2023
Performance of Thrombectomy-Capable, Comprehensive, and Primary Stroke Centers in Reperfusion Therapies for Acute Ischemic Stroke: Report From the Get With The Guidelines–Stroke Registry
Raychev R, Sun J, Schwamm L, Smith E, Fonarow G, Messé S, Xian Y, Chiswell K, Blanco R, Mac Grory B, Saver J. Performance of Thrombectomy-Capable, Comprehensive, and Primary Stroke Centers in Reperfusion Therapies for Acute Ischemic Stroke: Report From the Get With The Guidelines–Stroke Registry. Circulation 2023, 148: 2019-2028. PMID: 37855118, DOI: 10.1161/circulationaha.123.066114.Peer-Reviewed Original ResearchConceptsComprehensive stroke centerPrimary stroke centerThrombectomy-capable stroke centersAcute ischemic strokeGuidelines-Stroke registryEndovascular thrombectomyStroke centersReperfusion therapyIschemic strokeClinical outcomesHealth Stroke Scale scoreClinical efficacy outcomesStroke Scale scoreHigher National InstitutesOdds of dischargeGoal doorEVT proceduresHospital mortalityIntravenous thrombolysisEfficacy outcomesSuccessful reperfusionCohort studyDischarge destinationNeedle timePuncture timeASPECTS evolution after endovascular successful reperfusion in the early and extended time window.
Anadani M, Finitsis S, Pop R, Darcourt J, Clarençon F, Richard S, de Havenon A, Liebeskind D, Marnat G, Bourcier R, Sibon I, Dargazanli C, Arquizan C, Blanc R, Lapergue B, Consoli A, Eugène F, Vannier S, Caroff J, Denier C, Boulanger M, Gauberti M, Saleme S, Macian F, Rosso C, Turc G, Ozkul-Wermester O, Papagiannaki C, Olivot J, Le Bras A, Evain S, Wolff V, Timsit S, Gentric J, Bourdain F, Veunac L, Maïer B, Ben Hassen W, Gory B. ASPECTS evolution after endovascular successful reperfusion in the early and extended time window. Interventional Neuroradiology 2023, 15910199231196953. PMID: 37671452, DOI: 10.1177/15910199231196953.Peer-Reviewed Original ResearchSuccessful reperfusionEndovascular therapySafety outcomesAlberta Stroke Program Early CTAnterior circulation large vessel occlusionEarly neurological improvementProspective multicenter registrySuccessful endovascular therapyLarge vessel occlusionExtended time windowIncomplete reperfusionEarly CTMulticenter registryNeurological improvementStroke severityComplete reperfusionParenchymal hemorrhageStroke patientsExcellent outcomesInfarct extentVessel occlusionFavorable outcomeGood collateralsReliable imaging biomarkerReperfusionClinical and Safety Outcomes of Endovascular Therapy 6 to 24 Hours After Large Vessel Occlusion Ischemic Stroke With Tandem Lesions
Galecio-Castillo M, Farooqui M, Hassan A, Jumaa M, Divani A, Ribo M, Abraham M, Petersen N, Fifi J, Guerrero W, Malik A, Siegler J, Nguyen T, Sheth S, Yoo A, Linares G, Janjua N, Quispe-Orozco D, Tekle W, Zaidi S, Sabbagh S, Olivé-Gadea M, Barkley T, De Leacy R, Sprankle K, Abdalkader M, Salazar-Marioni S, Soomro J, Gordon W, Turabova C, Vivanco-Suarez J, Rodriguez-Calienes A, Mokin M, Yavagal D, Jovin T, Ortega-Gutierrez S. Clinical and Safety Outcomes of Endovascular Therapy 6 to 24 Hours After Large Vessel Occlusion Ischemic Stroke With Tandem Lesions. Journal Of Stroke 2023, 25: 378-387. PMID: 37607694, PMCID: PMC10574302, DOI: 10.5853/jos.2023.00759.Peer-Reviewed Original ResearchSymptomatic