2025
The Effect of Prenatal Marijuana Exposure on White Matter Microstructure and Cortical Morphology During Late Childhood.
Acosta-Rodriguez H, Bobba P, Zeevi T, Ment L, Payabvash S. The Effect of Prenatal Marijuana Exposure on White Matter Microstructure and Cortical Morphology During Late Childhood. American Journal Of Neuroradiology 2025, ajnr.a8774. PMID: 40194858, DOI: 10.3174/ajnr.a8774.Peer-Reviewed Original ResearchPrenatal marijuana exposureEffects of prenatal marijuana exposurePrenatal exposure to marijuanaExposure to marijuanaMarijuana exposurePregnant womenWhite matter microstructureBrain neurodevelopmentFractional anisotropyAssociated with brain alterationsAdolescent Brain Cognitive Development StudyLate childhoodReduced cortical surface areaAdolescent Brain Cognitive DevelopmentReduced white matter integrityMarijuana consumptionMarkers of brain healthCross-sectional studyDirect group comparisonsNeonatal outcomesCognitive Development StudyMulticenter cohortNeurite densityWhite matter integrityCortical surface area
2024
Online social activity time predicts ADHD problems in youth from late childhood to early adolescence in the ABCD study
Deng H, Song K, Geng X, Xu L, Zhang J, Li X, He J, Potenza M, Zhang J. Online social activity time predicts ADHD problems in youth from late childhood to early adolescence in the ABCD study. European Child & Adolescent Psychiatry 2024, 1-10. PMID: 39724179, DOI: 10.1007/s00787-024-02620-6.Peer-Reviewed Original ResearchAttention-deficit/hyperactivity disorder problemsAttention-deficit/hyperactivity disorderAdolescent Brain Cognitive DevelopmentEarly adolescenceRandom intercept cross-lagged panel modelDevelopment of attentional processesAdolescent Brain Cognitive Development StudyAdolescent Brain Cognitive Development dataCross-lagged panel modelLongitudinal bidirectional associationsCross-lagged effectsModerating effectPotential moderating effectsADHD problemsRI-CLPMTargeting of interventionsAttentional processesAttention-deficit/hyperactivityModeration analysisBidirectional associationsCognitive developmentLate childhoodLongitudinal associationsChild sexSocial interactionChildhood maltreatment and the structural development of hippocampus across childhood and adolescence
Doretto V, Salto A, Schivoletto S, Zugman A, Oliveira M, Brañas M, Croci M, Ito L, Santoro M, Jackowski A, Bressan R, Rohde L, Salum G, Miguel E, Pan P. Childhood maltreatment and the structural development of hippocampus across childhood and adolescence. Psychological Medicine 2024, 54: 4528-4536. PMID: 39773537, PMCID: PMC11769901, DOI: 10.1017/s0033291724001636.Peer-Reviewed Original ResearchChildhood maltreatmentRight hippocampal volumeHippocampal volumeDepressive disorderCommunity sampleReduced right hippocampal volumeExposure to childhood maltreatmentReduction of hippocampal volumeLongitudinal studyMagnetic resonance imagingPolygenic risk scoresHippocampal structureParent reportLate childhoodSelf-ReportMaltreatmentVolumetric developmentAdolescentsHippocampalChildhoodAged 6Brain magnetic resonance imagingDisordersDevelopment of hippocampusResonance imagingDevelopmental Timing of Associations Among Parenting, Brain Architecture, and Mental Health
Michael C, Gard A, Tillem S, Hardi F, Dunn E, Smith A, McLoyd V, Brooks-Gunn J, Mitchell C, Monk C, Hyde L. Developmental Timing of Associations Among Parenting, Brain Architecture, and Mental Health. JAMA Pediatrics 2024, 178: 1326-1336. PMID: 39466276, PMCID: PMC11581745, DOI: 10.1001/jamapediatrics.2024.4376.Peer-Reviewed Original ResearchConceptsParental psychological aggressionWarm parentingMiddle childhoodMental healthLate childhoodBrain architectureAssociated with mental healthPsychological aggressionLongitudinal birth cohort studyHarsh parentingLong-term health outcomesNeural associationsAssociated with reduced anxietyEarly adulthoodFunctional magnetic resonance imagingYouth-reported anxietyDevelopmental timing of exposureAssociated with brain developmentHealth outcomesMental illnessPopulation-basedMain OutcomesEarly childhoodCumulative associationDepressive symptomsNeurodevelopmental subtypes of functional brain organization in the ABCD study using a rigorous analytic framework
