2014
Supplementing a Low-Protein Diet with Dibasic Amino Acids Increases Urinary Calcium Excretion in Young Women 1,2
Bihuniak JD, Sullivan RR, Simpson CA, Caseria DM, Huedo-Medina TB, O’Brien K, Kerstetter JE, Insogna KL. Supplementing a Low-Protein Diet with Dibasic Amino Acids Increases Urinary Calcium Excretion in Young Women 1,2. Journal Of Nutrition 2014, 144: 282-288. PMID: 24431325, PMCID: PMC3927545, DOI: 10.3945/jn.113.185009.Peer-Reviewed Original ResearchConceptsIntestinal calcium absorptionLow-protein dietCalcium absorptionDual-stable calcium isotopesYoung womenUrinary calcium excretionDietary proteinControl diet periodAmino acid L-arginineHigh-protein dietAmino acid L-tryptophanCalcium excretionDiet periodClinical trialsSupplementation periodL-arginineDay 5Control dietRandom orderPhysiologic rangeDietTrialsWomenPossible benefitsL-tryptophan
2011
Post‐epidemic eosinophilia–myalgia syndrome associated with L‐tryptophan
Allen JA, Peterson A, Sufit R, Hinchcliff ME, Mahoney JM, Wood TA, Miller FW, Whitfield ML, Varga J. Post‐epidemic eosinophilia–myalgia syndrome associated with L‐tryptophan. Arthritis & Rheumatism 2011, 63: 3633-3639. PMID: 21702023, PMCID: PMC3848710, DOI: 10.1002/art.30514.Peer-Reviewed Original ResearchConceptsEosinophilia-myalgia syndromeL-tryptophan-associated eosinophilia-myalgia syndromeNew casesL-tryptophanGrowth factor βChronic neuropathyPeripheral eosinophiliaSubacute onsetLesional skinSkin indurationImmunogenetic featuresInterleukin-4Drug AdministrationFDA banFactor βSyndromeMyalgiaEosinophiliaNeuropathyHistopathologicIndurationIncidenceAdministration
2007
In vivo measurements of brain trapping of C-labelled alpha-methyl-L-tryptophan during acute changes in mood states.
Perreau-Linck E, Beauregard M, Gravel P, Paquette V, Soucy J, Diksic M, Benkelfat C. In vivo measurements of brain trapping of C-labelled alpha-methyl-L-tryptophan during acute changes in mood states. Journal Of Psychiatry And Neuroscience 2007, 32: 430-4. PMID: 18043767, PMCID: PMC2077345.Peer-Reviewed Original ResearchConceptsPositron emission tomographyBrain trappingEmotional statesRight anterior cingulate cortexNeutral emotional stateNeurobiology of emotionAnterior cingulate cortexWhole-brain analysisSubjects repeated-measures designState-related changesAcute changesL-tryptophanAutobiographical memoryRepeated-measures designHealthy peopleCingulate cortexBrain Imaging CenterEmission tomographyMood statesMcConnell Brain Imaging CentreBrain analysisNormal moodExperienced levelScan acquisitionSustained changes
2005
P.2.01 The effects of altering dietary L-tryptophan on the performance of an iterated Prisoner's Dilemma (PD) game in healthy volunteers
Wood R, Rilling J, Sanfey A, Bhagwagar Z, Rogers R. P.2.01 The effects of altering dietary L-tryptophan on the performance of an iterated Prisoner's Dilemma (PD) game in healthy volunteers. European Neuropsychopharmacology 2005, 15: s32. DOI: 10.1016/s0924-977x(05)80141-5.Peer-Reviewed Original Research
2000
The Suitability of [11C]-α-Methyl-L-tryptophan as a Tracer for Serotonin Synthesis: Studies With Dual Administration of [11C] and [14C] Labeled Tracer
Shoaf S, Carson R, Hommer D, Williams W, Higley J, Schmall B, Herscovitch P, Eckelman W, Linnoila M. The Suitability of [11C]-α-Methyl-L-tryptophan as a Tracer for Serotonin Synthesis: Studies With Dual Administration of [11C] and [14C] Labeled Tracer. Cerebrovascular And Brain Metabolism Reviews 2000, 20: 244-252. PMID: 10698060, DOI: 10.1097/00004647-200002000-00004.Peer-Reviewed Original ResearchConceptsPositron emission tomographySerotonin synthesisOverdose of phenobarbitalBrain serotonin synthesis rateIsoflurane-anesthetized rhesus monkeysSerotonin synthesis rateBrain concentrationsSecond doseBrain samplesEmission tomographyRhesus monkeysDual administrationTryptophan uptakePatlak plotSerotoninMinimal conversionAdministrationMonkeysSynthesis rateL-tryptophanPET imagesPET dataTotal countOverdoseExternal quantification
1996
Seasonal Variation in Neuroendocrine and Mood Responses to IV L-Tryptophan in Depressed Patients and Healthy Subjects
Cappiello A, Malison R, McDougle C, Vegso S, Charney D, Heninger G, Price L. Seasonal Variation in Neuroendocrine and Mood Responses to IV L-Tryptophan in Depressed Patients and Healthy Subjects. Neuropsychopharmacology 1996, 15: 475-483. PMID: 8914120, DOI: 10.1016/s0893-133x(96)00057-7.Peer-Reviewed Original ResearchConceptsHealthy subjectsTryptophan levelsDrug-free patientsVisual analog scaleL-tryptophanMale patientsAnalog scaleSerum prolactinDepressed patientsMajor depressionSerotonin functionNonpsychotic patientsMood disordersUnipolar patientsPatientsDSM-IIISuch abnormalitiesProlactinCosinor analysisMood responsesDepressionPrevious evidenceSubjectsInfusionNeuroendocrine
1995
Cerebrospinal fluid levels of kynurenine pathway metabolites in patients with eating disorders: Relation to clinical and biochemical variable
Demitrack M, Heyes M, Altemus M, Pigott T, Gold P. Cerebrospinal fluid levels of kynurenine pathway metabolites in patients with eating disorders: Relation to clinical and biochemical variable. Biological Psychiatry 1995, 37: 512-520. PMID: 7542489, DOI: 10.1016/0006-3223(94)00173-z.Peer-Reviewed Original ResearchConceptsCerebrospinal fluid levelsKynurenic acidKynurenine pathwayQuinolinic acidFluid levelsBody weightAnorexia nervosaMedication-free female patientsN-methyl-D-aspartate receptor agonistExcitatory amino acid receptorsL-kynurenineNormal weight bulimia nervosaAcid levelsQuinolinic acid levelsAmino acid receptorsKynurenic acid levelsNormal body weightNormal-weight femalesL-tryptophanEating Disorder PatientsUnderweight anorecticsUnderweight phaseEating-disordered patientsNutritional recoveryFemale patients
1990
Clinical data on the role of serotonin in the mechanism(s) of action of antidepressant drugs.