intracranial hemorrhageSafety outcomesMRS 0Secondary outcomesEndovascular therapyTandem lesionsLarge vessel occlusion ischemic strokeLower median National InstitutesHealth Stroke Scale scoreLarge vessel occlusion patientsEarly neurological improvementMedian National InstitutesStroke Scale scoreAlberta Stroke ProgramModified Rankin ScaleFirst-pass effectEarly windowIntravenous thrombolysisOrdinal mRSNeurological improvementSuccessful reperfusionTomography ScoreIschemic strokeRankin ScaleStroke ProgramSafety Outcomes of Mechanical Thrombectomy Versus Combined Thrombectomy and Intravenous Thrombolysis in Tandem Lesions
Rodriguez-Calienes A, Galecio-Castillo M, Farooqui M, Hassan A, Jumaa M, Divani A, Ribo M, Abraham M, Petersen N, Fifi J, Guerrero W, Malik A, Siegler J, Nguyen T, Yoo A, Linares G, Janjua N, Quispe-Orozco D, Tekle W, Alhajala H, Ikram A, Rizzo F, Qureshi A, Begunova L, Matsoukas S, Vigilante N, Salazar-Marioni S, Abdalkader M, Gordon W, Soomro J, Turabova C, Vivanco-Suarez J, Mokin M, Yavagal D, Jovin T, Sheth S, Ortega-Gutierrez S. Safety Outcomes of Mechanical Thrombectomy Versus Combined Thrombectomy and Intravenous Thrombolysis in Tandem Lesions. Stroke 2023, 54: 2522-2533. PMID: 37602387, PMCID: PMC10599264, DOI: 10.1161/strokeaha.123.042966.Peer-Reviewed Original ResearchConceptsRisk of sICHParenchymal hematoma type 2Symptomatic intracranial hemorrhageRankin Scale score 0Intravenous antiplatelet therapyIntravenous thrombolysisFavorable functional outcomeMechanical thrombectomyHemorrhagic transformationFunctional outcomeType 2Antiplatelet therapyHospital mortalitySuccessful reperfusionComplete reperfusionScore 0Tandem lesionsAnterior circulation tandem lesionsExcellent functional outcomeIVT treatmentStroke centersMulticenter cohortPrimary outcomeRevascularization techniquesAlone group
2022
Safety and efficacy of intensive systolic blood pressure lowering after successful endovascular therapy: a post hoc analysis of the BP TARGET trial
Anadani M, Maier B, Escalard S, Labreuche J, de Havenon A, Sabben C, Lapergue B, Mistry EA, Gory B, Spiotta AM, Richard S, Sibon I, Desilles JP, Blanc R, Piotin M, Mazighi M. Safety and efficacy of intensive systolic blood pressure lowering after successful endovascular therapy: a post hoc analysis of the BP TARGET trial. Journal Of NeuroInterventional Surgery 2022, 15: e142-e147. PMID: 36220337, DOI: 10.1136/jnis-2022-019130.Peer-Reviewed Original ResearchConceptsIntensive SBP treatmentHistory of hypertensionBlood pressure treatmentSuccessful endovascular therapyIntravenous thrombolysisLocation of occlusionEndovascular therapySBP treatmentAdmission SBPDiabetic patientsIntensive blood pressure loweringIntensive systolic blood pressureAcute ischemic stroke trialsTarget trialsEffect of SBPBlood pressure loweringNon-diabetic patientsFavorable functional outcomeSystolic blood pressureIschemic stroke trialsSite of occlusionIntensive SBPRecanalization statusSuccessful reperfusionBlood pressureStroke Severity and Early Ischemic Changes Predict Infarct Growth Rate and Clinical Outcomes in Patients With Large‐Vessel Occlusion