DeRosa J, Friedman N, Calhoun V, Banich M. Neurodevelopmental subtypes of functional brain organization in the ABCD study using a rigorous analytic framework. NeuroImage 2024, 299: 120827. PMID: 39245397, PMCID: PMC11779700, DOI: 10.1016/j.neuroimage.2024.120827.Peer-Reviewed Original ResearchConceptsResting-state functional connectivityAdolescent Brain Cognitive DevelopmentIndividual’s resting-state functional connectivityAdolescent Brain Cognitive Development StudyFunctional brain organizationMental health profilesMental health characteristicsRSFC dataBrain organizationFunctional connectivityDevelopmental trajectoriesChildren Aged 9Emotional functioningCognitive developmentLate childhoodAged 9SubtypesAdolescentsHealth characteristicsHealth profileChildhoodScreen time, sleep, brain structural neurobiology, and sequential associations with child and adolescent psychopathology: Insights from the ABCD study
Zhao Y, Paulus M, Tapert S, Bagot K, Constable R, Yaggi H, Redeker N, Potenza M. Screen time, sleep, brain structural neurobiology, and sequential associations with child and adolescent psychopathology: Insights from the ABCD study. Journal Of Behavioral Addictions 2024, 13: 542-553. PMID: 38662452, PMCID: PMC11220810, DOI: 10.1556/2006.2024.00016.Peer-Reviewed Original ResearchCross-lagged panel modelScreen media activitySleep problemsExternalizing symptomsAdolescent Brain Cognitive Development StudyLate childhoodCognitive Development StudyPredicted sleep problemsSleep durationAssociated with childrenAdolescent psychopathologyPsychopathological symptomsInternalizing symptomsExternalizing behaviorsPsychopathologyABCD studyStructural covarianceBidirectional associationsSleep concernsPredictive relationshipSleep disturbanceShort sleep durationPanel modelBrain covariesSleepEvaluating the sensitivity to threat and affiliative reward (STAR) model in relation to the development of conduct problems and callous‐unemotional traits across early adolescence
Paz Y, Perkins E, Colins O, Perlstein S, Wagner N, Hawes S, Byrd A, Viding E, Waller R. Evaluating the sensitivity to threat and affiliative reward (STAR) model in relation to the development of conduct problems and callous‐unemotional traits across early adolescence. Journal Of Child Psychology And Psychiatry 2024, 65: 1327-1339. PMID: 38480986, PMCID: PMC11393184, DOI: 10.1111/jcpp.13976.Peer-Reviewed Original ResearchCU traitsSensitivity to threatThreat sensitivityLow affiliationConduct problemsCallous-unemotionalAffiliative rewardsParent-reported CU traitsDevelopment of conduct problemsCallous-unemotional traitsTransdiagnostic risk factorSevere conduct problemsChild-reported dataMeasures of affiliationDSM-5Early adolescenceLate childhoodPreliminary evidencePsychopathologyAdolescentsAnxietyEarly childhoodRewardAssessment modalitiesTraitsReciprocal Effects Between Negative Parenting and Children’s Callous-Unemotional Traits From Mid to Late Childhood
Pezzoli P, Pingault J, Malanchini M, Voronin I, McCrory E, Fearon P, Viding E. Reciprocal Effects Between Negative Parenting and Children’s Callous-Unemotional Traits From Mid to Late Childhood. American Journal Of Psychiatry 2024, 181: 310-321. PMID: 38476045, DOI: 10.1176/appi.ajp.20230208.Peer-Reviewed Original ResearchChild CU traitsDevelopment of CU traitsCU traitsMid-to-late childhoodNegative parentingCallous-unemotionalTwins Early Development StudyLate childhoodLongitudinal cross-lagged modelsEffects of negative parentingCallous-unemotional traitsEarly Development StudyReciprocal effectsCross-lagged modelsCross-lagged effectsFamilies of childrenTwin pairsGenetic factorsParental disciplineParental feelingsChildhoodSmall effectsTraitsEnvironmental factorsParents
2023
Youth Screen Media Activity Patterns and Associations With Behavioral Developmental Measures and Resting-state Brain Functional Connectivity
Song K, Zhang J, Zhou N, Fu Y, Zou B, Xu L, Wang Z, Li X, Zhao Y, Potenza M, Fang X, Zhang J. Youth Screen Media Activity Patterns and Associations With Behavioral Developmental Measures and Resting-state Brain Functional Connectivity. Journal Of The American Academy Of Child & Adolescent Psychiatry 2023, 62: 1051-1063. PMID: 36963562, PMCID: PMC10509312, DOI: 10.1016/j.jaac.2023.02.014.Peer-Reviewed Original ResearchConceptsBrain functional connectivityResting-state brain functional connectivityDevelopmental measuresFunctional connectivityHuman participantsTotal behavioral problemsPsychotic-like experiencesPoorer neurocognitive performanceHuman Connectome ProjectCognitive processesAdolescent brainYouth developmentABCD dataHigh impulsivityNeurocognitive performanceBrain measuresPunishment/Behavioral problemsConnectome ProjectLate childhoodLinear mixed effectsBrain areasYouth lifeIndependent samplesParticipants
