2025
97. GLOBAL VARIATIONS IN ELECTROCONVULSIVE THERAPY USAGE: A COMPARATIVE CASE SERIES ON SCHIZOPHRENIA IN THE UNITED STATES
Park S, Kim J, Touponse S, Mandell A, Hong J, Crowell A, Hermida A, Kitay B, McDonald W, Posse P, Hershenberg R. 97. GLOBAL VARIATIONS IN ELECTROCONVULSIVE THERAPY USAGE: A COMPARATIVE CASE SERIES ON SCHIZOPHRENIA IN THE UNITED STATES. American Journal Of Geriatric Psychiatry 2025, 33: s71-s72. DOI: 10.1016/j.jagp.2025.04.099.Peer-Reviewed Original ResearchClinical Global Impression-SeverityClinical Global Impression-ImprovementBeck Depression InventoryElectroconvulsive therapy treatmentsTreatment-resistant depressionPatient Health Questionnaire-9Schizoaffective disorderElectroconvulsive therapyGAD-7Major depressionMood stabilizersECT treatmentDiagnosis of obsessive-compulsive disorderRemission of psychotic symptomsCGI-I scoreTreatment of schizophreniaECT initiationGeneralized Anxiety Disorder 7-itemObsessive-compulsive disorderSevere psychiatric conditionsStabilization of moodEffect of ECT treatmentECT literatureAutism spectrum disorderDegree of paranoiaTele-SPACE: group parent-based treatment for pediatric anxiety via telemedicine in a public health clinic
de la Fontaine N, Cohen T, Hertz-Palmor N, Dorman-Ilan S, Rubin N, Itav G, Tsafrir S, Carmel Y, Weisman H, Gothelf D, Lebowitz E. Tele-SPACE: group parent-based treatment for pediatric anxiety via telemedicine in a public health clinic. Frontiers In Psychiatry 2025, 16: 1570497. PMID: 40904571, PMCID: PMC12401934, DOI: 10.3389/fpsyt.2025.1570497.Peer-Reviewed Original ResearchObsessive-compulsive disorderChild anxiety symptomsEvidence-based treatmentsAnxiety symptomsAnxiety disordersChild self-report measuresPublic health clinicsPublic health settingsAnxious Childhood EmotionsSeparation anxiety symptomsParent-based treatmentSelf-report measuresParents of childrenHealth settingsLevel of satisfactionHealth clinicsTelemedicine formatAnxiety clinicPediatric anxietyParental accommodationDepressive symptomsChildhood EmotionalTreatment barriersSupportive parentingOutpatient settingAcceptability and feasibility of internet-based cognitive-behavioral therapy for obsessive-compulsive disorder in Brazil
de Mathis M, Flygare O, Costa D, Morais I, Rocha J, Borcato S, Shavitt R, Miguel E, Batistuzzo M, Rück C. Acceptability and feasibility of internet-based cognitive-behavioral therapy for obsessive-compulsive disorder in Brazil. Behavior Therapy 2025 DOI: 10.1016/j.beth.2025.08.001.Peer-Reviewed Original ResearchInternet-based cognitive-behavioral therapy programYale-Brown Obsessive-Compulsive ScaleInternet-based cognitive-behavioural therapyCognitive-behavioral therapy programCognitive-behavioral therapyObsessive-Compulsive ScaleObsessive-compulsive disorderOCD severityOCD treatmentResponse preventionTreatment manualsOpen-label trialDepressive symptomsTreatment respondersRE-AIM implementation science frameworkTotal scorePHQ-9OCDImplementation science frameworkPreliminary evidenceTreatment responseTherapy programRE-AIMPost-treatmentUnderserved areasTransdiagnostic Examination of Interrelationships Between Anxiety, Insistence on Sameness and Compulsions
Spackman E, Chetcuti L, Baker E, Ferguson E, Yerys B, Herrington J, Frazier T, Leekam S, Hardan A, Harrington J, Uljarević M. Transdiagnostic Examination of Interrelationships Between Anxiety, Insistence on Sameness and Compulsions. Autism Research 2025 PMID: 40878890, DOI: 10.1002/aur.70096.Peer-Reviewed Original ResearchObsessive-compulsive disorderTransdiagnostic natureScreen for Child Anxiety Related DisordersRepetitive Behavior Scale-RevisedAttention-deficit hyperactivity disorderOppositional defiant/conduct disorderAnxiety Related DisordersSample of childrenPatterns of associationTransdiagnostic sampleODD/CD groupADHD groupInternalizing disordersHyperactivity disorderBetween-group comparisonsSingular disordersScale-RevisedWithin-group comparisonsDiagnostic groupsCompulsionAnxietyAutismEffect sizeDisordersBetween-groupTransdiagnostic links of reward processing in obsessive-compulsive disorder and depression