Quispe‐Orozco D, Sequeiros J, Farooqui M, Zevallos C, Mendez‐Ruiz A, Dajles A, Kobsa J, Prasad A, Petersen N, Ortega‐Gutierrez S. Stroke Severity and Early Ischemic Changes Predict Infarct Growth Rate and Clinical Outcomes in Patients With Large‐Vessel Occlusion. Stroke Vascular And Interventional Neurology 2022, 2 DOI: 10.1161/svin.121.000182.Peer-Reviewed Original ResearchAlberta Stroke Program Early CT ScoreHealth Stroke Scale scoreStroke Scale scoreEarly ischemic changesFast progressorsScale scoreSuccessful reperfusionStroke severityEndovascular therapyIschemic changesClinical outcomesNational InstituteAnterior circulation large vessel occlusion strokeRetrospective cohort observational studyLarge vessel occlusion strokeInfarct growth ratesComprehensive stroke centerHealth Stroke ScaleCohort observational studyFinal infarct volumeLarge vessel occlusionMultivariate logistic regressionIschemic stroke progressionYouden's J indexInfarct progression
2021
Blood Pressure Management After Endovascular Thrombectomy
Peng TJ, Ortega-Gutiérrez S, de Havenon A, Petersen NH. Blood Pressure Management After Endovascular Thrombectomy. Frontiers In Neurology 2021, 12: 723461. PMID: 34539562, PMCID: PMC8446280, DOI: 10.3389/fneur.2021.723461.Peer-Reviewed Original ResearchEndovascular thrombectomyBlood pressureBP targetsAnterior circulation large vessel occlusion strokeImmediate post-stroke periodLower blood pressure targetsLarge vessel occlusion strokeAdequate BP targetsBlood pressure targetsOptimal hemodynamic managementOverall hemodynamic statusPost-stroke periodAcute stroke therapyBlood pressure managementDegree of reperfusionPotential neuroprotective strategiesIndividual patient factorsStandard of careBlood pressure optimizationNovel treatment strategiesWorse clinical recoveryBP controlKey observational studiesSuccessful reperfusionClinical recoveryEndovascular Therapy of Anterior Circulation Tandem Occlusions
Anadani M, Marnat G, Consoli A, Papanagiotou P, Nogueira RG, Siddiqui A, Ribo M, Spiotta AM, Bourcier R, Kyheng M, Labreuche J, de Havenon A, Sibon I, Dargazanli C, Arquizan C, Cognard C, Olivot JM, Anxionnat R, Audibert G, Mazighi M, Blanc R, Lapergue B, Richard S, Gory B, Turjman F, Piotin M, Steglich-Arnholm H, Holtmannspötter M, Taschner C, Eiden S, Haussen D, Boutchakova M, Dorn F, Killer-Oberpfalzer M, Mangiafico S, Psychogios M, Labeyrie M, Biondi A, Bracard S, Grossberg J, Guenego A, Darcourt J, Vukasinovic I, Pomero E, Davies J, Renieri L, Hecker C, Muchada M, Rodesch G, Houdart E, Lockau J, Kastrup A, Redjem H, Behme D, Shallwani H, Christopher M, Mione G, Humbertjean L, Riou-Comte N, Zhu F, Derelle A, Liao L, Piotin M, Redjem H, Escalard S, Maïer B, Desilles J, Ciccio G, Smajda S, Obadia M, Sabben C, Corabianu O, de Broucker T, Smadja D, Alamowitch S, Ille O, Manchon E, Garcia P, Taylor G, Maacha M, Wang A, Evrard S, Tchikviladze M, Ajili N, Weisenburger D, Gorza L, Coskun O, Di Maria F, Rodesh G, Leguen M, Gratieux J, Pico F, Rakotoharinandrasana H, Tassan P, Poll R, Marinier S, Gariel F, Barreau X, Berge J, Veunac L, Menegon P, Lucas L, Olindo S, Renou P, Sagnier S, Poli M, Debruxelles S, Tourdias T, Liegey J, Detraz L, Daumas-Duport B, Alexandre P, Roy M, Lenoble C, L’allinec V, Girot J, Desal H, Bechiri F, Bracard S, Braun M, Derelle A, Tonnelet R, Liao L, Zhu F, Schmitt E, Planel S, Humbertjean L, Mione G, Lacour J, Hossu G, Beaumont M, Bailang M, Reitter M, Masson A, Alb L, Tabarna A, Voicu M, Podar I, Brezeanu M, Guy S, Costalat V, Gascou G, Lefèvre P, Derraz I, Riquelme C, Gaillard N, Mourand I, Corti L. Endovascular Therapy of Anterior Circulation Tandem Occlusions. Stroke 2021, 52: 3097-3105. PMID: 34372671, DOI: 10.1161/strokeaha.120.033032.