2025
32. Cognitive Impairment in Patients With Early Onset Psychosis and Their Siblings: Age and Sex Differences
Mollon J, Lanzagorta N, Mathias S, Rodrigue A, Knowles E, Deaso E, Saavedra J, Cadavid L, Polat N, Nieto M, Brownstein C, D’Angelo E, Deo A, Gonzalez-Heydrich J, Sarmiento E, Walsh C, Almasy L, Nicolini H, Glahn D. 32. Cognitive Impairment in Patients With Early Onset Psychosis and Their Siblings: Age and Sex Differences. Biological Psychiatry 2025, 97: s87-s88. DOI: 10.1016/j.biopsych.2025.02.222.Peer-Reviewed Original ResearchBeyond screen time: The core influences of problematic screen use on adolescent development networks.
Xu L, Song K, Deng H, Geng X, Zhang J, Fang X, Potenza M, Zhang J. Beyond screen time: The core influences of problematic screen use on adolescent development networks. Journal Of Behavioral Addictions 2025 PMID: 40293811, DOI: 10.1556/2006.2025.00035.Peer-Reviewed Original ResearchAdolescent Brain Cognitive DevelopmentFunctional impairmentCross-sectional networksSelf-reported screen timeSelf-report questionnairesAdolescent Well-BeingChecking behaviorBehavioral tendenciesCognitive developmentProblematic useMotivational aspectsScreen timeScreen useStronger connectionsImpairmentHigh centralityWell-beingPredictive effectYouthAdolescentsFollow-upPsychopathologyScreening habitsScreening activitiesCohort dataA randomized, placebo-controlled, double-blind, pilot study of cannabis-related driving impairment assessed by driving simulator and self-report
Meda S, Stevens M, Boer E, Pittman B, Gueorguieva R, Huestis M, Pearlson G. A randomized, placebo-controlled, double-blind, pilot study of cannabis-related driving impairment assessed by driving simulator and self-report. Journal Of Psychopharmacology 2025, 39: 364-372. PMID: 40077985, DOI: 10.1177/02698811251324379.Peer-Reviewed Original ResearchConceptsCannabis-induced impairmentBlood THC levelsDouble-blindCannabis useVaporized cannabisTHC levelsActual impairmentAcute doseWithin-subjectSelf-ReportSimulated driving testDrug effectsDriving impairmentPlacebo-ControlledImpairment indicatorsImpairmentCannabisAssessment daysEffect of doseParticipants' willingnessPost-doseTHCBehavioral metricsCar-followingParticipantsSpecial Section: Self–Other Distinction in Personality Disorders
De Meulemeester C, Luyten P, Fonagy P. Special Section: Self–Other Distinction in Personality Disorders. Personality Disorders Theory Research And Treatment 2025, 16: 103-109. PMID: 40029301, DOI: 10.1037/per0000716.Peer-Reviewed Original ResearchConceptsSelf-other distinctionPersonality disorderSocial neuroscienceExperimental psychologyFeatures of personality disordersSelf-otherPerspective-taking difficultiesSelf-other boundariesPersonality pathologySociocognitive capacitiesClinical psychologyInterpersonal functioningDimensional viewEmotional contagionPsychologyDisordersImpairmentCoordination difficultiesEffects of treatmentNeurosciencePersonsSpecial sectionSelfResearch traditionsIncreased insightAssociations between diffusion tensor imaging patterns and cerebrospinal fluid markers in mild cognitive impairment
Niknam N, Khaefi S, Heidarpour H, Sadeghi M, Jafari N, Mohammadi S, Ahmadi Z, Ahangar-Sirous R, Mayeli M, Seyedmirzaei H, Initiative A. Associations between diffusion tensor imaging patterns and cerebrospinal fluid markers in mild cognitive impairment. Journal Of Clinical Neuroscience 2025, 135: 111141. PMID: 40010169, DOI: 10.1016/j.jocn.2025.111141.Peer-Reviewed Original ResearchConceptsMild cognitive impairmentDiffusion tensor imagingWhite matter tractsDiffusion tensor imaging metricsAlzheimer's Disease Neuroimaging InitiativeCognitive impairmentLeft uncinate fasciculusMild cognitive impairment groupDiffusion tensor imaging markersBrain changesUncinate fasciculusCerebrospinal fluidDTI patternsTensor imagingCerebrospinal fluid biomarkersStudy groupImpairmentIncreased water diffusionCerebrospinal fluid markersStatistically significant associationStatistically significant differenceEmbodied Cognition and Alcohol Use Disorder: Frequency of Impairments and Relationship to Neurocognitive Assessments
Bell M, Weinstein A, Ciosek D, Reilly S, Wang Y, Yoon G. Embodied Cognition and Alcohol Use Disorder: Frequency of Impairments and Relationship to Neurocognitive Assessments. Brain Sciences 2025, 15: 228. PMID: 40149750, PMCID: PMC11940586, DOI: 10.3390/brainsci15030228.Peer-Reviewed Original ResearchAlcohol use disorderEmbodied cognitionTotal scoreExecutive functionUse disorderNeurocognitive assessmentCognitive declineMeasure executive functionFrequency of impairmentPotential protective factorsPremorbid IQEF impairmentsMemory domainDelayed RecallOverall impairmentEF domainsCognitive processesNeurocognitive testsConcurrent validityFrequent impairmentCognitionSelf-RegulationCognitive scienceImpairmentProtective factorsSpecificity, Co-Occurrence, and Growth: Math and Reading Skill Development in Children With Learning Disabilities.
