2023
Targeting the Actions of Muscarinic Receptors on Dopamine Systems: New Strategies for Treating Neuropsychiatric Disorders
Nunes E, Addy N, Conn P, Foster D. Targeting the Actions of Muscarinic Receptors on Dopamine Systems: New Strategies for Treating Neuropsychiatric Disorders. The Annual Review Of Pharmacology And Toxicology 2023, 64: 277-289. PMID: 37552895, PMCID: PMC10841102, DOI: 10.1146/annurev-pharmtox-051921-023858.Peer-Reviewed Original ResearchCholinergic neuronsMuscarinic acetylcholine receptor subtypesDA neuron activityMidbrain DA neuronsAcetylcholine receptor subtypesMood-related disordersPotential clinical implicationsDA circuitryDA neuronsDA releaseMuscarinic receptorsCholinergic regulationReceptor subtypesDopamine systemNeuron activityClinical implicationsNeuropsychiatric disordersDopamine signalingNumerous disordersSubtypesNumerous receptorsDisordersNeuronsReceptorsPublication date
2022
The mirror mechanism in schizophrenia: A systematic review and qualitative meta-analysis
Valizadeh A, Mbwogge M, Yazdi A, Amlashi N, Haadi A, Shayestefar M, Moassefi M. The mirror mechanism in schizophrenia: A systematic review and qualitative meta-analysis. Frontiers In Psychiatry 2022, 13: 884828. PMID: 36213922, PMCID: PMC9532849, DOI: 10.3389/fpsyt.2022.884828.Peer-Reviewed Original ResearchMirror neuron activityCortical motor systemSchizophrenia patientsMirror neuron systemUnderlying pathophysiologyCertainty of evidenceCase-control studyNew rehabilitation methodWeb of ScienceObjective assessment toolEligible studiesHealthy controlsVisuomotor neuronsPatientsNeuron activityPositive symptomsSystematic reviewInvestigation of heterogeneityMicrostructural integrityVote counting methodNeuron systemPathophysiologySymptomsFunctional integrityRehabilitation methods
2020
Laminar Differences in the Targeting of Dendritic Spines by Cortical Pyramidal Neurons and Interneurons in Human Dorsolateral Prefrontal Cortex
Glausier J, Datta D, Fish K, Chung D, Melchitzky D, Lewis D. Laminar Differences in the Targeting of Dendritic Spines by Cortical Pyramidal Neurons and Interneurons in Human Dorsolateral Prefrontal Cortex. Neuroscience 2020, 452: 181-191. PMID: 33212224, PMCID: PMC7770119, DOI: 10.1016/j.neuroscience.2020.10.022.Peer-Reviewed Original ResearchConceptsCortical pyramidal neuronsDorsolateral prefrontal cortexHuman dorsolateral prefrontal cortexPyramidal neuronsDendritic spinesDensity of spinesMonkey dorsolateral prefrontal cortexPrefrontal cortexPrimate dorsolateral prefrontal cortexDeep cortical layersPyramidal neuron activitySpecific neural circuitsGABAergic inputsGlutamatergic inputsGABAergic interneuronsGlutamatergic synapsesLaminar differencesCore cognitive functionNeuron activitySynaptic informationNeuron synapseCortical layersInterneuronsRecurrent excitationCognitive functionAcetylcholine is released in the basolateral amygdala in response to predictors of reward and enhances learning of cue-reward contingency
Crouse RB, Kim K, Batchelor HM, Girardi EM, Kamaletdinova R, Chan J, Rajebhosale P, Pittenger ST, Role LW, Talmage DA, Jing M, Li Y, Gao XB, Mineur YS, Picciotto MR. Acetylcholine is released in the basolateral amygdala in response to predictors of reward and enhances learning of cue-reward contingency. ELife 2020, 9: e57335. PMID: 32945260, PMCID: PMC7529459, DOI: 10.7554/elife.57335.Peer-Reviewed Original ResearchConceptsBasolateral amygdalaCue-reward learningActivity of neuronsReward-related eventsNucleus basalisBLA responsesACh levelsPredictors of rewardTerminal fibersNeuron activityReward-predictive cuesCalcium indicatorsAChNeutral cuesEmotional stimuliAversive stimuliReward retrievalTask acquisitionAmygdalaSalient eventsMiceACh sensorTerminal activityQuick acquisitionCuesNesfatin-1 decreases the motivational and rewarding value of food