Wagner K, Cervin M, Cheng J, Arriaga J, Cruz V, Berrones D, Muñoz J, Frederick R, Anderberg J, Bracho B, Adorno V, Fontenelle L, Wiese A, Crowley J, Storch E, Adorno V, Agostini V, Aguilar W, Aguirre C, Alvarado-Quiroz V, Ancalade N, Anciburo M, Anderberg J, Antich A, Aponte D, Espinosa A, Arnold P, Carmelo B, Atkinson E, Avanesyan T, Avery J, Ayala J, Aziz H, Aguirre T, Barrera C, Contreras J, Barry K, Belanger A, Benitez L, Berrones D, Best J, Bigdeli T, Bommiasamy H, Borda T, Boyajian L, Muñoz D, Browning L, Burton C, Busto C, Buxbaum J, Rivera R, Callahan J, Gomez C, Ponce L, Canchari E, Torres R, Cervin M, Chang A, Chazelle E, Cheng J, Chire J, Muñoz M, Cicero D, Cifuentes-Espinoza A, Quiroz P, Colombo G, Comer J, Condori-Apaza L, Cortina J, Crosbie J, Crowley J, Cruz V, Cruz I, Cunning A, Perez G, Dailey M, Dang B, Checco K, Dawson A, del Río D, Dev A, Diaz S, Estrada F, Figueroa E, Flecha L, Flores-Garcia Á, Franklin M, Frederick R, Fujita R, Furr J, Gaeta A, Gamarra O, Garay-Contreras C, García-Bravo N, García-Jaimes C, Garrison S, Gil-Hernández D, Giusti-Rodriguez P, Gonzalez A, González R, Gonzalez-Barrios P, Goodman W, Gorosito J, Grice D, Guintivano J, Guttfreund D, Halvorsen M, Miles J, Núñez E, Hettema J, Hovey J, Ccarhuas B, Irreño-Sotomonte J, Jagannathan N, Jensen M, Reynolds A, Jiwani R, Johnson J, Joutteaux S, Lujambio J, Kehrer S, Kennedy J, Lanzagorta N, Lázaro-Muñoz G, Longhurst M, Martinez D, Luna E, MacLellan A, Quispe D, Marques A, Marquez M, Martinez M, Martínez G, Mallen M, Martinez-Gonzalez K, de Los Angeles Matos M, Mattheisen M, Mccarty R, McGuire J, McKay D, McOmber C, Minaya C, Miño T, Mithani S, Morales-Rivero A, Moya P, Moyano M, Mukunda P, Muñoz M, Muñoz M, Nicolini H, Bracho A, Bracho B, Obando D, Ochoa M, Ochoa-Panaifo M, O'Higgins M, Castaman L, Balmaceda T, Tobar M, Onyeka O, Ortega I, Paredes-Linares V, Pato M, Paz y Miño M, de Leon E, Orellana J, Sossa N, Pereira S, Morales N, Duarte T, Phan A, Placencia M, Ponce L, Poovey K, Qiao T, Quiroz-Padilla M, Correa M, Heros A, Ramos R, Ramos I, Ramsey K, Rancourt D, Gomez S, Espinosa R, Richter P, Rodriguez C, Barajas S, Romero M, Ruggero C, Ruiz-Chow A, Sagarnaga M, Montoya G, Salhadar N, Schachar R, Segovia L, Seligman L, Siegel I, Spencer S, Staples C, Stewart S, Storch E, Tapia-Cuevas V, Thompson P, Timpano K, Tonarelli S, la Garza B, Trujillo A, Villar C, Valdés C, Vallejo-Silva A, Mamani K, Vargas-Medrano J, Vásquez-Suyo M, Mellstrieng A, Vergara M, Vidal-Martinez G, Huaman M, Vollaro C, Wiese A, Wilkerson S, Zai G, Zappa L, Cruz V, Zepeda-Burgos R, Zoghbi A, Alves G, Alves G, Barbosa I, Cappi C, Carneiro M, Costa D, Delage F, Dreher C, Ferrão Y, Ferreira G, Fontenelle L, Fragoso D, Lima M, Menezes G, Miguel E, Moreira-de-Oliveira M, Stumpf B, Quarantini L, Quarantini-Alvim Y, Ramos V, do Rosário M, Sampaio A, Saraiva L, Shavitt R. Transdiagnostic links of reward processing in obsessive-compulsive disorder and depression. Journal Of Affective Disorders 2025, 391: 119886. PMID: 40675261, DOI: 10.1016/j.jad.2025.119886.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderReward responsivenessTransdiagnostic linkMental disordersSocial interactionMeasures of reward responsivenessAssociated with obsessive-compulsive disorderResponse to social interactionsHigher depression severityGoal-directed behaviorResponse domainOCD severityTransdiagnostic mechanismTransdiagnostic modelOCD symptomsReward processingDepression severityDepressionRewardDisordersIntervention strategiesIndividualsSeverityFuture researchNetwork analysisSuicidal obsessions from suicidal ideation: A first-person suicide image pilot study
