2025
Preliminary Evidence for Perturbation‐Based tACS‐EEG Biomarkers of Gamma Activity in Alzheimer's Disease
Palmisano A, Pezanko L, Cappon D, Tatti E, Macone J, Koch G, Smeralda C, Romanella S, Ruffini G, Rivolta D, Press D, Pascual‐Leone A, El‐Fakhri G, Santarnecchi E. Preliminary Evidence for Perturbation‐Based tACS‐EEG Biomarkers of Gamma Activity in Alzheimer's Disease. International Journal Of Geriatric Psychiatry 2025, 40: e70025. PMID: 39799469, DOI: 10.1002/gps.70025.Peer-Reviewed Original ResearchConceptsPeripheral neuroinflammationIdentification of novel biomarkersResponse to TACPatient's clinical phenotypeSpectral powerGABAergic dysfunctionNo significant correlationPrognostic valueInhibitory circuitryClinical severityClinical phenotypeAnimal modelsCognitive statusNeuroinflammatory markersAlzheimer's diseaseHuman patientsNeuroinflammatory biomarkersNovel biomarkersPatientsDisease severityTherapeutic targetGamma activityBiomarkersMild to moderate dementiaSignificant correlation
2024
Difficult to Treat Depression: Focus on Approach, Algorithms, and Access.
Karp J, Brinton R, Fournier J, Harding L, Jha M, Lenze E, Mathew S, Meltzer-Brody S, Mohr D, Riva-Posse P, Wiechers I, Williams N. Difficult to Treat Depression: Focus on Approach, Algorithms, and Access. The Journal Of Clinical Psychiatry 2024, 85 PMID: 39630090, DOI: 10.4088/jcp.psprmdd2408ah.Peer-Reviewed Original ResearchConceptsTreating depressionSpectrum of clinical severityTreatment of depressionEvolving treatment landscapeDepartment of PsychiatryBurden of depressionOral pharmacotherapyTreatment landscapeAdult patientsClinical severityCommunity health agenciesDepressionIncreased prevalenceHealth care systemPatientsDepression carePsychiatric workforcePsychiatryPatient advocatesCare systemTherapeutic engineeringHealth agenciesTelemedicine platformDo IRemission7829 Hydrocortisone Vs Prednisone During Recovery Following Surgical Cure For Endogenous Hypercortisolism: A Longitudinal Observational Study
Sandooja R, Saini J, Garcia R, Zhang C, Achenbach S, Atkinson E, Van Gompel J, Young W, Bancos I. 7829 Hydrocortisone Vs Prednisone During Recovery Following Surgical Cure For Endogenous Hypercortisolism: A Longitudinal Observational Study. Journal Of The Endocrine Society 2024, 8: bvae163.206. PMCID: PMC11454907, DOI: 10.1210/jendso/bvae163.206.Peer-Reviewed Original ResearchGlucocorticoid withdrawal syndromeMild autonomous cortisol secretionSeverity of hypercortisolismTreated with hydrocortisoneEndogenous hypercortisolismSurgical cureCushing's syndromeSF-36Clinical severityPost-surgeryFemale sexPatients treated with prednisoneSeverity scorePatients treated with hydrocortisoneSF-36 mental component scoreQuality of lifeSF-36 physical component scoreEtiology of hypercortisolismAutonomous cortisol secretionClinical severity scoreBaseline clinical severityConstellation of symptomsWeeks post-surgeryPhysical component scoreGlucocorticoid replacementGroup cohesion and alliance predict cognitive-behavioral group treatment outcomes for youth with anxiety disorders
