2025
Serum type I interferon score as a disease activity biomarker in patients with diffuse cutaneous systemic sclerosis: a retrospective cohort study
Hinchcliff M, Khanna D, De Lorenzis E, Di Donato S, Carriero A, Ross R, Huang S, Aren K, Bernstein E, Carns M, Castelino F, Domsic R, Frech T, Gordon J, Hant F, Shah A, Shanmugam V, Steen V, Assassi S, Del Galdo F. Serum type I interferon score as a disease activity biomarker in patients with diffuse cutaneous systemic sclerosis: a retrospective cohort study. The Lancet Rheumatology 2025, 7: e403-e414. PMID: 40179922, PMCID: PMC12107440, DOI: 10.1016/s2665-9913(24)00403-x.Peer-Reviewed Original ResearchConceptsDiffuse cutaneous systemic sclerosisCutaneous systemic sclerosisHealth Assessment Questionnaire-Disability IndexForced Vital CapacitySystemic sclerosisRetrospective cohort studyHealthy controlsIFN scoreIncident cohortDisease activityCohort studyModified Rodnan skin scoreCumulative 5-year mortalityEarly systemic sclerosisRodnan skin scoreSevere systemic sclerosisBaseline forced vital capacityMedian disease durationCohort of patientsDisease activity biomarkersHigh disease activityShorter median disease durationMinimal Clinically Important DifferenceKennedy Trust for Rheumatology ResearchConcentrations of CCL2
2024
A cluster of type I interferon-regulated genes associates with disease activity and prognosis in patients with IgA nephropathy
Qu S, Gan T, Wang Y, Qi Y, Zhang Y, Berthier C, Liu L, Shi S, Lv J, Zhang H, Zhou X. A cluster of type I interferon-regulated genes associates with disease activity and prognosis in patients with IgA nephropathy. International Immunopharmacology 2024, 131: 111920. PMID: 38522142, DOI: 10.1016/j.intimp.2024.111920.Peer-Reviewed Original ResearchIFN-regulated genesIFN-scoreIgAN patientsIgA nephropathyIFN-ITubular atrophy/interstitial fibrosisHigher IFN levelsCox regression analysisPathogenesis of IgA nephropathyType I interferonCross-sectional studyGross hematuriaMucosal infectionsRenal outcomesDisease activityIFN scoreInduce high levelsIFN levelsHealthy controlsMesangial hypercellularityIgANI interferonPatientsTherapeutic targetMicrobial infections
2020
Type I Interferon Gene Signature in Peripheral Blood Mononuclear Cells of Sickle Cell Disease Patients and a Connection to RBC Alloimmunization
Madany E, Lee J, Hendrickson J, Gibb D. Type I Interferon Gene Signature in Peripheral Blood Mononuclear Cells of Sickle Cell Disease Patients and a Connection to RBC Alloimmunization. Blood 2020, 136: 26-27. DOI: 10.1182/blood-2020-142935.Peer-Reviewed Original ResearchFrequency of alloimmunizationInterferon Stimulated GenesHigher IFN scoresInterferon gene signatureSS patientsSickle cell patientsIFN scoreSickle cell diseaseSS diseaseHealthy controlsGene signatureRBC alloimmunizationCell patientsCell diseaseType I interferon gene signaturePeripheral blood mononuclear cellsSickle cell disease patientsInflammatory autoimmune diseaseWhole bloodChronic inflammatory stateType 1 IFNBlood mononuclear cellsIFN gene signatureType 1 interferonMyxovirus resistance protein 1
2016
GG-06 Single cell gene expression studies in lupus patient monocytes reveal novel patterns reflecting disease activity, interferon, and medical treatment
