2025
Comparative Analysis of RT-PCR and a Colloidal Gold Immunochromatographic Assay for SARS-CoV-2 Detection
Li H, Liu D, Zhou Q, Rodriguez G, Pietz H, Singh V, Konadu E, James K, Lui C, Shao M, Chen J, Schreiner A, Urban C, Truong J, Prasad N, Rodgers W. Comparative Analysis of RT-PCR and a Colloidal Gold Immunochromatographic Assay for SARS-CoV-2 Detection. Diagnostics 2025, 15: 1362. PMID: 40506934, PMCID: PMC12154499, DOI: 10.3390/diagnostics15111362.Peer-Reviewed Original ResearchGold immunochromatographic assayColloidal gold immunochromatographic assaySARS-CoV-2 detectionRT-PCRLarge-scale screeningSARS-CoV-2Immunochromatographic assayResource-limited settingsAnalysis of RT-PCRRT-PCR resultsReceiver operating characteristic curve analysisProlonged turnaround timeRT-PCR Ct valuesCalculate area under the curveArea under the curveCharacteristic curve analysisPoint-of-care applicationsPerformance of RT-PCRAlternative diagnostic toolAssayClinical parametersRT-PCR testEarly detection effortsDiagnostic performanceCurve analysis
2024
Earlier Endovascular Thrombectomy and Mortality in Patients with Anterior Circulation Large Vessel Occlusion: A Propensity-Matched Analysis of the Stroke Thrombectomy and Aneurysm Registry
Matsukawa H, Crosa R, Cunningham C, Maier I, Al Kasab S, Jabbour P, Kim J, Wolfe S, Rai A, Starke R, Psychogios M, Shaban A, Goyal N, Yoshimura S, Cuellar H, Howard B, Alawieh A, Alaraj A, Ezzeldin M, Romano D, Tanweer O, Mascitelli J, Fragata I, Polifka A, Siddiqui F, Osbun J, Matouk C, Park M, Levitt M, Brinjikji W, Moss M, Williamson R, Navia P, Kan P, De Leacy R, Chowdhry S, Spiotta A, Collaborators S. Earlier Endovascular Thrombectomy and Mortality in Patients with Anterior Circulation Large Vessel Occlusion: A Propensity-Matched Analysis of the Stroke Thrombectomy and Aneurysm Registry. World Neurosurgery 2024, 189: e435-e441. PMID: 38908685, DOI: 10.1016/j.wneu.2024.06.082.Peer-Reviewed Original ResearchConceptsAIS-LVO patientsAnterior circulation large vessel occlusionLarge vessel occlusionEndovascular thrombectomyAcute ischemic strokePoor outcomeVessel occlusionReceiver operating characteristic curve analysisCharacteristic curve analysisPropensity-matched analysisScore matching analysisSecondary outcomesPrimary outcomeIntracranial hemorrhageNo significant differencePuncture timePatientsStroke thrombectomyCurve analysisIschemic strokeAneurysm RegistryMortalityThrombectomyOutcomesSignificant difference
2023
The Preoperative Lymphocyte-To-Monocyte Ratio Predicts Mortality Among Patients Undergoing Endovascular Aortic Repair for Abdominal Aortic Aneurysm
Nishibe T, Kano M, Akiyama S, Koizumi J, Dardik A. The Preoperative Lymphocyte-To-Monocyte Ratio Predicts Mortality Among Patients Undergoing Endovascular Aortic Repair for Abdominal Aortic Aneurysm. Vascular And Endovascular Surgery 2023, 58: 178-184. PMID: 37789604, DOI: 10.1177/15385744231204238.Peer-Reviewed Original ResearchConceptsEndovascular aortic repairAbdominal aortic aneurysmLower preoperative LMROverall mortalityPreoperative LMRMonocyte ratioAortic repairIndependent predictorsAortic aneurysmChronic obstructive pulmonary diseaseTokyo Medical University HospitalAbsolute lymphocyte countObstructive pulmonary diseaseAbsolute monocyte countMedical University HospitalPotential surrogate biomarkerPoor nutritional statusCharacteristic curve analysisPreoperative lymphocyteActive cancerMedian followLymphocyte countMultivariable analysisPulmonary diseasePoor prognosisIRF8 in Conjunction With CD123 and CD20 to Distinguish Lupus Erythematosus Panniculitis From Subcutaneous Panniculitis-like T-Cell Lymphoma
