2025
Variability in Implantable Cardioverter-Defibrillator Battery Longevity
Freeman J, Torre M, Sanders P, Varma N, Baykaner T, Deering T, Russo A, Zhang Y, Steinberg B. Variability in Implantable Cardioverter-Defibrillator Battery Longevity. Heart Rhythm 2025 PMID: 40412594, DOI: 10.1016/j.hrthm.2025.05.031.Peer-Reviewed Original Research
2024
Lack of diversity in patients undergoing carotid artery stenting: Implications for the Distressed Community Index
Pajarillo C, Romain G, Cleman J, Scierka L, Grubman S, Schenck C, Kluger J, Smolderen K, Mena-Hurtado C. Lack of diversity in patients undergoing carotid artery stenting: Implications for the Distressed Community Index. Vascular Medicine 2024, 30: 27-37. PMID: 39526556, DOI: 10.1177/1358863x241292545.Peer-Reviewed Original ResearchDistressed Communities IndexCommunity distressDistress groupCarotid artery stentingDistressed Communities Index scoreHierarchical Cox regressionCumulative incidence function curvesSocial determinantsNon-Hispanic/LatinoStroke incidenceAccess barriersFine-Gray modelArtery stentingDistressKaplan-Meier survival curvesVascular Quality Initiative databaseZip-codeFine-GrayMortality incidenceCox regressionAssociationAnalyzed patientsNo significant differenceMortalityLack of diversityTranscatheter versus surgical aortic valve replacement in lower-risk patients: an updated meta-analysis of randomised controlled trials
Reddy R, Howard J, Reardon M, Thyregod H, Jorgensen T, Toff W, Forrest J, Leon M, Ahmad Y. Transcatheter versus surgical aortic valve replacement in lower-risk patients: an updated meta-analysis of randomised controlled trials. European Heart Journal 2024, 45: ehae666.2456. DOI: 10.1093/eurheartj/ehae666.2456.Peer-Reviewed Original ResearchLower-risk patientsIndividual patient dataFollow-upNo significant differenceClinical outcomesPairwise random-effects meta-analysesNew-onset atrial fibrillationLong-term clinical outcomesSurgical aortic valve replacementKaplan-Meier survival curvesMeta-analysis of randomised controlled trialsLow-surgical riskMeta-analysesAortic valve reinterventionReconstructed individual patient dataLow surgical riskAortic valve replacementFollow-up durationSevere aortic stenosisMeta-analysisSignificant differenceCox proportional hazards regressionComposite of deathKaplan-Meier plotsLonger-term follow-upA Survival Analysis of Patients with Radiation-Induced Cancers after Prior Radiation for Head and Neck Cancer
Laseinde E, Guan L, Hildebrand R, Meurice N, Gensheimer M, Beadle B, Holsinger F, Sunwoo J, Baik F, Sirjani D, Divi V, Kaplan M, Pinto H, Colevas A, Rahman M, Le Q. A Survival Analysis of Patients with Radiation-Induced Cancers after Prior Radiation for Head and Neck Cancer. International Journal Of Radiation Oncology • Biology • Physics 2024, 120: e764. DOI: 10.1016/j.ijrobp.2024.07.1678.Peer-Reviewed Original ResearchHead and neck cancerNonsurgical groupNeck cancerRadiation treatmentTreated with non-surgical therapyIRB-approved retrospective reviewSurvival rateKaplan-Meier survival curvesSurvival rate of patientsNon-surgical therapySurvival analysis of patientsLog-rank testAnalysis of patientsNon-surgical groupNon-surgical treatmentRate of patientsRadiation-induced cancerCompare survival ratesPrior RTPostoperative RTMedian followPrior radiationSquamous histologyOverall survivalMedian ageP27. Renal transplant patients at increased odds off many perioperative adverse events following lumbar laminotomy/discectomy
