Intrathecal Dexamethasone as a FIRES Extinguisher: A 12-Patient Clinical Experience with Usage of Intrathecal Dexamethasone for Febrile Infection-Related Epilepsy Syndrome
Farias-Moeller R, Hanin A, Ahsan S, Brooks J, Caganap S, Czeisler B, Cheuret E, Cocuzzo B, Hahn C, Kyureghyan H, Marcoux M, Mohamed R, Park C, Stern Zimmer M, Barun V, Lai Y, Hirsch L. Intrathecal Dexamethasone as a FIRES Extinguisher: A 12-Patient Clinical Experience with Usage of Intrathecal Dexamethasone for Febrile Infection-Related Epilepsy Syndrome. Neurocritical Care 2025, 1-9. PMID: 40279013, DOI: 10.1007/s12028-025-02254-9.Peer-Reviewed Original ResearchFebrile infection-related epilepsy syndromeIT-DEXLong-term outcomesIntrathecal dexamethasoneDosing strategiesEpilepsy syndromesElevated levels of proinflammatory markersLevels of proinflammatory markersRefractory status epilepticusRefractory status epilepticus onsetStatus epilepticus onsetInternational multicenter cohortPersistently elevated levelsEvaluates treatment timeNo adverse effectsMedian doseResultsAll patientsCytokine profileMulticenter cohortCytokine analysisStatus epilepticusClinical outcomesContinuous infusionProinflammatory markersRetrospective analysis
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