2025
Dual Diagnosis
Caldwell E, Obiozor C, Kofos M, Martell J, Agerwala S, Petrakis I. Dual Diagnosis. 2025, 706-712. DOI: 10.1016/b978-0-323-95702-1.00275-x.Peer-Reviewed Original ResearchSubstance use disordersPsychiatric conditionsComorbid psychiatric conditionsAnxiety disordersPsychotic disordersStress disorderMood disordersAttention deficitHyperactivity disorderUse disorderEating DisordersMental illnessDisordersCo-occurrenceMoodAnxietyHyperactivityNicotineSubstancesDeficitsIllnessProfessional individualsAlcohol
2024
Sex‐specific topological structure associated with dementia via latent space estimation
Wang S, Wang Y, Xu F, Tian X, Fredericks C, Shen L, Zhao Y, Initiative F. Sex‐specific topological structure associated with dementia via latent space estimation. Alzheimer's & Dementia 2024, 20: 8387-8401. PMID: 39530632, PMCID: PMC11667551, DOI: 10.1002/alz.14266.Peer-Reviewed Original Research
2021
Convergent and Divergent Mechanisms of Epileptogenesis in mTORopathies
Nguyen LH, Bordey A. Convergent and Divergent Mechanisms of Epileptogenesis in mTORopathies. Frontiers In Neuroanatomy 2021, 15: 664695. PMID: 33897381, PMCID: PMC8064518, DOI: 10.3389/fnana.2021.664695.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsPI3K-mTOR pathwayCortical developmentGene variantsPotential therapeutic strategyIntractable epilepsyNeuronal placementTherapeutic strategiesAnimal modelsEpilepsyElectrophysiological phenotypeNeurodevelopmental disordersRapamycin complex 1Mechanistic targetEpileptogenesisIndependent mechanismsMTORopathiesGATOR1 complexPersonalized medicineDivergent mechanismsMosaic patternEverolimusMalformationsHyperactivityPathwayVariants
2019
Paroxysmal Sympathetic Hyperactivity
Gobeske K. Paroxysmal Sympathetic Hyperactivity. 2019, 122-124. DOI: 10.1093/med/9780190862923.003.0018.Peer-Reviewed Original ResearchIntensive care unitNeurocritical careAbnormal laboratory test resultsIll neurologic patientsParoxysmal sympathetic hyperactivityMagnetic resonance imagingSympathetic hyperactivityClinical courseInitial presentationNeurologic examinationNeurologic testsCare unitNeurologic patientsClinical practiceLesion localizationResonance imagingGold standardLaboratory test resultsCarePatientsPrognosisHyperactivityPhysiciansDiagnosisNeurology
2017
Animal Models of Attention-Deficit Hyperkinetic Disorder (ADHD)
Sharma N, Jamwal S, Bansal P. Animal Models of Attention-Deficit Hyperkinetic Disorder (ADHD). 2017, 217-232. DOI: 10.1007/978-981-10-5981-0_14.Peer-Reviewed Original ResearchAttention deficit hyperkinetic disorderAttention deficit disorderHyperactivity disorderDeficit disorderAttention deficit hyperactivity disorderDeficit hyperactivity disorderCommon childhood-onset neuropsychiatric disorderSchool-aged childrenADHD childrenAttention deficitsChildhood-onset neuropsychiatric disorderChildhood disordersBehavioral disordersSigns of hyperactivityHyperkinetic disorderHyperactivityChildrenTerms of choiceBrain damageNeuropsychiatric disordersDSM-IIIDisordersAdultsInattentionAnimal models
2016
Switching on mTORC1 induces neurogenesis but not proliferation in neural stem cells of young mice
Mahoney C, Feliciano DM, Bordey A, Hartman NW. Switching on mTORC1 induces neurogenesis but not proliferation in neural stem cells of young mice. Neuroscience Letters 2016, 614: 112-118. PMID: 26812181, DOI: 10.1016/j.neulet.2015.12.042.Peer-Reviewed Original ResearchConceptsNeural stem cellsSubventricular zoneNeonatal subventricular zoneWeek old miceTuberous sclerosis complexStem cellsNewborn neuroblastsYoung miceOld miceProgressive lossYoung adultsRapamycin complex 1Mechanistic targetRecent evidenceProliferative cellsMiceHyperactive mTORC1Terminal differentiationCellsMTORC1 activationProliferationActivationMTORC1NeurogenesisHyperactivity
