peer-Reviewed Original ResearchComposite kidney endpointRed blood cell castsMedian Follow-UpImmunosuppressive therapyKidney endpointsCell castsFollow-upIgA nephropathyKidney diseaseProgression of IgA nephropathyDisease progression of patientsCox regression analysisEnd stage kidney diseaseKidney disease progressionAcute active lesionsStage kidney diseaseProgression of patientsRenal prognosisCrescentic lesionsDeath due to kidney diseaseKidney biopsyKidney outcomesUnivariate analysisActive lesionsMultivariate analysis
2024
Impact of Response to Hypomethylating Agent-Based Therapy on Survival Outcomes in the Context of Baseline Clinical-Molecular Risk and Transplant Status in Patients with Myelodysplastic Syndromes/Neoplasms (MDS): An Analysis from the International Consortium for MDS (icMDS) Validate Database
Rolles B, Bewersdorf J, Kewan T, Blaha O, Stempel J, Lanino L, Al Ali N, DeZern A, Sekeres M, Uy G, Carraway H, Desai P, Griffiths E, Stein E, Brunner A, McMahon C, Shallis R, Zeidner J, Savona M, Frumm S, Barua S, Chandhok N, Logothetis C, Bidikian A, Getz T, Roboz G, Wang E, Harris A, Amaya M, Hawkins H, Ball S, Grenet J, Xie Z, Madanat Y, Abaza Y, Badar T, Haferlach T, Maciejewski J, Sallman D, Enjeti A, Al-Rabi K, Halahleh K, Hiwase D, Diez-Campelo M, Valcarcel D, Haferlach C, Pleyer L, Kotsianidis I, Pappa V, Santini V, Consagra A, Al-Kali A, Ogawa S, Nannya Y, Della Porta M, Komrokji R, Zeidan A, Stahl M. Impact of Response to Hypomethylating Agent-Based Therapy on Survival Outcomes in the Context of Baseline Clinical-Molecular Risk and Transplant Status in Patients with Myelodysplastic Syndromes/Neoplasms (MDS): An Analysis from the International Consortium for MDS (icMDS) Validate Database. Blood 2024, 144: 664-664. DOI: 10.1182/blood-2024-208034.Peer-Reviewed Original ResearchComposite complete responseAllo-HCTOverall survivalComplete responseIPSS-MHMA therapyMedian OSResponse criteriaAllogeneic stem cell transplantationPartial hematologic recoveryClinical response criteriaStem cell transplantationHypomethylating agent-based therapyAgent-based therapyClinical practiceCox regression analysisResponse to treatmentAvailability of donorsDecitabine monotherapyImpact OSOS benefitHematologic recoveryAzacitidine monotherapyCell transplantationCombination therapyEvaluating Molecular and Clinical Predictors in Myelodysplastic Syndromes through Machine Learning Integration
Mosquera Orgueira A, Perez Encinas M, Pérez Míguez C, Crucitti D, Piñeiro Fiel M, Díaz Varela N, Mora E, Díaz-Beyá M, Montoro M, Pomares H, Ramos Ortega F, Tormo M, Jerez A, Nomdedeu J, de Miguel Sanchez C, Arenillas L, Carcel Corella P, Cedena Romero M, Xicoy B, Rivero M, Del Orbe Barreto R, Bewersdorf J, Stahl M, Stempel J, Kewan T, Zeidan A, Diez-Campelo M, Valcarcel D. Evaluating Molecular and Clinical Predictors in Myelodysplastic Syndromes through Machine Learning Integration. Blood 2024, 144: 6683-6683. DOI: 10.1182/blood-2024-198114.Peer-Reviewed Original ResearchLeukemia-free survivalPredictors of OSMyelodysplastic syndromeOverall survivalIPSS-MC-indexFLT3-ITDPredictors of leukemia-free survivalRevised International Prognostic Scoring SystemPrognostication of myelodysplastic syndromesInternational Prognostic Scoring SystemPrognostic scoring systemCox regression analysisMolecular dataClinical trial designIPSS-RGenetic variabilityMLL-PTDRandom survival forestPrognostic landscapePrognostic significanceLaboratory parametersAffected prognosisClinical predictorsClinical indicesReal-World Use Patterns and Clinical Outcomes for Myelodysplastic Syndrome Patients Initiating Oral Decitabine and Cedazuridine or Intravenous/Subcutaneous Hypomethylating Agents