Mattera E, Sandoval K, Sipper C, Fitzpatrick M, Allen A, Pease J, Schild S, Ulaba-Samura Y, Cha C, Pittenger C, Zaboski B. Suicidal obsessions from suicidal ideation: A first-person suicide image pilot study. Journal Of Affective Disorders 2025, 391: 119916. PMID: 40675259, DOI: 10.1016/j.jad.2025.119916.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderSuicidal obsessionsSuicidal ideationObsessive-compulsive disorder symptom severitySelf-reported affective ratingsSuicide risk assessmentSense of selfIntrusive thoughtsDistressing thoughtsSense of threatPleasantness ratingsSymptom severityBehavioral engagementSuicide measuresSelf-harmAffective ratingsSmall positive effectsIdeationPilot studyObsessionSuicideThoughtsMedium effectsIndividualsAnxietyEvaluation of potential biomarker miRNAs and the levels of serotonin and dopamine in female patients with obsessive–compulsive disorder
Korkmaz N, Elibol B, Durmus Z, Ozdemir A, Akbas F, Guloksuz S, Sahbaz C. Evaluation of potential biomarker miRNAs and the levels of serotonin and dopamine in female patients with obsessive–compulsive disorder. Neuroscience 2025, 581: 50-57. PMID: 40614924, DOI: 10.1016/j.neuroscience.2025.07.001.Peer-Reviewed Original ResearchConceptsMiR-125b-5pObsessive-compulsive disorderObsessive-compulsive disorder patientsMiR-132Expression level of miR-132Dopamine levelsMiR-125b-5p expressionMiR-21-3pLevel of miR-132Pathogenesis of obsessive-compulsive disorderObsessive-compulsive disorder groupPlasma serotoninMiR-21Levels of serotoninBiomarker miRNAsPersistent obsessionsPsychiatric disordersSerotonin levelsExpression levelsSerotoninDopamineNo significant differenceFemale patientsReal-time PCRMiRNAsClinical predictors of readmission to psychiatric inpatient care: A 20-year follow up study of former adolescent inpatients
Leppanen J, Kieseppä V, Eskelinen S, Säynäjäkangas V, Rutten B, Gülöksüz S, Halt A, Riipinen P, Díaz-Caneja C, Kelleher I. Clinical predictors of readmission to psychiatric inpatient care: A 20-year follow up study of former adolescent inpatients. Psychiatry Research 2025, 351: 116606. PMID: 40578224, DOI: 10.1016/j.psychres.2025.116606.Peer-Reviewed Original ResearchConceptsPsychosis symptomsTransdiagnostic markerPsychiatric inpatientsSeverity of psychosis symptomsSeverity of depressive symptomsAdolescent psychiatric inpatientsSchizophrenia spectrum diagnosisObsessive-compulsive disorderSeverity of depressionPsychiatric inpatient careMarkers of illness severityDuration of readmissionsAdolescent inpatientsSpectrum diagnosisConduct disorderPsychiatric diagnosisDepressive symptomsEating DisordersPsychosisSubstance useInpatient admissionsIllness severityClinical predictorsCumulative durationInpatientsBenchmarking empirical severity for the Yale-Brown Obsessive Compulsive Scale-Second Edition
