2025
Translaminar synchronous neuronal activity is required for columnar synaptic strengthening in the mouse neocortex
Vargas-Ortiz J, Lin L, Martinez V, Liu R, Babij R, Duan Z, Wacks S, Sun L, Wang A, Khan S, Soto-Vargas J, De Marco García N, Che A. Translaminar synchronous neuronal activity is required for columnar synaptic strengthening in the mouse neocortex. Nature Communications 2025, 16: 1296. PMID: 39900899, PMCID: PMC11791040, DOI: 10.1038/s41467-024-55783-w.Peer-Reviewed Original ResearchThis study shows how connections across layers in the cortex synchronize early brain activity, guiding sensory development and informing strategies to address neurodevelopmental disorders.
2024
Brain state and cortical layer-specific mechanisms underlying perception at threshold
Morton M, Denagamage S, Blume I, Reynolds J, Jadi M, Nandy A. Brain state and cortical layer-specific mechanisms underlying perception at threshold. ELife 2024, 12: rp91722. PMID: 39556415, PMCID: PMC11573349, DOI: 10.7554/elife.91722.Peer-Reviewed Original ResearchConceptsHIT trialsProcessing of sensory stimuliStable retinal imageBehavioral statesExcitatory neuronsNeural activitySpontaneous activityElevated synchronyPerceptual thresholdsCortical layersMeasures of stateElectrophysiological activitySensory stimuliRetinal imagesVisual area V4TrialsHeightened arousalTarget stimuliStimulus identityElevated arousalSuperficial layersFeed-forward pathwayStimulus changeCortical columnsIdentical stimuliBrain state and cortical layer-specific mechanisms underlying perception at threshold
Morton M, Denagamage S, Blume I, Reynolds J, Jadi M, Nandy A. Brain state and cortical layer-specific mechanisms underlying perception at threshold. ELife 2024, 12 DOI: 10.7554/elife.91722.4.Peer-Reviewed Original ResearchHIT trialsProcessing of sensory stimuliStable retinal imageBehavioral statesExcitatory neuronsNeural activitySpontaneous activityElevated synchronyPerceptual thresholdsCortical layersMeasures of stateElectrophysiological activitySensory stimuliRetinal imagesVisual area V4TrialsHeightened arousalTarget stimuliStimulus identityElevated arousalSuperficial layersFeed-forward pathwayStimulus changeCortical columnsIdentical stimuliSmall molecule inhibition of glycogen synthase I reduces muscle glycogen content and improves biomarkers in a mouse model of Pompe disease
Gaspar R, Sakuma I, Nasiri A, Hubbard B, LaMoia T, Leitner B, Tep S, Xi Y, Green E, Ullman J, Petersen K, Shulman G. Small molecule inhibition of glycogen synthase I reduces muscle glycogen content and improves biomarkers in a mouse model of Pompe disease. AJP Endocrinology And Metabolism 2024, 327: e524-e532. PMID: 39171753, PMCID: PMC11482269, DOI: 10.1152/ajpendo.00175.2024.Peer-Reviewed Original ResearchGAA-KO miceMouse model of Pompe diseaseModel of Pompe diseasePompe diseaseMetabolic dysregulationRegular chowMouse modelSmall molecule inhibitionInsulin sensitivityReduced spontaneous activityGroups of male miceEnzyme acid alpha-glucosidaseProgressive muscle weaknessImprove metabolic dysregulationSynthase IWhole-body insulin sensitivityAcid alpha-glucosidaseImproved glucose toleranceIncreased AMPK phosphorylationWT miceAbnormal accumulation of glycogenGlycogen storage disorderMale miceSpontaneous activityImproved biomarkersAllergic Contact Dermatitis: A Model of Inflammatory Itch and Pain in Human and Mouse