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overAnterior Cerebral ArteryArterial Occlusive DiseasesCarotid Artery, InternalCarotid Artery, Internal, DissectionCerebral HemorrhageEndovascular ProceduresFemaleFranceHumansIntracranial ArteriosclerosisIschemic StrokeMaleMiddle AgedPatient SafetyPropensity ScoreRegistriesStentsStrokeThrombectomyTreatment OutcomeConceptsAnterior circulation tandem occlusionTandem occlusion strokeAcute ischemic strokeStent groupEndovascular therapyIntracerebral hemorrhageTandem occlusionsHigher oddsFavorable outcomeIschemic strokeOcclusion strokeTreatment approachesParenchymal hemorrhage type 2Internal carotid artery lesionsPropensity score-adjusted analysisAcute carotid stentingSymptomatic intracerebral hemorrhageCarotid artery lesionsIndividual patient dataBest treatment approachCurrent clinical practiceDifferent treatment approachesHigh rateSuccessful reperfusionAnterior circulationCollateral status reperfusion and outcomes after endovascular therapy: insight from the Endovascular Treatment in Ischemic Stroke (ETIS) Registry
Anadani M, Finitsis S, Clarençon F, Richard S, Marnat G, Bourcier R, Sibon I, Dargazanli C, Arquizan C, Blanc R, Lapergue B, Consoli A, Eugene F, Vannier S, Spelle L, Denier C, Boulanger M, Gauberti M, Liebeskind DS, de Havenon A, Saleme S, Macian F, Rosso C, Naggara O, Turc G, Ozkul-Wermester O, Papagiannaki C, Viguier A, Cognard C, Le Bras A, Evain S, Wolff V, Pop R, Timsit S, Gentric JC, Bourdain F, Veunac L, Maier B, Gory B. Collateral status reperfusion and outcomes after endovascular therapy: insight from the Endovascular Treatment in Ischemic Stroke (ETIS) Registry. Journal Of NeuroInterventional Surgery 2021, 14: 551-557. PMID: 34140288, DOI: 10.1136/neurintsurg-2021-017553.Peer-Reviewed Original ResearchConceptsIschemic Stroke RegistryPoor collateral groupSuccessful reperfusionCollateral statusEndovascular therapyGood collateralsEVT outcomesStroke RegistryCollateral groupEndovascular treatmentFunctional outcomeFavorable outcomeHigher oddsTherapeutic Neuroradiology/SocietyInterventional Radiology guidelinesPoor collateralsPretreatment angiogramsClinical benefitExcellent outcomesRadiology guidelinesReperfusionLower oddsBetter outcomesSignificant interactionOutcomesEndovascular therapy with or without intravenous thrombolysis in acute stroke with tandem occlusion
Anadani M, Marnat G, Consoli A, Papanagiotou P, Nogueira RG, Spiotta AM, Bourcier R, Kyheng M, Labreuche J, Siddiqui AH, Ribo M, de Havenon A, Fischer U, Sibon I, Dargazanli C, Arquizan C, Cognard C, Olivot JM, Anxionnat R, Audibert G, Mazighi M, Blanc R, Lapergue B, Richard S, Gory B, Investigators T. Endovascular therapy with or without intravenous thrombolysis in acute stroke with tandem occlusion. Journal Of NeuroInterventional Surgery 2021, 14: 314-320. PMID: 33911016, DOI: 