Fjermestad K, Wallin M, Naujokat F, McLeod B, Silverman W, Öst L, Lerner M, Heiervang E, Wergeland G. Group cohesion and alliance predict cognitive-behavioral group treatment outcomes for youth with anxiety disorders. Cognitive Behaviour Therapy 2024, 54: 96-114. PMID: 39105346, DOI: 10.1080/16506073.2024.2385906.Peer-Reviewed Original ResearchGroup cognitive behavioral therapyAnxiety disordersAnxiety symptomsDiagnostic recoveryParent-reported anxiety symptomsGroup cohesionCognitive behavioral therapyRandomized controlled effectiveness trialBehavioral therapyAlliance changeParent-reported outcomesEffectiveness trialClinical severityTreatment outcomesAnxietyPost-treatmentDisordersAllianceSymptomsYouthFollow-upGeneralized Estimating EquationsSeveritySessionsOutcomesEffectiveness of Updated 2023–2024 (Monovalent XBB.1.5) COVID-19 Vaccination Against SARS-CoV-2 Omicron XBB and BA.2.86/JN.1 Lineage Hospitalization and a Comparison of Clinical Severity—IVY Network, 26 Hospitals, 18 October 2023–9 March 2024
C K, Surie D, Lauring A, Martin E, Leis A, Papalambros L, Gaglani M, Columbus C, Gottlieb R, Ghamande S, Peltan I, Brown S, Ginde A, Mohr N, Gibbs K, Hager D, Saeed S, Prekker M, Gong M, Mohamed A, Johnson N, Srinivasan V, Steingrub J, Khan A, Hough C, Duggal A, Wilson J, Qadir N, Chang S, Mallow C, Kwon J, Parikh B, Exline M, Vaughn I, Ramesh M, Safdar B, Mosier J, Harris E, Shapiro N, Felzer J, Zhu Y, Grijalva C, Halasa N, Chappell J, Womack K, Rhoads J, Baughman A, Swan S, Johnson C, Rice T, Casey J, Blair P, Han J, Ellington S, Lewis N, Thornburg N, Paden C, Atherton L, Self W, Dawood F, DeCuir J. Effectiveness of Updated 2023–2024 (Monovalent XBB.1.5) COVID-19 Vaccination Against SARS-CoV-2 Omicron XBB and BA.2.86/JN.1 Lineage Hospitalization and a Comparison of Clinical Severity—IVY Network, 26 Hospitals, 18 October 2023–9 March 2024. Clinical Infectious Diseases 2024, ciae405. PMID: 39107255, DOI: 10.1093/cid/ciae405.Peer-Reviewed Original ResearchInvasive mechanical ventilationIntensive care unitCase-patientsOdds of severe outcomesCOVID-19 vaccineLogistic regressionOdds of ICU admissionCOVID-19 vaccine dosesControl-patientsAnalyzed patientsImmune escapeCase-control designVaccine compositionMechanical ventilationClinical severityICU admissionVaccine doseCare unitTest-negativeVaccine effectivenessSevere outcomesCOVID-19-like illnessCOVID-19 vaccine effectivenessSARS-CoV-2HospitalMesenchymal stem cell-derived small extracellular vesicles alleviate the immunometabolic dysfunction in murine septic encephalopathy
Koutroulis I, Kratimenos P, Hoptay C, O’Brien W, Sanidas G, Byrd C, Triantafyllou M, Goldstein E, Jablonska B, Bharadwaj M, Gallo V, Freishtat R. Mesenchymal stem cell-derived small extracellular vesicles alleviate the immunometabolic dysfunction in murine septic encephalopathy. IScience 2024, 27: 110573. PMID: 39165840, PMCID: PMC11334791, DOI: 10.1016/j.isci.2024.110573.Peer-Reviewed Original ResearchCentral nervous systemSeptic encephalopathyStem cell (MSC)-derived small extracellular vesiclesSmall extracellular vesiclesDysregulated host response to infectionRestored aerobic metabolismLife-threatening organ dysfunctionLong-term sequelaeHost response to infectionExtracellular vesiclesMesenchymal stem cell-derived small extracellular vesiclesPro-inflammatory cytokinesCell-derived small extracellular vesiclesResponse to infectionStem cell-derived small extracellular vesiclesImmune dysregulationOrgan dysfunctionSusceptible to injurySeptic miceClinical symptomsClinical severityImmunometabolic dysfunctionIntravenous administrationDisease outcomeInfectious processThe relationship between serum prolactin levels and cognitive function in drug-naïve schizophrenia patients: a cross-sectional study