Gouzoulis M, Seddio A, Zhu J, Day W, Jabbouri S, Rubio D, Grauer J. P27. Renal transplant patients at increased odds off many perioperative adverse events following lumbar laminotomy/discectomy. The Spine Journal 2024, 24: s76. DOI: 10.1016/j.spinee.2024.06.048.Peer-Reviewed Original ResearchSevere adverse eventsHistory of renal transplantationUrinary tract infectionRenal transplantationAcute kidney injuryAdverse eventsMinor adverse eventsElixhauser Comorbidity IndexIncreased oddsCurrent Procedural TerminologyTract infectionsLumbar discectomyKidney injuryED visitsIncreased odds of acute kidney injuryOdds of acute kidney injuryOdds ratioOdds of ED visitsKaplan-Meier survival curvesDays of follow-upRenal transplant groupRenal transplant patientsIncidence of reoperationRisk of reoperationOdds of sepsisImpact of Recipient and Donor Body Mass Index on Survival Outcomes After Intestinal Transplantation: A United Network for Organ Sharing Database Analysis
Ameyaw A, Boateng S, Annor E, Njei B. Impact of Recipient and Donor Body Mass Index on Survival Outcomes After Intestinal Transplantation: A United Network for Organ Sharing Database Analysis. Annals Of Transplantation 2024, 29: e943994-1-e943994-13. PMID: 38978263, PMCID: PMC11299477, DOI: 10.12659/aot.943994.Peer-Reviewed Original ResearchConceptsBody mass indexDonor body mass indexIncreased risk of mortalityIntestinal transplantationRisk of mortalityIT recipientsSurvival outcomesMass indexIncreased riskLong-term patient survivalImpact of body mass indexRecipient body mass indexMultivariate Cox regression analysisKaplan-Meier survival curvesBody mass index categoriesLower body mass indexImprove survival outcomesCox regression analysisRetrospective cohort studyAssociation of recipientPost-transplant mortalityImpact of recipientUnderweight patientsPatient survivalObesity class
2023
Comparison of lower extremity bypass and peripheral vascular intervention for chronic limb-threatening ischemia in the Medicare-linked Vascular Quality Initiative
Cleman J, Romain G, Grubman S, Guzman R, Smolderen K, Mena-Hurtado C. Comparison of lower extremity bypass and peripheral vascular intervention for chronic limb-threatening ischemia in the Medicare-linked Vascular Quality Initiative. Journal Of Vascular Surgery 2023, 78: 745-753.e6. PMID: 37207790, PMCID: PMC10964324, DOI: 10.1016/j.jvs.2023.05.015.Peer-Reviewed Original ResearchConceptsChronic limb-threatening ischemiaLower extremity bypassPeripheral vascular interventionsVascular Quality InitiativeLimb-threatening ischemiaCause mortalityRisk of deathExtremity bypassVascular interventionsQuality InitiativeCox proportional hazards regressionKaplan-Meier survival curvesProportional hazards regressionOverall mean ageLogistic regression modelsComparative effectiveness researchKnee poplitealMedicare registryInfrapopliteal arteriesHazards regressionMean ageThirty-dayHispanic ethnicityOutcome dataTreatment groupsThe Presence Of Clinical COPD Predicts Mortality In Heart Failure Patient Population
Adeel M, Wakefield D, Soucier R, ZuWallack R, Tabtabai S. The Presence Of Clinical COPD Predicts Mortality In Heart Failure Patient Population. Journal Of Cardiac Failure 2023, 29: 643. DOI: 10.1016/j.cardfail.2022.10.237.Peer-Reviewed Original ResearchChronic obstructive pulmonary diseaseHFpEF patientsHFrEF patientsHeart failurePrognostic impact of chronic obstructive pulmonary diseaseMedian LOSDiagnosis groupsHF typePresence of chronic obstructive pulmonary diseaseClinical diagnosis of chronic obstructive pulmonary diseaseConcurrent chronic obstructive pulmonary diseaseKaplan-Meier survival curvesComorbid chronic obstructive pulmonary diseaseDiagnosis of chronic obstructive pulmonary diseaseHeart failure patient populationCalcium channel blockersCox regression analysisClinical chronic obstructive pulmonary diseaseIn-Hospital MortalityChronic obstructive pulmonary disease diagnosisDiagnosis of HFYears of ageImpact of chronic obstructive pulmonary diseaseObstructive pulmonary diseasePrognostic impactLower extremity symptoms and ankle–brachial index screening as predictors of cardiovascular outcomes in Black adults