10.1136/neurintsurg-2020-017202.Peer-Reviewed Original ResearchConceptsCervical internal carotid arteryIntravenous thrombolysisAcute ischemic strokeTandem occlusionsEndovascular therapyInternal carotid arteryFavorable outcomeAcute strokeIschemic strokeCarotid arteryHigher oddsAnterior circulation tandem occlusionAcute tandem occlusionIschemic Stroke RegistrySignificant hemorrhagic complicationsIVT treatmentHemorrhagic complicationsStroke RegistrySuccessful reperfusionRankin ScaleConsecutive patientsIPTW analysisPrimary outcomeEndovascular treatmentPuncture timeDuration of symptomatic stroke and successful reperfusion with endovascular thrombectomy for anterior circulation large vessel occlusive stroke
de Havenon A, Alexander MD, Nogueira RG, Haussen DC, Castonguay AC, Linfante I, Johnson MA, Nguyen TN, Mokin M, Zaidat OO. Duration of symptomatic stroke and successful reperfusion with endovascular thrombectomy for anterior circulation large vessel occlusive stroke. Journal Of NeuroInterventional Surgery 2021, 13: 1128-1131. PMID: 33526478, PMCID: PMC8325713, DOI: 10.1136/neurintsurg-2020-016961.Peer-Reviewed Original ResearchConceptsAcute ischemic stroke patientsIschemic stroke patientsSymptomatic strokeSuccessful reperfusionLogistic regression modelsAcute strokeEndovascular therapyStroke patientsLarge vessel occlusive strokeAnterior circulation occlusionCerebral Infarction scoreReal-world cohortLarge vessel occlusionBalloon guide catheterMiddle cerebral arteryIndividual patient dataInternal carotid arteryProbability of reperfusionLower ratesOcclusive strokeEndovascular thrombectomyMechanical thrombectomySecondary outcomesStroke onsetPrimary outcome
2020
Benefit of endovascular thrombectomy for M2 middle cerebral artery occlusion in the ARISE II study
de Havenon A, Narata AP, Amelot A, Saver JL, Bozorgchami H, Mattle HP, Ribo M, Andersson T, Zaidat OO, investigators A. Benefit of endovascular thrombectomy for M2 middle cerebral artery occlusion in the ARISE II study. Journal Of NeuroInterventional Surgery 2020, 13: 779-783. PMID: 33219148, PMCID: PMC8134506, DOI: 10.1136/neurintsurg-2020-016427.Peer-Reviewed Original ResearchConceptsMiddle cerebral artery occlusionM2 occlusionsCerebral artery occlusionM1 occlusionEndovascular thrombectomyAdverse eventsBetter outcomesArtery occlusionIschemic strokeReperfusion ratesM2-segment middle cerebral artery occlusionM2 middle cerebral artery occlusionsScale scoreHealth Stroke Scale scoreBaseline National InstitutesStroke Scale scoreAcute ischemic strokeMajor adverse eventsRankin Scale scorePaucity of dataLogistic regression modelsII trialSuccessful reperfusionII studyPrespecified analysisThe Effect of Hyperglycemia on Infarct Growth after Reperfusion: An Analysis of the DEFUSE 3 trial
Yaghi S, Dehkharghani S, Raz E, Jayaraman M, Tanweer O, Grory BM, Henninger N, Lansberg MG, Albers GW, Havenon A. The Effect of Hyperglycemia on Infarct Growth after Reperfusion: An Analysis of the DEFUSE 3 trial. Journal Of Stroke And Cerebrovascular Diseases 2020, 30: 105380. PMID: 33166769, PMCID: PMC7736545, DOI: 10.1016/j.jstrokecerebrovasdis.2020.105380.Peer-Reviewed Original ResearchConceptsDEFUSE-3 trialsBaseline glucose levelsInfarct growthGlucose levelsPrimary outcomeAcute ischemic stroke patientsAggressive glycemic controlDEFUSE 3 patientsIschemic core volumePotential neuroprotective benefitsIschemic stroke patientsGood functional outcomeLarge vessel occlusionEffects of hyperglycemiaSuccessful endovascular reperfusionAdmission glucoseInfarction growthEndovascular reperfusionSuccessful reperfusionTICI 2bIschemic strokeNeuroprotective benefitsEndovascular therapyGlycemic controlStroke patients