Luo G, Bai F, Qu X, Jing Y, Wang S, Xuekelaiti Z, Yao C, Li M, Li J. The relationship between serum prolactin levels and cognitive function in drug-naïve schizophrenia patients: a cross-sectional study. Journal Of Neural Transmission 2024, 131: 385-391. PMID: 38277043, DOI: 10.1007/s00702-024-02748-4.Peer-Reviewed Original ResearchSerum prolactin levelsSchizophrenia patientsCognitive functionProlactin levelsCognitive deficitsHealthy controlsPatients serum prolactin levelsConsensus Cognitive BatterySignificant cognitive deficitsSevere cognitive deficitsCognitive batteryTreatment researchPsychiatric symptomsSchizophreniaCognitionMCCBDeficitsCross-sectional studyProlactinClinical symptomsClinical dataClinical severitySymptomsPatientsSymptomatology
2023
Clinical presentation of calmodulin mutations: the International Calmodulinopathy Registry
Crotti L, Spazzolini C, Nyegaard M, Overgaard M, Kotta M, Dagradi F, Sala L, Aiba T, Ayers M, Baban A, Barc J, Beach C, Behr E, Bos J, Cerrone M, Covi P, Cuneo B, Denjoy I, Donner B, Elbert A, Eliasson H, Etheridge S, Fukuyama M, Girolami F, Hamilton R, Horie M, Iascone M, Jiménez-Jaimez J, Jensen H, Kannankeril P, Kaski J, Makita N, Muñoz-Esparza C, Odland H, Ohno S, Papagiannis J, Porretta A, Prandstetter C, Probst V, Robyns T, Rosenthal E, Rosés-Noguer F, Sekarski N, Singh A, Spentzou G, Stute F, Tfelt-Hansen J, Till J, Tobert K, Vinocur J, Webster G, Wilde A, Wolf C, Ackerman M, Schwartz P. Clinical presentation of calmodulin mutations: the International Calmodulinopathy Registry. European Heart Journal 2023, 44: 3357-3370. PMID: 37528649, PMCID: PMC10499544, DOI: 10.1093/eurheartj/ehad418.Peer-Reviewed Original ResearchConceptsClinical presentationPrimary neurological manifestationsCardiac structural abnormalitiesLife-threatening arrhythmia syndromesArrhythmic event rateAbsence of symptomsLife-threatening arrhythmiasSodium channel blockersCongenital heart defectsAntiadrenergic interventionsCardiac eventsHeart failureNeurological manifestationsUnderlying molecular mechanismsDefinitive recommendationsClinical severityChannel blockersObservational studySudden deathIndex caseArrhythmia syndromesHeart defectsPrevalent phenotypeStructural abnormalitiesCurrent managementMultiomic analyses implicate a neurodevelopmental program in the pathogenesis of cerebral arachnoid cysts
Kundishora A, Allington G, McGee S, Mekbib K, Gainullin V, Timberlake A, Nelson-Williams C, Kiziltug E, Smith H, Ocken J, Shohfi J, Allocco A, Duy P, Elsamadicy A, Dong W, Zhao S, Wang Y, Qureshi H, DiLuna M, Mane S, Tikhonova I, Fu P, Castaldi C, López-Giráldez F, Knight J, Furey C, Carter B, Haider S, Moreno-De-Luca A, Alper S, Gunel M, Millan F, Lifton R, Torene R, Jin S, Kahle K. Multiomic analyses implicate a neurodevelopmental program in the pathogenesis of cerebral arachnoid cysts. Nature Medicine 2023, 29: 667-678. PMID: 36879130, PMCID: PMC12178143, DOI: 10.1038/s41591-023-02238-2.Peer-Reviewed Original ResearchConceptsArachnoid cystCerebral arachnoid cystsDe novo variantsAC pathogenesisDevelopmental brain lesionsStructural brain diseaseAppropriate clinical contextPatients' medical recordsDamaging de novo variantsMedical recordsClinical severityBrain lesionsHealthy individualsAC subtypesBrain diseasesGenetic testingNeurodevelopmental pathologyClinical contextPathogenesisPatient phenotypesNeurodevelopmental programsNovo variantsRNA sequencing transcriptomeHuman brainCysts