Wong J, Roy S, McNiff J, Xu M. IRF8 in Conjunction With CD123 and CD20 to Distinguish Lupus Erythematosus Panniculitis From Subcutaneous Panniculitis-like T-Cell Lymphoma. The American Journal Of Surgical Pathology 2023, 47: 1425-1431. PMID: 37767989, DOI: 10.1097/pas.0000000000002133.Peer-Reviewed Original ResearchConceptsSubcutaneous panniculitis-like T-cell lymphomaLupus erythematosus panniculitisPanniculitis-like T-cell lymphomaCase of SPTCLT-cell lymphomaPlasmacytoid dendritic cell differentiationPlasmacytoid dendritic cellsExpression of IRF8Dendritic cell differentiationCharacteristic curve analysisImportant clinical implicationsRegulatory factor 8Dendritic cellsCutaneous biopsyLymphoid aggregatesDiagnostic challengeImmunohistochemical panelImmunohistochemical expressionCD123CD20Distinct patientsClinical implicationsSubcutaneous fatDiagnostic testsPositive markersCommunity distress and risk of adverse outcomes after peripheral vascular intervention
Schenck C, Strand E, Smolderen K, Romain G, Nagpal S, Cleman J, Blume P, Mena-Hurtado C. Community distress and risk of adverse outcomes after peripheral vascular intervention. Journal Of Vascular Surgery 2023, 78: 166-174.e3. PMID: 36944389, PMCID: PMC11146282, DOI: 10.1016/j.jvs.2023.03.027.Peer-Reviewed Original ResearchConceptsPeripheral vascular interventionsDistressed Communities IndexMajor amputationRisk of mortalityAdverse outcomesVascular interventionsVascular Quality Initiative databaseDCI scoresCommunity distressCox regression modelTime-dependent receiverCharacteristic curve analysisClinical characteristicsFinal cohortPrimary outcomeClinical outcomesCardiovascular diseasePatientsAmputationZip code dataMortalityRisk categoriesCurve analysisInitiative databaseOutcomesUtility of promoter hypermethylation in malignant risk stratification of intraductal papillary mucinous neoplasms
Chhoda A, Sharma A, Sailo B, Tang H, Ruzgar N, Tan W, Ying L, Khatri R, Narayanan A, Mane S, De Kumar B, Wood L, Iacobuzio-Donahue C, Wolfgang C, Kunstman J, Salem R, Farrell J, Ahuja N. Utility of promoter hypermethylation in malignant risk stratification of intraductal papillary mucinous neoplasms. Clinical Epigenetics 2023, 15: 28. PMID: 36803844, PMCID: PMC9942382, DOI: 10.1186/s13148-023-01429-5.Peer-Reviewed Original ResearchConceptsPapillary mucinous neoplasmMalignant risk stratificationCACNA1G geneRisk stratificationMucinous neoplasmsBiomarker panelBackgroundIntraductal papillary mucinous neoplasmIntraductal papillary mucinous neoplasmEarly detectionPrevious case-control studyHigh-grade dysplasiaCase-control studyPancreatic cancer precursorsReceiver Operating Characteristic (ROC) curve analysisSignificant diagnostic challengeCross-sectional imagingCharacteristic curve analysisOperating Characteristic curve analysisG geneHigh diagnostic specificityPrior validation studiesSignificant procedural riskIPMN tissuesSurgical resectionAdvanced neoplasiaNoninvasive determinants of pulmonary hypertension in interstitial lung disease
