2025
Current Landscape of Children's Surgery in Africa: A Multicenter Analysis of 16,000 Cases
Hsu P, Carroll M, Zambeli‐Ljepovic A, Olatunji‐Banire B, Mathew P, Axt J, Diallo T, Eshete M, Ki B, Macharia J, Ngock G, Serawit A, Bryce E, Ozgediz D, Cheung M. Current Landscape of Children's Surgery in Africa: A Multicenter Analysis of 16,000 Cases. World Journal Of Surgery 2025 PMID: 40913246, DOI: 10.1002/wjs.70066.Peer-Reviewed Original ResearchSurgical careBurden of pediatric surgical diseaseChildren's surgical careHousehold-based surveyMiddle-income countriesBurden of diseasePediatric surgical carePerioperative clinical dataAssociated with much higher ratesHigher mortalityPediatric surgical diseasesFrequency of proceduresEffective interventionsYoung childrenChildren’s SurgeryMulticenter analysisIntestinal perforationCongenital malformationsGlobal disparitiesCareElective operationsClinical dataCongenital conditionSurgical proceduresSurgical diseaseEndovascular management of tandem occlusions: current evidence and future directions
Krothapalli N, Heit J, de Havenon A, Singhal A, Sussman E, Hasan D, Mac Grory B. Endovascular management of tandem occlusions: current evidence and future directions. Journal Of NeuroInterventional Surgery 2025, jnis-2025-023793. PMID: 40780815, PMCID: PMC12338063, DOI: 10.1136/jnis-2025-023793.Peer-Reviewed Original ResearchRandomized Controlled TrialsEndovascular thrombectomyEndovascular managementAssociated with high mortalityArtery steno-occlusionOptimal antithrombotic therapyStandard treatment approachExtracranial carotid lesionsIntracranial revascularizationAntithrombotic therapyClot burdenTandem occlusionSteno-occlusionClinical predicamentCarotid lesionsIntravenous thrombolysisOptimal managementOcclusion strokeObservational studyPractice patternsControlled TrialsTreatment approachesHigher mortalityAnterograde flowNarrative reviewOptimal ECLS Support in Mixed Cardiogenic and Septic Shock An ELSO Registry Analysis
Labrada L, Alarfaj M, Tran L, Granger H, Hernandez A, Hu J, Baker J, Grandin E, Delgado A, Katz J, Miller P, Alviar C, Osborn E, Bacchetta M, Lindenfeld J, Shah Z, Rali A. Optimal ECLS Support in Mixed Cardiogenic and Septic Shock An ELSO Registry Analysis. JACC Advances 2025, 101965. PMID: 40704940, DOI: 10.1016/j.jacadv.2025.101965.Peer-Reviewed Original ResearchVA-ECLSSeptic shockExtracorporeal Life Support Organization databaseVeno-arterial extracorporeal life supportExtracorporeal life supportBaseline Charlson Comorbidity IndexMixed shockCharlson Comorbidity IndexCardiogenic shockCardiac arrestOverall mortalityRegistry analysisComorbidity indexHemodynamic phenotypesPost-ECLSECLS supportPatientsCirculatory supportHigher mortalityHypothesis-generatingMortalityOlder ageLife supportContinuous variablesSurvivalOver Two Decades of Experience in Aortic Arch Reoperations: Long-Term Outcomes and Mortality Risk Factors
Bozini N, Piber N, Vitanova K, Sideris K, Herold U, Guenzinger R, Amabile A, Georgescu T, Krane M, Prinzing A. Over Two Decades of Experience in Aortic Arch Reoperations: Long-Term Outcomes and Mortality Risk Factors. Journal Of Clinical Medicine 2025, 14: 4087. PMID: 40565833, PMCID: PMC12193799, DOI: 10.3390/jcm14124087.Peer-Reviewed Original ResearchAortic arch reoperationArch reoperationLong-term outcomesTemporary mechanical circulatory supportBleeding complicationsMechanical circulatory supportRisk factorsOverall survivalVentilation timeAdverse outcomesAssociated with significantly lower overall survivalSignificantly lower overall survivalAortic type B dissectionHistory of coronary artery diseaseMultivariate Cox regression analysisPredictor of adverse outcomesIncreased long-term survivalCirculatory supportAortic arch surgeryProlonged ventilation timeAssociated with high mortalityPreoperative risk factorsType B dissectionHigher mortalityTranscatheter aortic valve implantationRisk Factors in Patients Who Had Prior Renal or Liver Transplant Undergoing Primary Total Hip Arthroplasty
