2025
Diurnal changes of salivary oxytocin in healthy and psychiatric adolescents
Gizuterman A, Zgoory-Sharon O, Avirame K, Mevorach T, Foul Y, Feldman R, Eitan R. Diurnal changes of salivary oxytocin in healthy and psychiatric adolescents. Journal Of Psychiatric Research 2025, 186: 273-279. PMID: 40267842, DOI: 10.1016/j.jpsychires.2025.04.007.Peer-Reviewed Original ResearchConceptsSalivary oxytocinMeasures of emotion regulationCompleted self-report questionnairesPsychiatric inpatient wardsSelf-report questionnairesMental health stateEmotion regulationPsychiatric adolescentsYouth mental healthPsychiatric assessmentOxytocin levelsInterpersonal relationshipsDiurnal rhythmMental healthPsychopathologyOxytocin productionHealthy controlsOxytocinDaily time pointsHealthy peersAdolescent patientsAdolescentsBaseline levelsConsecutive daysPatient groupComputationally derived parent-child interaction patterns and oxytocin in children with and without OCD
Mora-Jensen A, Thoustrup C, Lebowitz E, Hagstrøm J, Pretzmann L, Korsbjerg N, Thorsen E, Uhre V, Christensen S, Uhre C, Ritter M, Plessen K, Pagsberg A, Clemmensen L, Lønfeldt N. Computationally derived parent-child interaction patterns and oxytocin in children with and without OCD. Journal Of Anxiety Disorders 2025, 111: 102996. PMID: 40117840, DOI: 10.1016/j.janxdis.2025.102996.Peer-Reviewed Original ResearchParent-child interaction behaviorsPediatric OCDMother-childParent-child interaction processMother-child interaction patternsParent-child interaction patternsParent-child behaviorsSalivary oxytocin levelsParent-child interactionsFather-child interactionsAssociated with oxytocinFather-child pairsFamily engagementEnzyme-linked immunosorbent assayFrustration taskInteraction patternsOCDInteraction behaviorOxytocin levelsConflictual interactionsBiological mechanismsPositive associationArchetypal analysisFathering behaviorMachine learning techniquesBirthing parents’ neural response to infant cry: moderating effects of oxytocin and perceived childhood care
Grande L, Xie Y, Zagoory-Sharon O, Watamura S, Yeh T, Feldman R, Kim P. Birthing parents’ neural response to infant cry: moderating effects of oxytocin and perceived childhood care. Social Cognitive And Affective Neuroscience 2025, 20: nsaf010. PMID: 39849833, PMCID: PMC11804881, DOI: 10.1093/scan/nsaf010.Peer-Reviewed Original ResearchConceptsMaternity careParental Bonding InstrumentParenting behaviorsOxytocin levelsInfant cryingNeural responses to infant cryNeural responses to infant stimuliResponse to infant cryingResponses to infant stimuliEarly postpartum periodObservations of parental behaviorEarly caregiving experiencesSensitive parenting behaviorsCaregiving experienceHigher oxytocin levelsBirth parentsParent-infant playEffects of oxytocinControlled cryingMonths postpartumPostpartum periodCareCuneus activationInfant stimuliBonding Instrument
2024
Infants' salivary oxytocin and positive affective reactions to people
Zeng G, Leung T, Maylott S, Malik A, Adornato A, Lebowitz M, Messinger D, Szeto A, Feldman R, Simpson E. Infants' salivary oxytocin and positive affective reactions to people. Hormones And Behavior 2024, 164: 105579. PMID: 38905820, DOI: 10.1016/j.yhbeh.2024.105579.Peer-Reviewed Original ResearchOxytocin levelsSalivary oxytocinFacial affectAffective reactionsEarly Social Communication ScalesInfant positive affectStable individual differencesPositive facial affectSocial Communication ScalesHigher oxytocin levelsPositive affective reactionsSocio-emotional developmentPositive affectIndividual differencesSocial behaviorSmiling womenCommunication ScaleAffectOxytocinPhysiological measuresMonths of ageProsocialityStatistically significant changesU.S. infantsInfants
2021
Moderators of response to child‐based and parent‐based child anxiety treatment: a machine learning‐based analysis
Lebowitz ER, Zilcha‐Mano S, Orbach M, Shimshoni Y, Silverman WK. Moderators of response to child‐based and parent‐based child anxiety treatment: a machine learning‐based analysis. Journal Of Child Psychology And Psychiatry 2021, 62: 1175-1182. PMID: 33624848, DOI: 10.1111/jcpp.13386.Peer-Reviewed Original ResearchConceptsModerators of responseParent negativityChild anxiety treatmentOxytocin levelsBaseline anxietyCognitive behavioral therapyPrimary anxiety disorderChild-reported outcomesParent-reported outcomesChildhood anxietyAnxiety treatmentAnxiety symptomsPotential moderatorsAnxiety disordersTreatment conditionsModeratorMachine learning-based analysisAnxietyNegativitySignificant interactionChildrenNonoptimal treatmentTreatment efficacyParentingSocioemotional
2019
Oxytocin and early parent-infant interactions: A systematic review
Scatliffe N, Casavant S, Vittner D, Cong X. Oxytocin and early parent-infant interactions: A systematic review. International Journal Of Nursing Sciences 2019, 6: 445-453. PMID: 31728399, PMCID: PMC6838998, DOI: 10.1016/j.ijnss.2019.09.009.Peer-Reviewed Original ResearchSkin-to-skin contactMaternal oxytocin levelsParent-infant contactMother-infantOxytocin levelsElectronic databasesSystematic reviewInclusion criteriaMother-infant contactSystematic searchMaternal-InfantFather-infant interactionsSocial factorsHigher oxytocin levelsReview studiesOxytocinergic mechanismsEarly contactSocial relationshipsInfant interactionsOxytocin releaseOxytocinMothersParentsInfantsInfancy period
2018
Negative peer social interactions and oxytocin levels linked to suicidal ideation in anxious youth
Lebowitz ER, Blumberg HP, Silverman WK. Negative peer social interactions and oxytocin levels linked to suicidal ideation in anxious youth. Journal Of Affective Disorders 2018, 245: 806-811. PMID: 30699863, PMCID: PMC6361537, DOI: 10.1016/j.jad.2018.11.070.Peer-Reviewed Original ResearchConceptsNegative peer interactionsPeer social interactionSalivary oxytocin levelsAnxious youthPeer interactionsHigher oxytocin levelsAnxiety disordersOxytocin levelsSocial interactionSuicidal ideationSocial eventsSelf-report measuresPrimary anxiety disorderSemi-structured diagnostic interviewNegative social interactionsPeripheral oxytocin levelsSample of childrenPeer victimization
2015
Parental oxytocin responses during skin-to-skin contact in pre-term infants
Cong X, Ludington-Hoe S, Hussain N, Cusson R, Walsh S, Vazquez V, Briere C, Vittner D. Parental oxytocin responses during skin-to-skin contact in pre-term infants. Early Human Development 2015, 91: 401-406. PMID: 25988992, DOI: 10.1016/j.earlhumdev.2015.04.012.Peer-Reviewed Original ResearchConceptsPre-term infantsSkin-to-skin contactMaternal skin-to-skin contactAdverse consequences of prematurityDay 1Day 2Consequences of prematurityCross-over studyPost-partum periodMaternal oxytocinOxytocin responseOxytocin mechanismsAnxiety responsesMaternal cortisolOxytocin releaseReduce adverse consequencesOxytocin levelsPost-SSCInfantsOxytocinNeurobiological mechanismsStudy protocolMother-father dyadsReduce stressAnxiety levels
2002
Effects of Emotion on Oxytocin, Prolactin, and ACTH in Women
Turner R, Altemus M, Yip D, Kupferman E, Fletcher D, Bostrom A, Lyons D, Amico J. Effects of Emotion on Oxytocin, Prolactin, and ACTH in Women. Stress 2002, 5: 269-276. PMID: 12475731, DOI: 10.1080/1025389021000037586-1.Peer-Reviewed Original ResearchConceptsNegative emotion inductionEmotion inductionNegative emotionsAttachment-related emotionsPositive emotion inductionEffects of emotionPositive emotionsSad emotionsHuman attachmentNon-human mammalsPlasma oxytocin levelsEmotionsInterpersonal relationshipsOxytocin levelsPlasma oxytocinPrevious researchOxytocinDegree of changeResearchParticipantsFemale volunteersUniversity communityAttachmentFindingsRelationship
1999
Preliminary Research on Plasma Oxytocin in Normal Cycling Women: Investigating Emotion and Interpersonal Distress
Turner R, Altemus M, Enos T, Cooper B, McGuinness T. Preliminary Research on Plasma Oxytocin in Normal Cycling Women: Investigating Emotion and Interpersonal Distress. Psychiatry 1999, 62: 97-113. PMID: 10420425, DOI: 10.1080/00332747.1999.11024859.Peer-Reviewed Original ResearchConceptsOxytocin levelsPositive emotionsImagery tasksInterpersonal problemsInterpersonal distressInterpersonal characteristicsPositive social contactAdult pair bondsPlasma oxytocinEmotional stimuliSad emotionsSocial stimuliNegative emotionsIndividual differencesLower anxietyEmotionsCouple relationshipsNeurohormone oxytocinNonhuman mammalsSocial contactMaternal behaviorDistressStimuliOxytocinTask
1994
Changes in Cerebrospinal Fluid Neurochemistry During Treatment of Obsessive-compulsive Disorder With Clomipramine
Altemus M, Swedo S, Leonard H, Richter D, Rubinow D, Potter W, Rapoport J. Changes in Cerebrospinal Fluid Neurochemistry During Treatment of Obsessive-compulsive Disorder With Clomipramine. JAMA Psychiatry 1994, 51: 794-803. PMID: 7524463, DOI: 10.1001/archpsyc.1994.03950100042004.Peer-Reviewed Original ResearchConceptsCorticotropin-releasing hormoneLong-term treatmentObsessive-compulsive disorderCSF levelsHomovanillic acidCSF monoamine metabolite levelsCentral administrationCerebrospinal fluid levelsSignificant decreaseCSF homovanillic acidMonoamine metabolite levelsCerebrospinal fluid neurochemistryCSF oxytocin levelsOpposite behavioral effectsPharmacologic treatmentSomatostatin levelsMonoamine metabolitesPathophysiologic processesFluid levelsBehavioral effectsOxytocin levelsClomipramine hydrochlorideMetabolite levelsDisordersVasopressinElevated Cerebrospinal Fluid Levels of Oxytocin in Obsessive-compulsive Disorder: Comparison With Tourette's Syndrome and Healthy Controls
Leckman J, Goodman W, North W, Chappell P, Price L, Pauls D, Anderson G, Riddle M, McSwiggan-Hardin M, McDougle C, Barr L, Cohen D. Elevated Cerebrospinal Fluid Levels of Oxytocin in Obsessive-compulsive Disorder: Comparison With Tourette's Syndrome and Healthy Controls. JAMA Psychiatry 1994, 51: 782-792. PMID: 7524462, DOI: 10.1001/archpsyc.1994.03950100030003.Peer-Reviewed Original ResearchConceptsCerebrospinal fluid levelsObsessive-compulsive disorderCSF oxytocin levelsTourette syndromeArginine vasopressinFamily historyFluid levelsElevated cerebrospinal fluid levelsTic-related obsessive-compulsive disorderOxytocin levelsSubgroup of patientsSubset of patientsElevated CSF levelsCentral arginine vasopressinSubtype of OCDCSF levelsFamily genetic dataHealthy controlsTic disordersForms of OCDPatientsRelated syndromesCurrent severitySyndromeFamily study data
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