2022
Cortical profiles of numerous psychiatric disorders and normal development share a common pattern
Cao Z, Cupertino R, Ottino-Gonzalez J, Murphy A, Pancholi D, Juliano A, Chaarani B, Albaugh M, Yuan D, Schwab N, Stafford J, Goudriaan A, Hutchison K, Li C, Luijten M, Groefsema M, Momenan R, Schmaal L, Sinha R, van Holst R, Veltman D, Wiers R, Porjesz B, Lett T, Banaschewski T, Bokde A, Desrivières S, Flor H, Grigis A, Gowland P, Heinz A, Brühl R, Martinot J, Martinot M, Artiges E, Nees F, Orfanos D, Paus T, Poustka L, Hohmann S, Millenet S, Fröhner J, Robinson L, Smolka M, Walter H, Winterer J, Schumann G, Whelan R, Bhatt R, Zhu A, Conrod P, Jahanshad N, Thompson P, Mackey S, Garavan H. Cortical profiles of numerous psychiatric disorders and normal development share a common pattern. Molecular Psychiatry 2022, 28: 698-709. PMID: 36380235, DOI: 10.1038/s41380-022-01855-6.Peer-Reviewed Original ResearchConceptsCortical thicknessPsychiatric disordersNumerous psychiatric disordersNeurological disordersDesikan-Killiany atlasLower cortical thicknessNormative maturationAllen Human Brain AtlasHealthy adult participantsCortical maturationExpression of PC1Cortical changesEmergence of psychopathologyBrain maturationPsychiatric diseasesMultiple gene ontology categoriesHuman Brain AtlasCortical profilesPubertal transitionCT differencesDisordersLate childhoodABCD studyAdult participantsNeurobiological basis
2021
Maternal Prenatal Anxiety and the Fetal Origins of Epigenetic Aging
McGill MG, Pokhvisneva I, Clappison AS, McEwen LM, Beijers R, Tollenaar MS, Pham H, Kee MZL, Garg E, de Mendonça Filho EJ, Karnani N, Silveira PP, Kobor MS, de Weerth C, Meaney MJ, O'Donnell KJ. Maternal Prenatal Anxiety and the Fetal Origins of Epigenetic Aging. Biological Psychiatry 2021, 91: 303-312. PMID: 34756561, DOI: 10.1016/j.biopsych.2021.07.025.Peer-Reviewed Original ResearchConceptsPrenatal maternal anxietyFetal originEpigenetic age accelerationMaternal anxietyAge accelerationPrenatal anxietyMental healthPrenatal maternal mental healthMaternal mental healthYears of ageGenetic risk factorsMonths of ageMental health supportMaternal prenatal anxietyRisk factorsLongitudinal cohortPrenatal adversityPregnant individualsLarge effect sizesLongitudinal assessmentHealth supportEffective mental health supportCohortPrenatal environmentLate childhood
2020
Functional neural network configuration in late childhood varies by age and cognitive state
Le TM, Huang AS, O’Rawe J, Leung HC. Functional neural network configuration in late childhood varies by age and cognitive state. Developmental Cognitive Neuroscience 2020, 45: 100862. PMID: 32920279, PMCID: PMC7494462, DOI: 10.1016/j.dcn.2020.100862.Peer-Reviewed Original ResearchConceptsWhole-brain networksCognitive demandsLate childhoodConnectivity patternsFunctional network characteristicsFunctional network connectivityNetwork connectivity patternsPerceptual tasksFrontoparietal networkVisual processingCognitive developmentCognitive stateVisual perceptionBehavioral performanceTask statesEarly adolescenceBrain maturationConnectivity profilesDistinct tasksYoung adultsNeural network configurationMemoryNetwork architectureExploratory analysisTaskChapter 4 The development of multisensory processes for perceiving the environment and the self
Lewkowicz D, Bremner A. Chapter 4 The development of multisensory processes for perceiving the environment and the self. 2020, 89-112. DOI: 10.1016/b978-0-12-812492-5.00004-8.Peer-Reviewed Original ResearchAudiovisual perceptionVisuotactile perceptionAudiovisual inputYoung children's abilityEndogenous attentionMultisensory processesMultisensory processingSelective attentionPerceptual abilitiesEarly experienceChildren's abilitySensorimotor abilitiesInfants' responsesGreater salienceLate childhoodOwn bodySocial surroundingsTactile inputPerceptionEmpirical findingsSelfEmpirical evidenceInfancyAbilityAttention
2019
Are serum brain-derived neurotrophic factor concentrations related to brain structure and psychopathology in late childhood and early adolescence?