Dore R, Krotenko R, Reising JP, Murru L, Sundaram SM, Di Spiezio A, Müller-Fielitz H, Schwaninger M, Jöhren O, Mittag J, Passafaro M, Shanabrough M, Horvath TL, Schulz C, Lehnert H. Nesfatin-1 decreases the motivational and rewarding value of food. Neuropsychopharmacology 2020, 45: 1645-1655. PMID: 32353862, PMCID: PMC7419560, DOI: 10.1038/s41386-020-0682-3.Peer-Reviewed Original ResearchConceptsNUCB2/nesfatinNesfatin-1Nucleobindin-2Food intakeNesfatin-1 actionDopaminergic neuron activityFasting-induced increaseReward-related brain areasOutward potassium currentHedonic pathwaysHedonic feedingGABA neuronsLeptin resistanceBrain areasPotassium currentNeuron activityFood rewardEnergy intakeReward circuitryElectrophysiological recordingsNesfatinCentral administrationEnhanced sensitizationIntakeHomeostatic mechanisms
2014
Developmental Expression Patterns of GABAA Receptor Subunits in Layer 3 and 5 Pyramidal Cells of Monkey Prefrontal Cortex
Datta D, Arion D, Lewis D. Developmental Expression Patterns of GABAA Receptor Subunits in Layer 3 and 5 Pyramidal Cells of Monkey Prefrontal Cortex. Cerebral Cortex 2014, 25: 2295-2305. PMID: 24610118, PMCID: PMC4494034, DOI: 10.1093/cercor/bhu040.Peer-Reviewed Original ResearchConceptsGABAA receptor subunitsPyramidal cellsMonkey prefrontal cortexReceptor subunitsSubunit expressionLayer 3 pyramidal cellsGABAA receptor subunit expressionPrefrontal cortexGABAA receptor subunit mRNAsLayer 5 pyramidal cellsReceptor subunit changesPrefrontal pyramidal neuronsReceptor subunit expressionPyramidal neuron activityGlutamate receptor subunitsReceptor subunit mRNAsPyramidal cell firingPostnatal developmental changesPyramidal neuronsGABAA receptorsInhibitory inputsNeuron activityFunctional maturationPostnatal developmentCell firingDisrupted in Schizophrenia 1 Modulates Medial Prefrontal Cortex Pyramidal Neuron Activity Through cAMP Regulation of Transient Receptor Potential C and Small-Conductance K+ Channels
El-Hassar L, Simen AA, Duque A, Patel KD, Kaczmarek LK, Arnsten AF, Yeckel MF. Disrupted in Schizophrenia 1 Modulates Medial Prefrontal Cortex Pyramidal Neuron Activity Through cAMP Regulation of Transient Receptor Potential C and Small-Conductance K+ Channels. Biological Psychiatry 2014, 76: 476-485. PMID: 24560582, PMCID: PMC4104266, DOI: 10.1016/j.biopsych.2013.12.019.Peer-Reviewed Original ResearchConceptsCyclic adenosine monophosphateIntracellular Ca2Prefrontal cortical pyramidal neuronsReceptor-mediated intracellular Ca2Regulation of cAMPPrefrontal cortical slicesCortical pyramidal neuronsDISC1 functionMajor depressive disorderPyramidal neuron activityPatch-clamp recordingsTRPC channel activityDISC1 disruptionPrefrontal cortex activityPyramidal neuronsCortical slicesDepressive disorderAdult ratsIntracellular calcium wavesSustained depolarizationViral knockdownNeuron activityBipolar disorderMental disordersCAMP generation
2012
Lack of GPR88 enhances medium spiny neuron activity and alters motor- and cue-dependent behaviors