Gill V, Boddu S, Mansour E, Abu Jawdeh B, Khan M, McGary A, Clarke H, Spangehl M, Abdel M, Ledford C, Bingham J. Risk Factors in Patients Who Had Prior Renal or Liver Transplant Undergoing Primary Total Hip Arthroplasty. Journal Of Clinical Medicine 2025, 14: 3486. PMID: 40429481, PMCID: PMC12111864, DOI: 10.3390/jcm14103486.Peer-Reviewed Original ResearchAmerican Society of Anesthesiologists classSolid organ transplantationAmerican Society of Anesthesiologists class 4Associated with high mortalitySurgical complicationsAcute medical complicationsRenal transplantationLiver transplantationMedical complicationsOlder agePeri-operative risk profileOrgan transplantationHistory of solid organ transplantationMedian follow-up periodRisk factorsLikelihood of surgical complicationsTotal hip arthroplastyKaplan-Meier survival analysisRate of reoperationHigher mortalityAssociated with higher riskProportion of patientsFollow-up periodEstimate median survivalLow surgical complicationsAssociation of age with adverse events following coronary atherectomy during percutaneous coronary intervention.
Park D, Hu J, DeAngelo S, Vij A, Jamil Y, Babapour G, Akman Z, Pazooki P, Damluji A, DO J, Li D, Nanna M. Association of age with adverse events following coronary atherectomy during percutaneous coronary intervention. Journal Of Geriatric Cardiology 2025, 22: 497-505. PMID: 40607137, PMCID: PMC12209150, DOI: 10.26599/1671-5411.2025.05.007.Peer-Reviewed Original ResearchOlder adultsIn-Hospital MortalityMiddle-oldYoung adultsOdds of in-hospital mortalityOldest-old adultsVizient Clinical Data BaseAge groupsAcute kidney injuryMiddle-older adultsAssociation of ageYoungest-oldClaims-based studyClinical data baseOldest-oldHigher oddsGastrointestinal hemorrhageComparing adultsSecondary outcomesHigher mortalityPrimary outcomeCoronary atherectomyIncreasing ageAdultsSeverely calcified coronary artery lesionsPost-transfusion activation of coagulation pathways during severe COVID-19 correlates with COVID-19 convalescent plasma antibody profiles
Weiss S, Lin H, Acosta E, Komarova N, Chen P, Wodarz D, Baine I, Duerr R, Wajnberg A, Gervais A, Bastard P, Casanova J, Arinsburg S, Swartz T, Aberg J, Bouvier N, Liu S, Alvarez R, Chen B. Post-transfusion activation of coagulation pathways during severe COVID-19 correlates with COVID-19 convalescent plasma antibody profiles. Journal Of Clinical Investigation 2025, 135: e181136. PMID: 40091845, PMCID: PMC11910229, DOI: 10.1172/jci181136.Peer-Reviewed Original ResearchConceptsCOVID-19 convalescent plasmaCOVID-19 convalescent plasma unitsActivation of coagulation pathwaysSevere COVID-19Post-transfusionAntibody profilesEffectiveness of COVID-19 convalescent plasmaSevere SARS-CoV-2 infectionCoagulation pathwayD-dimer levelsHospitalized COVID-19 patientsHigher-riskCCP recipientsSARS-CoV-2 infectionTreat severe COVID-19SARS-CoV-2 spikeCOVID-19 patientsAntibody therapyD-dimerD-dimer trendsConvalescent plasmaSevere diseaseBetacoronavirus OC43Higher mortalityIn vitro assaysThe Challenging Problems of Cancer and Serious Mental Illness
Grassi L, McFarland D, Riba M, Ferrara M, Zaffarami G, Belvederi Murri M, Cruciata M, Caruso R. The Challenging Problems of Cancer and Serious Mental Illness. Current Psychiatry Reports 2025, 27: 41-57. PMID: 39786658, PMCID: PMC11724792, DOI: 10.1007/s11920-024-01570-9.Peer-Reviewed Original ResearchConceptsSerious mental illnessProblem of cancerMental illnessGeneral populationPhysical health careRates of screeningMental health servicesHealth-care systemMedication side effectsHealth servicesOncology settingUnhealthy lifestyleHealth careCancer preventionStandard cancer treatmentHigher mortalitySomatic disordersCareVulnerable segmentsNegative outcomesIllnessOncologyCancer treatmentDelayed TreatmentCancerHarmonization of alcohol use data and mortality across a multi‐national HIV cohort collaboration