LaMotte R. Allergic Contact Dermatitis: A Model of Inflammatory Itch and Pain in Human and Mouse. 2024, 23-32. DOI: 10.1007/978-981-99-8921-8_2.Peer-Reviewed Original ResearchSquaric acid dibutyl esterAllergic contact dermatitisPersistent itchingPathogenesis of allergic contact dermatitisPain-like behaviorsMechanically evoked itchMechanisms of itchPeripheral neural mechanismsClinically significant problemReceptor CXCR3Excitatory responsesIP-10Chemokine CXCL10In vivo recordingsCutaneous sitesLocal inflammationSpontaneous activityPruritic disordersAnimal modelsPainTopical applicationItchingItch disordersMiceTherapeutic targetHebbian instruction of axonal connectivity by endogenous correlated spontaneous activity
Matsumoto N, Barson D, Liang L, Crair M. Hebbian instruction of axonal connectivity by endogenous correlated spontaneous activity. Science 2024, 385: eadh7814-eadh7814. PMID: 39146415, PMCID: PMC12148345, DOI: 10.1126/science.adh7814.Peer-Reviewed Original ResearchConceptsSpontaneous activitySpontaneous retinal wavesAxonal connectionsPatterns of correlated activityNeonatal miceEvidence in vivoRetinal wavesPostsynaptic neuronsNeuronal activityIn vivoAxonal arborsAxonal processesAxonsRetinocollicular axonsNeural connectionsIndividual axonsMorphological changesSubcellular precisionEndogenous pattern
2023
Longitudinal simultaneous fMRI and mesoscale calcium imaging in a mouse model of Alzheimer’s disease
Mandino F, Shen X, Desrosiers-Gregoire G, O'Connor D, Mukherjee B, DeLuca K, Hamodi A, Owens A, Ha Y, Qu A, Onofrey J, Papademetris X, Chakravarty M, Crair M, Strittmatter S, Lake E. Longitudinal simultaneous fMRI and mesoscale calcium imaging in a mouse model of Alzheimer’s disease. Proceedings Of The International Society For Magnetic Resonance In Medicine ... Scientific Meeting And Exhibition. 2023 DOI: 10.58530/2023/3914.Peer-Reviewed Original ResearchMouse model of Alzheimer's diseaseModel of Alzheimer's diseaseMesoscale calcium imagingAlzheimer's diseaseBehavioral deficitsExcitatory neural activityMultimodal neuroimagingBOLD signalSimultaneous fMRINeuroimaging changesNeural activityBOLD fMRIPreliminary evidenceCalcium imagingClinically accessible biomarkersMesoscopic calcium imagingSpontaneous activityFMRINeuroimagingBOLDDeficitsComplex relationship
2021
Retinal waves prime visual motion detection by simulating future optic flow
Ge X, Zhang K, Gribizis A, Hamodi AS, Sabino AM, Crair MC. Retinal waves prime visual motion detection by simulating future optic flow. Science 2021, 373 PMID: 34437090, PMCID: PMC8841103, DOI: 10.1126/science.abd0830.Peer-Reviewed Original ResearchConceptsEye-specific segregationSpontaneous retinal wavesVisual response propertiesSpontaneous retinal activityDirection-selective responsesSuperior colliculus neuronsOptic flow patternsRetinal wavesRetinal activityColliculus neuronsRetinal circuitsSpontaneous activityChronic disruptionVisual motion detectionEye openingTransient windowResponse propertiesOptic flowSensory experienceNeuronsEfferent feedback controls bilateral auditory spontaneous activity
Wang Y, Sanghvi M, Gribizis A, Zhang Y, Song L, Morley B, Barson DG, Santos-Sacchi J, Navaratnam D, Crair M. Efferent feedback controls bilateral auditory spontaneous activity. Nature Communications 2021, 12: 2449. PMID: 33907194, PMCID: PMC8079389, DOI: 10.1038/s41467-021-22796-8.Peer-Reviewed Original ResearchConceptsSpontaneous activityEfferent modulationEfferent pathwaysMedial olivocochlear systemCentral nervous systemCentral auditory systemInner hair cellsAuditory systemNicotinic acetylcholine receptorsSpontaneous activity patternsOlivocochlear systemHearing onsetEfferent systemChemogenetic experimentsBilateral couplingNervous systemAcetylcholine receptorsCircuit formationEfferent feedbackFiring patternsHair cellsΑ9/Auditory sensitivityBilateral correlationActivity patterns