Connors K, Guertin E, Nichol M, Bosson-Heenan J, Gruen J, Frijters J. Specificity, Co-Occurrence, and Growth: Math and Reading Skill Development in Children With Learning Disabilities. Journal Of Learning Disabilities 2025, 222194241312189. PMID: 39924773, DOI: 10.1177/00222194241312189.Peer-Reviewed Original ResearchLearning DisabilitiesMath disabilitiesReading disabilityCo-occurring disabilitiesDomain-SpecificReading skills of childrenGrade 1 childrenCo-occurrenceGroup-level differencesSkills of childrenTrajectories of childrenMath deficitsMath difficultiesGrowth trajectories of childrenMath interventionReading skillsReading trajectoriesSkill growthPatterns of childrenImpairment levelMathDisabilityImpairmentLinear mixed-effects modelsElementary schoolDifferential links in 16p11.2 deletion carriers reveal aberrant connections between large-scale networks
Qureshi A, Nielsen J, Sepulcre J. Differential links in 16p11.2 deletion carriers reveal aberrant connections between large-scale networks. Cerebral Cortex 2025, 35: bhae474. PMID: 40007052, PMCID: PMC11859958, DOI: 10.1093/cercor/bhae474.Peer-Reviewed Original ResearchConceptsInferior parietal lobuleSuperior temporal gyrusLarge-scale networksDeletion carriersHeteromodal association areasDifferential linksHypo-connectivitySocial impairmentTemporal gyrusParietal lobulePosterior insulaAssociated with greater communicationAberrant connectivityAssociation areasCingulate sulcusBehavioral changesGlobal coherenceEntangled connectionsSulcusGreater communicationInsulaCingulateGyrusCopy number variationsImpairmentNeurobiology of Autism Spectrum Disorder and Intellectual Disability
Massa A, Costales J, Rubeis S, Foss-Feig J, Hof P, Kolevzon A. Neurobiology of Autism Spectrum Disorder and Intellectual Disability. 2025, 855-864. DOI: 10.1093/med/9780197640654.003.0063.Peer-Reviewed Original ResearchAbstract Autism spectrum disorderIntellectual disabilityAutism spectrum disorderSpectrum disorderNeurobiology of autism spectrum disordersAssociated with IDRepetitive behaviorsNeurodevelopmental disordersSocial communicationNeurobiologyInhibitory neurotransmissionSynaptic dysfunctionDisordersEarly childhoodASD riskGenetic factorsAnimal studiesASD genesNeurotransmissionGenetic studiesImpairmentDisability
2024
Correlates of Impaired Timing Abilities in Schizophrenia
Croce E, Simonelli G, Ferrara M, Escelsior A, Folesani F, Bovio A, Muscettola A, Toffanin T, De Bellis G, Nanni M, Caruso R, Murri M, Grassi L. Correlates of Impaired Timing Abilities in Schizophrenia. The Journal Of Nervous And Mental Disease 2024, 212: 603-622. PMID: 39808471, DOI: 10.1097/nmd.0000000000001810.Peer-Reviewed Original ResearchSymptom severityTiming abilityDisorganized symptomsNeurobiological correlatesWorking memoryExecutive functionTiming impairmentsNeurobiological dataSchizophreniaCognitive impairmentNeural circuitsImpairmentSymptomsPreferred Reporting ItemsSystematic literature searchClinical heterogeneityCognitionAbilitySeverityReporting ItemsMemoryStudy designSystematic reviewPsycINFOAssociationMentalization-Based Treatment for Adolescent Depression.