Ingle S, Trickey A, Lankina A, McGinnis K, Justice A, Cavassini M, Monforte A, van Sighem A, Gill M, Crane H, Obel N, Jarrin I, Wallner E, Guest J, Silverberg M, Vourli G, Wittkop L, Sterling T, Satre D, Burkholder G, Costagliola D, Sterne J. Harmonization of alcohol use data and mortality across a multi‐national HIV cohort collaboration. Alcohol Clinical And Experimental Research 2025, 49: 407-417. PMID: 39779221, PMCID: PMC11828971, DOI: 10.1111/acer.15522.Peer-Reviewed Original ResearchAUDIT-CAlcohol useAlcohol use dataCohort CollaborationAlcohol Use Disorders Identification TestAssociation of alcohol useAntiretroviral Therapy Cohort CollaborationNo alcohol useDisorders Identification TestJ-shaped relationshipEffects of alcohol useStudy of peopleMeasures of alcohol useHIV Cohort StudyHeavy alcohol useMeasure alcohol useAUDIT-C.Estimate associationsStandard drinksAdult PWHWhite ethnicityCohort studyHigher mortalityItem 1PWH
2024
Challenges with Formulating Accurate Prognosis for Patients with Severe Acute Brain Injury
Carhuapoma L, Hwang D. Challenges with Formulating Accurate Prognosis for Patients with Severe Acute Brain Injury. Neurocritical Care 2024, 42: 772-779. PMID: 39627563, DOI: 10.1007/s12028-024-02170-4.Peer-Reviewed Original ResearchSevere acute brain injuryAcute brain injuryBrain injurySelf-Fulfilling ProphecyClinical grading scaleCritically ill patientsEarly withdrawalPrognostic outcomesGrading scaleIll patientsPatientsAccurate prognosisHigher mortalityPredicting OutcomeLack of complete dataWithdrawal of life-sustaining treatmentComplete dataOutcomesPrognosticationInjuryLife-sustaining treatmentSuccinate dehydrogenase–complex II regulates skeletal muscle cellular respiration and contractility but not muscle mass in genetically induced pulmonary emphysema
Balnis J, Tufts A, Jackson E, Drake L, Singer D, Lacomis D, Lee C, Elias J, Doles J, Maher L, Jen A, Coon J, Jourd’heuil D, Singer H, Vincent C, Jaitovich A. Succinate dehydrogenase–complex II regulates skeletal muscle cellular respiration and contractility but not muscle mass in genetically induced pulmonary emphysema. Science Advances 2024, 10: eado8549. PMID: 39167644, PMCID: PMC11338223, DOI: 10.1126/sciadv.ado8549.Peer-Reviewed Original ResearchConceptsPulmonary emphysemaMuscle massSuccinate dehydrogenaseReduced skeletal muscle massAssociated with high mortalityCellular respirationSkeletal muscle massReduced cellular respirationKnockout miceMuscle dysfunctionActivity of succinate dehydrogenaseComplex I respirationMitochondrial oxygen consumptionMyopathic changesTransgenic miceSubunit cMuscle atrophyProteomic effectsMyofiber contractilityRespirometry analysisSuccinate accumulationMuscle mitochondriaEmphysemaHigher mortalityAnimal dataExposure to hyperoxemia and mortality in cardiac intensive care unit patients
Alviar C, Jentzer J, Van Diepen S, Metkus T, Miller P, Kashani K. Exposure to hyperoxemia and mortality in cardiac intensive care unit patients. European Heart Journal Acute Cardiovascular Care 2024, 13: zuae036.138. DOI: 10.1093/ehjacc/zuae036.138.Peer-Reviewed Original ResearchIn-Hospital MortalityCardiac intensive care unitCardiac intensive care unit admissionJ-shaped associationJ-shaped relationshipCritical care settingCardiac intensive care unit patientsCare settingsAssociated with increased in-hospital mortalityCare conditionsInpatient deathCharlson Comorbidity IndexMayo Clinic CICU patientsIntensive care unit patientsAssociated with adverse outcomesAdmission diagnosisLogistic regressionCICU patientsExposure to hyperoxemiaHigher mortalityPrimary outcomeIntensive care unitIll cardiac patientsGeneral critical care settingCardiac patientsImpact of anemia on outcomes and resource utilization in patients with myocardial infarction: A national database analysis
Jhand A, Abusnina W, Tak H, Ahmed A, Ismayl M, Altin S, Sherwood M, Alexander J, Rao S, Abbott J, Carson J, Goldsweig A. Impact of anemia on outcomes and resource utilization in patients with myocardial infarction: A national database analysis. International Journal Of Cardiology 2024, 408: 132111. PMID: 38697401, DOI: 10.1016/j.ijcard.2024.132111.Peer-Reviewed Original ResearchLength of stayNational Inpatient SampleMyocardial infarctionDiagnosis codesAnemic patientsAdverse eventsPatients admitted with MIAssociated with higher in-hospital mortalityAssociated with high mortalityAssociated with increased mortalityNational database analysisHigher In-Hospital MortalityAssociation of anemiaHigher mortalityImpact of anemiaIn-Hospital Adverse EventsPrimary diagnosis codeSecondary diagnosis codesLonger length of stayMultivariate logistic regressionIn-Hospital MortalityIn-Hospital OutcomesMI hospitalizationConcomitant anemiaBlood transfusionSoft phenotyping for sepsis via EHR time-aware soft clustering
