2022
Opioid tapering support using a web-based app: Development and protocol for a pilot randomized controlled trial
Edmond SN, Wesolowicz DM, Moore BA, Ibarra J, Chhabra M, Fraenkel L, Becker WC. Opioid tapering support using a web-based app: Development and protocol for a pilot randomized controlled trial. Contemporary Clinical Trials 2022, 119: 106857. PMID: 35863697, DOI: 10.1016/j.cct.2022.106857.Peer-Reviewed Original ResearchConceptsPilot trialLong-term opioid therapyPatient-reported outcomesRandomized-controlled trialQuality of lifeSelf-management skillsOpioid taperOpioid therapyOpioid usePrimary outcomePrimary careTwo-armLimited efficacyInteractive web-based programControl groupIntervention MappingWeb-based programPatientsPeer specialistsTrialsPotential harmSummit programWeb-based appCareOutcomes
2021
Rationale and design of the prone position and respiratory outcomes in non-intubated COVID-19 patients: The “PRONE” study
Friedman E, Franzone J, Ko E, Corey K, Mock J, Alavian N, Schwartz A, Drummond M, Suber T, Linstrum K, Bain W, Castiblanco S, Zak M, Zaeh S, Gupta I, Damarla M, Punjabi N. Rationale and design of the prone position and respiratory outcomes in non-intubated COVID-19 patients: The “PRONE” study. Contemporary Clinical Trials 2021, 109: 106541. PMID: 34400361, PMCID: PMC8363159, DOI: 10.1016/j.cct.2021.106541.Peer-Reviewed Original ResearchConceptsNon-intubated COVID-19 patientsCOVID-19 patientsProne positioningProne positionRespiratory outcomesRespiratory rateCoronavirus disease 2019 (COVID-19) pneumoniaInvasive mechanical ventilationRandomized-controlled trialHigher acuity levelsDuration of effectLevel of careRespiratory supportHospitalized patientsMechanical ventilationSupplemental oxygenAcute pneumoniaOxyhemoglobin saturationRespiratory parametersAcuity levelsPatientsSecondary objectivePneumoniaOutcomesTrialsPsychiatric comorbidity as predictor and moderator of binge-eating disorder treatment outcomes: an analysis of aggregated randomized controlled trials
Lydecker JA, Grilo CM. Psychiatric comorbidity as predictor and moderator of binge-eating disorder treatment outcomes: an analysis of aggregated randomized controlled trials. Psychological Medicine 2021, 52: 4085-4093. PMID: 33849682, PMCID: PMC8514588, DOI: 10.1017/s0033291721001045.Peer-Reviewed Original ResearchBinge-eating disorderBinge-eating frequencyEating-disorder psychopathologyPsychiatric comorbidityBED treatment outcomesCognitive behavioral therapySelf-report measuresModerators of outcomeBinge-eating remissionDisorder treatment outcomesBehavioral weight lossRandomized-controlled trialCurrent psychiatric comorbidityMore effective interventionsTreatment outcomesAnxiety disordersTreatment researchSemi-structured interviewsMood comorbiditiesControl conditionPsychopathologyEffective interventionsComorbidity effectsWeight lossCurrent study
2019
Trim the fat: the role of omega-3 fatty acids in psychopharmacology
Nasir M, Bloch MH. Trim the fat: the role of omega-3 fatty acids in psychopharmacology. Therapeutic Advances In Psychopharmacology 2019, 9: 2045125319869791. PMID: 31489174, PMCID: PMC6713969, DOI: 10.1177/2045125319869791.Peer-Reviewed Original ResearchPost-traumatic stress disorderDepressive disorderAmerican Psychiatric AssociationFindings of RCTsRecent negative studiesSide effect profileFatty acid supplementationFatty acidsRandomized-controlled trialEvidence of efficacySubstantial methodological shortcomingsEvidence-based treatmentsImpulse control disordersIncomplete blindingHeterogeneous sample populationsBipolar maniaTreatment guidelinesCurrent guidelinesCardiovascular diseaseAcid supplementationNegative studiesPatient complianceUnipolar depressionIneffective treatmentPsychotic disorders
2018
Efficacy of Extended-Release Naltrexone on HIV-Related and Drinking Outcomes Among HIV-Positive Patients: A Randomized-Controlled Trial
Edelman EJ, Moore BA, Holt SR, Hansen N, Kyriakides TC, Virata M, Brown ST, Justice AC, Bryant KJ, Fiellin DA, Fiellin LE. Efficacy of Extended-Release Naltrexone on HIV-Related and Drinking Outcomes Among HIV-Positive Patients: A Randomized-Controlled Trial. AIDS And Behavior 2018, 23: 211-221. PMID: 30073637, PMCID: PMC6476298, DOI: 10.1007/s10461-018-2241-z.Peer-Reviewed Original ResearchConceptsHIV-positive patientsHeavy drinking daysVACS Index scoreXR-NTXART adherenceDrinking daysIndex scoreUndetectable HIV viral loadCD4 cell countExtended-release naltrexoneDouble-blind placeboHIV viral loadRandomized-controlled trialDrinking outcomesHIV biomarkersSecondary outcomesHIV outcomesPrimary outcomeViral loadAntiretroviral adherenceClinical trialsCell countAlcohol treatmentHIVPatients
2016
Improvements in emotion regulation following repetitive transcranial magnetic stimulation for generalized anxiety disorder