Luyten P, Malcorps S, Fonagy P. Mentalization-Based Treatment for Adolescent Depression. Psychodynamic Psychiatry 2024, 52: 490-511. PMID: 39679698, DOI: 10.1521/pdps.2024.52.4.490.Peer-Reviewed Original ResearchConceptsMentalization-based treatmentHistory of attachment traumaSeverity of depressionTreatment of depressionTreatment of adolescentsMental health problemsLong-term impairmentAttachment traumaAdolescent depressionPsychological interventionsMental perspectiveDepressionAdolescentsMental approachSpectrum of severityMentalMeta-analysesSevere endHealth problemsRelated problemsEmpirical evidenceImpairmentPersonsThoughtsTreatmentScreening for Cognitive Impairment in the Emergency Department: Agreement between Older Adult Patient- and Informant-Completed Ascertain Dementia 8 Tool
Galske J, Sather A, Chera T, Hwang U, Carpenter C, Babcock M, Gettel C. Screening for Cognitive Impairment in the Emergency Department: Agreement between Older Adult Patient- and Informant-Completed Ascertain Dementia 8 Tool. Dementia And Geriatric Cognitive Disorders 2024, 54: 160-166. PMID: 39616991, PMCID: PMC12119964, DOI: 10.1159/000542895.Peer-Reviewed Original ResearchAscertain Dementia 8Intraclass correlation coefficientEmergency departmentCognitive impairmentTrained research assistantsDiagnosis of dementiaClinicians providing careModerate agreementSuspected CIEmergency careOlder adultsAnalytic sampleResearch assistantsED patientsCareScreening protocolSelf-identifyEarly interventionDementiaScoresCorrelation coefficientDepartmentDyadsPatientsImpairmentGeneralizable and replicable brain-based predictions of cognitive functioning across common psychiatric illness
Chopra S, Dhamala E, Lawhead C, Ricard J, Orchard E, An L, Chen P, Wulan N, Kumar P, Rubenstein A, Moses J, Chen L, Levi P, Holmes A, Aquino K, Fornito A, Harpaz-Rotem I, Germine L, Baker J, Yeo B, Holmes A. Generalizable and replicable brain-based predictions of cognitive functioning across common psychiatric illness. Science Advances 2024, 10: eadn1862. PMID: 39504381, PMCID: PMC11540040, DOI: 10.1126/sciadv.adn1862.Peer-Reviewed Original ResearchConceptsPrediction of cognitionCognitive functionPrediction of cognitive functionFunctional neuroimaging dataTransdiagnostic sampleComputational psychiatryPsychiatric illnessNeuroimaging dataCognitive impairmentCognitionPopulation-level datasetsPsychiatryAssociated with poor outcomesUK BiobankImpairmentBrainIllnessSymptomsPrediction studiesParticipantsPoor outcomeClinical studiesSamplesReorganization of integration and segregation networks in brain-based visual impairment
Diez I, Troyas C, Bauer C, Sepulcre J, Merabet L. Reorganization of integration and segregation networks in brain-based visual impairment. NeuroImage Clinical 2024, 44: 103688. PMID: 39432973, PMCID: PMC11535411, DOI: 10.1016/j.nicl.2024.103688.Peer-Reviewed Original ResearchIntraparietal sulcusReduced gray matter volumeResting state functional connectivityCerebral visual impairmentGray matter volumeFunctional network architectureMultimodal integration areasMode networkMatter volumeNeurotypical developmentFunctional connectivityVisual processingEnvironmental experiencesCerebral connectivityPrimary visual cortexHuman brainConnectome analysisBrain injuryNetwork organizationVisual cortexImpairmentInvestigate differencesCompared to controlsFunctional changesParticipantsThe Impact of Body Contouring Following Bariatric Surgery: A Prospective Examination of Psychosocial and Medical Impairment
Ivezaj V, Alperovich M, Price G, Dunford A, Metzler A, Grilo C. The Impact of Body Contouring Following Bariatric Surgery: A Prospective Examination of Psychosocial and Medical Impairment. Aesthetic Plastic Surgery 2024, 49: 269-276. PMID: 39402193, DOI: 10.1007/s00266-024-04427-x.Peer-Reviewed Original ResearchAssociated with heightened levelsBariatric surgeryFollow-up assessmentMeasures of impairmentLoose skinPsychosocial impairmentFollow-upPsychosocial concernsLevel of Evidence IIThis journalHeightened levelsPsychological concernsEvidence-Based Medicine ratingsSkin concernsClinical attentionDepressionImpairmentLevel of evidenceBCS patientsProspective examinationContouring surgerySurgeryConclusionsOver halfWeight lossBody contouringEvidence-based2.49 Climate Distress: An Analysis of Risk Factors and Functional Impairment in a Clinical Sample of Young People