Pinciotti C, Avery J, Zhang C, Muñoz J, Berrones D, Cruz V, Wiese A, Anderberg J, Frederick R, Miño T, Lanzagorta N, Restrepo J, Ochoa-Panaifo M, Goodman W, Crowley J, Storch E, Cervin M, Adorno V, Agostini V, Aguilar W, Aguirre C, Alvarado-Quiroz V, Ancalade N, L M, Anderberg J, Aponte D, Espinosa A, Arnold P, Carmelo B, Atkinson E, Avanesyan T, Avery J, Ayala J, Aziz H, Aguirre T, Barrera C, Contreras J, Barry K, Belanger A, Benitez L, Berrones D, Best J, Bigdeli T, Bommiasamy H, Borda T, Boyajian L, Muñoz D, Browning L, Burton C, Busto C, Buxbaum J, Rivera R, Callahan J, Gomez C, Ponce L, Canchari E, Torres R, Cervin M, Chang A, Chazelle E, Cheng J, Chire J, Muñoz M, Cicero D, Cifuentes-Espinoza A, Quiroz P, Colombo G, Comer J, Condori-Apaza L, Cortina J, Crosbie J, Crowley J, Cruz V, Cruz I, Cunning A, Perez G, Dailey M, Dang B, Checco K, Dawson A, del Río D, Dev A, Diaz S, Fay L, Figueroa E, Flecha L, Flores-Garcia Á, Franklin M, Frederick R, Fujita R, Furr J, Gaeta A, Gamarra O, Garay-Contreras C, García-Bravo N, García-Jaimes C, Garrison S, Gil-Hernández D, Giusti-Rodriguez P, Gonzalez A, González R, Gonzalez-Barrios P, Goodman W, Gorosito J, Grice D, Guintivano J, Guttfreund D, Halvorsen M, Miles J, Núñez E, Hettema J, Hovey J, Ccarhuas B, Irreño-Sotomonte J, Jagannathan N, Jensen M, Reynolds A, Jiwani R, Johnson J, Joutteaux S, Lujambio J, Kehrer S, Kennedy J, Lanzagorta N, Lázaro-Muñoz G, Longhurst M, Martinez D, Luna E, MacLellan A, Quispe D, Marques A, Marquez M, Martinez M, Martínez G, Mallen M, Martinez-Gonzalez K, de Los Angeles Matos M, Mattheisen M, McCarty R, McGuire J, McKay D, McOmber C, Minaya C, Miño T, Mithani S, Morales-Rivero A, Moya P, Moyano M, Mukunda P, Muñoz M, Muñoz M, Nicolini H, Bracho A, Bracho B, Obando D, Ochoa M, Ochoa-Panaifo M, O'Higgins M, Castaman L, Balmaceda T, Tobar M, Onyeka O, Ortega I, Paredes-Linares V, Pato M, Paz y Miño M, de Leon E, Orellana J, Sossa N, Pereira S, Morales N, Duarte T, Phan A, Placencia M, Ponce L, Poovey K, Prieto M, Qiao T, Quiroz-Padilla M, Quispe-Correa M, Heros A, Ramos R, Ramos I, Ramsey K, Rancourt D, Gomez S, Espinosa R, Richter P, Rodriguez C, Barajas S, Romero M, Ruggero C, Ruiz-Chow A, Sagarnaga M, Montoya G, Salhadar N, Schachar R, Segovia L, Seligman L, Siegel I, Spencer S, Staples C, Stewart S, Storch E, Tapia-Cuevas V, Thompson P, Timpano K, Tonarelli S, la Garza B, Trujillo A, Villar C, Valdés C, Vallejo-Silva A, Mamani K, Vargas-Medrano J, Vásquez-Suyo M, Mellstrieng A, Vergara M, Vidal-Martinez G, Huaman M, Vollaro C, Wiese A, Wilkerson S, Zai G, Zappa L, Cruz V, Zepeda-Burgos R, Zoghbi A, Alves G, Alves G, Barbosa I, Cappi C, Carneiro M, Costa D, Delage F, Dreher C, Ferrão Y, Ferreira G, Fontenelle L, Fragoso D, Lima M, Menezes G, Miguel E, Moreira-de-Oliveira M, Stumpf B, Quarantini L, Quarantini-Alvim Y, Ramos V, Rosario M, Sampaio A, Saraiva L, Shavitt R. Benchmarking empirical severity for the Yale-Brown Obsessive Compulsive Scale-Second Edition. Journal Of Affective Disorders 2025, 390: 119719. PMID: 40541829, DOI: 10.1016/j.jad.2025.119719.Peer-Reviewed Original ResearchYale-Brown Obsessive Compulsive ScaleY-BOCS-IIObsessive-compulsive disorderYale-Brown Obsessive Compulsive Scale - Second EditionSeverity of obsessive-compulsive disorderSample of OCD patientsObsessive Compulsive ScaleResearch settingsOCD presentationsOCD severityCompulsive ScaleObsessive-CompulsiveOCD patientsPsychometric propertiesDiverse sampleSeveral benchmarksEmpirical critiqueHoldout sampleSeverityScoresDisordersAge groupsDeep learning in obsessive-compulsive disorder: a narrative review
Zaboski B, Bednarek L, Ayoub K, Pittenger C. Deep learning in obsessive-compulsive disorder: a narrative review. Frontiers In Psychiatry 2025, 16: 1581297. PMID: 40585546, PMCID: PMC12202444, DOI: 10.3389/fpsyt.2025.1581297.Peer-Reviewed Original ResearchDeep learningObsessive-compulsive disorderDeep learning advancesMultimodal datasetWearable sensorsMonitoring solutionsMachine learningLearning advancesObsessive-compulsive disorder researchComplex datasetsDebilitating psychiatric conditionImplementation modelIntrusive thoughtsLearningDatasetPsychiatric conditionsRepetitive behaviorsPrecision psychiatryElectronic medical recordsTreatment response predictionDiagnostic classificationClassificationNarrative reviewTreatment outcomesTreatment predictionAnalyzing the Contents of a Large, Public Online Peer Support Forum for Obsessive-Compulsive Disorder: Thematic Analysis