de Araujo C, Swardfager W, Zugman A, Cogo-Moreira H, Belangero S, Ota V, Spindola L, Hakonarson H, Pellegrino R, Gadelha A, Salum G, Pan P, Mansur R, Hoexter M, Picon F, Sato J, Brietzke E, Grassi-Oliveira R, Rohde L, Miguel E, Bressan R, Jackowski A. Are serum brain-derived neurotrophic factor concentrations related to brain structure and psychopathology in late childhood and early adolescence? CNS Spectrums 2019, 25: 790-796. PMID: 31845634, DOI: 10.1017/s1092852919001688.Peer-Reviewed Original ResearchConceptsSerum BDNF concentrationsBrain-derived neurotrophic factorBDNF concentrationsBDNF genotypeCortical thicknessPsychiatric disordersSerum brain-derived neurotrophic factor (BDNF) concentrationsBrain-derived neurotrophic factor concentrationSubcortical volumesMental disordersWell-Being Behavior AssessmentBrain structuresBDNF serum concentrationsNeurotrophic factor concentrationsPeripheral blood concentrationsHigh Risk Cohort StudyLate childhoodAdult psychiatric disordersLarge independent samplesCohort studyNeurotrophic factorCortical maturationSerum concentrationsBlood concentrationsMet carriersAssociation between spontaneous activity of the default mode network hubs and leukocyte telomere length in late childhood and early adolescence
Rebello K, Moura L, Xavier G, Spindola L, Carvalho C, Hoexter M, Gadelha A, Picon F, Pan P, Zugman A, Grassi-Oliveira R, Brietzke E, Belangero S, Salum G, Rohde L, Miguel E, Bressan R, Jackowski A, Sato J. Association between spontaneous activity of the default mode network hubs and leukocyte telomere length in late childhood and early adolescence. Journal Of Psychosomatic Research 2019, 127: 109864. PMID: 31706071, DOI: 10.1016/j.jpsychores.2019.109864.Peer-Reviewed Original ResearchConceptsAdverse childhood experiencesMedial prefrontal cortexPosterior cingulate cortexDefault mode networkResting-state functional magnetic resonanceEarly life stressBrain's default mode networkFunctional magnetic resonanceBlood samplesSpontaneous activityDefault mode network hubCingulate cortexDMN hubsPsychiatric conditionsFamily environmentLength shorteningPrefrontal cortexMental healthFractional amplitudeLow-frequency fluctuationsMode networkFamily Environment ScaleHypothesis-driven studiesTelomere lengthLate childhood
2015
Restricted and Repetitive Behaviors as Predictors of Outcome in Autism Spectrum Disorders
Troyb E, Knoch K, Herlihy L, Stevens MC, Chen CM, Barton M, Treadwell K, Fein D. Restricted and Repetitive Behaviors as Predictors of Outcome in Autism Spectrum Disorders. Journal Of Autism And Developmental Disorders 2015, 46: 1282-1296. PMID: 26676629, PMCID: PMC8054273, DOI: 10.1007/s10803-015-2668-2.Peer-Reviewed Original ResearchConceptsAutism spectrum disorderSpectrum disorderRepetitive behaviorsGreater ASD symptom severityAge 8ASD symptom severityParts of objectsASD symptomatologyCognitive functioningAdaptive skillsSensory interestsStereotyped motor movementsPreschool yearsMotor movementsLate childhoodSymptom severityAdaptive abilityRRBsChildrenPredictors of outcomeOutcome of childrenDisordersFunctioningSkillsSymptomatologyCellular and Deafness Mechanisms Underlying Connexin Mutation-Induced Hearing Loss – A Common Hereditary Deafness
Wingard J, Zhao H. Cellular and Deafness Mechanisms Underlying Connexin Mutation-Induced Hearing Loss – A Common Hereditary Deafness. Frontiers In Cellular Neuroscience 2015, 9: 202. PMID: 26074771, PMCID: PMC4448512, DOI: 10.3389/fncel.2015.00202.Peer-Reviewed Original ResearchHearing lossPathological changesDeafness mechanismCongenital deafnessActive cochlear amplificationProgressive hearing lossDetailed cellular mechanismsCochlear hair cellsHair cell degenerationHereditary deafnessConnexin 26 mutationsDistinct pathological changesNon-syndromic hearing lossProfound congenital deafnessAuditory phenotypeHigh incidenceTherapeutic strategiesGap junctional proteinCell degenerationConnexin expressionHair cellsDeafnessCellular mechanismsLate childhoodCx26 mutations