2015
Extended-Release Guanfacine for Hyperactivity in Children With Autism Spectrum Disorder
Scahill L, McCracken JT, King BH, Rockhill C, Shah B, Politte L, Sanders R, Minjarez M, Cowen J, Mullett J, Page C, Ward D, Deng Y, Loo S, Dziura J, McDougle CJ. Extended-Release Guanfacine for Hyperactivity in Children With Autism Spectrum Disorder. American Journal Of Psychiatry 2015, 172: 1197-1206. PMID: 26315981, DOI: 10.1176/appi.ajp.2015.15010055.Peer-Reviewed Original ResearchConceptsExtended-release guanfacineModal doseGuanfacine groupWeek 8Common adverse eventsAutism spectrum disorderWeeks of treatmentAttention deficit hyperactivity disorderDeficit hyperactivity disorderPlacebo groupAdverse eventsBlood pressurePlacebo subjectsClinical trialsSpectrum disorderPlaceboGuanfacineHyperactivityPulse rateHyperactivity disorderGroup differencesMotor planningWeeksBrief cognitive batteryDisordersAcute Disseminated Encephalomyelitis in an Adult: An Uncommon Case of Paroxysmal Sympathetic Hyperactivity
Holder EK, McCall JC, Feeko KJ. Acute Disseminated Encephalomyelitis in an Adult: An Uncommon Case of Paroxysmal Sympathetic Hyperactivity. PM&R 2015, 7: 781-784. PMID: 25724850, DOI: 10.1016/j.pmrj.2015.02.006.Peer-Reviewed Case Reports and Technical NotesConceptsAcute disseminated encephalomyelitisParoxysmal sympathetic hyperactivitySympathetic hyperactivityDisseminated encephalomyelitisCentral nervous systemList of diagnosesAutonomic dysreflexiaProgressive autoimmuneFulminant casesHypertensive emergenciesAdult patientsMultiple sclerosisPediatric casesCase reportUncommon caseNervous systemHyperactivityEncephalomyelitisDysreflexiaAutoimmuneAcuteSclerosisPatientsRecurrenceImmunization
2014
Clinical Correlates and Predictors of Caregiver Strain in Children With Chronic Tic Disorders
Ramanujam K, Himle MB, Hayes LP, Woods DW, Scahill L, Sukhodolsky DG, Wilhelm S, Deckersbach T, Peterson AL, Specht M, Walkup JT, Chang S, Piacentini J. Clinical Correlates and Predictors of Caregiver Strain in Children With Chronic Tic Disorders. Children's Health Care 2014, 44: 249-263. PMID: 26855465, PMCID: PMC4739807, DOI: 10.1080/02739615.2014.948166.Peer-Reviewed Original ResearchChronic tic disorderCaregiver strainClinical correlatesInattention/hyperactivityTic disordersRandomized-controlled trialTic intensityParents of childrenCare providersBehavior therapyComorbid internalizingExternalizing problemsDisruptive behaviorChildrenObjective strainHyperactivityPredictorsDisordersCurrent studyBest predictorCorrelatesTherapyImpairmentTrials
2012
Lack of GPR88 enhances medium spiny neuron activity and alters motor- and cue-dependent behaviors
Quintana A, Sanz E, Wang W, Storey GP, Güler AD, Wanat MJ, Roller BA, La Torre A, Amieux PS, McKnight GS, Bamford NS, Palmiter RD. Lack of GPR88 enhances medium spiny neuron activity and alters motor- and cue-dependent behaviors. Nature Neuroscience 2012, 15: 1547-1555. PMID: 23064379, PMCID: PMC3483418, DOI: 10.1038/nn.3239.Peer-Reviewed Original ResearchMeSH KeywordsAnalysis of VarianceAnimalsAvoidance LearningBenzylaminesBiophysicsCells, CulturedChromonesCorpus StriatumCuesElectric StimulationEmbryo, MammalianExcitatory Amino Acid AntagonistsExcitatory Postsynaptic PotentialsFemaleGABA Antagonistsgamma-Aminobutyric