2022
Gut microbiome dysbiosis in antibiotic-treated COVID-19 patients is associated with microbial translocation and bacteremia
Bernard-Raichon L, Venzon M, Klein J, Axelrad J, Zhang C, Sullivan A, Hussey G, Casanovas-Massana A, Noval M, Valero-Jimenez A, Gago J, Putzel G, Pironti A, Wilder E, Thorpe L, Littman D, Dittmann M, Stapleford K, Shopsin B, Torres V, Ko A, Iwasaki A, Cadwell K, Schluter J. Gut microbiome dysbiosis in antibiotic-treated COVID-19 patients is associated with microbial translocation and bacteremia. Nature Communications 2022, 13: 5926. PMID: 36319618, PMCID: PMC9626559, DOI: 10.1038/s41467-022-33395-6.Peer-Reviewed Original ResearchConceptsGut microbiome dysbiosisCOVID-19 patientsMicrobiome dysbiosisSecondary infectionSARS-CoV-2 infection inducesLife-threatening secondary infectionsTranslocation of bacteriaBlood culture resultsCOVID-19 severityAntimicrobial-resistant speciesCOVID-19Different clinical sitesMicrobial translocationBloodstream infectionsInfection inducesBarrier permeabilitySystemic circulationDysbiosisGoblet cellsPaneth cellsClinical sitesCulture resultsPatient healthGut microbiomePatients
2020
Performance of a Semiquantitative Multiplex Bacterial and Viral PCR Panel Compared With Standard Microbiological Laboratory Results: 396 Patients Studied With the BioFire Pneumonia Panel
Rand K, Beal S, Cherabuddi K, Couturier B, Lingenfelter B, Rindlisbacher C, Jones J, Houck H, Lessard K, Tremblay E. Performance of a Semiquantitative Multiplex Bacterial and Viral PCR Panel Compared With Standard Microbiological Laboratory Results: 396 Patients Studied With the BioFire Pneumonia Panel. Open Forum Infectious Diseases 2020, 8: ofaa560. PMID: 33447631, PMCID: PMC7793460, DOI: 10.1093/ofid/ofaa560.Peer-Reviewed Original ResearchPneumonia PanelLower respiratory tract infectionsRespiratory tract infectionsWhite blood cellsTract infectionsBronchoalveolar lavageAntibiotic stewardshipInflammatory responseMicrobiologic resultsPatient managementCommon bacterial speciesPatientsCulture resultsOptimal managementRapid turnaround timeBlood cellsPCR panelCopy numberClinical laboratoriesAdditional targetsPotential pathogensLaboratory resultsBacterial detectionStandard cultureStainSpecies-Specific Immunoassay Aids Identification of Pathogen and Tracks Infectivity in Foot Infection
Hao SP, Masters EA, Ninomiya MJ, Beck CA, Schwarz EM, Daiss JL, Oh I. Species-Specific Immunoassay Aids Identification of Pathogen and Tracks Infectivity in Foot Infection. Foot & Ankle International 2020, 42: 363-372. PMID: 33161780, PMCID: PMC7946706, DOI: 10.1177/1071100720965136.Peer-Reviewed Original ResearchConceptsFoot infectionsHost immune responseWound healing statusImmune responseHealing statusFoot ulcer patientsProspective comparative studyCulture-positive patientsCulture-negative patientsSpecific serum antibodiesDominant pathogenAnalysis of serumConventional bacterial cultureUlcer patientsMusculoskeletal infectionsSurgical interventionAntibody titersSerum antibodiesTherapeutic responseInfection diagnosisSpecies-specific immunoassaySurgeon's decisionCulture resultsInfectionLevel IIHospital Microbiologic Culture Results to Predict the Use of Anti–methicillin-Resistant Staphylococcus aureus (MRSA)
Wu H, Kratzer T, Zhou L, Soe M, Edwards J, Neuhauser M, Benin A, Hicks L, Srinivasan A, Pollock D. Hospital Microbiologic Culture Results to Predict the Use of Anti–methicillin-Resistant Staphylococcus aureus (MRSA). Infection Control And Hospital Epidemiology 2020, 41: s40-s40. DOI: 10.1017/ice.2020.521.Peer-Reviewed Original ResearchAnti-MRSA agentsNational Healthcare Safety NetworkPositive infectionsMicrobiologic culture resultsInfection burdenAntimicrobial useHospital characteristicsCulture resultsStandardized antimicrobial administration ratioStaphylococcus aureusRisk adjustmentLower respiratory specimensIntensive care unitAcute care hospitalsQuinupristin/dalfopristinResistant Staphylococcus aureusMedical school affiliationAU ratesIntravenous vancomycinMicrobiologic dataCare unitDay patientsRespiratory specimensAntimicrobial daysHigh prevalence
2019
Medical Management of the Infected Diabetic Foot
Wasser J, Edmonds M, Banach D. Medical Management of the Infected Diabetic Foot. 2019, 505-516. DOI: 10.1007/978-3-319-17918-6_40.ChaptersInfected diabetic footAntibiotic therapyIntravenous antibioticsMedical managementDiabetic footSevere infectionsInitial empiric antibiotic therapyBroad-spectrum intravenous antibioticsDefinitive antibiotic therapyEmpiric antibiotic therapyMicrobiology culture resultsSeverity of infectionAntibiotic-resistant organismsLocal antibiotic sensitivitiesOral antibioticsUrgent admissionOutpatient basisClinical severityMild infectionSurgical assessmentCulture resultsTypical signsAntibiotic sensitivityInfectionTherapyMedical and Surgical Management of Empyema
Godfrey M, Bramley K, Detterbeck F. Medical and Surgical Management of Empyema. Seminars In Respiratory And Critical Care Medicine 2019, 40: 361-374. PMID: 31525811, DOI: 10.1055/s-0039-1694699.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsVideo-assisted thoracic surgeryChest tube drainageCommon clinical problemIntrapleural fibrinolyticsSurgical decorticationMost patientsTube drainageClinical courseSurgical managementTherapeutic optionsThoracic surgeryPresent cliniciansPleural spaceClinical problemDisease processEarly interventionCulture resultsEarly drainagePhysiologic impactEmpyemaMultidisciplinary collaborationClear benefitCliniciansAntibioticsIntervention
2018
Hip Synovial Fluid Cell Counts in Children From a Lyme Disease Endemic Area
Dart AH, Michelson KA, Aronson PL, Garro AC, Lee TJ, Glerum KM, Nigrovic PA, Kocher MS, Bachur RG, Nigrovic LE. Hip Synovial Fluid Cell Counts in Children From a Lyme Disease Endemic Area. 2018, 141: e20173810. PMID: 29669751, PMCID: PMC5914490, DOI: 10.1542/peds.2017-3810.Peer-Reviewed Original ResearchConceptsSynovial fluid WBC countWhite blood cellsLyme disease endemic areaSynovial fluid white blood cellDisease-endemic areasLyme arthritisSeptic arthritisWBC countEndemic areasCulture resultsSurgical drainagePositive synovial fluid culture resultsSynovial fluid cell countPositive blood culture resultsSynovial fluid culture resultsSeptic hip arthritisBlood culture resultsSynovial fluid cultureBacterial culture resultsUnnecessary operative proceduresYears of ageEligible patientsRetrospective cohortMonoarticular arthritisHip arthritisTransient bacteremia induced by dental cleaning is not associated with infection of central venous catheters in patients with cancer
Usmani S, Choquette L, Bona R, Feinn R, Shahid Z, Lalla RV. Transient bacteremia induced by dental cleaning is not associated with infection of central venous catheters in patients with cancer. Oral Surgery Oral Medicine Oral Pathology And Oral Radiology 2018, 125: 286-294. PMID: 29428697, PMCID: PMC5944361, DOI: 10.1016/j.oooo.2017.12.022.Peer-Reviewed Original ResearchConceptsCentral venous cathetersCVC-related infectionsAbsolute neutrophil countBlood culture resultsDental cleaningBloodstream infectionsNeutrophil countVenous cathetersCulture resultsIncidence of bacteremiaAntibiotic prophylaxisPeriodontal screeningPeriodontal statusTransient bacteremiaMedical recordsBlood culturesPatientsBacteremiaPSR scoresOral microorganismsInfectionCancerRecording scoresCatheterBaseline
2017
Rapid detection and ruling out of neonatal sepsis by PCR coupled with Electrospray Ionization Mass Spectrometry (PCR/ESI-MS)
Delcò C, Karam O, Pfister R, Gervaix A, Renzi G, Emonet S, Schrenzel J, Posfay-Barbe KM. Rapid detection and ruling out of neonatal sepsis by PCR coupled with Electrospray Ionization Mass Spectrometry (PCR/ESI-MS). Early Human Development 2017, 108: 17-22. PMID: 28343091, DOI: 10.1016/j.earlhumdev.2017.03.004.Peer-Reviewed Original ResearchConceptsNegative predictive valuePCR/ESI-MSBlood culturesPredictive valueNeonatal sepsisGood negative predictive valueProspective observational studyBlood culture resultsInitiation of antibioticsPositive blood culturesConventional blood culturePositive predictive valueEmpiric antibioticsConsecutive neonatesAdverse eventsClinical suspicionMedian ageNeonatal populationObservational studySepsisBlood samplesEarly reassessmentImportant causeCulture resultsBacterial infections
2016
Undiagnosed pulmonary tuberculosis among prisoners in Malaysia: an overlooked risk for tuberculosis in the community
Al-Darraji HA, Altice FL, Kamarulzaman A. Undiagnosed pulmonary tuberculosis among prisoners in Malaysia: an overlooked risk for tuberculosis in the community. Tropical Medicine And International Health 2016, 21: 1049-1058. PMID: 27197601, DOI: 10.1111/tmi.12726.Peer-Reviewed Original ResearchGeneXpert MTB/RIFCase-finding strategyActive TBMTB/RIFTB treatmentMalaysia's largest prisonUndiagnosed pulmonary tuberculosisActive tuberculosis casesOlder age groupsLargest prisonPulmonary tuberculosisHIV infectionTuberculosis casesHigh prevalenceSputum samplesSmear microscopyClinical informationAverage ageCulture resultsAge groupsScreening studyComplete dataHIVRegression analysisTuberculosis
2012
Pseudomonas aeruginosa serology and risk for re-isolation in the EPIC trial
Anstead M, Heltshe SL, Khan U, Barbieri JT, Langkamp M, Döring G, Dharia S, Gibson RL, Treggiari MM, Lymp J, Rosenfeld M, Ramsey B. Pseudomonas aeruginosa serology and risk for re-isolation in the EPIC trial. Journal Of Cystic Fibrosis 2012, 12: 147-153. PMID: 22944725, PMCID: PMC3696392, DOI: 10.1016/j.jcf.2012.08.001.Peer-Reviewed Original ResearchConceptsPulmonary exacerbationsCF patientsP. aeruginosa eradicationP. aeruginosa isolationCystic fibrosis patientsEarly P. aeruginosaBaseline seropositivityEPIC trialPositive serologyAntibiotic therapyChild TrialTreatment failurePrognostic valuePseudomonas infectionWeek 10Fibrosis patientsSerologyCulture resultsPatientsClinicians' effortsExacerbationSeropositivityP. aeruginosaRiskTrials
2011
Full impact of laboratory information system requires direct use by clinical staff: cluster randomized controlled trial
Blaya J, Shin S, Contreras C, Yale G, Suarez C, Asencios L, Kim J, Rodriguez P, Cegielski P, Fraser H. Full impact of laboratory information system requires direct use by clinical staff: cluster randomized controlled trial. Journal Of The American Medical Informatics Association 2011, 18: 11-16. PMID: 21113076, PMCID: PMC3005868, DOI: 10.1136/jamia.2010.005280.Peer-Reviewed Original ResearchConceptsPeripheral health centresDrug susceptibility testHealth centersIntervention groupControl groupElectronic laboratory reportingE-ChasquiCare accessClinical staffCulture resultsLaboratory reportingHealth establishmentsSusceptibility testsLaboratory information systemBaseline dataTrialsLaboratory resultsMonthsLower proportionGroupPaper-based systemProportion
2010
The role of STEP in Alzheimer's disease
Kurup P, Zhang Y, Venkitaramani DV, Xu J, Lombroso PJ. The role of STEP in Alzheimer's disease. Channels 2010, 4: 347-350. PMID: 20699650, PMCID: PMC3230511, DOI: 10.4161/chan.4.5.12910.Peer-Reviewed Original ResearchConceptsN-methyl-D-aspartate (NMDA) type glutamate receptorsAlzheimer's diseaseProtein tyrosine Phosphatase 61AD prefrontal cortexAD mouse modelType glutamate receptorsGlutamate receptor traffickingNeuronal surface membraneNMDAR internalizationAβ treatmentPutative causative agentGlutamate receptorsMouse modelCulture resultsGluN1/Prefrontal cortexDiseaseNeuronal membranesNMDAR endocytosisAdditional studiesAβCausative agentSurface expressionUbiquitin-proteasome systemReceptor complex
2007
Imaging-guided bone biopsy for osteomyelitis: are there factors associated with positive or negative cultures?
Wu JS, Gorbachova T, Morrison WB, Haims AH. Imaging-guided bone biopsy for osteomyelitis: are there factors associated with positive or negative cultures? American Journal Of Roentgenology 2007, 188: 1529-34. PMID: 17515372, DOI: 10.2214/ajr.06.1286.Peer-Reviewed Original Research
2006
Ventilator-Associated Pneumonia: A Review
Davis KA. Ventilator-Associated Pneumonia: A Review. Journal Of Intensive Care Medicine 2006, 21: 211-226. PMID: 16855056, DOI: 10.1177/0885066606288837.Peer-Reviewed Original ResearchConceptsVentilator-associated pneumoniaDuration of therapyClinical responseMechanical ventilationMortality rateFrequent intensive care unitBroad-spectrum antibiotic administrationPatient's clinical responseIntensive care unitDifferent patient populationsFinal culture resultsLower mortality rateHealth care systemICU lengthAntibiotic administrationCare unitRisk of resistancePatient populationVaried presentationsMicrobiologic floraDisease processPneumoniaICUProlong durationCulture results
2005
Outcomes of Febrile Children Presumed to be Immunocompetent Who Present with Leukopenia or Neutropenia to an Ambulatory Setting
Serwint JR, Dias MM, Chang H, Sharkey M, Walker AR. Outcomes of Febrile Children Presumed to be Immunocompetent Who Present with Leukopenia or Neutropenia to an Ambulatory Setting. Clinical Pediatrics 2005, 44: 593-600. PMID: 16151565, DOI: 10.1177/000992280504400707.Peer-Reviewed Original ResearchConceptsFebrile childrenAmbulatory settingRetrospective medical record reviewPositive blood culture resultsComplete blood cell countSignificant medical outcomesAbsolute neutrophil countMajority of patientsMedical record reviewBlood cell countBlood culture resultsNon-oncologic diseasesWhite blood cellsCell linesNeutrophil countFebrile patientsRecord reviewPhysical findingsBlood culturesMedical outcomesCell countClinical judgmentMore cell linesPatientsCulture results
2003
Cerebellar Brain Abscess Associated with Tongue Piercing
Martinello RA, Cooney EL. Cerebellar Brain Abscess Associated with Tongue Piercing. Clinical Infectious Diseases 2003, 36: e32-e34. PMID: 12522766, DOI: 10.1086/345755.Peer-Reviewed Original Research
2000
Using electronic data to predict the probability of true bacteremia from positive blood cultures.
Wang S, Kuperman G, Ohno-Machado L, Onderdonk A, Sandige H, Bates D. Using electronic data to predict the probability of true bacteremia from positive blood cultures. AMIA Annual Symposium Proceedings 2000, 893-7. PMID: 11080013, PMCID: PMC2243892.Peer-Reviewed Original ResearchConceptsPositive blood culturesClinical prediction ruleBlood culturesTreatment decisionsTrue bacteremiaCulture resultsPositive blood culture resultsPrediction rulePaper chart reviewProbability of bacteremiaBlood culture resultsInfectious disease expertsAppropriate treatment decisionsLogistic regression modelsRevalidation studyChart reviewDisease expertsOne-year periodBacteremiaPhysiciansRegression modelsTrue positivesPatientsHospitalHousestaff
1998
Elevated amniotic fluid levels of leukemia inhibitory factor, interleukin 6, and interleukin 8 in intra-amniotic infection
Hsu C, Meaddough E, Aversa K, Hong S, Lu L, Jones D, Copel J. Elevated amniotic fluid levels of leukemia inhibitory factor, interleukin 6, and interleukin 8 in intra-amniotic infection. American Journal Of Obstetrics And Gynecology 1998, 179: 1267-1270. PMID: 9822513, DOI: 10.1016/s0002-9378(98)70144-9.Peer-Reviewed Original ResearchConceptsIntra-amniotic infectionAmniotic fluid levelsLeukemia inhibitory factorInterleukin-6Interleukin-8Fluid levelsInhibitory factorCreatinine levelsPregnant womenPositive amniotic fluid culture resultsAmniotic fluid creatinine levelsElevated amniotic fluid levelsAmniotic fluid culture resultsAmniotic fluid testsEnzyme-linked immunoassayPreterm contractionsPremature rupturePrognostic importanceLeukocyte countSignificant elevationAmniotic fluidMedian levelsCulture resultsInfectionGram stainDetection of urinary tract infections by reduction of nitroblue tetrazolium Technical Note
Smith S, Wheeler M, Weiss R. Detection of urinary tract infections by reduction of nitroblue tetrazolium Technical Note. Kidney International 1998, 54: 1331-1336. PMID: 9767552, DOI: 10.1046/j.1523-1755.1998.00102.x.Peer-Reviewed Original ResearchConceptsUrinary tract infectionNitric oxide synthaseNegative predictive accuracyDismutase/catalaseNitrite dipstickTract infectionsPresence of UTINOS cofactorUrine pelletsInducible nitric oxide synthaseHigh negative predictive accuracyHigh positive predictive accuracyUrine screening testsUrine culture resultsNBT reductionInducible NOS activityLeukocyte esterase dipstickNitroblue tetrazolium reductionPositive predictive accuracyNOS inhibitorNOS activityOxide synthaseEarly predictorCulture resultsScreening test
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