Wortzel J. 2.49 Climate Distress: An Analysis of Risk Factors and Functional Impairment in a Clinical Sample of Young People. Journal Of The American Academy Of Child & Adolescent Psychiatry 2024, 63: s199. DOI: 10.1016/j.jaac.2024.08.148.Peer-Reviewed Original ResearchBeyond the Descriptive: A Comprehensive, Multidomain Validation of Symptom Trajectories for Individuals at Clinical High Risk for Psychosis
Deng W, Chong B, Addington J, Bearden C, Cadenhead K, Cornblatt B, Keshavan M, Mathalon D, Perkins D, Stone W, Walker E, Woods S, Cannon T. Beyond the Descriptive: A Comprehensive, Multidomain Validation of Symptom Trajectories for Individuals at Clinical High Risk for Psychosis. Biological Psychiatry Cognitive Neuroscience And Neuroimaging 2024, 10: 195-202. PMID: 39260565, DOI: 10.1016/j.bpsc.2024.08.020.Peer-Reviewed Original ResearchClinical high riskCHR-PTrajectory groupsMaintenance of symptomsOnset of psychosisNon-convertersHealthy controlsDiagnostic constructSymptom trajectoriesPsychosisAffective comorbiditiesAssess symptomsHeightened riskFunctional impairmentSymptomsEtiological risk factorsFunctional outcomesImminent onsetLevels of intensityRemissionRisk factorsIndividualsPhase 3DistressImpairmentWhite matter hyperintensity on MRI and plasma Aβ42/40 ratio additively increase the risk of cognitive impairment in hypertensive adults
de Havenon A, Gottesman R, Willamson J, Rost N, Sharma R, Li V, Littig L, Stulberg E, Falcone G, Prabhakaran S, Schneider A, Sheth K, Pajewski N, Brickman A. White matter hyperintensity on MRI and plasma Aβ42/40 ratio additively increase the risk of cognitive impairment in hypertensive adults. Alzheimer's & Dementia 2024, 20: 6810-6819. PMID: 39229896, PMCID: PMC11485393, DOI: 10.1002/alz.14126.Peer-Reviewed Original ResearchRisk of cognitive impairmentYears of follow-upCognitive impairmentExposure categoriesHigh-risk categoryWhite matter hyperintensitySystolic Blood Pressure Intervention TrialRates of cognitive impairmentSPRINT-MIND trialDementia preventionFollow-upLow-risk categoryMIND trialAdditional risk factorsDevelopment of cognitive impairmentIntervention trialsHypertensive adultsHazard ratioRisk factorsHigh riskLow riskVascular healthTertileRiskImpairmentLoss of synaptic density in nucleus basalis of meynert indicates distinct neurodegeneration in Alzheimer’s disease: the RJNB-D study
Li B, Chen H, Zheng Y, Xu X, You Z, Huang Q, Huang Y, Guan Y, Zhao J, Liu J, Xie F, Wang J, Xu W, Zhang J, Deng Y. Loss of synaptic density in nucleus basalis of meynert indicates distinct neurodegeneration in Alzheimer’s disease: the RJNB-D study. European Journal Of Nuclear Medicine And Molecular Imaging 2024, 52: 134-144. PMID: 39112615, DOI: 10.1007/s00259-024-06862-z.Peer-Reviewed Original ResearchWhite matter tractsCognitive impairmentSynaptic densityCognitive performancePositron emission tomographyNucleus basalisSeverity of cognitive impairmentAlzheimer's diseaseSynaptic lossNucleus basalis of MeynertBasalis of MeynertSynaptic vesicle glycoprotein 2Pathogenesis of Alzheimer's diseaseStandardized uptake value ratioCholinergic systemProfile of ADCN participantsPotential impairmentMMSE scoreMedial tractNBMImpairmentEmission tomographyLoss of synaptic densityNormal controlsLinking mentalizing capacity, shame, and depressive symptoms in the context of childhood maltreatment
Schwarzer N, Nolte T, Fonagy P, Feigenbaum J, King-Casas B, Rüfenacht E, Gingelmaier S, Leibowitz J, Pilling S, Montague P, Network L. Linking mentalizing capacity, shame, and depressive symptoms in the context of childhood maltreatment. Children And Youth Services Review 2024, 163: 107787. DOI: 10.1016/j.childyouth.2024.107787.Peer-Reviewed Original ResearchExperiences of childhood maltreatmentFeelings of shameChildhood maltreatmentDepressive symptomsMental capacityContext of childhood maltreatmentNon-clinical participantsPredictors of depressive symptomsDomains of depressionCurrent depressive symptomsHistory of maltreatmentReducing depressive symptomsReduce feelings of shameSample of adultsMental health problemsPsychological treatmentStructural equation modelingMetacognitive processesCross-sectional designMaltreatmentMentalReduce feelingsShameImpairmentResults Associations
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