2022
Features that define clinical severity of ulcerative pyoderma gangrenosum: a Delphi consensus study of experts and patients on behalf of the US Medical Dermatology Society
Pimentel M, Li M, Noe M, Latour E, Seminario-Vidal L, Greiling T, Shinkai K, Hamilton A, Alavi A, Bolognia J, Cowen E, Dominguez A, Fernandez A, Fivenson D, Huang W, Madigan L, Mauskar M, Means A, Nelson C, Patsatsi A, Pugliese D, Rojek N, Rosenbach M, Smith G, Swerlick R, Heffernan M, Mostaghimi A, Ortega-Loayza A. Features that define clinical severity of ulcerative pyoderma gangrenosum: a Delphi consensus study of experts and patients on behalf of the US Medical Dermatology Society. British Journal Of Dermatology 2022, 188: 566-568. PMID: 36746554, PMCID: PMC11110082, DOI: 10.1093/bjd/ljac137.Peer-Reviewed Original ResearchCharacterizing Impulsivity in Individuals with Heroin Use Disorder
Kang T, Zhang Y, Zhao J, Li X, Jiang H, Niu X, Xie R, Ding X, Steele V, Yuan T. Characterizing Impulsivity in Individuals with Heroin Use Disorder. International Journal Of Mental Health And Addiction 2022, 22: 1530-1545. DOI: 10.1007/s11469-022-00941-8.Peer-Reviewed Original ResearchHeroin use disorderHealthy controlsUse disordersClinical severityMale healthy controlsSubstance use disordersDaily dosageRehabilitation hospitalFormer groupBIS-11 scoresMale participantsDisordersMale individualsSeverityParticipantsImpulsivityScoresTotal net scoreCognitive impulsivityGroupHospitalIGTIndividualsChildhood Adversity, Addiction Severity, and Comorbidity Among Patients Receiving Opioid Use Disorder Treatment
Carr M, Ellis J, Saules K, Ledgerwood D. Childhood Adversity, Addiction Severity, and Comorbidity Among Patients Receiving Opioid Use Disorder Treatment. The Journal Of Nervous And Mental Disease 2022, 211: 150-156. PMID: 36112518, DOI: 10.1097/nmd.0000000000001581.Peer-Reviewed Original ResearchConceptsOpioid use disorder treatmentUse disorder treatmentClinical severityChildhood adversityDisorder treatmentOpioid agonist treatmentChildhood adversity exposureGreater childhood adversityOUD treatmentAgonist treatmentTreatment strategiesEmotion dysregulationEmotion regulationCurrent psychopathologyAddiction severityPatientsAdversity exposureSymptom typeSeverityWomenStrongest predictorTreatmentHigh rateDysregulationGreater exposurePatient and Treatment Characteristics Associated With Receipt of Core Patient-Reported Outcome Measures in VA Mental Health
Liebmann EP, Resnick SG, Austin KL, Jedele JM. Patient and Treatment Characteristics Associated With Receipt of Core Patient-Reported Outcome Measures in VA Mental Health. Military Medicine 2022, 188: 3613-3620. PMID: 35849075, DOI: 10.1093/milmed/usac218.Peer-Reviewed Original ResearchConceptsPatient-reported outcome measuresMeasurement-based carePROM administrationTreatment characteristicsOutcome measuresSet of PROMsOutpatient mental health careVA mental healthPatient-level barriersMental health careMental health care organizationsPercent of veteransType of treatmentElectronic health recordsCore patientsFiscal year 2019Clinical severityDepressive disorderDecreased oddsPROM dataPsychotic disordersTreatment encountersCognitive impairmentVeterans AffairsOlder age
2021
D‐bifunctional protein deficiency caused by splicing variants in a neonate with severe peroxisomal dysfunction and persistent hypoglycemia