2019
Association between spontaneous activity of the default mode network hubs and leukocyte telomere length in late childhood and early adolescence
Rebello K, Moura L, Xavier G, Spindola L, Carvalho C, Hoexter M, Gadelha A, Picon F, Pan P, Zugman A, Grassi-Oliveira R, Brietzke E, Belangero S, Salum G, Rohde L, Miguel E, Bressan R, Jackowski A, Sato J. Association between spontaneous activity of the default mode network hubs and leukocyte telomere length in late childhood and early adolescence. Journal Of Psychosomatic Research 2019, 127: 109864. PMID: 31706071, DOI: 10.1016/j.jpsychores.2019.109864.Peer-Reviewed Original ResearchConceptsAdverse childhood experiencesMedial prefrontal cortexPosterior cingulate cortexDefault mode networkResting-state functional magnetic resonanceEarly life stressBrain's default mode networkFunctional magnetic resonanceBlood samplesSpontaneous activityDefault mode network hubCingulate cortexDMN hubsPsychiatric conditionsFamily environmentLength shorteningPrefrontal cortexMental healthFractional amplitudeLow-frequency fluctuationsMode networkFamily Environment ScaleHypothesis-driven studiesTelomere lengthLate childhoodDeletion of the Creatine Transporter (Slc6a8) in Dopaminergic Neurons Leads to Hyperactivity in Mice
Abdulla ZI, Pahlevani B, Lundgren KH, Pennington JL, Udobi KC, Seroogy KB, Skelton MR. Deletion of the Creatine Transporter (Slc6a8) in Dopaminergic Neurons Leads to Hyperactivity in Mice. Journal Of Molecular Neuroscience 2019, 70: 102-111. PMID: 31520365, PMCID: PMC7001766, DOI: 10.1007/s12031-019-01405-w.Peer-Reviewed Original ResearchConceptsCr transporter deficiencyDopaminergic neuronsMotor functionLocomotor activityChallenging beam testSpontaneous activity testMonths of ageAttention deficit hyperactivity disorderCerebral Cr deficiencySpecific neuronal systemsUnique metabolic demandsCerebral creatineHindlimb stepsControl miceNeurological effectsSpontaneous activityMice ageSLC6A8 geneTransporter deficiencyNeurodegenerative disordersDopamine transporterNeuronal systemsMiceCreatine transporterHuntington's diseaseCorrection to: Socioeconomic status in children is associated with spontaneous activity in right superior temporal gyrus
Biazoli C, Salum G, Gadelha A, Rebello K, Moura L, Pan P, Brietzke E, Miguel E, Rohde L, Bressan R, Jackowski A, Sato J. Correction to: Socioeconomic status in children is associated with spontaneous activity in right superior temporal gyrus. Brain Imaging And Behavior 2019, 14: 639-639. PMID: 31144115, DOI: 10.1007/s11682-019-00125-4.Peer-Reviewed Original ResearchSocioeconomic status in children is associated with spontaneous activity in right superior temporal gyrus
Biazoli C, Salum G, Gadelha A, Rebello K, Moura L, Pan P, Brietzke E, Miguel E, Rohde L, Bressan R, Jackowski A, Sato J. Socioeconomic status in children is associated with spontaneous activity in right superior temporal gyrus. Brain Imaging And Behavior 2019, 14: 961-970. PMID: 30868400, DOI: 10.1007/s11682-019-00073-z.Peer-Reviewed Original ResearchConceptsRight superior temporal gyrusSuperior temporal gyrusTemporal gyrusExtended language networkDifferent developmental trajectoriesBrain functional organizationSchool-based sampleFunctional organizationStructural neuroimaging findingsCognitive controlSocioeconomic statusLanguage networkExternalizing problemsInternalizing problemsDevelopmental trajectoriesEmotional problemsSpontaneous activityRegional spontaneous activityLanguage processingFMRI featuresBrain regionsBrain areasNeuroimaging findingsFunctional networksLinguistic environment
