2025
Impact of Preoperative LDL Level on Lower Extremity Revascularization Outcomes
Carter W, Alappan U, Chetty A, Wells N, Alameddine D, Slade M, Possick S, Ochoa Chaar C. Impact of Preoperative LDL Level on Lower Extremity Revascularization Outcomes. Annals Of Vascular Surgery 2025, 122: 239-247. PMID: 40651525, DOI: 10.1016/j.avsg.2025.07.016.Peer-Reviewed Original ResearchLower extremity revascularizationPeripheral arterial diseaseRetrospective chart reviewProportion of patientsRetrospective chart review of patientsChart review of patientsLDL testingReview of patientsCox regression analysisAdverse cardiovascular eventsChronic limb-threatening ischemiaHybrid lower extremity revascularizationBurden of comorbiditiesAssociated with outcomeLimb-threatening ischemiaOld white maleBaseline LDLTertiary centerStatin useLipid testingCardiovascular eventsFollow-upLDL levelsLower LDLRevascularization outcomes
2023
Efficacy and safety of alirocumab in children and adolescents with heterozygous familial hypercholesterolaemia inadequately controlled with statins
Santos R, Wiegman A, Caprio S, Cariou B, Averna M, Poulouin Y, Scemama M, Manvelian G, Garon G, Daniels S. Efficacy and safety of alirocumab in children and adolescents with heterozygous familial hypercholesterolaemia inadequately controlled with statins. European Heart Journal 2023, 44: ehad655.2809. DOI: 10.1093/eurheartj/ehad655.2809.Peer-Reviewed Original ResearchProprotein convertase subtilisin/kexin type 9Safety of alirocumabKey secondary endpointHeterozygous familial hypercholesterolaemiaWeek 24Secondary endpointsPediatric patientsLipid parametersFamilial hypercholesterolaemiaTreatment periodTreatment groupsInternational phase 3 trialConvertase subtilisin/kexin type 9Subtilisin/kexin type 9Atherogenic lipid parametersEfficacy of alirocumabMean baseline LDLOpen-label periodPhase 3 trialLDL cholesterol levelsSignificant treatment differencesAlirocumab treatmentBaseline LDLPlacebo Q2WWeek 104
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