Werner KM, Cox AJ, Qian E, Jain P, Ji W, Tikhonova I, Castaldi C, Bilguvar K, Knight J, Ferdinandusse S, Fawaz R, Jiang Y, Gallagher PG, Bizzarro M, Gruen JR, Bale A, Zhang H. D‐bifunctional protein deficiency caused by splicing variants in a neonate with severe peroxisomal dysfunction and persistent hypoglycemia. American Journal Of Medical Genetics Part A 2021, 188: 357-363. PMID: 34623748, PMCID: PMC8678290, DOI: 10.1002/ajmg.a.62520.Peer-Reviewed Original ResearchConceptsBifunctional protein deficiencyEarly mortalityClinical spectrumPersistent hypoglycemiaDBP deficiencyFat-soluble vitamin deficiencyImportant prognostic informationProtein deficiencyEnzyme deficiencyYears of lifePeroxisomal enzyme deficienciesResidual enzyme functionAbsent enzyme activityRapid whole-genome sequencingUnexplained hypoglycemiaEarly managementPrognostic informationVitamin deficiencyClinical severityNeonatal hypotoniaHigh burdenPeroxisomal dysfunctionPatient's fatherPsychomotor delayLong-chain fatty acidsThe Level of Alcohol Consumption in the Prior Year Does Not Impact Clinical Outcomes in Patients With Alcohol‐Associated Hepatitis
Musto JA, Eickhoff J, Ventura‐Cots M, Abraldes JG, Bosques‐Padilla F, Verna EC, Brown RS, Vargas V, Altamirano J, Caballería J, Shawcross D, Louvet A, Mathurin P, Garcia‐Tsao G, Schnabl B, Bataller R, Lucey MR. The Level of Alcohol Consumption in the Prior Year Does Not Impact Clinical Outcomes in Patients With Alcohol‐Associated Hepatitis. Liver Transplantation 2021, 27: 1382-1391. PMID: 34109723, PMCID: PMC11075741, DOI: 10.1002/lt.26203.Peer-Reviewed Original ResearchConceptsAlcohol-associated hepatitisAUDIT-C scoresMELD-NaAUDIT-10Recent alcohol consumptionAlcohol consumptionLiver injuryLiver diseaseSurvival statusAUDIT-ConsumptionEnd-stage liver diseaseAUDIT scoresAlcohol‐Associated HepatitisProspective international databaseMELD-Na scoreAlcohol Use Disorders Identification TestShort-term mortalityShort-term outcomesPrior yearDisorders Identification TestSeverity of drinkingPresenting featuresPrimary outcomeClinical outcomesClinical severityAdmission computed tomography radiomic signatures outperform hematoma volume in predicting baseline clinical severity and functional outcome in the ATACH‐2 trial intracerebral hemorrhage population
Haider SP, Qureshi AI, Jain A, Tharmaseelan H, Berson ER, Zeevi T, Majidi S, Filippi CG, Iseke S, Gross M, Acosta JN, Malhotra A, Kim JA, Sansing LH, Falcone GJ, Sheth KN, Payabvash S. Admission computed tomography radiomic signatures outperform hematoma volume in predicting baseline clinical severity and functional outcome in the ATACH‐2 trial intracerebral hemorrhage population. European Journal Of Neurology 2021, 28: 2989-3000. PMID: 34189814, PMCID: PMC8818333, DOI: 10.1111/ene.15000.Peer-Reviewed Original ResearchConceptsAdmission Glasgow Coma ScaleGlasgow Coma ScaleRadiomics signatureMRS scoreHematoma volumeICH volumeClinical severityNoncontrast head CT scansAdmission National InstitutesHealth Stroke ScaleRankin Scale scoreStrong associationBaseline clinical severityMedium-term outcomesIndependent validation cohortHead CT scanATACH-2 trialStroke ScaleAdmission NIHSSIndependent predictorsClinical presentationComa ScaleBaseline CTICH patientsValidation cohortThe impact of generalized anxiety disorder in obsessive-compulsive disorder patients.