2014
Age effects on the default mode and control networks in typically developing children
Sato J, Salum G, Gadelha A, Picon F, Pan P, Vieira G, Zugman A, Hoexter M, Anés M, Moura L, Del'Aquilla M, Amaro E, McGuire P, Crossley N, Lacerda A, Rohde L, Miguel E, Bressan R, Jackowski A. Age effects on the default mode and control networks in typically developing children. Journal Of Psychiatric Research 2014, 58: 89-95. PMID: 25085608, DOI: 10.1016/j.jpsychires.2014.07.004.Peer-Reviewed Original ResearchConceptsDefault mode networkMode networkYears of ageCross-sectional community sampleRight anterior insulaDefault modePosterior temporal cortexDorsal anteriorAge effectsNeurodevelopment studiesHealthy subjectsTemporal cortexPosterior cingulateState fMRI dataAnterior insulaBrain developmentSame acquisition parametersLeft posterior temporal cortexNeuronal modulesState fMRILate childhoodDevelopmental formationBrain networksCommunity sampleField of neuroimagingPrimary hypertrophic osteoarthropathy caused by homozygous deletion in HPGD gene in a family: changing clinical and radiological findings with long-term follow-up
Tüysüz B, Yılmaz S, Kasapçopur Ö, Erener-Ercan T, Ceyhun E, Bilguvar K, Günel M. Primary hypertrophic osteoarthropathy caused by homozygous deletion in HPGD gene in a family: changing clinical and radiological findings with long-term follow-up. Rheumatology International 2014, 34: 1539-1544. PMID: 24816859, DOI: 10.1007/s00296-014-3037-8.Peer-Reviewed Original ResearchConceptsRadiological findingsClinical findingsDigital clubbingHPGD geneYears of agePrimary hypertrophic osteoarthropathyMonths of ageHomozygous deletionPainful swellingHypertrophic osteoarthropathyInfantile periodPalmoplantar hyperkeratosisHand radiographsOssification defectsHomozygous mutationIntrafamilial variabilityLate childhoodAgePatientsClubbingMonthsFindingsSiblingsExon 3Years
2008
Neuroimaging Studies of Normal Brain Development and Their Relevance for Understanding Childhood Neuropsychiatric Disorders
Marsh R, Gerber A, Peterson B. Neuroimaging Studies of Normal Brain Development and Their Relevance for Understanding Childhood Neuropsychiatric Disorders. Journal Of The American Academy Of Child & Adolescent Psychiatry 2008, 47: 1233-1251. PMID: 18833009, PMCID: PMC2759682, DOI: 10.1097/chi.0b013e318185e703.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAge FactorsAgedAged, 80 and overAnimalsAtrophyAttentionBrainChildChild, PreschoolDiffusion Magnetic Resonance ImagingEmotionsFemaleHumansImage Processing, Computer-AssistedImaging, Three-DimensionalInfantInfant, NewbornMagnetic Resonance ImagingMagnetic Resonance SpectroscopyMental DisordersMiddle AgedNeuropsychological TestsPregnancyYoung AdultConceptsEarly brain developmentChildhood psychiatric disordersAttention-deficit/hyperactivity disorderHigher-order cognitive functionsLate childhoodBrain developmentDorsolateral prefrontal cortexNormal developmental trajectoryFunctional imaging findingsDevelopmental dyslexiaPsychiatric disordersNormal brain developmentHyperactivity disorderChildhood neuropsychiatric disordersDevelopmental trajectoriesCognitive functionPrefrontal cortexSuperior temporalFrontal cortexChildhood-onset schizophreniaSensorimotor areasHealthy individualsLongitudinal dataAdolescenceDevelopmental patterns
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