Price LH, Charney DS, Delgado PL, Goodman WK, Krystal JH, Woods SW, Heninger GR. Clinical data on the role of serotonin in the mechanism(s) of action of antidepressant drugs. The Journal Of Clinical Psychiatry 1990, 51 Suppl: 44-50; discussion 51-2. PMID: 2182616.Peer-Reviewed Original ResearchConceptsIntravenous L-tryptophanBrain serotonin functionAntidepressant drug actionRole of serotoninL-tryptophanThymoleptic drugsPlasma TrpView of evidencePRL responseNeuroendocrine effectsSerum prolactinSerotonin functionAntidepressant drugsClinical dataTherapeutic effectPreclinical studiesReceptor sensitivityClinical settingChallenge paradigmDrug actionRecent evidenceAntidepressantsProlactinDrugsDepression
1989
The Effect of L-Tryptophan on Daytime Sleep Latency in Normals: Correlation with Blood Levels
George C, Millar T, Hanly P, Kryger M. The Effect of L-Tryptophan on Daytime Sleep Latency in Normals: Correlation with Blood Levels. Sleep 1989, 12: 345-353. PMID: 2669092, DOI: 10.1093/sleep/12.4.345.Peer-Reviewed Original ResearchConceptsSleep latencyBlood levelsRandom double-blind fashionRapid eye movement (REM) sleepDaytime sleep latencyL-tryptophan's effectsDouble-blind fashionEye movement sleepL-tryptophanSlow-wave sleepL-tryptophan levelsObjective sleepiness measuresKynurenic acidMovement sleepHealthy volunteersWave sleepDrug conditionsSeparate daysSleepSleepiness measuresPlaceboSignificant correlationEssential amino acidsDoseUrine
1972
SYNAPTOSOMES FROM FOREBRAINS OF RATS WITH MIDBRAIN RAPHE LESIONS: SELECTIVE REDUCTION OF SEROTONIN UPTAKE
KUHAR M, ROTH R, AGHAJANIAN G. SYNAPTOSOMES FROM FOREBRAINS OF RATS WITH MIDBRAIN RAPHE LESIONS: SELECTIVE REDUCTION OF SEROTONIN UPTAKE. Journal Of Pharmacology And Experimental Therapeutics 1972, 181: 36-45. PMID: 4552069, DOI: 10.1016/s0022-3565(25)29173-x.Peer-Reviewed Original ResearchConceptsConcentrations of 5-HTRaphe lesionsSynaptosomal uptakeUptake of 3H-5-HTTricyclic agent imipramineMidbrain raphe lesionsNerve endingsMidbrain raphe nucleiTryptophan hydroxylase activityTime coursePlacement of lesionsRaphe nucleusSerotonin uptakeRaphe neuronsLesioned animalsUptake activityMidbrain areaL-norepinephrineLesionsHydroxylase activityRapheIncubation mediumForebrainL-tryptophanAnimals
1970
Abnormalities of Tryptophan Metabolism and Plasma Pyridoxal Phosphate in Hodgkin's Disease
Chabner B, DeVita V, Livingston D, Oliverio V. Abnormalities of Tryptophan Metabolism and Plasma Pyridoxal Phosphate in Hodgkin's Disease. New England Journal Of Medicine 1970, 282: 838-843. PMID: 5418547, DOI: 10.1056/nejm197004092821504.Peer-Reviewed Original ResearchConceptsHodgkin's diseaseUntreated patientsPlasma levelsPlasma pyridoxal phosphate levelsPlasma pyridoxal phosphatePyridoxal phosphate levelsAdvanced diseaseComplete remissionSymptomatic diseaseImmunosuppressive effectsAbnormal resultsPyridoxine deficiencyNormal limitsTryptophan metabolismPatientsDiseasePyridoxal phosphatePhosphate levelsDeficiencyL-tryptophanLittle evidenceMetabolismRemissionChemotherapyAnemia
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