Jiang S, Gai X, Treggiari M, Stead W, Zhao Y, Page C, Zhang A. Soft phenotyping for sepsis via EHR time-aware soft clustering. Journal Of Biomedical Informatics 2024, 152: 104615. PMID: 38423266, PMCID: PMC11073833, DOI: 10.1016/j.jbi.2024.104615.Peer-Reviewed Original ResearchElectronic health recordsRecovery trajectoriesSub-phenotypesHealth recordsClustering algorithmTiming of interventionLogistic regressionCondition associated with high mortalitySoft clustering algorithmDisease sub-phenotypesSepsis prediction modelSoft clusteringClinical variablesOptimal timing of interventionTemporal informationMedical plausibilityHigher mortalityClustering procedureAccurate informationOrgan dysfunctionAlgorithmDysregulated immune response to infectionInterventionHospitalSepsis-related organ dysfunctionSerum aryl hydrocarbon receptor activity is associated with survival in patients with alcohol-associated hepatitis
Yamazaki T, Kouno T, Hsu C, Hartmann P, Mayo S, Zhang X, Stärkel P, Bosques-Padilla F, Verna E, Abraldes J, Brown R, Vargas V, Altamirano J, Caballería J, Shawcross D, Louvet A, Lucey M, Mathurin P, Garcia-Tsao G, Bataller R, Investigators A, Schnabl B. Serum aryl hydrocarbon receptor activity is associated with survival in patients with alcohol-associated hepatitis. Hepatology 2024, 80: 403-417. PMID: 38377466, PMCID: PMC11268475, DOI: 10.1097/hep.0000000000000777.Peer-Reviewed Original ResearchAlcohol-associated hepatitisAlcohol use disorderSevere AHAH patientsAhR activationMicrobiota-derived tryptophan metabolitesSurvival rateAssociated with high mortalityCumulative survival rateAssociated with survivalAryl hydrocarbon receptor activationMulticenter cohortFecal metabolomePrognostic markerTryptophan metabolitesReceptor activationAryl hydrocarbon receptorPatientsUse disorderAH cohortSerumHigher mortalityAhRHepatitisCohort
2023
Risk Factors in Patients Who Had Prior Renal or Liver Transplant Undergoing Primary Total Knee Arthroplasty
Mansour E, Boddu S, Gill V, Abu Jawdeh B, McGary A, Clarke H, Spangehl M, Abdel M, Ledford C, Bingham J. Risk Factors in Patients Who Had Prior Renal or Liver Transplant Undergoing Primary Total Knee Arthroplasty. The Journal Of Arthroplasty 2023, 39: s199-s204. PMID: 38048964, DOI: 10.1016/j.arth.2023.11.030.Peer-Reviewed Original ResearchConceptsSolid organ transplantationRisk of reoperationAssociated with lower riskCoronary artery diseaseSurgical complicationsAcute medical complicationsTotal knee arthroplastyMedical complicationsArtery diseaseHigher risk of reoperationSolid organ transplant patientsLow riskRisk factorsLevels of serum creatinineAssociated with high mortalityMedian Follow-UpHigher mortalityVitamin D supplementationLow surgical complicationsPrimary total knee arthroplastyKnee arthroplastyMedian survivalTotal knee arthroplasty patientsSerum creatinineD supplementationLowering PCO2 with Non-Invasive Ventilation is Associated with Improved Survival in Chronic Hypercapnic Respiratory Failure
Jimenez J, Ackrivo J, Hsu J, Wilson M, Labaki W, Hansen-Flaschen J, Hyzy R, Choi P. Lowering PCO2 with Non-Invasive Ventilation is Associated with Improved Survival in Chronic Hypercapnic Respiratory Failure. Respiratory Care 2023, 68: respcare.10813. PMID: 37137711, PMCID: PMC10676248, DOI: 10.4187/respcare.10813.Peer-Reviewed Original ResearchConceptsChronic hypercapnic respiratory failureHypercapnic respiratory failureRespiratory failureAssociated with improved survivalAssociated with high mortalityNon-invasive ventilationNoninvasive ventilationImproved survivalChronic hypercapniaHigher mortalityNon-invasiveMortalityVentilationLowering pCO2Non-operative management of cirrhotic patients with acute calculous cholecystitis: How effective is it?