Lee M, Smolderen K, Ionescu C, Hillegass W, Romain G, Mena-Hurtado C. Lower extremity symptoms and ankle–brachial index screening as predictors of cardiovascular outcomes in Black adults. Vascular Medicine 2023, 28: 197-204. PMID: 37293738, DOI: 10.1177/1358863x231151729.Peer-Reviewed Original ResearchConceptsPeripheral artery diseaseAbnormal ABILower extremity symptomsNormal ABILeg symptomsHigh riskBlack adultsExtremity symptomsStepwise Cox proportional hazards modelKaplan-Meier survival curvesCox proportional hazards modelAnkle-brachial indexFramingham risk factorsJackson Heart StudyProportional hazards modelCardiovascular outcomesCause mortalityArtery diseaseAsymptomatic diseaseAdverse outcomesMean ageSymptom assessmentAsymptomatic participantsRisk factorsSymptomatic participants
2022
Total shoulder arthroplasty: ninety-day adverse events and 5-year implant survival in patients with hidradenitis suppurativa
Gouzoulis M, Ratnasamy P, Caruana D, Wiznia D, Medvecky M, Grauer J. Total shoulder arthroplasty: ninety-day adverse events and 5-year implant survival in patients with hidradenitis suppurativa. Seminars In Arthroplasty JSES 2022, 32: 676-680. DOI: 10.1053/j.sart.2022.07.012.Peer-Reviewed Original ResearchTotal shoulder arthroplastySurgical site infectionMinor adverse eventsAdverse eventsSite infectionTSA patientsImplant survivalHS patientsSkin lesionsLog-rank Mantel-Cox testFive-year implant survivalKaplan-Meier survival curvesHigher comorbidity burdenMethods Adult patientsNon-HS groupsSevere adverse eventsElixhauser Comorbidity IndexChronic skin disorderPotential risk factorsMantel-Cox testRisk of infectionComorbidity burdenComorbidity indexPostoperative complicationsReoperation rateSubsequent Surgery Up to 10 Years After Osteochondral Allograft and Osteochondral Autograft: An Analysis of More Than 2000 Patients
Burroughs P, Kahan J, Moran J, Gillinov S, Joo P, Schneble C, Moore H, Grauer J, Medvecky M. Subsequent Surgery Up to 10 Years After Osteochondral Allograft and Osteochondral Autograft: An Analysis of More Than 2000 Patients. Orthopaedic Journal Of Sports Medicine 2022, 10: 23259671221139127. PMID: 36582936, PMCID: PMC9793021, DOI: 10.1177/23259671221139127.Peer-Reviewed Original ResearchOsteochondral allograft transplantOsteochondral autograft transferSubsequent knee surgerySubsequent surgeryKnee surgeryMantel-Cox log-rank testKaplan-Meier survival curvesHigh rateLog-rank testLevel of evidenceCohort studyPatients 10Meier survivalAllograft transplantsKnee arthroplastySecondary surgeryAdministrative databasesAutograft transferPatientsSurgeryOsteochondral autograftSurvival analysisSurvival curvesOsteochondral allograftsStatistical differenceChondrosarcoma patient characteristics, management, and outcomes based on over 5,000 cases from the National Cancer Database (NCDB)
Ottesen TD, Shultz BN, Munger AM, Amick M, Toombs CS, Friedaender GE, Grauer JN. Chondrosarcoma patient characteristics, management, and outcomes based on over 5,000 cases from the National Cancer Database (NCDB). PLOS ONE 2022, 17: e0268215. PMID: 35901087, PMCID: PMC9333210, DOI: 10.1371/journal.pone.0268215.Peer-Reviewed Original ResearchConceptsNational Cancer DatabaseLong-term survivalMultivariate Cox analysisDistant metastasisSurgical treatmentChondrosarcoma patientsCox analysisCancer DatabaseLong-term survival dataKaplan-Meier survival curvesKaplan-Meier survival analysisPrimary osseous tumorsMainstay of treatmentExtent of diseasePoor prognostic factorPrimary tumor siteAge categoriesLikelihood of deathAxial involvementPatient characteristicsWorse survivalPrognostic factorsSurgical excisionMale sexOsseous tumorsHidradenitis Suppurativa Leads to Increased Risk of Wound-Related Complications following Total Joint Arthroplasty