Quintana A, Sanz E, Wang W, Storey GP, Güler AD, Wanat MJ, Roller BA, La Torre A, Amieux PS, McKnight GS, Bamford NS, Palmiter RD. Lack of GPR88 enhances medium spiny neuron activity and alters motor- and cue-dependent behaviors. Nature Neuroscience 2012, 15: 1547-1555. PMID: 23064379, PMCID: PMC3483418, DOI: 10.1038/nn.3239.Peer-Reviewed Original ResearchMeSH KeywordsAnalysis of VarianceAnimalsAvoidance LearningBenzylaminesBiophysicsCells, CulturedChromonesCorpus StriatumCuesElectric StimulationEmbryo, MammalianExcitatory Amino Acid AntagonistsExcitatory Postsynaptic PotentialsFemaleGABA Antagonistsgamma-Aminobutyric AcidGene Expression ProfilingGreen Fluorescent ProteinsIn Vitro TechniquesMaleMaze LearningMiceMice, Inbred C57BLMice, TransgenicMotor ActivityMutationNeuronsOligonucleotide Array Sequence AnalysisPhosphinic AcidsReceptors, AMPAReceptors, G-Protein-CoupledReceptors, GABA-BRotarod Performance TestConceptsMedium spiny neuronsMedium spiny neuron activityStriatal medium spiny neuronsOrphan G protein-coupled receptorPoor motor coordinationG protein-coupled receptorsProtein-coupled receptorsSpiny neuronsMotor coordinationGPR88Neuron activityFiring rateReduced inhibitionHyperactivityMiceNeuronsReceptors
2011
Attenuating GABAA Receptor Signaling in Dopamine Neurons Selectively Enhances Reward Learning and Alters Risk Preference in Mice
Parker JG, Wanat MJ, Soden ME, Ahmad K, Zweifel LS, Bamford NS, Palmiter RD. Attenuating GABAA Receptor Signaling in Dopamine Neurons Selectively Enhances Reward Learning and Alters Risk Preference in Mice. Journal Of Neuroscience 2011, 31: 17103-17112. PMID: 22114279, PMCID: PMC3235504, DOI: 10.1523/jneurosci.1715-11.2011.Peer-Reviewed Original ResearchConceptsDA neuronsDA neuron activityGABAA Receptor SignalingPhasic dopamine transmissionPhasic DA responsesAversive learningAppetitive learningGABAergic toneExcitatory afferentsMidbrain slicesDA releaseDopamine neuronsExcitatory driveDopamine transmissionNucleus accumbensDA responseElectrical stimulationNeuron activityDA signalingPsychiatric conditionsCompensatory upregulationMiceNeuronsReceptor signalingAppetitive task
2009
Dopamine
Elsworth J, Roth R. Dopamine. 2009, 539-547. DOI: 10.1016/b978-008045046-9.00683-5.Peer-Reviewed Original ResearchCo-localized peptidesDA neuron activityDopamine cell groupsDendritic spine synapsesDifferent firing patternsSpine densityDA neurotransmissionSpine synapsesParkinson's diseaseNeuron activityVolume transmissionPharmacological perspectiveCell groupsFiring patternsEndogenous mechanismsDiseaseAutoreceptorsNeurotransmissionSchizophreniaBrainSynapses
2002
Hypocretin/Orexin Excites Hypocretin Neurons via a Local Glutamate Neuron—A Potential Mechanism for Orchestrating the Hypothalamic Arousal System
Li Y, Gao X, Sakurai T, van den Pol AN. Hypocretin/Orexin Excites Hypocretin Neurons via a Local Glutamate Neuron—A Potential Mechanism for Orchestrating the Hypothalamic Arousal System. Neuron 2002, 36: 1169-1181. PMID: 12495630, DOI: 10.1016/s0896-6273(02)01132-7.Peer-Reviewed Original ResearchMeSH KeywordsAction PotentialsAnimalsArousalCarrier ProteinsExcitatory Amino Acid AgonistsFeedbackGABA Agonistsgamma-Aminobutyric AcidGenes, ReporterGlutamic AcidGreen Fluorescent ProteinsHypothalamusImmunohistochemistryIntracellular Signaling Peptides and ProteinsLuminescent ProteinsMiceMice, TransgenicNeural InhibitionNeural PathwaysNeuronsNeuropeptidesOrexinsPresynaptic TerminalsSodium Channel BlockersSynaptic TransmissionConceptsHypothalamic arousal systemsHypocretin neuronsArousal systemSpike frequencyLocal glutamatergic neuronsMouse brain slicesGlutamate releaseGlutamatergic neuronsHypocretin-1Hypocretin cellsPresynaptic facilitationBrain slicesNeuron activityOutward currentsEnergy homeostasisModulates sleepNeuronsPotential mechanismsDirect effectPossible mechanismCellsNarcolepsyHypocretinNorepinephrineAcetylcholine