Joseph P, Savarimuthu S, Zhao J, Yan X, Oakland H, Cullinan M, Heerdt P, Singh I. Noninvasive determinants of pulmonary hypertension in interstitial lung disease. Pulmonary Circulation 2023, 13: e12197. PMID: 36814586, PMCID: PMC9939578, DOI: 10.1002/pul2.12197.Peer-Reviewed Original ResearchInterstitial lung diseaseFVC/DLCO ratioPH-ILDRight heart catheterizationPulmonary hypertensionHeart catheterizationILD patientsLung diseaseDiagnostic right heart catheterizationRight ventricular systolic pressurePulmonary vascular capacitanceVentricular systolic pressureCharacteristic curve analysisMaximum oxygen uptakeExertional capacityNoninvasive determinantsSystolic pressureVascular capacitancePhysiologic evaluationPatientsNoninvasive variablesMultivariate analysisMmHgDiagnostic standardPotential initiation
2022
Perceived Age and Personality Profiling after Orthognathic Surgery
Pourtaheri N, Peck CJ, Gowda A, Parsaei Y, Allam O, Patel VK, Park E, Yu J, Lopez J, Steinbacher DM. Perceived Age and Personality Profiling after Orthognathic Surgery. Plastic & Reconstructive Surgery 2022, 150: 146-154. PMID: 35575641, DOI: 10.1097/prs.0000000000009229.Peer-Reviewed Original ResearchConceptsPatient's facial profileOrthognathic surgeryPatient sociodemographicsFacial profileOlder ageCLINICAL QUESTION/LEVELTime of surgerySignificant decreaseCharacteristic curve analysisUnpaired t-testOlder patientsYounger patientsPatient factorsSingle surgeonAge changesSurgeryPatientsPostoperative imagesCurve analysisSociodemographicsAgeSignificant differencesMultivariate regressionT-testBase of evidenceUntargeted metabolomics analysis of esophageal squamous cell cancer progression
Yang T, Hui R, Nouws J, Sauler M, Zeng T, Wu Q. Untargeted metabolomics analysis of esophageal squamous cell cancer progression. Journal Of Translational Medicine 2022, 20: 127. PMID: 35287685, PMCID: PMC8919643, DOI: 10.1186/s12967-022-03311-z.Peer-Reviewed Original ResearchConceptsEsophageal squamous cell carcinomaPhosphatidylserine synthase 1Metabolic pathway genesGene Set Enrichment AnalysisESCC progressionMetabolic pathwaysGlycerophospholipid metabolismPathway genesTumor/node/metastasis stageStage IIMRNA expressionSquamous cell cancer progressionSquamous cell carcinomaKey metabolic pathwaysAdjacent cancerous tissuePotential therapeutic targetCharacteristic curve analysisGood diagnostic valueTandem mass spectrometry analysisCancer Genome AtlasKyoto EncyclopediaMass spectrometry analysisExpression heatmapsPathway databasesPoor prognosis
2021
Development and external validation of a diagnostic model for biopsy-proven acute interstitial nephritis using electronic health record data
Moledina DG, Eadon MT, Calderon F, Yamamoto Y, Shaw M, Perazella MA, Simonov M, Luciano R, Schwantes-An TH, Moeckel G, Kashgarian M, Kuperman M, Obeid W, Cantley LG, Parikh CR, Wilson FP. Development and external validation of a diagnostic model for biopsy-proven acute interstitial nephritis using electronic health record data. Nephrology Dialysis Transplantation 2021, 37: 2214-2222. PMID: 34865148, PMCID: PMC9755995, DOI: 10.1093/ndt/gfab346.Peer-Reviewed Original ResearchConceptsAcute interstitial nephritisInterstitial nephritisUrine