Zeidan A, Zhao R, Pierre-Victor D, Wang Y, Tepsick J, Lan Z, Salimi T. Real-World Use Patterns and Clinical Outcomes for Myelodysplastic Syndrome Patients Initiating Oral Decitabine and Cedazuridine or Intravenous/Subcutaneous Hypomethylating Agents. Blood 2024, 144: 5189-5189. DOI: 10.1182/blood-2024-205495.Peer-Reviewed Original ResearchAML-free survivalTreated with hypomethylating agentsOral hypomethylating agentsHypomethylating agentsMyelodysplastic syndrome patientsMyelodysplastic syndromeDEC-CClinical characteristicsMDS diagnosisNext treatmentMonths median follow-upRisk of AML transformationHigh-risk myelodysplastic syndromeReal-world treatment outcomesTreatment of adult patientsHypomethylating agent treatmentKaplan-Meier survival analysis methodMedian Follow-UpCox regression analysisReal-world studyAML transformationHMA therapyOral decitabineECOG 0Electronic health record databaseInvestigating synergy between beta-blockers and transarterial chemoembolization in the treatment of hepatocellular carcinoma: preliminary data from a propensity matched analysis
Mutonga M, Shewarega A, Gross M, Kahl V, Madoff D. Investigating synergy between beta-blockers and transarterial chemoembolization in the treatment of hepatocellular carcinoma: preliminary data from a propensity matched analysis. Clinical Imaging 2024, 115: 110283. PMID: 39278042, DOI: 10.1016/j.clinimag.2024.110283.Peer-Reviewed Original ResearchBeta-blockersTumor responseImaging timepointsTumor sizeEtiology of liver diseaseAssociated with high mortalityTransplant free survivalTransplant-free survivalTreatment of hepatocellular carcinomaFavorable clinical outcomesChild-Pugh scoreFirst-line treatmentBeta-blocker groupPredictors of survivalCox regression analysisTreatment of HCCStudent's t-testFree survivalTransarterial chemoembolizationChi-square testPost-TACETACE treatmentPugh scoreSurvival predictorsAdjunctive useNeocortical serotonin 2A receptor binding, neuroticism and risk of developing depression in healthy individuals
Sankar A, Ziersen S, Ozenne B, Dam V, Beaman E, Kessing L, Fisher P, Budtz-Jørgensen E, Knudsen G, Miskowiak K, Frokjaer V. Neocortical serotonin 2A receptor binding, neuroticism and risk of developing depression in healthy individuals. Nature Mental Health 2024, 2: 1231-1238. DOI: 10.1038/s44220-024-00299-x.Peer-Reviewed Original ResearchRisk of depressionFacets of neuroticismPersonality trait neuroticismPathophysiology of depressionSerotonin 2A receptorMolecular brain imagingHigh neuroticismTrait neuroticismDepressive episodeNeuroticismDepression diagnosisHealthy individualsDepressionReceptor bindingBrain imagingDanish registersCause-specific Cox regression analysesEvaluation of clinical strategiesIndividualsCox regression analysisPsychotherapyClinical strategiesPsychedelicsSerotoninRegression analysisNormothermic Machine Perfusion Is Associated With Improvement in Mortality and Graft Failure in Donation After Cardiac Death Liver Transplant Recipients in the United States
Okumura K, Dhand A, Misawa R, Sogawa H, Veillette G, Nishida S. Normothermic Machine Perfusion Is Associated With Improvement in Mortality and Graft Failure in Donation After Cardiac Death Liver Transplant Recipients in the United States. Transplantation Direct 2024, 10: e1679. PMID: 38988687, PMCID: PMC11230788, DOI: 10.1097/txd.0000000000001679.Peer-Reviewed Original ResearchNormothermic machine perfusion groupNormothermic machine perfusionLiver transplantationLT recipientsGraft survivalPropensity score matchingOverall survivalGraft failureDCD LT recipientsTwo-year overall survivalEnd-stage liver disease scoreMultivariate Cox regression analysisAdult LT recipientsScore matchingLiver transplant recipientsLiver Disease scoreCox regression analysisMachine perfusionUnited Network for Organ SharingUtilization of donationPosttransplant patientsTransplant recipientsAssociated with improvementsNon-MPSOlder donorsUltra-sensitive ctDNA dynamics to capture therapy response in pembrolizumab-treated gastroesophageal cancer.