1996
Stiff-Man Syndrome and Glutamic Acid Decarboxylase: An Updated View
Solimena M, Dirkx R, Butler M, Hermel J, Guernaccia J, Marek K, David C, De Camilli P. Stiff-Man Syndrome and Glutamic Acid Decarboxylase: An Updated View. Advances In Pharmacological Sciences 1996, 31-43. DOI: 10.1007/978-3-0348-8990-2_5.Peer-Reviewed Original Research
1992
6 Many neurones in the Aplysia abdominal ganglion are active during the gill-withdrawal reflex
Falk C, Wu J, Cohen L, Hopp H, Zecevic D, London J, Roschin V. 6 Many neurones in the Aplysia abdominal ganglion are active during the gill-withdrawal reflex. 1992, 88-101. DOI: 10.1016/b978-0-08-041986-2.50011-4.Peer-Reviewed Original ResearchAplysia abdominal ganglionGill withdrawal reflexAbdominal ganglionActive neuronsAction potential activityNumber of spikesGenital nerveOptical recording methodVoltage-sensitive dyeGill withdrawalNeuron activityNervous tissueGangliaSensitized stateNeuronsInvertebrate gangliaAplysia californicaReflexExtracellular electrodesOptical recordingPotential activityRecording methodNerveInterneuronsRecordings
1991
Effects of neurotensin on midbrain dopamine neurons: Are they mediated by formation of a neurotensin—dopamine complex?
Shi W, Bunney B. Effects of neurotensin on midbrain dopamine neurons: Are they mediated by formation of a neurotensin—dopamine complex? Synapse 1991, 9: 157-164. PMID: 1776128, DOI: 10.1002/syn.890090302.Peer-Reviewed Original ResearchConceptsEffects of neurotensinNeurotensin receptorsDopamine neuronsDopamine cellsCell activitySingle-unit recording techniquesFiring rateMidbrain dopamine neuron activityAction of neurotensinBasal firing rateDopamine receptor blockadeDopamine-induced inhibitionDopamine neuron activityMidbrain dopamine neuronsReceptor blockadeDepolarization inactivationExcitatory effectsNative neurotensinBrain slicesNeuron activityNeurotensinNeurotensin analoguesSame receptorRecording techniquesReceptors
1989
Hundreds of neurons in the Aplysia abdominal ganglion are active during the gill-withdrawal reflex
Zecevic D, Wu J, Cohen L, London J, Hopp H, Falk C. Hundreds of neurons in the Aplysia abdominal ganglion are active during the gill-withdrawal reflex. Journal Of Neuroscience 1989, 9: 3681-3689. PMID: 2795148, PMCID: PMC6569909, DOI: 10.1523/jneurosci.09-10-03681.1989.Peer-Reviewed Original Research
1988
Optical monitoring of activity of many neurons in invertebrate ganglia during behaviors
Wu J, London JA, Zecevic D, Höpp H, Cohen LB, Xiao C. Optical monitoring of activity of many neurons in invertebrate ganglia during behaviors. Cellular And Molecular Life Sciences 1988, 44: 369-376. PMID: 3286282, DOI: 10.1007/bf01940529.Peer-Reviewed Original Research
1987
Simultaneous optical recording of activity from many neurons during feeding in Navanax
London JA, Zecević D, Cohen LB. Simultaneous optical recording of activity from many neurons during feeding in Navanax. Journal Of Neuroscience 1987, 7: 649-661. PMID: 2435862, PMCID: PMC6569073, DOI: 10.1523/jneurosci.07-03-00649.1987.Peer-Reviewed Original ResearchChronic Neuroleptic Effects on Dopamine Neuron Activity: A Model for Predicting Therapeutic Efficacy and Side Effects?