Sharma P, Rosário M, Ferrão Y, Albertella L, Miguel E, Fontenelle L. The impact of generalized anxiety disorder in obsessive-compulsive disorder patients. Psychiatry Research 2021, 300: 113898. PMID: 33812219, DOI: 10.1016/j.psychres.2021.113898.Peer-Reviewed Original ResearchConceptsGeneralized anxiety disorderObsessive-compulsive disorderComorbid generalized anxiety disorderAnxiety disordersOnset of OCDType II bipolar disorderDiagnosis of GADTreatment of OCDObsessive-compulsive disorder patientsSevere anxiety symptomsMann-Whitney U testChi-square testPrevalent comorbiditiesClinical profileClinical severityMood disordersDisorder patientsComorbid anxietyPanic disorderBipolar disorderAvoidant behaviorComorbiditiesGreater suicidalityLogistic regressionU test12 Novel clonal groups of Leptospira infecting humans in multiple contrasting epidemiological contexts in Sri Lanka
Jayasundara D, Senavirathna I, Warnasekara J, Gamage C, Siribaddana S, Kularatne SAM, Matthias M, Mariet JF, Picardeau M, Agampodi S, Vinetz J. 12 Novel clonal groups of Leptospira infecting humans in multiple contrasting epidemiological contexts in Sri Lanka. PLOS Neglected Tropical Diseases 2021, 15: e0009272. PMID: 33735202, PMCID: PMC8009393, DOI: 10.1371/journal.pntd.0009272.Peer-Reviewed Original ResearchConceptsClonal groupsAcute kidney injuryL. interrogansMajor clinical challengeGlobal disease threatsLeptospira speciesL. interrogans infectionKidney injuryLiver impairmentCardiovascular involvementL. borgpeterseniiClinical presentationProspective studyClinical severityClinical challengePathogenic Leptospira speciesAnnual epidemicsUbiquitous zoonotic diseaseNew serogroupEpidemiological contextZoonotic diseaseCulture isolationLeptospiral culturesL. weiliiLeptospira diversityAtypical Anorexia Nervosa, not so atypical after all: Prevalence, correlates, and clinical severity among United States military Veterans
Masheb RM, Ramsey CM, Marsh AG, Snow JL, Brandt CA, Haskell SG. Atypical Anorexia Nervosa, not so atypical after all: Prevalence, correlates, and clinical severity among United States military Veterans. Eating Behaviors 2021, 41: 101496. PMID: 33711788, DOI: 10.1016/j.eatbeh.2021.101496.Peer-Reviewed Original ResearchConceptsAtypical anorexia nervosaBinge Eating DisorderAnorexia nervosaBulimia nervosaMental healthUnited States military veteransSample of veteransDSM-5AAN groupAverage BMISevere underweightMean ageClinical severitySignificant diagnosisMultivariate analysisWorse functioningPast monthDietary restraintDisorder diagnosisDisorder groupNervosaEra veteransDisordersEating DisordersDiagnosisAssociation of Aβ deposition and regional synaptic density in early Alzheimer’s disease: a PET imaging study with [11C]UCB-J
O’Dell R, Mecca AP, Chen MK, Naganawa M, Toyonaga T, Lu Y, Godek TA, Harris JE, Bartlett HH, Banks ER, Kominek VL, Zhao W, Nabulsi NB, Ropchan J, Ye Y, Vander Wyk BC, Huang Y, Arnsten AFT, Carson RE, van Dyck CH. Association of Aβ deposition and regional synaptic density in early Alzheimer’s disease: a PET imaging study with [11C]UCB-J. Alzheimer's Research & Therapy 2021, 13: 11. PMID: 33402201, PMCID: PMC7786921, DOI: 10.1186/s13195-020-00742-y.Peer-Reviewed Original ResearchConceptsRegional Aβ depositionAβ depositionEarly Alzheimer's diseaseSynaptic lossSynaptic densityAlzheimer's diseaseDistribution volume ratioPositron emission tomographyHippocampal synaptic densityMild AD dementiaDeposition of AβSignificant inverse associationAmnestic mild cognitive impairmentWhole-brain analysisMild cognitive impairmentCerebellar reference regionPET imaging studiesPlaque burdenAD dementiaInverse associationPostmortem studiesClinical severityNeurodegenerative processesClinical diseaseLarge cohort
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