2025
Sex and hormonal effects on drug cue-reactivity and its regulation in human addiction
Huang Y, Butelman E, Ceceli A, Kronberg G, King S, McClain N, Wong Y, Boros M, Drury K, Sinha R, Alia-Klein N, Goldstein R. Sex and hormonal effects on drug cue-reactivity and its regulation in human addiction. Biological Psychiatry 2025 PMID: 40441339, PMCID: PMC12359307, DOI: 10.1016/j.biopsych.2025.05.016.Peer-Reviewed Original ResearchDrug cue-reactivityCue-reactivityPrefrontal cortexFrontal eye fieldCue-induced drug cravingVentromedial prefrontal cortexCocaine use disorderMedial prefrontal cortexAnterior prefrontal cortexDrug cravingHuman addictsUse disorderFunctional MRIEye fieldLuteal phaseCravingDevelopment of personalized treatmentsLate-follicularFollicular phaseReappraisalVmPFCDLPFCHormonal effectsProtective factorsAddiction
2024
Inflammation and Ovarian Function in Reproductive‐Aged Women
Long A, Steiner A, Thompson A, Jahnke H, Harris B, Jukic A. Inflammation and Ovarian Function in Reproductive‐Aged Women. American Journal Of Human Biology 2024, 37: e24196. PMID: 39623697, PMCID: PMC11671284, DOI: 10.1002/ajhb.24196.Peer-Reviewed Original ResearchFollicle-stimulating hormoneC-reactive proteinAnti-Mullerian hormoneOvarian functionInhibin BOvarian reserveFollicular phase follicle-stimulating hormoneMarkers of immune activationBiomarker of ovarian functionTime to ConceiveInhibin B levelsDiminished ovarian reserveAnti-Mullerian hormone levelsCross-sectional analysis of dataPolycystic ovarian syndromeCohort study sampleSecondary cross-sectional analysisNatural-logInhibin B.Menstrual cycleImmune activationLogistic regression modelsFollicular phaseHormone levelsHigher inflammationHormonal Fluctuation and Ankle Instability in Women—Is There a Correlation?
Hartman H, Fehr S, Gianakos A. Hormonal Fluctuation and Ankle Instability in Women—Is There a Correlation? Foot & Ankle Orthopaedics 2024, 9: 24730114241300140. PMID: 39610646, PMCID: PMC11603572, DOI: 10.1177/24730114241300140.Peer-Reviewed Original ResearchAnkle joint laxityAnkle instabilityAnkle stabilitySway rateFemale athletesIncidence of ankle sprainsChronic ankle instabilityLigamentous laxityJoint laxityPostural swayAnkle sprainFollicular phaseInjury preventionLateral gastrocnemiusPeroneus longusHormonal fluctuationsTibialis anteriorImpaired balanceAnkleSystematic reviewCochrane Library databasesPRISMA guidelinesAthletesMenstrual cycle phaseDecreased muscleHormonal Fluctuation and Ankle Instability in Women – Is There a Correlation?
Boggiano V, Hartman H, Fehr S, Gianakos A. Hormonal Fluctuation and Ankle Instability in Women – Is There a Correlation? Foot & Ankle Orthopaedics 2024, 9: 2473011424s00313. PMCID: PMC11681521, DOI: 10.1177/2473011424s00313.Peer-Reviewed Original ResearchAnkle joint laxityAnkle instabilityAnkle stabilityAnkle sprainSway rateLigamentous laxityFemale athletesIncidence of ankle sprainsSystematic reviewLateral ankle sprainChronic ankle instabilityJoint laxityMuscle tonePreferred Reporting ItemsCross-sectional studyDecreased muscle toneFollicular phasePostural stabilityPostural swayHormonal fluctuationsInjury preventionLateral gastrocnemiusLuteal phasePeroneus longusAnkle function
2023
Pretreatment with a long-acting GnRH agonist for frozen-thawed embryo transfer cycles: how to improve live birth?
Xu B, Hou Z, Liu N, Zhao J, Li Y. Pretreatment with a long-acting GnRH agonist for frozen-thawed embryo transfer cycles: how to improve live birth? Journal Of Ovarian Research 2023, 16: 197. PMID: 37743479, PMCID: PMC10518919, DOI: 10.1186/s13048-023-01277-0.Peer-Reviewed Original ResearchConceptsFrozen-thawed embryo transferFrozen-thawed embryo transfer cyclesHormone replacement treatmentLive birth rateLong-acting GnRH agonistPolycystic ovary syndromeFET groupEndometrial preparationGnRHa groupFET cyclesClinical pregnancyGnRH agonistPrimary infertilityLive birthsFollicular phaseIncreased chance of clinical pregnancyIrregular menstruationDay of progesterone administrationGonadotropin-releasing hormone agonistBirth rateChance of clinical pregnancyEmbryo transfer cyclesLong-acting GnRHaDay of menstruationSubgroups of age
2020
Menstrual cycle and thermoregulation during exercise in the heat: A systematic review and meta-analysis
Giersch GEW, Morrissey MC, Katch RK, Colburn AT, Sims ST, Stachenfeld NS, Casa DJ. Menstrual cycle and thermoregulation during exercise in the heat: A systematic review and meta-analysis. Journal Of Science And Medicine In Sport 2020, 23: 1134-1140. PMID: 32499153, DOI: 10.1016/j.jsams.2020.05.014.Peer-Reviewed Original ResearchConceptsSystematic reviewHeart rateSweat rateSkin temperatureMenstrual cycle phaseMenstrual cycle variationsAerobic exerciseFollicular phaseMenstrual cycleLuteal phaseInclusion criteriaMenstrual phaseLimited available dataMean skin temperatureEffect size estimatesSignificant differencesBody temperatureEffect sizeExerciseWomenCycle phaseInternal body temperatureReviewTotal number
2019
Compromised endothelial function in transgender men taking testosterone
Gulanski BI, Flannery CA, Peter PR, Leone CA, Stachenfeld NS. Compromised endothelial function in transgender men taking testosterone. Clinical Endocrinology 2019, 92: 138-144. PMID: 31765022, PMCID: PMC6957681, DOI: 10.1111/cen.14132.Peer-Reviewed Original ResearchConceptsEndothelial functionTransgender menEndothelial dysfunctionCisgender femalesClinical cardiovascular riskCardiovascular risk factorsImpaired endothelial functionEarly follicular phaseAndrogen excessCardiovascular riskVasodilatory responseCoronary arteryHormonal milieuFollicular phaseTestosterone treatmentMenstrual cycleRisk factorsFemale genderAtherosclerotic plaquesEarly signsTestosteroneTotal TSImportant markerDysfunctionMenCompromised endothelial function in transgender men taking testosterone
Stachenfeld N, Leone C, Gulanski B. Compromised endothelial function in transgender men taking testosterone. The FASEB Journal 2019, 33: 696.4-696.4. DOI: 10.1096/fasebj.2019.33.1_supplement.696.4.Peer-Reviewed Original ResearchEndothelial functionEndothelial dysfunctionBlood pressureTransgender menRisk factorsCisgender femalesCardiovascular risk factorsEarly follicular phaseSystolic blood pressureFull-text articlesTestosterone therapyAndrogen excessCardiovascular riskVasodilatory responseBlood lipidsHDL cholesterolSystolic BPLDL cholesterolCoronary arteryHormonal milieuFollicular phaseAndrogen treatmentMenstrual cycleCardiovascular diseaseAtherosclerotic plaques
2015
Effect of Menstrual Cycle Phase on Background Parenchymal Uptake at Molecular Breast Imaging
Hruska CB, Conners AL, Vachon CM, O'Connor MK, Shuster LT, Bartley AC, Rhodes DJ. Effect of Menstrual Cycle Phase on Background Parenchymal Uptake at Molecular Breast Imaging. Academic Radiology 2015, 22: 1147-1156. PMID: 26112057, PMCID: PMC4532620, DOI: 10.1016/j.acra.2015.04.003.Peer-Reviewed Original ResearchMeSH KeywordsAdultBreastBreast DensityChromatography, LiquidCohort StudiesEstradiolEstroneFemaleFollicle Stimulating HormoneFollicular PhaseHumansLuteal PhaseMammographyMiddle AgedMolecular ImagingPremenopauseProgesteroneProspective StudiesRadiopharmaceuticalsSex Hormone-Binding GlobulinTandem Mass SpectrometryTechnetium Tc 99m SestamibiTestosteroneConceptsBackground parenchymal uptakeMolecular breast imagingMenstrual cycle phaseLuteal phaseMenstrual cycleNondense breastsFollicular phaseHormone levelsParenchymal uptakeDense breastsExogenous hormone useRegular menstrual cyclesLevels of TCCycle phaseNormal fibroglandular tissuePremenopausal volunteersPremenopausal womenHormone useSpearman correlation coefficientBreast imagingStudy radiologistsMammographic densityBreastFibroglandular tissueWomenSystematic and Meta-Analytic Review of Research Examining the Impact of Menstrual Cycle Phase and Ovarian Hormones on Smoking and Cessation
Weinberger AH, Smith PH, Allen SS, Cosgrove KP, Saladin ME, Gray KM, Mazure CM, Wetherington CL, McKee SA. Systematic and Meta-Analytic Review of Research Examining the Impact of Menstrual Cycle Phase and Ovarian Hormones on Smoking and Cessation. Nicotine & Tobacco Research 2015, 17: 407-421. PMID: 25762750, PMCID: PMC4429881, DOI: 10.1093/ntr/ntu249.Peer-Reviewed Original ResearchConceptsMenstrual cycle phaseHormone levelsOvarian hormonesLuteal phaseSmoking behaviorSearch termsOvarian hormone levelsMenstrual phase effectsCessation-related behaviorsTiming of interventionNegative subjective effectsMenstrual cycle effectsProgesterone administrationFollicular phaseMedication responseQuit ratesTonic cravingInclusion criteriaMenstrual phaseNonsignificant trendSmoking outcomesCycle phaseSmokingSystematic reviewGreater tonic
2010
Menstrual cycle phase at quit date and smoking abstinence at 6 weeks in an open label trial of bupropion
Mazure CM, Toll B, McKee SA, Wu R, O’Malley S. Menstrual cycle phase at quit date and smoking abstinence at 6 weeks in an open label trial of bupropion. Drug And Alcohol Dependence 2010, 114: 68-72. PMID: 20832955, PMCID: PMC3016455, DOI: 10.1016/j.drugalcdep.2010.07.024.Peer-Reviewed Original ResearchConceptsMenstrual cycle phaseQuit datePoint prevalence abstinencePremenopausal womenBupropion SRFollicular phaseLuteal phaseAbsence of pharmacotherapySustained release bupropionOpen-label trialCycle phaseMechanism of actionRelease bupropionLabel trialNicotine replacementCessation interventionsOpen trialTreatment completionCessation outcomesContinuous abstinenceQuit dayGonadal hormonesTreatment periodAbstinence outcomesQuit attempts
2008
Characterizing the reproductive hormone milieu in infertile women with diminished ovarian reserve
Pal L, Zhang K, Zeitlian G, Santoro N. Characterizing the reproductive hormone milieu in infertile women with diminished ovarian reserve. Fertility And Sterility 2008, 93: 1074-1079. PMID: 19100532, DOI: 10.1016/j.fertnstert.2008.10.069.Peer-Reviewed Original ResearchConceptsDiminished ovarian reserveReproductive hormone profilesOvarian reserveInfertile womenUrinary excretionMenstrual cycleHealthy controlsHormone profilesAge-comparable healthy controlsUrinary FSH levelsProspective observational studyEarly follicular phaseEntire menstrual cycleAge-comparable controlsMetabolites of estrogenFSH levelsHormone milieuInfertility practiceMenopause transitionUrine voidsFollicular phaseEstrone conjugatesFSH surgeObservational studyMAIN OUTCOMESimple Tools for Assessment of Ovarian Reserve (OR): Individual Ovarian Dimensions Are Reliable Predictors of OR
Bowen S, Norian J, Santoro N, Pal L. Simple Tools for Assessment of Ovarian Reserve (OR): Individual Ovarian Dimensions Are Reliable Predictors of OR. Obstetrical & Gynecological Survey 2008, 63: 98-99. DOI: 10.1097/01.ogx.0000300473.00069.0f.Peer-Reviewed Original ResearchSerum FSH levelsFSH levelsFollicle-stimulating hormoneOvarian reserveOvarian dimensionsPremenopausal womenAcademic infertility practicePremenopausal infertile womenProspective observational studyEarly follicular phaseBody mass indexTransvaginal ultrasound measurementCause of infertilityTreatment of infertilityOvarian widthOvarian stimulationIndependent predictorsInfertile womenMass indexSmoking statusInfertility practiceFollicular phaseMale factorOvarian measurementsCommon cause
2007
Biologic markers of ovarian reserve and reproductive aging: application in a cohort study of HIV infection in women
Seifer DB, Golub ET, Lambert-Messerlian G, Springer G, Holman S, Moxley M, Cejtin H, Nathwani N, Anastos K, Minkoff H, Greenblatt RM. Biologic markers of ovarian reserve and reproductive aging: application in a cohort study of HIV infection in women. Fertility And Sterility 2007, 88: 1645-1652. PMID: 17418155, PMCID: PMC2682326, DOI: 10.1016/j.fertnstert.2007.01.122.Peer-Reviewed Original ResearchConceptsWomen's Interagency HIV StudyEarly follicular phaseOvarian reserveInhibin BHIV infectionMIS levelsFollicular phaseHIV StudyLower inhibin B levelsReproductive agingSerum samplesHIV infection influencesInhibin B levelsMulticenter prospective studyCross-sectional studyMenstrual cycle phaseCycle phaseUninfected womenCohort studyFSH levelsMenstrual bleedingNegative womenHIV serostatusSerum markersProspective studyLuteal-Phase Accentuation of Acoustic Startle Response in Women with Premenstrual Dysphoric Disorder
Epperson CN, Pittman B, Czarkowski KA, Stiklus S, Krystal JH, Grillon C. Luteal-Phase Accentuation of Acoustic Startle Response in Women with Premenstrual Dysphoric Disorder. Neuropsychopharmacology 2007, 32: 2190-2198. PMID: 17314917, PMCID: PMC2713599, DOI: 10.1038/sj.npp.1301351.Peer-Reviewed Original ResearchConceptsPremenstrual dysphoric disorderMenstrual cycle phaseMenstrual cycleHealthy womenFollicular phaseDysphoric disorderLuteal phasePhysiologic responsesMenstrual cycle-related fluctuationsStartle magnitudeCentral nervous system responseHealthy menstruating womenAcoustic startle responseAcoustic startle paradigmNervous system responsesPowerful modulatory effectsStartle response magnitudeVisual affective stimuliNeuroactive steroidsMenstruating womenASR magnitudeModulatory effectsCycle phaseNeuroendocrine milieuAcoustic startle response magnitudes
2006
Decreased Cerebrospinal Fluid Allopregnanolone Levels in Women with Posttraumatic Stress Disorder
Rasmusson AM, Pinna G, Paliwal P, Weisman D, Gottschalk C, Charney D, Krystal J, Guidotti A. Decreased Cerebrospinal Fluid Allopregnanolone Levels in Women with Posttraumatic Stress Disorder. Biological Psychiatry 2006, 60: 704-713. PMID: 16934764, DOI: 10.1016/j.biopsych.2006.03.026.Peer-Reviewed Original ResearchConceptsPosttraumatic stress disorderPremenopausal womenALLO levelsStress disorderCerebrospinal fluid levelsPTSD re-experiencing symptomsAllopregnanolone levelsOral contraceptivesGABAergic neurotransmissionDHEAS levelsPsychotropic medicationsFollicular phaseMenstrual cycleDHEA ratioExcitatory neurotransmissionNeurotransmitter systemsRe-experiencing symptomsDepressive symptomsPTSD subjectsFluid levelsGroup differencesIllicit drugsWomenNeurotransmissionProgesterone
2005
Sex, GABA, and nicotine: The impact of smoking on cortical GABA levels across the menstrual cycle as measured with proton magnetic resonance spectroscopy
Epperson CN, O’Malley S, Czarkowski KA, Gueorguieva R, Jatlow P, Sanacora G, Rothman DL, Krystal JH, Mason GF. Sex, GABA, and nicotine: The impact of smoking on cortical GABA levels across the menstrual cycle as measured with proton magnetic resonance spectroscopy. Biological Psychiatry 2005, 57: 44-48. PMID: 15607299, PMCID: PMC4097033, DOI: 10.1016/j.biopsych.2004.09.021.Peer-Reviewed Original ResearchConceptsCortical GABA levelsOccipital cortex GABA concentrationsGABA levelsProton magnetic resonance spectroscopyImpact of nicotineMenstrual cycleGABA concentrationFemale smokersCortical gamma-aminobutyric acid (GABA) levelsUnderwent proton magnetic resonance spectroscopyGamma-aminobutyric acid (GABA) levelsCentral GABAergic functionCortical GABA concentrationsNicotine-dependent menAmino acid neurotransmissionImpact of smokingPotential risk factorsMenstrual cycle phaseShort-term abstinenceGABAergic functionNicotine modulationSmoking menSmoking cessationFollicular phaseSmoking abstinence
2004
Plasma Lipid and Lipoprotein Levels during the Follicular and Luteal Phases of the Menstrual Cycle
Barnett JB, Woods MN, Lamon-Fava S, Schaefer EJ, McNamara JR, Spiegelman D, Hertzmark E, Goldin B, Longcope C, Gorbach SL. Plasma Lipid and Lipoprotein Levels during the Follicular and Luteal Phases of the Menstrual Cycle. The Journal Of Clinical Endocrinology & Metabolism 2004, 89: 776-782. PMID: 14764796, DOI: 10.1210/jc.2003-030506.Peer-Reviewed Original ResearchConceptsMenstrual cycle phaseLuteal phasePremenopausal womenFollicular phaseMenstrual cycleTotal cholesterol/high-density lipoprotein cholesterolLow-density lipoprotein cholesterol levelsHigh-density lipoprotein cholesterolCoronary heart disease riskTotal cholesterol/HDLPremenopausal Caucasian womenLipoprotein cholesterol levelsHeart disease riskBody mass indexCholesterol/HDLLevels of LDLSex hormone levelsLevels of estradiolLipoprotein cholesterolLipoprotein levelsMass indexEstrogen levelsLipoprotein profilePlasma lipidsCholesterol levels
2003
Regulation of Insulin-Like Growth Factor Binding Protein-1 Promoter Activity by FKHR and HOXA10 in Primate Endometrial Cells1
Kim JJ, Taylor HS, Akbas GE, Foucher I, Trembleau A, Jaffe RC, Fazleabas AT, Unterman TG. Regulation of Insulin-Like Growth Factor Binding Protein-1 Promoter Activity by FKHR and HOXA10 in Primate Endometrial Cells1. Biology Of Reproduction 2003, 68: 24-30. PMID: 12493691, DOI: 10.1095/biolreprod.102.009316.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBase SequenceBinding SitesCells, CulturedCloning, MolecularDNADNA-Binding ProteinsEndometriumFemaleForkhead Box Protein O1Forkhead Transcription FactorsGene Expression RegulationHomeobox A10 ProteinsHomeodomain ProteinsHumansInsulin-Like Growth Factor Binding Protein 1Molecular Sequence DataMutationPapioPregnancyPromoter Regions, GeneticRecombinant Fusion ProteinsRNA, MessengerSequence DeletionSequence Homology, Nucleic AcidSpecies SpecificityTranscription FactorsConceptsIGFBP-1 promoter activityProtein-1 promoter activityInsulin-like growth factorInsulin response sequencePromoter activityBaboon endometriumFollicular phaseMenstrual cycleEndometrial cellsDecidualization processLiver cellsGrowth factorProtein 1HOXA10PregnancyEndometriumTranscription factorsReporter gene studiesForkhead transcription factorHomeobox transcription factorGene studiesFKHRCellsActivityFactors
2002
Cortical γ-Aminobutyric Acid Levels Across the Menstrual Cycle in Healthy Women and Those With Premenstrual Dysphoric Disorder: A Proton Magnetic Resonance Spectroscopy Study
Epperson CN, Haga K, Mason GF, Sellers E, Gueorguieva R, Zhang W, Weiss E, Rothman DL, Krystal JH. Cortical γ-Aminobutyric Acid Levels Across the Menstrual Cycle in Healthy Women and Those With Premenstrual Dysphoric Disorder: A Proton Magnetic Resonance Spectroscopy Study. JAMA Psychiatry 2002, 59: 851-858. PMID: 12215085, DOI: 10.1001/archpsyc.59.9.851.Peer-Reviewed Original ResearchConceptsPremenstrual dysphoric disorderCortical GABA levelsGABA neuronal functionBrain GABA concentrationsHealthy womenMenstrual cycleGABA levelsNeuronal functionNeuroactive steroidsFollicular phaseDysphoric disorderGABA concentrationOccipital cortex GABA levelsProton magnetic resonance spectroscopy studyUniversity-based medical centerHealthy menstruating womenΓ-aminobutyric acid (GABA) levelsMagnetic resonance spectroscopy studyLate luteal phaseMenstrual cycle phaseHealth Research programmeMid lutealNeurosteroid levelsGABAergic systemMenstruating women
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