Freeman A, Bunney B. Chronic Neuroleptic Effects on Dopamine Neuron Activity: A Model for Predicting Therapeutic Efficacy and Side Effects? Psychopharmacology Series 1987, 3: 225-235. PMID: 2881290, DOI: 10.1007/978-3-642-71288-3_26.Peer-Reviewed Original ResearchConceptsMost psychotic patientsDA receptor blockerTreatment of choiceDopamine neuron activityCentral catecholamine systemsReceptor blockadeReceptor blockersCatecholamine neuronsNeuroleptic effectsMajor symptomsAntipsychotic drugsCatecholamine systemsAntipsychotic propertiesForebrain regionsNeuronal activityCatecholamine receptorsSide effectsDopamine systemNeuron activityPsychotic patientsTherapeutic efficacyMode of actionFeedback pathwaysTreatmentNeuroleptics
1980
Effect of sensory stimuli on the activity of dopaminergic neurons: Involvement of non-dopaminergic nigral neurons and striato-nigral pathways
Hommer D, Bunney B. Effect of sensory stimuli on the activity of dopaminergic neurons: Involvement of non-dopaminergic nigral neurons and striato-nigral pathways. Life Sciences 1980, 27: 377-386. PMID: 7412480, DOI: 10.1016/0024-3205(80)90185-x.Peer-Reviewed Original ResearchConceptsStriato-nigral pathwayDopaminergic neuronsReticulata neuronsInhibitory periodSingle-unit recording techniquesNon-dopaminergic neuronsNigro-striatal pathwaySciatic nerve stimulationRat substantia nigraDopaminergic neuron activitySensory stimuliInitial inhibitionStimulation-induced changesActivity of dopaminergicNigral neuronsNerve stimulationSubstantia nigraNeuron activityNeuronsRecording techniquesHaloperidolLesionsInhibitionStimulationPathway
1979
Paradoxical GABA excitation of nigral dopaminergic cells: Indirect mediation through reticulata inhibitory neurons
Grace A, Bunney B. Paradoxical GABA excitation of nigral dopaminergic cells: Indirect mediation through reticulata inhibitory neurons. European Journal Of Pharmacology 1979, 59: 211-218. PMID: 527646, DOI: 10.1016/0014-2999(79)90283-8.Peer-Reviewed Original ResearchConceptsZona reticulataGABA agonistsGABAergic inputsZona compactaSubstantia nigraLow dosesCell activitySingle-unit recording techniquesNigral dopaminergic cellsInhibitory GABAergic inputMeans of microiontophoresisPopulations of neuronsCell firing rateGABA excitationExcitatory effectsDopaminergic neuronsDopaminergic cellsInhibitory neuronsSame doseElectrophysiological studiesNeuron activityZR cellsFiring rateNeuronsAgonists
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