Diefenbach GJ, Assaf M, Goethe JW, Gueorguieva R, Tolin DF. Improvements in emotion regulation following repetitive transcranial magnetic stimulation for generalized anxiety disorder. Journal Of Anxiety Disorders 2016, 43: 1-7. PMID: 27467027, DOI: 10.1016/j.janxdis.2016.07.002.Peer-Reviewed Original ResearchConceptsRepetitive transcranial magnetic stimulationGeneralized anxiety disorderDorsolateral prefrontal cortexTranscranial magnetic stimulationMagnetic stimulationSham repetitive transcranial magnetic stimulationAnxiety disordersGlobal clinician ratingsFronto-limbic regionsRandomized-controlled trialRight dorsolateral prefrontal cortexEmotion regulation difficultiesSecondary analysisNeural circuitsClinician ratingsPrefrontal cortexPatientsRegulation difficultiesGoal-directed behaviorEmotion regulationDisordersStimulationImproved emotion regulationActive groupSelf-reported emotion regulation difficulties
2014
Clinical Correlates and Predictors of Caregiver Strain in Children With Chronic Tic Disorders
Ramanujam K, Himle MB, Hayes LP, Woods DW, Scahill L, Sukhodolsky DG, Wilhelm S, Deckersbach T, Peterson AL, Specht M, Walkup JT, Chang S, Piacentini J. Clinical Correlates and Predictors of Caregiver Strain in Children With Chronic Tic Disorders. Children's Health Care 2014, 44: 249-263. PMID: 26855465, PMCID: PMC4739807, DOI: 10.1080/02739615.2014.948166.Peer-Reviewed Original ResearchChronic tic disorderCaregiver strainClinical correlatesInattention/hyperactivityTic disordersRandomized-controlled trialTic intensityParents of childrenCare providersBehavior therapyComorbid internalizingExternalizing problemsDisruptive behaviorChildrenObjective strainHyperactivityPredictorsDisordersCurrent studyBest predictorCorrelatesTherapyImpairmentTrials
2012
Sudden unexpected death in epilepsy in lamotrigine randomized‐controlled trials
Tomson T, Hirsch LJ, Friedman D, Bester N, Hammer A, Irizarry M, Ishihara L, Krishen A, Spaulding T, Wamil A, Leadbetter R. Sudden unexpected death in epilepsy in lamotrigine randomized‐controlled trials. Epilepsia 2012, 54: 135-140. PMID: 23030403, DOI: 10.1111/j.1528-1167.2012.03689.x.Peer-Reviewed Original ResearchConceptsSudden unexpected deathProbable SUDEPTreatment armsAntiepileptic drugsClinical trialsOdds ratioUnexpected deathTonic-clonic seizure frequencyRate of SUDEPRisk of SUDEPRandomized clinical trialsRandomized-controlled trialPotential risk factorsCause deathPossible SUDEPStudy medicationPatient yearsSeizure frequencyTreatment deathsComparator armActive comparatorNonrandomized studyUnadjusted ratesComparator groupRisk factorsAnemia and functional disability in older adults with cancer.
Owusu C, Tew W, Hardt M, Mohile S, Klepin H, Gross C, Gajra A, Lichtman S, Ramani R, Katheria V, Zavala L, Hurria A. Anemia and functional disability in older adults with cancer. Journal Of Clinical Oncology 2012, 30: 9109-9109. DOI: 10.1200/jco.2012.30.15_suppl.9109.Peer-Reviewed Original ResearchFunctional disabilityProspective studyOlder adultsMulti-center prospective studyUnintentional weight lossCorrection of anemiaRandomized-controlled trialPre-treatment variablesOlder ptsChemotherapy toxicityGeriatric assessmentPatient agePrimary outcomeMean HbFunctional statusInstrumental activitiesDaily livingAnemiaAdvanced stageMultivariate analysisAge 65Secondary analysisModifiable strategiesBivariate analysisLogistic regressionDiagnosis and Treatment of Sleep Apnea in patients' homes: the rationale and methods of the "GoToSleep" randomized-controlled trial.
Bravata DM, Ferguson J, Miech EJ, Agarwal R, McClain V, Austin C, Struve F, Foresman B, Li X, Wang Z, Williams LS, Dallas MI, Couch CD, Sico J, Fragoso C, Matthias MS, Chumbler N, Myers J, Burrus N, Dube A, French DD, Schmid AA, Concato J, Yaggi HK. Diagnosis and Treatment of Sleep Apnea in patients' homes: the rationale and methods of the "GoToSleep" randomized-controlled trial. Journal Of Clinical Sleep Medicine 2012, 8: 27-35. PMID: 22334806, PMCID: PMC3266333, DOI: 10.5664/jcsm.1654.Peer-Reviewed Original ResearchConceptsContinuous positive airway pressureAuto-titrating continuous positive airway pressureTransient ischemic attackSleep apneaVeterans Health AdministrationCerebrovascular diseaseControl groupAntihypertensive medicationsIntervention groupPatient's homePressure continuous positive airway pressureUsual care control groupControl of hypertensionPositive airway pressureCare control groupLaboratory-based sleep studiesUndiagnosed sleep apneaBlood pressure assessmentInclusion of patientsRandomized-controlled trialBlood pressure measurementsHome-based polysomnographySleep laboratory polysomnographyOne-year study periodTherapeutic intervention strategies
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