2018
Associations between children’s family environment, spontaneous brain oscillations, and emotional and behavioral problems
Sato J, Biazoli C, Salum G, Gadelha A, Crossley N, Vieira G, Zugman A, Picon F, Pan P, Hoexter M, Amaro E, Anés M, Moura L, Del’Aquilla M, Mcguire P, Rohde L, Miguel E, Bressan R, Jackowski A. Associations between children’s family environment, spontaneous brain oscillations, and emotional and behavioral problems. European Child & Adolescent Psychiatry 2018, 28: 835-845. PMID: 30392120, DOI: 10.1007/s00787-018-1240-y.Peer-Reviewed Original ResearchConceptsFamily environmentMental health outcomesFamily coherenceEmotional problemsOrbitofrontal cortexTemporal poleResting-state fMRI dataLeft temporal poleSpontaneous brain oscillationsChild's family environmentRight orbitofrontal cortexOscillatory neural activityHealth outcomesBrain oscillationsBehavioral problemsNeural activityFMRI dataFMRI metricsBrain areasLow-frequency fluctuationsFractional amplitudeLower incidenceSpontaneous activityHigh incidenceExploratory studyPkd2l1 is required for mechanoception in cerebrospinal fluid-contacting neurons and maintenance of spine curvature
Sternberg JR, Prendergast AE, Brosse L, Cantaut-Belarif Y, Thouvenin O, Orts-Del’Immagine A, Castillo L, Djenoune L, Kurisu S, McDearmid JR, Bardet PL, Boccara C, Okamoto H, Delmas P, Wyart C. Pkd2l1 is required for mechanoception in cerebrospinal fluid-contacting neurons and maintenance of spine curvature. Nature Communications 2018, 9: 3804. PMID: 30228263, PMCID: PMC6143598, DOI: 10.1038/s41467-018-06225-x.Peer-Reviewed Original ResearchConceptsCentral canalCSF-cNsSpontaneous activityCSF flowCerebrospinal fluid-contacting neuronsSpine curvatureCSF-contacting neuronsCerebrospinal fluid flowSpinal cordIdiopathic scoliosisSingle-channel openingsCalcium activityPKD2L1 channelPKD2L1Mechanosensory cellsNeuronsCanalChannel openingMechanoceptionKyphosisCilia motilityCordAcute physical exercise increases leptin‐induced hypothalamic extracellular signal‐regulated kinase1/2 phosphorylation and thermogenesis of obese mice
Gaspar R, Muñoz V, Kuga G, Nakandakari S, Minuzzi L, Botezelli J, da Silva A, Cintra D, de Moura L, Ropelle E, Pauli J. Acute physical exercise increases leptin‐induced hypothalamic extracellular signal‐regulated kinase1/2 phosphorylation and thermogenesis of obese mice. Journal Of Cellular Biochemistry 2018, 120: 697-704. PMID: 30206970, DOI: 10.1002/jcb.27426.Peer-Reviewed Original ResearchConceptsAcute physical exerciseBrown adipose tissueObese micePhysical exerciseEnergy expenditureERK1/2 phosphorylationTreatment of obesityExtracellular signal-regulated kinase1/2 (ERK1/2) phosphorylationProtein 1 (UCP1) contentExtracellular signal-regulated kinase 1/2Signal-regulated kinase 1/2Sympathetic signalsSpontaneous activityAdipose tissueP-ERK1/2Main interventionThermoregulatory effectsMiceKey mediatorThermogenesisOxygen uptakeMolecular changesKinase 1/2ObeseObesityHomeostatic Control of Spontaneous Activity in the Developing Auditory System
Babola TA, Li S, Gribizis A, Lee BJ, Issa JB, Wang HC, Crair MC, Bergles DE. Homeostatic Control of Spontaneous Activity in the Developing Auditory System. Neuron 2018, 99: 511-524.e5. PMID: 30077356, PMCID: PMC6100752, DOI: 10.1016/j.neuron.2018.07.004.Peer-Reviewed Original ResearchConceptsSpiral ganglion neuronsSpontaneous activityAuditory systemDirect neuronal excitationGlutamate releaseEnhanced excitabilityGanglion neuronsUnanesthetized miceSynaptic excitationHearing onsetNeuronal excitationTherapeutic approachesMouse modelSpontaneous burstsCongenital formSynchronized activityHair cellsHomeostatic mechanismsNeuronsHomeostatic controlSimilar frequencyCircuit developmentMiceInfluence developmentDeafness