Sun N, Pittenger C, Ching T. Analyzing the Contents of a Large, Public Online Peer Support Forum for Obsessive-Compulsive Disorder: Thematic Analysis. JMIR Formative Research 2025, 9: e60899. PMID: 40418853, PMCID: PMC12129411, DOI: 10.2196/60899.Peer-Reviewed Original ResearchConceptsSupport forumsPeer support forumUser's abilityShare treatment experiencesUsersOnline peer support forumForum usersObsessive-compulsive disorderOnline communitiesHelpful informationAssociated with improved treatment adherenceRates of remissionOnline forumsThematic analysisReddit websiteObsessive-compulsive disorder symptomsHealth care professionalsChronic anxiety disordersMinority of postsReceiving social supportReassurance-seekingTreatment adherenceMedical treatmentHippocampal and amygdala subfield volumes in obsessive–compulsive disorder by medication status
Ntwatwa Z, Lochner C, Roos A, Sevenoaks T, van Honk J, Batistuzzo M, Choi S, Hoexter M, Kim M, Kwon J, Mataix-Cols D, Menchón J, Miguel E, Nakamae T, Soriano-Mas C, Veltman D, Groenewold N, van den Heuvel O, Stein D, Ipser J. Hippocampal and amygdala subfield volumes in obsessive–compulsive disorder by medication status. Journal Of Psychiatry And Neuroscience 2025, 50: e170-e180. PMID: 40398928, PMCID: PMC12114122, DOI: 10.1503/jpn.230119.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderSubfield volumesMedical statusSymptom severityNeuroimaging studies of obsessive-compulsive disorderObsessive-compulsive disorder symptom severityStudies of obsessive-compulsive disorderNeurobiology of obsessive-compulsive disorderHealthy controlsObsessive-compulsive disorder severityBrain volumetric alterationsPsychotropic medication useHippocampal dentate gyrusQuadratic effects of ageAssess between-group differencesComorbid anxietyUnmedicated peopleNeuroimaging studiesPsychotropic medicationsVolumetric findingsBetween-group differencesVolumetric alterationsHippocampal subfieldsAmygdalaBrain volumeGenome-wide analyses identify 30 loci associated with obsessive–compulsive disorder
Strom N, Gerring Z, Galimberti M, Yu D, Halvorsen M, Abdellaoui A, Rodriguez-Fontenla C, Sealock J, Bigdeli T, Coleman J, Mahjani B, Thorp J, Bey K, Burton C, Luykx J, Zai G, Alemany S, Andre C, Askland K, Bäckman J, Banaj N, Barlassina C, Nissen J, Bienvenu O, Black D, Bloch M, Børte S, Bosch R, Breen M, Brennan B, Brentani H, Buxbaum J, Bybjerg-Grauholm J, Byrne E, Cabana-Dominguez J, Camarena B, Camarena A, Cappi C, Carracedo A, Casas M, Cavallini M, Ciullo V, Cook E, Crosby J, Cullen B, De Schipper E, Delorme R, Djurovic S, Elias J, Estivill X, Falkenstein M, Fundin B, Garner L, Gironda C, Goes F, Grados M, Grove J, Guo W, Haavik J, Hagen K, Harrington K, Havdahl A, Höffler K, Hounie A, Hucks D, Hultman C, Janecka M, Jenike E, Karlsson E, Kelley K, Klawohn J, Krasnow J, Krebs K, Lange C, Lanzagorta N, Levey D, Lindblad-Toh K, Macciardi F, Maher B, Mathes B, McArthur E, McGregor N, McLaughlin N, Meier S, Miguel E, Mulhern M, Nestadt P, Nurmi E, O’Connell K, Osiecki L, Ousdal O, Palviainen T, Pedersen N, Piras F, Piras F, Potluri S, Rabionet R, Ramirez A, Rauch S, Reichenberg A, Riddle M, Ripke S, Rosário M, Sampaio A, Schiele M, Skogholt A, Sloofman L, Smit J, Artigas