2019
Blood pressure reduction and outcome after endovascular therapy with successful reperfusion: a multicenter study
Anadani M, Arthur AS, Alawieh A, Orabi Y, Alexandrov A, Goyal N, Psychogios MN, Maier I, Kim JT, Keyrouz SG, de Havenon A, Petersen NH, Pandhi A, Swisher CB, Inamullah O, Liman J, Kodali S, Giles JA, Allen M, Wolfe SQ, Tsivgoulis G, Cagle BA, Oravec CS, Gory B, De Marini P, Kan P, Rahman S, Richard S, Nascimento FA, Spiotta A. Blood pressure reduction and outcome after endovascular therapy with successful reperfusion: a multicenter study. Journal Of NeuroInterventional Surgery 2019, 12: 932-936. PMID: 31806668, PMCID: PMC7998040, DOI: 10.1136/neurintsurg-2019-015561.Peer-Reviewed Original ResearchConceptsSBP reductionSystolic blood pressureSuccessful reperfusionMechanical thrombectomyPoor outcomeSafety outcomesAnterior circulation large vessel occlusionElevated systolic blood pressureModified Rankin Scale scoreBlood pressure reductionComprehensive stroke centerSymptomatic intracerebral hemorrhageAcute ischemic strokeMulticenter retrospective studyRankin Scale scoreLarge vessel occlusionIncomplete reperfusionReperfusion statusSafety endpointIschemic strokeStroke centersBlood pressureComplete reperfusionEndovascular therapyIntracerebral hemorrhage
2018
Time From Imaging to Endovascular Reperfusion Predicts Outcome in Acute Stroke
Tsai JP, Mlynash M, Christensen S, Kemp S, Kim S, Mishra NK, Federau C, Nogueira RG, Jovin TG, Devlin TG, Akhtar N, Yavagal DR, Bammer R, Straka M, Zaharchuk G, Marks MP, Albers GW, Lansberg MG. Time From Imaging to Endovascular Reperfusion Predicts Outcome in Acute Stroke. Stroke 2018, 49: 952-957. PMID: 29581341, PMCID: PMC5875452, DOI: 10.1161/strokeaha.117.018858.Peer-Reviewed Original ResearchMeSH KeywordsActivities of Daily LivingAgedAngiography, Digital SubtractionCerebral AngiographyCohort StudiesEndovascular ProceduresFemaleHumansInfarction, Middle Cerebral ArteryMaleMiddle AgedPerfusion ImagingPrognosisRecovery of FunctionReperfusionStrokeThrombectomyTime-to-TreatmentTomography, X-Ray ComputedTreatment OutcomeConceptsTarget mismatch profileReperfusion timeFunctional independenceMismatch profileInfarct growthCTP scansLarger final infarct volumeTarget mismatch patientsAcute ischemic strokeCohort of patientsFinal infarct volumeTarget mismatchSuccessful endovascular reperfusionMismatch patientsEndovascular reperfusionInfarct volumeRadiological outcomesSuccessful reperfusionAcute strokeIschemic strokeRadiographic outcomesEndovascular therapyBaseline imagingMalignant profileTomographic perfusion
2016
Endovascular Stroke Treatment Outcomes After Patient Selection Based on Magnetic Resonance Imaging and Clinical Criteria