biomarkersBiopsy-proven acute interstitial nephritisElectronic health record dataExternal validation cohortTypical clinical featuresBlood urea nitrogenTumor necrosis factorCharacteristic curve analysisHealth record dataExternal validationElectronic health recordsAIN diagnosisModest AUCsSerum creatinineCreatinine ratioKidney biopsyClinical featuresValidation cohortNecrosis factorUnrecognized casesInterleukin-9PatientsUrea nitrogenSeverity of substance use as an indicator of suicide risk among U.S. military veterans
Na PJ, Nichter B, Hill ML, Kim B, Norman SB, Pietrzak RH. Severity of substance use as an indicator of suicide risk among U.S. military veterans. Addictive Behaviors 2021, 122: 107035. PMID: 34246987, DOI: 10.1016/j.addbeh.2021.107035.Peer-Reviewed Original ResearchConceptsAlcohol Use Disorders Identification TestHigh-risk subsampleAlcohol use disorderPosttraumatic stress disorderPast-year suicidal ideationDrug use disordersMajor depressive disorderSevere alcohol use disorderUse disordersSuicide risk assessmentSuicidal ideationPast-year alcohol use disorderSubstance usePast-year drug use disordersStrong risk factorNon-prescription drugsCharacteristic curve analysisDisorders Identification TestU.S. military veteransDepressive disorderNational HealthRisk factorsClinical utilityElevated riskDrug useDifferential Metabolites in Chinese Autistic Children: A Multi-Center Study Based on Urinary 1H-NMR Metabolomics Analysis
Ma Y, Zhou H, Li C, Zou X, Luo X, Wu L, Li T, Chen X, Mao M, Huang Y, Li E, An Y, Zhang L, Wang T, Xu X, Yan W, Jiang Y, Wang Y. Differential Metabolites in Chinese Autistic Children: A Multi-Center Study Based on Urinary 1H-NMR Metabolomics Analysis. Frontiers In Psychiatry 2021, 12: 624767. PMID: 34045978, PMCID: PMC8144639, DOI: 10.3389/fpsyt.2021.624767.Peer-Reviewed Original ResearchDifferential metabolitesHealthy childrenPathogenic mechanismsControl groupGuanidinoacetic acidAutism spectrum disorderROC curveMulti-center studyCharacteristic curve analysisH NMR metabolomics analysisSignificant diagnostic valueAmino acid metabolitesMetabolomic analysisN-methylnicotinamideEarly-onset neurodevelopmental disorderUnivariate analysisEarly diagnosisValuable biomarkerAcid metabolitesAmino acid metabolic pathwaysDiagnostic valueAutistic childrenCreatinineCurve analysisMetabolic variations
2020
Species-Specific Immunoassay for Diagnosis and Tracking Treatment Response in Foot and Ankle Infection
Oh I, Hao S, Waldman O, Holleran A, Daiss J. Species-Specific Immunoassay for Diagnosis and Tracking Treatment Response in Foot and Ankle Infection. Foot & Ankle Orthopaedics 2020, 5: 2473011420s00372. PMCID: PMC8702934, DOI: 10.1177/2473011420s00372.Peer-Reviewed Original ResearchAnkle infectionWound healing statusHealing statusDFU patientsOngoing infectionTreatment responseS. aureusDiabetic foot ulcer patientsFellowship-trained orthopedic footFoot ulcer patientsCharacteristic curve analysisDiagnostic toolSpecies-specific immunoassayReliable diagnostic toolOrthopaedic FootSpecific diagnostic toolsUlcer patientsAntibiotic therapyClinical resolutionSurgical treatmentClinical outcomesInitial presentationAntibody titersSerum antibodiesAnkle surgeonsThe impact of delirium on withdrawal of life-sustaining treatment after intracerebral hemorrhage.
Reznik ME, Moody S, Murray K, Costa S, Grory BM, Madsen TE, Mahta A, Wendell LC, Thompson BB, Rao SS, Stretz C, Sheth KN, Hwang DY, Zahuranec DB, Schrag M, Daiello LA, Asaad WF, Jones RN, Furie KL. The impact of delirium on withdrawal of life-sustaining treatment after intracerebral hemorrhage. Neurology 2020, 95: e2727-e2735. PMID: 32913011, PMCID: PMC7734724, DOI: 10.1212/wnl.0000000000010738.Peer-Reviewed Original ResearchConceptsImpact of deliriumIntracerebral hemorrhageLife-sustaining treatmentScore-based modelSingle-center cohort studyCox regression modelCharacteristic curve analysisDSM-5 criteriaHospital daysCohort studyConsecutive patientsMedian timeDelirium groupPoor outcomeDeliriumWLSTPatientsLogistic regressionCurve analysisHemorrhageSevere respiratory viral infection induces procalcitonin in the absence of bacterial pneumonia
Gautam S, Cohen AJ, Stahl Y, Toro P, Young GM, Datta R, Yan X, Ristic NT, Bermejo SD, Sharma L, Restrepo M, Dela Cruz CS. Severe respiratory viral infection induces procalcitonin in the absence of bacterial pneumonia. Thorax 2020, 75: 974-981. PMID: 32826284, DOI: 10.1136/thoraxjnl-2020-214896.Peer-Reviewed Original ResearchConceptsPure viral infectionBacterial coinfectionViral infectionInfluenza infectionSevere respiratory viral infectionsAbility of procalcitoninRetrospective cohort studyViral respiratory infectionsRespiratory viral infectionsMarker of severityRespiratory viral illnessSevere viral infectionsSpecificity of procalcitoninCharacteristic curve analysisCellular modelHigher procalcitoninProcalcitonin expressionElevated procalcitoninCohort studyViral illnessRespiratory infectionsAntibiotic administrationBacterial pneumoniaSevere diseaseProcalcitoninSAT-624 Predictive Ability of Lipoprotein Insulin Resistance (LPIR) Score in South Asians: A Comparison of Surrogate Indices of Insulin Sensitivity/Resistance
Fosam A, Grewal S, Armiyaw A, Sarcone C, Rabel A, Auh S, Muniyappa R. SAT-624 Predictive Ability of Lipoprotein Insulin Resistance (LPIR) Score in South Asians: A Comparison of Surrogate Indices of Insulin Sensitivity/Resistance. Journal Of The Endocrine Society 2020, 4: sat-624. PMCID: PMC7209077, DOI: 10.1210/jendso/bvaa046.1740.Peer-Reviewed Original ResearchLipoprotein insulin resistance scoreInsulin resistance scoreInsulin resistanceLPIR scoreSurrogate indexSouth AsiansInsulin sensitivity/resistanceIntravenous glucose tolerance testGlucose tolerance testLipoprotein particle concentrationsInsulin-resistant individualsType 2 diabetesInsulin-resistant subjectsCross-sectional studyInsulin-resistant statesCharacteristic curve analysisMinimal model analysisResistance scoreSensitivity/resistanceHOMA-IRLipoprotein abnormalitiesTolerance testInsulin sensitivityHigh riskResistant subjects
2019
Venous thrombosis at altitude presents with distinct biochemical profiles: a comparative study from the Himalayas to the plains
Prabhakar A, Chatterjee T, Bajaj N, Tyagi T, Sahu A, Gupta N, Kumari B, Nair V, Kumar B, Ashraf MZ. Venous thrombosis at altitude presents with distinct biochemical profiles: a comparative study from the Himalayas to the plains. Blood Advances 2019, 3: 3713-3723. PMID: 31765479, PMCID: PMC6880906, DOI: 10.1182/bloodadvances.2018024554.Peer-Reviewed Original ResearchConceptsVenous thromboembolismAdhesion molecule-1VTE patientsHA exposureMolecule-1Vascular cell adhesion molecule-1Toll-like receptor 2Intracellular adhesion molecule-1Receiver operator characteristic curve analysisCell adhesion molecule-1Operator characteristic curve analysisMost VTEElevated platelet countVascular endothelial growth factorCharacteristic curve analysisYounger age groupsPlatelet factor 4Endothelial growth factorDistinct biochemical profilesVon Willebrand factorAltered coagulationVTE eventsVenous thrombosisEndothelial activationPlatelet countPrediction of Hypoxia in Brain Tumors Using a Multivariate Model Built from MR Imaging and 18F-Fluorodeoxyglucose Accumulation Data
Shimizu Y, Kudo K, Kameda H, Harada T, Fujima N, Toyonaga T, Tha KK, Shirato H. Prediction of Hypoxia in Brain Tumors Using a Multivariate Model Built from MR Imaging and 18F-Fluorodeoxyglucose Accumulation Data. Magnetic Resonance In Medical Sciences 2019, 19: 227-234. PMID: 31611541, PMCID: PMC7553805, DOI: 10.2463/mrms.mp.2019-0049.Peer-Reviewed Original ResearchConceptsF-fluorodeoxyglucoseBrain tumorsMultivariate modelVascular permeabilityBlood flowExtent of hypoxiaReceiver-operating characteristic curve analysisPositron emission tomography scanMultivariate prediction modelMultivariate logistic regression modelDynamic contrast-enhanced perfusionEmission tomography scanCharacteristic curve analysisContrast-enhanced perfusionLogistic regression modelsPrediction of hypoxiaGlycometabolism parametersUnivariate analysisMRI markersTomography scanF-fluoromisonidazoleMRI scansArterial spin labeling imagesMRI parametersMR imagingValidation of a Machine Learning Model That Outperforms Clinical Risk Scoring Systems for Upper Gastrointestinal Bleeding
Shung DL, Au B, Taylor RA, Tay JK, Laursen SB, Stanley AJ, Dalton HR, Ngu J, Schultz M, Laine L. Validation of a Machine Learning Model That Outperforms Clinical Risk Scoring Systems for Upper Gastrointestinal Bleeding. Gastroenterology 2019, 158: 160-167. PMID: 31562847, PMCID: PMC7004228, DOI: 10.1053/j.gastro.2019.09.009.Peer-Reviewed Original ResearchConceptsUpper gastrointestinal bleedingHospital-based interventionsComposite endpointScoring systemRockall scoreGastrointestinal bleedingClinical riskConsecutive unselected patientsLow-risk patientsClinical scoring systemRisk-scoring systemExternal validation cohortCharacteristic curve analysisInternal validation setOutpatient managementUnselected patientsValidation cohortEmergency departmentMedical CenterGreater AUCPatientsAbstractTextCurve analysisEndpointAUCMetabolic Syndrome Exponentially Increases the Risk of Adverse Outcomes in Operative Diverticulitis
Jehan F, Zeeshan M, Con J, Hanna K, Tang A, Hamidi M, Latifi R, Joseph B. Metabolic Syndrome Exponentially Increases the Risk of Adverse Outcomes in Operative Diverticulitis. Journal Of Surgical Research 2019, 245: 544-551. PMID: 31470335, DOI: 10.1016/j.jss.2019.07.075.Peer-Reviewed Original ResearchConceptsBody mass indexAcute diverticulitis patientsReceiver operating characteristic curveMetabolic syndromeAdverse eventsLength of stayDiverticulitis patientsAdverse outcomesGt;30 kg/m<sup>2</sup>Deep surgical-site infectionMean body mass indexReceiver operating characteristic curve analysisOdds of reintubationRisk of adverse outcomesSurgical-site infectionHospital length of stayRate of complicationsOutcome measuresCharacteristic curve analysisPredicting Adverse OutcomesArea under the receiver operating characteristic curveLevel III-prognosticPrimary outcome measureLonger length of staySecondary outcome measures
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