Jin Z, Fan W, Jensen M, Dorschner J, Vsetecka D, Amin S, Makol A, Ernste F, Osborn T, Moder K, Chowdhary V, Niewold T. GG-06 Single cell gene expression studies in lupus patient monocytes reveal novel patterns reflecting disease activity, interferon, and medical treatment. Lupus Science & Medicine 2016, 3: a30. DOI: 10.1136/lupus-2016-000179.58.Peer-Reviewed Original ResearchNon-classical monocytesSLE patientsDisease activityClassical monocytesPatients' monocytesCell gene expressionAnti-dsDNA titersHigh disease activityHigher IFN scoresSLE patient groupAnti-inflammatory genesMonocyte gene expressionPrednisone useGene expressionMedication useClinical featuresInterferon signatureC3 complementIFN scorePatient groupImmunologic characteristicsUnsupervised hierarchical clusteringMedical treatmentPatients
2015
ID: 209 Single cell interferon signatures in lupus patient monocytes reveal a differential impact of interferon signaling between monocyte subtypes
Jin Z, Fan W, Jensen M, Dorschner J, Vsetecka D, Amin S, Makol A, Ernste F, Osborn T, Moder K, Chowdhary V, Niewold T. ID: 209 Single cell interferon signatures in lupus patient monocytes reveal a differential impact of interferon signaling between monocyte subtypes. Cytokine 2015, 76: 102-103. DOI: 10.1016/j.cyto.2015.08.213.Peer-Reviewed Original ResearchSystemic lupus erythematosusHigher IFN scoresClassical monocytesIFN scoreI interferonPatients' monocytesCD16 expressionEffects of IFNHuman systemic lupus erythematosusNon-classical subtypesPrimary pathogenic factorImmune cell populationsNon-classical monocytesCell populationsSingle immune cellsType I interferonPatient blood samplesSLE patientsLupus erythematosusMonocyte subtypesInflammatory mediatorsIFN signatureImmune cellsPathogenic factorsBlood samplesTHU0022 Single Cell Interferon Signatures in Lupus Patient Monocytes Reveal a Differential Impact of Interferon Signaling Between Monocyte Subtypes
Jin Z, Fan W, Jensen M, Dorschner J, Vsetecka D, Amin S, Makol A, Ernste F, Osborn T, Moder K, Chowdhary V, Niewold T. THU0022 Single Cell Interferon Signatures in Lupus Patient Monocytes Reveal a Differential Impact of Interferon Signaling Between Monocyte Subtypes. Annals Of The Rheumatic Diseases 2015, 74: 200. DOI: 10.1136/annrheumdis-2015-eular.5326.Peer-Reviewed Original ResearchSystemic lupus erythematosusHigher IFN scoresClassical monocytesIFN scoreI interferonSLE patientsCD16 expressionEffects of IFNHuman systemic lupus erythematosusNon-classical subtypesPrimary pathogenic factorImmune cell populationsNon-classical monocytesCell populationsSingle immune cellsType I interferonPatient blood samplesLupus erythematosusMonocyte subtypesInflammatory mediatorsInterferon signatureIndividual monocytesPatients' monocytesIFN signatureImmune cells
2006
Association of increased interferon‐inducible gene expression with disease activity and lupus nephritis in patients with systemic lupus erythematosus
Feng X, Wu H, Grossman J, Hanvivadhanakul P, FitzGerald J, Park G, Dong X, Chen W, Kim M, Weng H, Furst D, Gorn A, McMahon M, Taylor M, Brahn E, Hahn B, Tsao B. Association of increased interferon‐inducible gene expression with disease activity and lupus nephritis in patients with systemic lupus erythematosus. Arthritis & Rheumatism 2006, 54: 2951-2962. PMID: 16947629, DOI: 10.1002/art.22044.Peer-Reviewed Original ResearchConceptsSystemic lupus erythematosus patientsSystemic lupus erythematosusActive renal diseaseLupus nephritis patientsIFN scoreDisease activityLupus erythematosusNephritis patientsLupus nephritisPresence of anti-double-stranded DNARenal diseaseNormal controlsPhysician Global Assessment scoreAnti-dsDNA antibody positivityAnti-double-stranded DNAHigher IFN scoresInactive lupus nephritisSafety of EstrogensGlobal assessment scoreAssociated with neurological manifestationsAssociated with proteinuriaLupus nephritis therapyPeripheral blood cellsRheumatic disease controlsExpression levels
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