Nixon A, Navarro F, Zhou K, Abbott C, Howard L, Brady J, Liu Y, Jia J, Niedzwiecki D, Chen R, Strickler J, Boyle S, Uronis H. Ultra-sensitive ctDNA dynamics to capture therapy response in pembrolizumab-treated gastroesophageal cancer. Journal Of Clinical Oncology 2024, 42: 4025-4025. DOI: 10.1200/jco.2024.42.16_suppl.4025.Peer-Reviewed Original ResearchMetastatic esophagogastric cancerMolecular residual diseaseImmune checkpoint blockadeProgression-free survivalCtDNA dynamicsCtDNA levelsHigher hazard ratioOverall survivalDetection of molecular residual diseasePhase II study of pembrolizumabSingle-arm phase II studyWhole-genome sequencingSingle nucleotide variantsMolecular progressionResponse rateStudy of pembrolizumabBaseline prior to treatmentUnivariate Cox regression analysisCox regression analysisFFPE tumor samplesOverall response rateMedian lead timeImprove treatment decision-makingLong-term survivalLiquid biopsy platformImpact of Recipient and Donor Body Mass Index on Survival Outcomes After Intestinal Transplantation: A United Network for Organ Sharing Database Analysis
Ameyaw A, Boateng S, Annor E, Njei B. Impact of Recipient and Donor Body Mass Index on Survival Outcomes After Intestinal Transplantation: A United Network for Organ Sharing Database Analysis. Annals Of Transplantation 2024, 29: e943994-1-e943994-13. PMID: 38978263, PMCID: PMC11299477, DOI: 10.12659/aot.943994.Peer-Reviewed Original ResearchConceptsBody mass indexDonor body mass indexIncreased risk of mortalityIntestinal transplantationRisk of mortalityIT recipientsSurvival outcomesMass indexIncreased riskLong-term patient survivalImpact of body mass indexRecipient body mass indexMultivariate Cox regression analysisKaplan-Meier survival curvesBody mass index categoriesLower body mass indexImprove survival outcomesCox regression analysisRetrospective cohort studyAssociation of recipientPost-transplant mortalityImpact of recipientUnderweight patientsPatient survivalObesity classAdjuvant Chemotherapy and Survival After Radical Cystectomy in Histologic Subtype Bladder Cancer
Koehne E, Bakaloudi D, Ghali F, Nyame Y, Schade G, Grivas P, Yezefski T, Hawley J, Yu E, Hsieh A, Montgomery R, Psutka S, Gore J, Wright J. Adjuvant Chemotherapy and Survival After Radical Cystectomy in Histologic Subtype Bladder Cancer. Clinical Genitourinary Cancer 2024, 22: 102100. PMID: 38763862, DOI: 10.1016/j.clgc.2024.102100.Peer-Reviewed Original ResearchNational Cancer DatabaseAdjuvant chemotherapyReceipt of ACRadical cystectomyBladder cancerOverall survivalAssociated with significantly longer OSAssociated with OS benefitNon-metastatic bladder cancerMultivariate Cox regression analysisPrevalence of adenocarcinomaSquamous cell histologyMultivariate Cox regressionCox regression analysisMultivariate logistic regressionAssociated with lower oddsAssociated with greater oddsNeuroendocrine histologyLonger OSOS benefitCell histologyHistological subtypesCancer DatabaseClinicopathological featuresCox regressionIndications and outcomes of liver transplantation for liver tumors in the United States
Okumura K, Dhand A, Hanna K, Misawa R, Sogawa H, Veillette G, Nishida S. Indications and outcomes of liver transplantation for liver tumors in the United States. Surgery In Practice And Science 2024, 17: 100245. PMID: 39845637, PMCID: PMC11749412, DOI: 10.1016/j.sipas.2024.100245.Peer-Reviewed Original ResearchBile duct cancerLiver transplantationLiver tumorsHepatocellular carcinomaLT recipientsBenign tumorsSecondary tumorsDuct cancerMultivariate Cox regression analysisHighest prevalence of hepatitis COutcome of liver transplantationMultivariate Cox proportional-hazards modelUnited Network for Organ Sharing databaseOutcomes of LTPrevalence of hepatitis CKaplan-Meier methodOne-year survivalCox regression analysisCox proportional-hazards modelProportional-hazards modelNeuroendocrine tumorsSurvival outcomesHepatitis CHepatic tumorsHigher BMIDoes the shape of the copper intrauterine device play a role in expulsion? Results from the ongoing European Active Surveillance Study on LCS12