AcidGene Expression ProfilingGreen Fluorescent ProteinsIn Vitro TechniquesMaleMaze LearningMiceMice, Inbred C57BLMice, TransgenicMotor ActivityMutationNeuronsOligonucleotide Array Sequence AnalysisPhosphinic AcidsReceptors, AMPAReceptors, G-Protein-CoupledReceptors, GABA-BRotarod Performance TestConceptsMedium spiny neuronsMedium spiny neuron activityStriatal medium spiny neuronsOrphan G protein-coupled receptorPoor motor coordinationG protein-coupled receptorsProtein-coupled receptorsSpiny neuronsMotor coordinationGPR88Neuron activityFiring rateReduced inhibitionHyperactivityMiceNeuronsReceptors
2006
AProspective Open Trial of Guanfacine in Children with Pervasive Developmental Disorders
Scahill L, Aman MG, McDougle CJ, McCracken JT, Tierney E, Dziura J, Arnold LE, Posey D, Young C, Shah B, Ghuman J, Ritz L, Vitiello B. AProspective Open Trial of Guanfacine in Children with Pervasive Developmental Disorders. Journal Of Child And Adolescent Psychopharmacology 2006, 16: 589-598. PMID: 17069547, DOI: 10.1089/cap.2006.16.589.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdrenergic alpha-AgonistsAttention Deficit Disorder with HyperactivityCentral Nervous System StimulantsChildChild Development Disorders, PervasiveChild, PreschoolFemaleGuanfacineHumansMaleMethylphenidatePersonality AssessmentPilot ProjectsProspective StudiesTreatment FailureTreatment OutcomeConceptsOpen-label trialAberrant Behavior ChecklistPervasive developmental disorderClinical Global Impression-ImprovementHyperactivity subscaleEfficacy of guanfacinePlacebo-controlled trialCommon adverse effectsWeeks of treatmentTreatment of hyperactivityDevelopmental disordersBlood pressureOpen trialMean ageSleep disturbancesCommon complaintClinical practiceGuanfacineHyperactivityPilot studyAdverse effectsTrialsBehavior ChecklistChildrenMethylphenidate
2003
A placebo-controlled, cross-over trial of lamotrigine in depersonalization disorder
Sierra M, Phillips ML, Ivin G, Krystal J, David AS. A placebo-controlled, cross-over trial of lamotrigine in depersonalization disorder. Journal Of Psychopharmacology 2003, 17: 103-105. PMID: 12680746, DOI: 10.1177/0269881103017001712.Peer-Reviewed Original ResearchConceptsDepersonalization disorderEfficacy of lamotrigineWeeks of treatmentCross-over trialCross-over periodCross-over designDSM-IV depersonalization disorderSole medicationGlutamate releaseLamotriginePatientsCambridge Depersonalization ScaleDisordersTreatmentDepersonalization ScalePlaceboMedicationsHyperactivityRespondersTrialsWeeks
1991
Sudden Death in Children Receiving Norpramin®: A Review of Three Reported Cases and Commentary
RIDDLE M, NELSON J, KLEINMAN C, RASMUSSON A, LECKMAN J, KING R, COHEN D. Sudden Death in Children Receiving Norpramin®: A Review of Three Reported Cases and Commentary. Journal Of The American Academy Of Child & Adolescent Psychiatry 1991, 30: 104-108. PMID: 2005044, DOI: 10.1097/00004583-199101000-00016.Peer-Reviewed Original Research
1986
Gilles de la Tourette's Syndrome and Attention Deficit Disorder With Hyperactivity: Evidence Against a Genetic Relationship
Pauls D, Hurst C, Kruger S, Leckman J, Kidd K, Cohen D. Gilles de la Tourette's Syndrome and Attention Deficit Disorder With Hyperactivity: Evidence Against a Genetic Relationship. JAMA Psychiatry 1986, 43: 1177-1179. PMID: 3465279, DOI: 10.1001/archpsyc.1986.01800120063012.Peer-Reviewed Original ResearchCold Water Stress Abolishes Hyperactivity Produced by Cortical Suction Lesions Without Altering Noradrenergic Depletion