M, Thomas L, Tifft E, Vallada H, van Kirk N, Veenstra-VanderWeele J, Vulink N, Walker C, Wang Y, Wendland J, Winsvold B, Yao Y, Zhou H, Agrawal A, Alonso P, Berberich G, Bucholz K, Bulik C, Cath D, Denys D, Eapen V, Edenberg H, Falkai P, Fernandez T, Fyer A, Gaziano J, Geller D, Grabe H, Greenberg B, Hanna G, Hickie I, Hougaard D, Kathmann N, Kennedy J, Lai D, Landén M, Hellard S, Leboyer M, Lochner C, McCracken J, Medland S, Mortensen P, Neale B, Nicolini H, Nordentoft M, Pato M, Pato C, Pauls D, Piacentini J, Pittenger C, Posthuma D, Ramos-Quiroga J, Rasmussen S, Richter M, Rosenberg D, Ruhrmann S, Samuels J, Sandin S, Sandor P, Spalletta G, Stein D, Stewart S, Storch E, Stranger B, Turiel M, Werge T, Andreassen O, Børglum A, Walitza S, Hveem K, Hansen B, Rück C, Martin N, Milani L, Mors O, Reichborn-Kjennerud T, Ribasés M, Kvale G, Mataix-Cols D, Domschke K, Grünblatt E, Wagner M, Zwart J, Breen G, Nestadt G, Kaprio J, Arnold P, Grice D, Knowles J, Ask H, Verweij K, Davis L, Smit D, Crowley J, Scharf J, Stein M, Gelernter J, Mathews C, Derks E, Mattheisen M. Genome-wide analyses identify 30 loci associated with obsessive–compulsive disorder. Nature Genetics 2025, 57: 1389-1401. PMID: 40360802, PMCID: PMC12165847, DOI: 10.1038/s41588-025-02189-z.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderGenome-wide association studiesGenetic riskObsessive-compulsive disorder casesGenome-wide significant lociMedium spiny neuronsGenome-wide analysisMajor histocompatibility complexGene-based approachPsychiatric disordersSpiny neuronsTourette syndromeAnorexia nervosaSignificant lociEffector genesAssociation studiesAssociated with excitatory neuronsMultiple genesGenetic variantsAssociated with inflammatory bowel diseaseBody mass indexGenetic heritabilityDisordersExcitatory neuronsInflammatory bowel diseasePsychometric properties of the Spanish Yale-Brown Obsessive-Compulsive Scale – Second Edition
Storch E, Cheng J, Higham M, Muñoz J, Cruz V, Berrones D, Obando D, Anderberg J, Frederick R, Tapia-Cuevas V, Muñoz M, Villar C, Moya P, Ochoa-Panaifo M, Mallen M, Wiese A, Pinciotti C, Sagarnaga M, McGuire J, Onyeka O, Moyano M, genomics L, Adorno V, Agostini V, Aguilar W, Aguirre C, Alvarado-Quiroz V, Ancalade N, Anderberg J, Aponte D, Espinosa A, Arnold P, Ascencio-Chicana E, Atkinson E, Ayala J, Aziz H, Aguirre T, Barrera C, Contreras J, Barry K, Belanger A, Benitez L, Berrones D, Best J, Bigdeli T, Bommiasamy H, Borda T, Boyajian L, Muñoz D, Browning L, Burton C, Busto C, Buxbaum J, Rivera R, Callahan J, Gomez C, Canchari E, Carrrera M, Chang A, Chazelle E, Cheng J, Chire J, Muñoz M, Cicero D, Cifuentes-Espinoza A, Quiroz P, Colombo G, Comer J, Condori-Apaza L, Cortina J, Crivelari J, Crosbie J, Crowley J, Cruz V, Cruz I, Cunning A, Perez G, Dailey M, Dang B, Dawson A, del Río D, Dev A, Diaz S, Fay L, Fernandez A, Figueroa E, Flecha L, Flores-Garcia Á, Forero D, Franklin M, Frederick R, Furr J, Gamarra O, Garay-Contreras C, García-Bravo N, García-Jaimes C, Garrison S, Giusti-Rodriguez P, Gonzalez A, González R, Gonzalez-Barrios P, Goodman W, Gorosito J, Grice D, Guintivano J, Guttfreund D, Halvorsen M, Miles J, Hettema J, Hovey J, Irreño-Sotomonte J, Janssen-Aguilar R, Jensen M, Reynolds A, Jiwani R, Johnson J, Joutte S, Lujambio J, Kehrer S, Kennedy J, Lack C, Lanzagorta N, Lázaro-Muñoz G, Longhurst M, Martinez D, Luna E, MacLellan A, Quispe D, Marques A, Marquez M, Martinez M, Martínez G, Mallen M, Martinez-Gonzalez K, de Los Angeles Matos M, Mattheisen M, McGuire J, McKay D, McOmber C, Minaya C, Miño T, Mithani S, Morales-Rivero A, Moya P, Moyano M, Muñoz J, Muñoz M, Nicolini H, Bracho A, Bracho B, O'Higgins M, Obando D, Ochoa M, Ochoa-Panaifo M, Castaman L, Balmaceda T, Tobar M, Onyeka O, Ortega I, Paredes-Linares V, Pato M, Paz y Miño M, de Leon E, Orellana J, Pereira S, Duarte T, Phan A, Placencia M, Ponce L, Poovey K, Prieto M, Qiao T, Quiroz-Padilla M, Correa M, Heros A, Ramos R, Ramos I, Ramsey K, Rancourt D, da Silva K, Espinosa R, Richter P, Rodriguez C, Barajas S, Romero M, Ruggero C, Ruiz-Chow A, Sadruddin Z, Sagarnaga M, Salhadar N, Sanchez N, Schachar R, Segovia L, Seligman L, Siegel I, Staples C, Stewart S, Storch E, Tapia-Cuevas V, Timpano K, Tonarelli S, la Garza B, Trujillo A, Villar C, Valdés C, Vallejo-Silva A, Mamani K, Vargas-Medrano J, Vásquez M, Vásquez-Ayala J, Vásquez-Suyo I, Mellstrieng A, Vergara M, Vidal-Martinez G, Vollaro C, Wiese A, Wilkerson S, Zai G, Zappa L, Cruz V, Zepeda-Burgos R, Zoghbi A, Group B, Alves G, Alves G, Barbosa I, Cappi C, Carneiro M, Costa D, Delage F, Dreher C, Ferrão Y, Ferreira G, Fontenelle L, Fragoso D, Lima M, Menezes G, Miguel E, Moreira-de-Oliveira M, Stumpf B, Quarantini L, Quarantini-Alvim Y, Ramos V, Rosario M, Sampaio A, Saraiva L, Shavitt R, Goodman W, Crowley J. Psychometric properties of the Spanish Yale-Brown Obsessive-Compulsive Scale – Second Edition. Psychiatry Research 2025, 348: 116456. PMID: 40188616, PMCID: PMC12082261, DOI: 10.1016/j.psychres.2025.116456.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderY-BOCS-IIAnxiety symptomsYale-Brown Obsessive-Compulsive Scale-Second EditionSeverity of obsessive-compulsive symptomsPsychometric propertiesYale-Brown Obsessive-Compulsive ScaleObsessive-compulsive symptom severityClinician-rated measuresObsessive-Compulsive ScaleObsessive-compulsive symptomsFactor analysisMeasures of depressionSecond editionBattery of measuresOne-factor solutionConfirmatory factor analysisSatisfactory construct validityExploratory factor analysisObsession severityCompulsion severitySymptom severityTotal severitySymptom ChecklistTotal scorePrecision Psychiatry for Obsessive-Compulsive Disorder: Clinical Applications of Deep Learning Architectures
Zaboski B, Bednarek L. Precision Psychiatry for Obsessive-Compulsive Disorder: Clinical Applications of Deep Learning Architectures. Journal Of Clinical Medicine 2025, 14: 2442. PMID: 40217892, PMCID: PMC11989962, DOI: 10.3390/jcm14072442.Peer-Reviewed Original ResearchNeural networkDeep learningObsessive-compulsive disorderApplication of deep learning architecturesRecurrent neural networkConvolutional neural networkDeep learning architectureHigh-dimensional dataAdversarial networkLearning architectureMultimodal datasetData generationObsessive-compulsive disorder researchNeural predictorsPredictors of treatment responseComplex psychiatric conditionsNetworkTreatment responseArchitecturePsychiatric conditionsPrecision psychiatryImplementation of DLDatasetClassificationLearningCharacterizing Rare DNA Copy-Number Variants in Pediatric Obsessive-Compulsive Disorder
Abdallah S, Olfson E, Cappi C, Greenspun S, Zai G, Rosário M, Willsey A, Shavitt R, Miguel E, Kennedy J, Richter M, Fernandez T. Characterizing Rare DNA Copy-Number Variants in Pediatric Obsessive-Compulsive Disorder. Journal Of The American Academy Of Child & Adolescent Psychiatry 2025 PMID: 40122455, PMCID: PMC12353602, DOI: 10.1016/j.jaac.2025.03.014.Peer-Reviewed Original ResearchCopy-number variantsWhole-exome DNA sequencingEXome-Hidden Markov ModelDetect copy-number variantsSingle-nucleotide variantsGenetic factorsWhole-exome sequencingExamination of genesBiological systems analysisTrio familiesDNA sequencesMicroarray dataOCD riskBurden analysisBiological processesGenesSequenceVariantsObsessive-compulsive disorderPrimary analysisXHMMPediatric obsessive-compulsive disorderCompared to controlsFamilySilicoEfficacy of a parent-based treatment for children and adolescents with obsessive-compulsive disorder: Protocol of a multiple baseline, single-case experimental design study
Veeger J, Stapersma L, Lebowitz E, Zijlstra B, Lindauer R, Utens E, Huijser C. Efficacy of a parent-based treatment for children and adolescents with obsessive-compulsive disorder: Protocol of a multiple baseline, single-case experimental design study. Contemporary Clinical Trials Communications 2025, 44: 101456. PMID: 40034722, PMCID: PMC11874722, DOI: 10.1016/j.conctc.2025.101456.Peer-Reviewed Original ResearchObsessive-compulsive disorderSingle-case experimental designCognitive behavioral therapyObsessive-compulsive disorder severityFamily accommodationParent-based treatmentSupportive parentingPediatric obsessive-compulsive disorderChild's OCDBaseline single-case experimental designSingle-case experimental design studiesAnxious Childhood EmotionsReducing OCD severityAssociated with higher levelsOCD severityBehavioral therapyFollow-up phaseImpairing disorderChildhood EmotionalMultiple baselineReduced FAWeekly sessionsTeaching parentsStandard clinical measuresExperimental design studyImpact of age-related changes in buccal epithelial cells on pediatric epigenetic biomarker research
Merrill S, Konwar C, Fatima F, Dever K, MacIsaac J, Letourneau N, Giesbrecht G, Dewey D, England-Mason G, Lewis C, Wang D, Teh A, Meaney M, Gonzalez A, Noll J, De Weerth C, Bush N, O’Donnell K, Stewart S, Kobor M. Impact of age-related changes in buccal epithelial cells on pediatric epigenetic biomarker research. Nature Communications 2025, 16: 609. PMID: 39800776, PMCID: PMC11725590, DOI: 10.1038/s41467-025-55909-8.Peer-Reviewed Original ResearchConceptsBuccal epithelial cellsAge-related changesObsessive-compulsive disorderEpithelial cellsDiurnal cortisol slopeCheek swabsImpact of age-related changesCortisol slopeAssociated with ageOral cellsDevelopmental rangeAge accelerationDNA methylation studiesHeterogeneous sampleNeutrophil proportionBiomarker researchMethylation studiesAgeSwabsWeak associationEpigenetic ageChapter 52 Obsessive–compulsive disorder
Abdallah S, Olfson E, Fernandez T. Chapter 52 Obsessive–compulsive disorder. 2025, 937-950. DOI: 10.1016/b978-0-443-19176-3.00011-x.ChaptersObsessive-compulsive disorderObsessive-compulsive disorder etiologiesCognitive behavioral therapySerotonin reuptake inhibitorsReuptake inhibitorsBehavioral therapyMedication augmentationNeuroanatomical alterationsNeurochemical imbalanceMedication trialsGenetic influencesImprove treatment outcomesEvidence-based therapeutic strategiesTreatment outcomesRobust clinical trialsDisordersClinical manifestationsTreatment optionsClinical trialsTherapeutic strategiesSerotoninMultifactorial naturePharmacotherapyNeuromodulationTrials
2024
Parent-Only Treatment of Children and Adolescents
Etkin R, Shimshoni Y, Lebowitz E. Parent-Only Treatment of Children and Adolescents. CBT: Science Into Practice 2024, 207-228. DOI: 10.1007/978-3-031-74838-7_9.Peer-Reviewed Original ResearchAdolescent obsessive-compulsive disorderObsessive-compulsive disorderTreatment of childrenIllustrative case vignetteEtiology of childrenAnxious distressChildhood anxietyAnxiety disordersChild anxietyParental behavior changeAccommodation behaviorAnxietyCase vignettesSupportive responsesBehavioral changesCultural considerationsTreatment approachesDisordersChildrenParentsEmpirical researchSystems perspectiveAdolescentsDistressVignettes
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