Boehnke T, Bauerfeind A, Eggebrecht L, Cellier C, Lange J, Heinemann K, Madden T. Does the shape of the copper intrauterine device play a role in expulsion? Results from the ongoing European Active Surveillance Study on LCS12. Contraception 2024, 140: 110444. PMID: 38552821, DOI: 10.1016/j.contraception.2024.110444.Peer-Reviewed Original ResearchConceptsCopper intrauterine deviceEuropean Active Surveillance StudyIntrauterine deviceCopper IUD usersActive surveillance studyNova-TFrameless intrauterine deviceRisk of expulsionIUD usersIntrauterine ballHazard ratioSurveillance studyHeavy menstrual bleedingCox regression analysisIncidence of expulsionHigher risk of expulsionMenstrual bleedingCumulative incidenceCounseling patientsClinical importanceLow riskHigh riskSecondary analysisClinician experienceCliniciansAn algorithm for standardization of tumor Infiltrating lymphocyte evaluation in head and neck cancers
Xirou V, Moutafi M, Bai Y, Nwe Aung T, Burela S, Liu M, Kimple R, Shabbir Ahmed F, Schultz B, Flieder D, Connolly D, Psyrri A, Burtness B, Rimm D. An algorithm for standardization of tumor Infiltrating lymphocyte evaluation in head and neck cancers. Oral Oncology 2024, 152: 106750. PMID: 38547779, PMCID: PMC11060915, DOI: 10.1016/j.oraloncology.2024.106750.Peer-Reviewed Original ResearchConceptsTumor-infiltrating lymphocytesHead and neck cancerTILs evaluationHPV-PositiveNeck cancerPrognostic valueHead and neck squamous cell cancer casesTIL variablesAssociated with favorable prognosisHPV-negative headHPV-negative populationHematoxylin-eosin-stained sectionsCox regression analysisPotential clinical implicationsInter-observer variabilityInfiltrating lymphocytesClinicopathological factorsFavorable prognosisValidation cohortTumor cellsCancer casesProspective settingQuPath softwareRetrospective collectionPredictive significanceA cluster of type I interferon-regulated genes associates with disease activity and prognosis in patients with IgA nephropathy
Qu S, Gan T, Wang Y, Qi Y, Zhang Y, Berthier C, Liu L, Shi S, Lv J, Zhang H, Zhou X. A cluster of type I interferon-regulated genes associates with disease activity and prognosis in patients with IgA nephropathy. International Immunopharmacology 2024, 131: 111920. PMID: 38522142, DOI: 10.1016/j.intimp.2024.111920.Peer-Reviewed Original ResearchIFN-regulated genesIFN-scoreIgAN patientsIgA nephropathyIFN-ITubular atrophy/interstitial fibrosisHigher IFN levelsCox regression analysisPathogenesis of IgA nephropathyType I interferonCross-sectional studyGross hematuriaMucosal infectionsRenal outcomesDisease activityIFN scoreInduce high levelsIFN levelsHealthy controlsMesangial hypercellularityIgANI interferonPatientsTherapeutic targetMicrobial infectionsCerebral Amyloid Angiopathy and Risk of Isolated Nontraumatic Subdural Hemorrhage
Rivier C, Kamel H, Sheth K, Iadecola C, Gupta A, de Leon M, Ross E, Falcone G, Murthy S. Cerebral Amyloid Angiopathy and Risk of Isolated Nontraumatic Subdural Hemorrhage. JAMA Neurology 2024, 81: 163-169. PMID: 38147345, PMCID: PMC10751656, DOI: 10.1001/jamaneurol.2023.4918.Peer-Reviewed Original ResearchCerebral amyloid angiopathyMultivariable logistic regression analysisSubdural hemorrhageLogistic regression analysisIntracerebral hemorrhageIntracranial hemorrhageUK Biobank cohortAmyloid angiopathyMean ageUS cohortRisk factorsHigher oddsDiagnosis of CAAPopulation-based cohort studyBiobank cohortClinical Modification diagnosis codesCAA-related intracerebral hemorrhageCox proportional hazards modelRegression analysisAntithrombotic medication useIndependent risk factorCox regression analysisMultivariable logistic regressionNovel risk factorsSpontaneous intracerebral hemorrhage
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