Moran T, Zern K, Pearlson G, Kubos K, Robinson R. Cold Water Stress Abolishes Hyperactivity Produced by Cortical Suction Lesions Without Altering Noradrenergic Depletion. Behavioral Neuroscience 1986, 100: 422-426. PMID: 3730151, DOI: 10.1037/0735-7044.100.3.422.Peer-Reviewed Original ResearchConceptsSuction lesionsControl animalsSham-operated control animalsFirst postoperative weekWeekly intervalsDevelopment of hyperactivityCold water swimmingPostoperative periodNoradrenergic depletionNorepinephrine depletionPostoperative weekCatecholamine depletionBehavioral hyperactivitySwim testLesion groupLesionsHyperactivityWeekly stress
1985
Inappropriate Uses of Stimulant Medications
Volkmar F, Hoder E, Cohen D. Inappropriate Uses of Stimulant Medications. Clinical Pediatrics 1985, 24: 127-130. PMID: 2578911, DOI: 10.1177/000992288502400301.Peer-Reviewed Original Research
1984
Effect of anterior-posterior lesion location on the asymmetrical behavioral and biochemical response to cortical suction ablations in the rat
Pearlson G, Kubos K, Robinson R. Effect of anterior-posterior lesion location on the asymmetrical behavioral and biochemical response to cortical suction ablations in the rat. Brain Research 1984, 293: 241-250. PMID: 6697218, DOI: 10.1016/0006-8993(84)91231-9.Peer-Reviewed Original ResearchConceptsSuction ablationLesion locationRight hemisphereConcentrations of norepinephrineContralateral cortexCortical lesionsAnterior lesionsLocus coeruleusSpontaneous activityNeurotransmitter pathwaysLocomotor activityGreater reductionLesionsRatsCortexBehavioral findingsBiochemical responsesAblationAnalysis of varianceAnterior-posterior axisNorepinephrineCoeruleusHyperactivityHemisphere
1982
Brain catecholamine metabolites and behavior in morphine withdrawal
Swann A, Elsworth J, Charney D, Jablons D, Roth R, Redmond D, Maas J. Brain catecholamine metabolites and behavior in morphine withdrawal. European Journal Of Pharmacology 1982, 86: 167-175. PMID: 6297931, DOI: 10.1016/0014-2999(82)90314-4.Peer-Reviewed Original ResearchConceptsCatecholamine metabolitesMorphine withdrawal behaviorsBeta-receptor bindingWithdrawal behaviorDebrisoquin sulfateAcute treatmentMorphine withdrawalNorepinephrine metaboliteMorphine pelletsWithdrawal signsPlasma levelsBrain 3Noradrenergic hyperactivityReceptor bindingMHPGBrainMetabolitesNaloxoneHVARatsHyperactivityEnvironmental and biologic interactions on behavior: Effects of artificial rearing in rat pups treated with 6‐hydroxydopamine
Goldenring J, Shaywitz B, Wool R, Batter D, Anderson G, Cohen D. Environmental and biologic interactions on behavior: Effects of artificial rearing in rat pups treated with 6‐hydroxydopamine. Developmental Psychobiology 1982, 15: 297-307. PMID: 6809512, DOI: 10.1002/dev.420150403.Peer-Reviewed Original ResearchIntracortical kainic acid induces an assymmetrical behavioral response in the rat
Kubos K, Pearlson G, Robinson R. Intracortical kainic acid induces an assymmetrical behavioral response in the rat. Brain Research 1982, 239: 303-309. PMID: 7093686, DOI: 10.1016/0006-8993(82)90857-5.Peer-Reviewed Original ResearchConceptsKainic acidCortical noradrenergic terminalsDay postoperative periodRight frontal cortexNoradrenergic terminalsPostoperative periodRight hemisphere lesionsSpontaneous hyperactivityFrontal cortexIdentical injectionsHemisphere lesionsNanomolar dosesLeft hemisphereHyperactivityRatsNeural asymmetriesInjectionBehavioral responsesPrevious studiesLesionsCortexDosesWeeks
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