Gouzoulis MJ, Kammien AJ, Caruana DL, Wiznia DH, Grauer JN. Hidradenitis Suppurativa Leads to Increased Risk of Wound-Related Complications following Total Joint Arthroplasty. Arthroplasty Today 2022, 16: 169-174. PMID: 35789782, PMCID: PMC9249970, DOI: 10.1016/j.artd.2022.05.013.Peer-Reviewed Original ResearchTotal knee arthroplastyTotal hip arthroplastyAdverse eventsHS patientsImplant survivalSkin lesionsKaplan-Meier survival curvesNon-HS patientsSurgical site infectionElixhauser Comorbidity IndexInflammatory skin lesionsSpecific adverse eventsLog-rank testPotential risk factorsTotal joint arthroplastyWound-related issuesRisk of woundComorbidity indexAdult patientsSite infectionDegenerative etiologyWound dehiscenceKnee arthroplastyRevision rateRisk factorsSingle-level posterior lumbar fusions in patients with Ehlers Danlos Syndrome not found to be associated with increased postoperative adverse events or five-year reoperations
Gouzoulis MJ, Kammien AJ, Zhu JR, Gillinov SM, Moore HG, Grauer JN. Single-level posterior lumbar fusions in patients with Ehlers Danlos Syndrome not found to be associated with increased postoperative adverse events or five-year reoperations. North American Spine Society Journal (NASSJ) 2022, 11: 100136. PMID: 35783003, PMCID: PMC9241136, DOI: 10.1016/j.xnsj.2022.100136.Peer-Reviewed Original ResearchSingle-level posterior lumbar fusionPosterior lumbar fusionEhlers-Danlos syndromeMinor adverse eventsElixhauser Comorbidity IndexAdverse eventsEDS patientsAdult patientsLumbar fusionDanlos syndromeKaplan-Meier survival curvesRare connective tissue disorderPostoperative adverse eventsRate of reoperationRisk of complicationsNon-ED patientsLog-rank testConnective tissue disordersMultivariate logistical regressionSignificant differencesChi-square testPLF casesComorbidity indexReoperation rateRetrospective studyKMSubtraction: reconstruction of unreported subgroup survival data utilizing published Kaplan-Meier survival curves
Zhao J, Syn N, Tan B, Yap D, Teo C, Chan Y, Sundar R. KMSubtraction: reconstruction of unreported subgroup survival data utilizing published Kaplan-Meier survival curves. BMC Medical Research Methodology 2022, 22: 93. PMID: 35369867, PMCID: PMC8978435, DOI: 10.1186/s12874-022-01567-z.Peer-Reviewed Original ResearchConceptsMonte Carlo simulationsLimits of errorSubgroup survival dataCarlo simulationsSurvival dataKaplan-MeierKaplan-Meier survival curvesExtensive Monte Carlo simulationsOriginal survival dataFollow-up timeCox proportional hazards modelsSubgroups of clinical interestPublished Kaplan-Meier survival curvesMarginal Cox proportional hazards modelsProportional hazards modelMatched patientsSecondary data analysisSystematic errorsSurvival curvesProportion of missing dataHazards modelClinical interestPatientsPrimary manuscriptsKM plotsCharacteristics, Management, and Outcomes of Patients With Osteosarcoma: An Analysis of Outcomes From the National Cancer Database
Ottesen TD, Shultz BN, Munger AM, Sibindi C, Yurter A, Varthi AG, Grauer JN. Characteristics, Management, and Outcomes of Patients With Osteosarcoma: An Analysis of Outcomes From the National Cancer Database. JAAOS Global Research And Reviews 2022, 6: e22.00009. PMID: 35192571, PMCID: PMC8865506, DOI: 10.5435/jaaosglobal-d-22-00009.Peer-Reviewed Original ResearchConceptsLikelihood of deathDistant metastasisKaplan-Meier survival curvesNational Cancer DatabaseOutcomes of patientsPoor prognostic signMultivariate Cox analysisMeier survival curvesAnalysis of outcomesPatient characteristicsCox analysisPrognostic signSurgical excisionMale sexPatient survivalPatient numbersCancer DatabasePatient variablesTumor managementPrimary siteTumor typesSurvival curvesTreatment dataOsteosarcomaPatients
2021
Risk and predictors of mortality after implantable cardioverter-defibrillator implantation in patients with sarcoid cardiomyopathy