2017
Low frequency fluctuation of brain spontaneous activity and obsessive-compulsive symptoms in a large school-age sample
Hoexter M, Biazoli C, Alvarenga P, Batistuzzo M, Salum G, Gadelha A, Pan P, Anés M, Mancini-Martins L, Moura L, Soriano-Mas C, Aquilla M, Amaro E, Rohde L, Jackowski A, Bressan R, Miguel E, do Rosario M, Sato J. Low frequency fluctuation of brain spontaneous activity and obsessive-compulsive symptoms in a large school-age sample. Journal Of Psychiatric Research 2017, 96: 224-230. PMID: 29102817, DOI: 10.1016/j.jpsychires.2017.10.009.Peer-Reviewed Original ResearchConceptsObsessive-compulsive symptomsBrain spontaneous activityLow-frequency fluctuationsSpontaneous activityRight sensorimotor cortexHigh Risk Cohort StudyState functional magnetic resonance imaging (rs-fMRI) dataSpontaneous activity changesPredictors of riskWell-Being AssessmentSpontaneous brain activitySuperior temporal cortexSuperior temporal gyrusCohort studyObsessive-compulsive disorderSensorimotor cortexMagnetic resonance imaging dataPsychiatric disordersOverall psychopathologyTemporal gyrusFractional amplitudeGeneral linear modelFunctional magnetic resonance imaging (fMRI) dataCompulsive symptomsBrain activity
2016
Retinal Wave Patterns Are Governed by Mutual Excitation among Starburst Amacrine Cells and Drive the Refinement and Maintenance of Visual Circuits
Xu HP, Burbridge TJ, Ye M, Chen M, Ge X, Zhou ZJ, Crair MC. Retinal Wave Patterns Are Governed by Mutual Excitation among Starburst Amacrine Cells and Drive the Refinement and Maintenance of Visual Circuits. Journal Of Neuroscience 2016, 36: 3871-3886. PMID: 27030771, PMCID: PMC4812142, DOI: 10.1523/jneurosci.3549-15.2016.Peer-Reviewed Original ResearchMeSH KeywordsAction PotentialsAge FactorsAmacrine CellsAnimalsAnimals, NewbornCalciumCholera ToxinCholine O-AcetyltransferaseCholinergic AgentsGene Expression Regulation, DevelopmentalGreen Fluorescent ProteinsIn Vitro TechniquesMiceMice, TransgenicPatch-Clamp TechniquesReceptors, NicotinicRetinaRetinal Ganglion CellsVesicular Glutamate Transport Protein 1Visual PathwaysConceptsEye-specific segregationVisual circuit developmentStarburst amacrine cellsStage III retinal wavesRetinal ganglion cellsRetinal wavesAmacrine cellsGlutamatergic wavesGanglion cellsSpontaneous activityVisual circuitsStage IICircuit developmentHigher-order visual areasNicotinic acetylcholine receptorsRetinal cell typesMammalian visual systemAcetylcholine receptorsΒ2-nAChRsVisual areasPatterned activityPatterning of activityΒ2 subunitCell typesCellsAllergic Contact Dermatitis: A Model of Inflammatory Itch and Pain in Human and Mouse
LaMotte RH. Allergic Contact Dermatitis: A Model of Inflammatory Itch and Pain in Human and Mouse. Advances In Experimental Medicine And Biology 2016, 904: 23-32. PMID: 26900060, PMCID: PMC4910628, DOI: 10.1007/978-94-017-7537-3_2.Peer-Reviewed Original ResearchConceptsAllergic contact dermatitisPersistent itchPathogenesis of ACDSquaric acid dibutyl esterPain-like behaviorsSmall-diameter neuronsPeripheral neural mechanismsPossible therapeutic targetInflammatory itchPruritic disordersCutaneous sitesChemokine CXCL10Excitatory responsesLocal inflammationReceptor CXCR3Contact dermatitisUnmyelinated axonsSpontaneous activityTherapeutic targetAnimal modelsPainSubsequent challengeTopical applicationItchMice
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply