2022
The serotonin reuptake inhibitor fluoxetine induces human fetal membrane sterile inflammation through p38 MAPK activation
Fabrizio V, Lindsay C, Wilcox M, Hong S, Lynn T, Norwitz E, Yonkers K, Abrahams V. The serotonin reuptake inhibitor fluoxetine induces human fetal membrane sterile inflammation through p38 MAPK activation. Journal Of Reproductive Immunology 2022, 155: 103786. PMID: 36528909, PMCID: PMC9851981, DOI: 10.1016/j.jri.2022.103786.Peer-Reviewed Original ResearchMeSH KeywordsAntidepressive AgentsExtraembryonic MembranesFemaleFetal Membranes, Premature RuptureFluoxetineHumansHydroxymethylglutaryl-CoA Reductase InhibitorsInfant, NewbornInflammationInterleukin-6p38 Mitogen-Activated Protein KinasesPregnancyPremature BirthSelective Serotonin Reuptake InhibitorsConceptsSerotonin reuptake inhibitorsP38 MAPK activitySerotonin reuptake inhibitor fluoxetineSubsequent preterm birthFirst-line therapyPreterm premature ruptureReuptake inhibitor fluoxetineInflammatory IL-6Normal term deliveryIL-6 productionIL-6 secretionFetal membrane inflammationUnexposed womenAntidepressant treatmentLine therapyPreterm birthAntidepressant useReuptake inhibitorsTerm deliveryMembrane inflammationPremature ruptureIL-6SRI useSterile inflammationP38 MAPK pathway
2021
Antibiotics for Preterm Premature Rupture of Membranes
Kohari K, Pettker C. Antibiotics for Preterm Premature Rupture of Membranes. 2021, 43-47. DOI: 10.1093/med/9780190947088.003.0008.Peer-Reviewed Original ResearchNeonatal outcomesProlongation of pregnancyPreterm premature rupturePreterm prelabor ruptureBroad-spectrum antibioticsLength of pregnancyDays of gestationNeonatal complicationsPrelabor rupturePremature birthPremature ruptureSpectrum antibioticsPPROMPregnancyAntibioticsRisk reductionOutcomesMembrane ruptureWeeksRuptureOne-halfComplicationsPatientsGestationEtiology
2018
A Novel Approach to Serial Amnioinfusion in a Case of Premature Rupture of Membranes Near the Limit of Viability
Kohari K, Mehlhaff K, Merriam A, Abdel-Razeq S, Grechukhina O, Leon-Martinez D, Bahtiyar MO. A Novel Approach to Serial Amnioinfusion in a Case of Premature Rupture of Membranes Near the Limit of Viability. American Journal Of Perinatology Reports 2018, 08: e180-e183. PMID: 30250757, PMCID: PMC6138466, DOI: 10.1055/s-0038-1669964.Peer-Reviewed Original ResearchLimit of viabilityIntra-amniotic infectionSerial transabdominal amnioinfusionsIntra-amniotic infusionSerial amnioinfusionsMaternal morbidityPlacental abruptionPreterm laborTransabdominal amnioinfusionPrelabor rupturePulmonary hypoplasiaPremature rupturePersistent oligohydramniosNormal salineNeonatal survivalLatency periodClinical scenariosAdditional riskSignificant riskAmnioinfusionRiskFetusesInfectionImmediate riskRupture6 Thymus
Zuckerwise L, Li L, Copel J. 6 Thymus. 2018, 25-28.e1. DOI: 10.1016/b978-0-323-44548-1.00006-1.ChaptersGrowth restrictionThymic hypoplasiaFetal inflammatory response syndromeWorse fetal prognosisInflammatory response syndromeThree-vessel trachea viewFetal growth restrictionFetal prognosisPreterm laborAnterior mediastinumResponse syndromePremature ruptureThree-vesselThymic aplasiaFetal thymusSmall thymusFetal lifeMajor vesselsLymphoepithelial structuresThymusGenetic conditionsHypoplasiaTransverse planeMediastinumPrognosis
2017
Viral Infection Sensitizes Human Fetal Membranes to Bacterial Lipopolysaccharide by MERTK Inhibition and Inflammasome Activation.
Cross SN, Potter JA, Aldo P, Kwon JY, Pitruzzello M, Tong M, Guller S, Rothlin CV, Mor G, Abrahams VM. Viral Infection Sensitizes Human Fetal Membranes to Bacterial Lipopolysaccharide by MERTK Inhibition and Inflammasome Activation. The Journal Of Immunology 2017, 199: 2885-2895. PMID: 28916522, PMCID: PMC5659726, DOI: 10.4049/jimmunol.1700870.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsc-Mer Tyrosine KinaseCells, CulturedChorioamnionitisExtraembryonic MembranesFemaleGammaherpesvirinaeHerpesviridae InfectionsHerpesvirus 2, HumanHumansImmunizationInflammasomesIntercellular Signaling Peptides and ProteinsInterleukin-1betaLipopolysaccharidesMiceMice, Inbred C57BLMice, KnockoutPregnancyPremature BirthProto-Oncogene ProteinsReceptor Protein-Tyrosine KinasesConceptsFetal membranesViral infectionImmune responseTAM receptorsSubsequent preterm birthAdverse pregnancy outcomesIL-1β productionIL-1β responseHerpes viral infectionsInnate immune responseVivo mouse modelHuman fetal membranesAggravated inflammationIL-1β processingPregnancy outcomesPreterm birthAssociated complicationsPremature rupturePregnant womenLocal infectionInflammasome activationMerTK inhibitionMouse modelBacterial LPSLigand expressionPublic Health Data in Action: An Analysis of Using Louisiana Vital Statistics for Quality Improvement and Payment Reform
Danilack V, Gee R, Berthelot D, Gurvich R, Muri J. Public Health Data in Action: An Analysis of Using Louisiana Vital Statistics for Quality Improvement and Payment Reform. Maternal And Child Health Journal 2017, 21: 988-994. PMID: 28316039, DOI: 10.1007/s10995-016-2254-z.Peer-Reviewed Original ResearchConceptsICD-9-CM codesEarly deliveryBirth certificatesHospital recordsPremature ruptureWomen's HospitalNational Perinatal Information CenterEarly term birthGestational hypertensive disordersSpontaneous active laborTerm singleton birthsHospital discharge recordsAdministrative dataAbnormal heart rateHypertensive disordersGestational diabetesFetal distressTerm birthsActive laborSingleton birthsMaternal deliveryHeart rateCommon reasonDischarge dataMedical reasons
2016
Limiting the Exposure of Select Fetuses to Intrauterine Infection/Inflammation Improves Short-Term Neonatal Outcomes in Preterm Premature Rupture of Membranes
Archabald KL, Buhimschi IA, Bahtiyar MO, Dulay AT, Abdel-Razeq SS, Pettker CM, Lipkind HS, Hardy JT, McCarthy ME, Zhao G, Bhandari V, Buhimschi CS. Limiting the Exposure of Select Fetuses to Intrauterine Infection/Inflammation Improves Short-Term Neonatal Outcomes in Preterm Premature Rupture of Membranes. Fetal Diagnosis And Therapy 2016, 42: 99-110. PMID: 27794570, PMCID: PMC11588317, DOI: 10.1159/000450997.Peer-Reviewed Original ResearchConceptsEarly-onset neonatal sepsisNeonatal outcomesPremature ruptureEarly deliveryIntrauterine infection/inflammationSetting of PPROMAdverse neonatal outcomesAmniotic fluid infectionPreterm premature ruptureShort-term outcomesInfection/inflammationIntra-amniotic infectionTerm neonatal outcomesSelect fetusesAntenatal exposureExpectant managementSingleton newbornsHospital dischargeNeonatal sepsisHaptoglobin-related proteinNewborn's riskFluid infectionGestational ageAdverse outcomesSelect subgroupRobot-Assisted Abdominal Cerclage During Pregnancy
Zeybek B, Hill A, Menderes G, Borahay MA, Azodi M, Kilic GS. Robot-Assisted Abdominal Cerclage During Pregnancy. JSLS Journal Of The Society Of Laparoscopic & Robotic Surgeons 2016, 20: e2016.00072. PMID: 27904309, PMCID: PMC5118107, DOI: 10.4293/jsls.2016.00072.Peer-Reviewed Original ResearchConceptsAbdominal cerclageMedian gestational ageMedian ageCase seriesGestational ageSystematic reviewMedian operating timePostoperative day 1Time of procedureRetrospective case studyCervical insufficiencyTransabdominal cerclageVaginal cerclagePreterm laborCervical lacerationPreterm birthTransvaginal cerclageBlood lossPrevious pregnancyPremature ruptureInfant morbidityPrevious dilatationMajor indicationCerclagePatients
2015
Effects of Placental Transfusion on Neonatal and 18 Month Outcomes in Preterm Infants: A Randomized Controlled Trial
Mercer J, Erickson-Owens D, Vohr B, Tucker R, Parker A, Oh W, Padbury J. Effects of Placental Transfusion on Neonatal and 18 Month Outcomes in Preterm Infants: A Randomized Controlled Trial. The Journal Of Pediatrics 2015, 168: 50-55.e1. PMID: 26547399, PMCID: PMC4698069, DOI: 10.1016/j.jpeds.2015.09.068.Peer-Reviewed Original ResearchConceptsLate-onset sepsisRisk of intraventricular hemorrhageIntraventricular hemorrhageMonths corrected agePreterm infantsPremature ruptureEffects of delayed cord clampingEffects of placental transfusionRate of intraventricular hemorrhageIncidence of intraventricular hemorrhageBayley Scales of Infant DevelopmentCord clamping timeICC groupMotor outcomeIntention-to-treatOnset sepsisPlacental transfusionRandomized Controlled TrialsSingleton fetusesDCC groupGestational ageCord clampingClamp timeBayley ScalesMonth outcomesThe phenotype of spontaneous preterm birth: application of a clinical phenotyping tool
Manuck TA, Esplin MS, Biggio J, Bukowski R, Parry S, Zhang H, Huang H, Varner MW, Andrews W, Saade G, Sadovsky Y, Reddy UM, Ilekis J, Research E. The phenotype of spontaneous preterm birth: application of a clinical phenotyping tool. American Journal Of Obstetrics And Gynecology 2015, 212: 487.e1-487.e11. PMID: 25687564, PMCID: PMC4456184, DOI: 10.1016/j.ajog.2015.02.010.Peer-Reviewed Original ResearchConceptsSpontaneous preterm birthEarly spontaneous preterm birthInfection/inflammationDecidual hemorrhageGestational ageCervical insufficiencyPreterm birthWeeks' gestationPlacental dysfunctionWhite womenMaternal stressSingleton spontaneous preterm birthDelivery gestational ageFinal common pathwayAfrican American womenMaternal comorbiditiesPremature ruptureProspective studyPlanned analysisUterine distentionClinical dataMultiple possible causesGestationHemorrhageComprehensive classification system
2014
Opioid Abuse and Dependence during Pregnancy
Maeda A, Bateman BT, Clancy CR, Creanga AA, Leffert LR. Opioid Abuse and Dependence during Pregnancy. Anesthesiology 2014, 121: 1158-1165. PMID: 25405293, DOI: 10.1097/aln.0000000000000472.Peer-Reviewed Original ResearchConceptsOpioid abuseObstetrical outcomesIntrauterine growth restrictionNationwide Inpatient SampleObstetrical morbidityPlacental abruptionPreterm laborCesarean deliveryMaternal deathsPremature rupturePregnant womenCardiac arrestRelevant confoundersInpatient SampleGrowth restrictionPreventive strategiesTherapeutic interventionsPregnancyLogistic regressionNationwide trendsHospitalizationPrevalenceAbuseOutcomesUnited StatesPreterm Premature Rupture of Membranes and the Rate of Neonatal Sepsis After Two Courses of Antenatal Corticosteroids
Gyamfi-Bannerman C, Son M. Preterm Premature Rupture of Membranes and the Rate of Neonatal Sepsis After Two Courses of Antenatal Corticosteroids. Obstetrics And Gynecology 2014, 124: 999-1003. PMID: 25437730, DOI: 10.1097/aog.0000000000000460.Peer-Reviewed Original ResearchConceptsNeonatal sepsisPreterm premature ruptureCorticosteroid coursesPremature ruptureMaternal-fetal medicine unitRespiratory distress syndromeMultivariable logistic regressionStudent's t-testAntenatal corticosteroidsPreterm PROMSingleton gestationsCohort studyPatient characteristicsDistress syndromePrimary outcomeGestational agePrimary exposureBirth weightMedicine unitSepsisSecondary analysisLogistic regressionCategorical variablesT-testLength of timeLongitudinal Profiling of Inflammatory Cytokines and C‐reactive Protein during Uncomplicated and Preterm Pregnancy
Ferguson K, McElrath T, Chen Y, Mukherjee B, Meeker J. Longitudinal Profiling of Inflammatory Cytokines and C‐reactive Protein during Uncomplicated and Preterm Pregnancy. American Journal Of Reproductive Immunology 2014, 72: 326-336. PMID: 24807462, PMCID: PMC4573571, DOI: 10.1111/aji.12265.Peer-Reviewed Original ResearchConceptsPreterm birthC-reactive proteinAssociated with increased oddsInflammation markersAssociated with increased odds of spontaneous preterm birthIL-10Associated with increased risk of preterm birthOdds of spontaneous preterm birthEtiology of preterm deliveryPredictors of preterm birthIL-6Risk of preterm birthPreterm premature ruptureSpontaneous preterm laborSpontaneous preterm birthIntrauterine growth restrictionNested Case-Control StudyProfile of inflammatory cytokinesAssociated with increased riskCase-control studyPreterm laborPreterm pregnanciesPreterm deliveryGestational agePremature ruptureHuman Fetal Membranes Generate Distinct Cytokine Profiles in Response to Bacterial Toll-Like Receptor and Nod-Like Receptor Agonists1
Hoang M, Potter JA, Gysler SM, Han CS, Guller S, Norwitz ER, Abrahams VM. Human Fetal Membranes Generate Distinct Cytokine Profiles in Response to Bacterial Toll-Like Receptor and Nod-Like Receptor Agonists1. Biology Of Reproduction 2014, 90: 39, 1-9. PMID: 24429216, PMCID: PMC4076407, DOI: 10.1095/biolreprod.113.115428.Peer-Reviewed Original ResearchConceptsBacterial toll-like receptorsToll-like receptorsPathogen-associated molecular patternsInnate immune pattern recognition receptorsNOD-like receptorsPattern recognition receptorsImmune pattern recognition receptorsCytokine profileIL1B secretionFetal membranesCpG ODNCaspase-1Subsequent preterm birthInflammatory cytokine profilePreterm premature ruptureDistinct cytokine profilesMaternal-fetal interfaceInfection-associated inflammationMild stimulatory effectNLR agonistsPreterm birthPremature ruptureProinflammatory cytokinesCytokine productionMCP-1
2011
Modulation of Amniotic Fluid Activin‐A and Inhibin‐A in Women With Preterm Premature Rupture of the Membranes and Infection‐Induced Preterm Birth
Rosenberg VA, Buhimschi IA, Dulay AT, Abdel‐Razeq S, Oliver EA, Duzyj CM, Lipkind H, Pettker CM, Buhimschi CS. Modulation of Amniotic Fluid Activin‐A and Inhibin‐A in Women With Preterm Premature Rupture of the Membranes and Infection‐Induced Preterm Birth. American Journal Of Reproductive Immunology 2011, 67: 122-131. PMID: 21992678, PMCID: PMC3253234, DOI: 10.1111/j.1600-0897.2011.01074.x.Peer-Reviewed Original ResearchConceptsPreterm premature rupturePreterm birthPremature ruptureVillous explantsRecombinant activinInflammation-induced preterm birthRelease of activinIntra-amniotic infectionPlacental villous explantsIL-8 releasePreterm laborInflammatory processInflammatory reactionGram-negative lipopolysaccharideInhibinFetal membranesHuman AFImportant modulatorAF samplesInfectionActivinLipopolysaccharidePPROMAmniochorionIntact membranesIL-6 Trans-Signaling System in Intra-Amniotic Inflammation, Preterm Birth, and Preterm Premature Rupture of the Membranes
Lee SY, Buhimschi IA, Dulay AT, Ali UA, Zhao G, Abdel-Razeq SS, Bahtiyar MO, Thung SF, Funai EF, Buhimschi CS. IL-6 Trans-Signaling System in Intra-Amniotic Inflammation, Preterm Birth, and Preterm Premature Rupture of the Membranes. The Journal Of Immunology 2011, 186: 3226-3236. PMID: 21282511, PMCID: PMC3800180, DOI: 10.4049/jimmunol.1003587.Peer-Reviewed Original ResearchMeSH KeywordsAdultAmniocentesisAmniotic FluidCytokine Receptor gp130FemaleFetal Membranes, Premature RuptureHumansInfant, NewbornInfant, PrematureInflammation MediatorsInterleukin-6Matrix Metalloproteinase 9Matrix Metalloproteinase InhibitorsPregnancyPregnancy ComplicationsPremature BirthReceptors, Interleukin-6Signal TransductionYoung AdultConceptsIntra-amniotic inflammationSIL-6RIL-6RPremature ruptureIL-6Classic IL-6 signalingAF IL-6RT-PCRPreterm premature ruptureIL-6 signalingMatrix metalloprotease-9Real-time RT-PCRActivation of cellsPhysiologic constituentPreterm laborPreterm birthIL-6 TransGestational ageThird trimesterInflammatory cellsSecond trimesterNormal gestationMetalloprotease-9IL-6 bindsFetal membranes9: Calcifying nanoparticles (NP) as novel etiologic agents of idiopathic preterm birth (iPTB) and preterm premature rupture of the membranes (PPROM)
Shook L, Buhimschi C, Dulay A, Zhao G, Ali U, Han C, Campbell K, Werner E, Buhimschi I. 9: Calcifying nanoparticles (NP) as novel etiologic agents of idiopathic preterm birth (iPTB) and preterm premature rupture of the membranes (PPROM). American Journal Of Obstetrics And Gynecology 2011, 204: s7. DOI: 10.1016/j.ajog.2010.10.016.Peer-Reviewed Original Research
2009
527: Interleukin-6 trans-signaling molecules soluble GP130 and soluble IL-6 receptor in the amniotic fluid (AF) of women with intra-amniotic inflammation (IAI) and preterm premature rupture of membranes (PPROM)
Lee S, Buhimschi I, Zhao G, Dulay A, Bahtiyar M, Han C, Buhimschi C. 527: Interleukin-6 trans-signaling molecules soluble GP130 and soluble IL-6 receptor in the amniotic fluid (AF) of women with intra-amniotic inflammation (IAI) and preterm premature rupture of membranes (PPROM). American Journal Of Obstetrics And Gynecology 2009, 201: s196. DOI: 10.1016/j.ajog.2009.10.693.Peer-Reviewed Original Research
2008
Multidimensional Proteomics Analysis of Amniotic Fluid to Provide Insight into the Mechanisms of Idiopathic Preterm Birth
Buhimschi IA, Zhao G, Rosenberg VA, Abdel-Razeq S, Thung S, Buhimschi CS. Multidimensional Proteomics Analysis of Amniotic Fluid to Provide Insight into the Mechanisms of Idiopathic Preterm Birth. PLOS ONE 2008, 3: e2049. PMID: 18431506, PMCID: PMC2315798, DOI: 10.1371/journal.pone.0002049.Peer-Reviewed Original ResearchMeSH KeywordsAdultAmniotic FluidBiomarkersDown-RegulationElectrophoresis, Gel, Two-DimensionalFemaleHemorrhageHumansInflammationPlacentaPregnancyPregnancy ProteinsPremature BirthProteomeProteomicsRNA, MessengerSoftwareSpectrometry, Mass, Matrix-Assisted Laser Desorption-IonizationTreatment OutcomeUmbilical CordUp-RegulationConceptsPreterm birthAmniotic fluidIdiopathic preterm birthIntra-amniotic inflammationMost preterm birthsSubgroup of patientsAbsence of inflammationDistinct pathogenetic mechanismsFuture drug developmentProteomic fingerprintExpectant managementNovel pathogenetic pathwaysPreterm laborPremature ruptureClinical resultsPathogenetic mechanismsPathogenetic pathwaysConsecutive sampleTherapeutical interventionsInflammationSELDI peaksBirthBleedingProtein metabolismDrug developmentUsing Proteomic Analysis of the Human Amniotic Fluid to Identify Histologic Chorioamnionitis
Buhimschi IA, Zambrano E, Pettker CM, Bahtiyar MO, Paidas M, Rosenberg VA, Thung S, Salafia CM, Buhimschi CS. Using Proteomic Analysis of the Human Amniotic Fluid to Identify Histologic Chorioamnionitis. Obstetrics And Gynecology 2008, 111: 403-412. PMID: 18238979, DOI: 10.1097/aog.0b013e31816102aa.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAmniocentesisAmniotic FluidBiomarkersBlack or African AmericanChorioamnionitisFemaleHumansInflammationPregnancyPregnancy Complications, InfectiousPregnancy OutcomePrevalenceProteomeProteomicsReproducibility of ResultsSensitivity and SpecificitySeverity of Illness IndexSpectrometry, Mass, Matrix-Assisted Laser Desorption-IonizationWhite PeopleConceptsHistologic chorioamnionitisAmniotic fluidIntra-amniotic inflammationGrade of inflammationAbsence of biomarkersHuman amniotic fluidSurface-enhanced laser desorption ionization timeAfrican American womenPreterm laborSingleton pregnanciesDelivery intervalPlacental pathologyGestational agePremature ruptureSevere inflammationEarly recognitionChorioamnionitisChorionic plateInflammationTherapeutic interventionsProteomic biomarkersCalgranulin CBiomarkersProteomic analysisScores
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