Higgins AY, Annapureddy AR, Wang Y, Minges KE, Bellumkonda L, Lampert R, Rosenfeld LE, Jacoby DL, Curtis JP, Miller EJ, Freeman JV. Risk and predictors of mortality after implantable cardioverter-defibrillator implantation in patients with sarcoid cardiomyopathy. American Heart Journal 2021, 246: 21-31. PMID: 34968442, DOI: 10.1016/j.ahj.2021.12.011.Peer-Reviewed Original ResearchConceptsNon-ischemic cardiomyopathyAtrial fibrillation/flutterChronic lung diseaseCardiac sarcoidosisHeart failureCS patientsNICM patientsICD implantationLung diseaseNew York Heart Association class III heart failureNational Cardiovascular Data Registry ICD RegistryNYHA class IV heart failureClass III heart failureClass IV heart failureImplantable cardioverter defibrillator implantationKaplan-Meier survival curvesCox proportional hazards modelPredictors of mortalityCardioverter-defibrillator implantationVentricular ejection fractionMultivariable logistic regressionPrior ventricular arrhythmiasProportional hazards modelRate of deathTime of implantationIdentifying enhancement-based staging markers on baseline MRI in patients with colorectal cancer liver metastases undergoing intra-arterial tumor therapy
Ghani MA, Fereydooni A, Chen E, Letzen B, Laage-Gaupp F, Nezami N, Deng Y, Gan G, Thakur V, Lin M, Papademetris X, Schernthaner RE, Huber S, Chapiro J, Hong K, Georgiades C. Identifying enhancement-based staging markers on baseline MRI in patients with colorectal cancer liver metastases undergoing intra-arterial tumor therapy. European Radiology 2021, 31: 8858-8867. PMID: 34061209, PMCID: PMC8848338, DOI: 10.1007/s00330-021-08058-7.Peer-Reviewed Original ResearchConceptsColorectal cancer liver metastasesCancer liver metastasesTotal tumor volumeIntra-arterial therapyTotal liver volumeLiver metastasesTumor volumeTumor burdenTumor diameterPatient survivalBaseline MRILiver volumeMultivariable Cox proportional hazards modelsKaplan-Meier survival curvesWhole liverCox proportional hazards modelKaplan-Meier methodPrognostic staging systemSurvival of patientsColorectal cancer metastasisMethodsThis retrospective studyPre-treatment MRIProportional hazards modelAppropriate cutoff valueHR 1.7Interplay between RNA Methylation Eraser FTO and Writer METTL3 in Renal Clear Cell Carcinoma Patient Survival
Zhao J, Lu L. Interplay between RNA Methylation Eraser FTO and Writer METTL3 in Renal Clear Cell Carcinoma Patient Survival. Recent Patents On Anti-Cancer Drug Discovery 2021, 16: 363-376. PMID: 33563180, DOI: 10.2174/1574892816666210204125155.Peer-Reviewed Original ResearchConceptsMETTL3 mRNASurvival analysisFTO mRNAKaplan-Meier survival curvesAdjusted hazard ratioMultivariate Cox regressionRenal clear cell carcinomaClear cell carcinomaInflammation-related genesPotential prognostic markerM6A methyltransferase METTL3Upregulation of FTOHazard ratioCox regressionPatient survivalPrognostic valueCell carcinomaPrognostic markerSuperior survivalImmune responseMETTL3 expressionDifferential expressionClinical relevanceLower DNA methylationSurvival curves
2020
Omission of Surgical Axillary Lymph Node Staging in Patients with Tubular Breast Cancer
Özkurt E, Wong S, Rhei E, Golshan M, Brock J, Barbie TU. Omission of Surgical Axillary Lymph Node Staging in Patients with Tubular Breast Cancer. Annals Of Surgical Oncology 2020, 28: 2589-2598. PMID: 33078312, DOI: 10.1245/s10434-020-09223-w.Peer-Reviewed Original ResearchConceptsInvasive ductal carcinomaER-positive invasive ductal carcinomasSurgical axillary stagingNational Cancer DatabaseTubular carcinomaLN involvementAxillary stagingOverall survivalDuctal carcinomaGrade IBreast cancerPositive invasive ductal carcinomaAxillary lymph node stagingKaplan-Meier survival curvesAxillary LN involvementFavorable breast cancerLN-positive diseasePropensity-matched analysisKaplan-Meier methodLymph node metastasisLymph node stagingTubular breast cancerLN diseaseNCDB cohortNodal involvement
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