Hanna K, Zangbar B, Kirsch J, Bronstein M, Okumura K, Gogna S, Shnaydman I, Prabhakaran K, Con J. Non-operative management of cirrhotic patients with acute calculous cholecystitis: How effective is it? The American Journal Of Surgery 2023, 226: 668-674. PMID: 37482476, DOI: 10.1016/j.amjsurg.2023.07.019.Peer-Reviewed Original ResearchConceptsAcute calculous cholecystitisFailure of nonoperative managementLength of stayPercutaneous cholecystostomyNonoperative managementCirrhotic patientsCalculous cholecystitisPredictors of NOM failureOutcomes of cirrhotic patientsManagement of cirrhotic patientsFailed nonoperative managementNon-operative managementHigher mortalityTreated with antibioticsAssociated with mortalityNOM failureCirrhosis patientsLevel IIIOperation groupReadmissions DatabaseMorbid diseasePatientsCholecystectomyMortalityCholecystitisTrends in mortality and causes of death among Chinese adolescents aged 10–19 years from 1990 to 2019
Zhu J, Li Y, Zhang C, He J, Niu L. Trends in mortality and causes of death among Chinese adolescents aged 10–19 years from 1990 to 2019. Frontiers In Public Health 2023, 11: 1075858. PMID: 36825144, PMCID: PMC9941149, DOI: 10.3389/fpubh.2023.1075858.Peer-Reviewed Original ResearchConceptsNon-communicable diseasesNon-communicable disease mortality ratesAdolescent HealthRates of non-communicable diseasesGlobal Burden of Disease StudyMortality rateBurden of Disease StudyPromote adolescent healthChinese adolescentsAdolescent mortality ratesAdolescent mortalityGlobal burdenRoad injuriesSelf-harmHealthy ChinaAge disparitiesHigher mortalityDisease StudyMedical practiceCongenital birth defectsSocioeconomic conditionsHealthRate of communicationDisease patternsNutritional diseases
2022
The immune response to COVID‐19: Does sex matter?
Ho J, Sepand M, Bigdelou B, Shekarian T, Esfandyarpour R, Chauhan P, Serpooshan V, Beura L, Hutter G, Zanganeh S. The immune response to COVID‐19: Does sex matter? Immunology 2022, 166: 429-443. PMID: 35470422, PMCID: PMC9111683, DOI: 10.1111/imm.13487.Peer-Reviewed Original ResearchConceptsSARS-CoV-2 infectionImmune responseImmune response to SARS-CoV-2 infectionResponse to SARS-CoV-2 infectionImmune response to COVID-19Pathophysiology of SARS-CoV-2 infectionClinical outcomesSevere acute respiratory syndrome coronavirus 2Acute respiratory syndrome coronavirus 2Behavioral risk factorsRespiratory syndrome coronavirus 2More severe symptomsSex-specific differencesRisk factorsUnderstanding sex differencesEvidence of sex-specific differencesImmune systemSyndrome coronavirus 2Coronavirus disease 2019Epidemiological dataSevere symptomsHigher mortalitySARS-CoV-2
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