Leslie-Mazwi TM, Hirsch JA, Falcone GJ, Schaefer PW, Lev MH, Rabinov JD, Rost NS, Schwamm L, González RG. Endovascular Stroke Treatment Outcomes After Patient Selection Based on Magnetic Resonance Imaging and Clinical Criteria. JAMA Neurology 2016, 73: 1-7. PMID: 26524074, DOI: 10.1001/jamaneurol.2015.3000.Peer-Reviewed Original ResearchConceptsMagnetic resonance imagingSelection of patientsClinical criteriaFavorable outcomeSuccessful reperfusionMRS scoreLTB patientsIschemic strokeTerminal internal carotid artery occlusionResonance imagingInternal carotid artery occlusionStroke treatment outcomesEndovascular stroke treatmentAcute ischemic strokeCarotid artery occlusionProspective cohort studyMiddle cerebral arterySpecific magnetic resonance imagingInfarct volume determinationArtery occlusionCohort studyStroke treatmentCerebral arteryEndovascular treatmentPatient selection
2009
Mismatch-Based Delayed Thrombolysis
Mishra NK, Albers GW, Davis SM, Donnan GA, Furlan AJ, Hacke W, Lees KR. Mismatch-Based Delayed Thrombolysis. Stroke 2009, 41: e25-e33. PMID: 19926836, DOI: 10.1161/strokeaha.109.566869.Peer-Reviewed Original ResearchConceptsSymptomatic intracerebral hemorrhageIntracerebral hemorrhageFavorable outcomeMismatch patientsSuccessful reperfusionStroke onsetClinical outcomesClinical benefitRecanalization/reperfusionPhase III trialsFavorable clinical outcomeWeb of KnowledgeDelayed thrombolysisMismatch selectionThrombolysis trialsIII trialsRelevant trialsCase seriesRoutine careThrombolytic therapyClinical findingsClinical trialsImproved outcomesOdds ratioPretreatment imaging
1991
Reperfusion arrhythmias after thrombolysis. Electrophysiologic tempest, or much ado about nothing.
Krumholz HM, Goldberger AL. Reperfusion arrhythmias after thrombolysis. Electrophysiologic tempest, or much ado about nothing. CHEST Journal 1991, 99: 135s-140s. PMID: 2009810, DOI: 10.1378/chest.99.4.135s.Peer-Reviewed Original ResearchConceptsThrombolytic therapyMyocardial infarctionAcute myocardial infarctionSignificant clinical interestReperfusion arrhythmiasSuccessful reperfusionMyocardial reperfusionIdioventricular rhythmClinical eventsVentricular tachyarrhythmiasNoninvasive markerAnimal studiesArrhythmiasConsistent markerReperfusionClinical interestInfarctionTherapyCurrent dataMarkersThrombolysisTachyarrhythmias
1990
Serial changes in myocardial perfusion using tomographic technetium-99m-hexakis-2-methoxy-2-methylpropyl-isonitrile imaging following reperfusion therapy of myocardial infarction.
Pellikka P, Behrenbeck T, Verani M, Mahmarian J, Wackers F, Gibbons R. Serial changes in myocardial perfusion using tomographic technetium-99m-hexakis-2-methoxy-2-methylpropyl-isonitrile imaging following reperfusion therapy of myocardial infarction. Journal Of Nuclear Medicine 1990, 31: 1269-75. PMID: 2143527.Peer-Reviewed Original ResearchConceptsReperfusion therapyMyocardial infarctionTc-sestamibiAcute reperfusion therapyFirst myocardial infarctionSuccessful reperfusionTomographic myocardial perfusion imagesSerial changesHypoperfused myocardiumMean decreaseFinal studyMyocardial perfusionPatientsSignificant improvementMyocardial perfusion imagesSecond studyTherapyPerfusion imagesReperfusionInfarctionPerfusionFurther decreaseHrTomographic imagingImaging
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