2025
Prophylactic anticoagulant therapy is associated with improved survival in ICU patients with non-COVID-19 pneumonia: a retrospective cohort study
Hu H, Zhu Y, Hu R, Zhao L, Zeng X, Wu X, Qiu R, Nie Y, Sharma L, Chang D. Prophylactic anticoagulant therapy is associated with improved survival in ICU patients with non-COVID-19 pneumonia: a retrospective cohort study. Frontiers In Pharmacology 2025, 16: 1597885. PMID: 40406481, PMCID: PMC12095157, DOI: 10.3389/fphar.2025.1597885.Peer-Reviewed Original ResearchProphylactic anticoagulant therapyShort-term mortalityKaplan-Meier survival analysisAnticoagulant therapyICU patientsPropensity score matchingPulmonary infectionImproved survivalNon-COVID-19Subgroup analysisNon-COVID-19 pneumoniaDuration of anticoagulant therapyAssociated with improved survivalMultivariate Cox regression modelSurvival analysisEffect of anticoagulant therapyMedical Information Mart for Intensive Care IV databaseCox regression analysisRetrospective cohort studyAssociated with reduced short-term mortalityOptimal administration strategiesCox regression modelsPrognostic factorsAnticoagulation groupCoagulation disorders
2023
Easing Suffering for ICU Patients and Their Families: Evidence and Opportunities for Primary and Specialty Palliative Care in the ICU
Doherty C, Feder S, Gillespie-Heyman S, Akgün K. Easing Suffering for ICU Patients and Their Families: Evidence and Opportunities for Primary and Specialty Palliative Care in the ICU. Journal Of Intensive Care Medicine 2023, 39: 715-732. PMID: 37822226, DOI: 10.1177/08850666231204305.Peer-Reviewed Original ResearchSurrogate decision makersPalliative needsCritical illnessICU patientsPalliative medicineIntensive care unit admissionChronic critical illnessPalliative medicine teamsPost-ICU disabilitySpecialty palliative careCare unit admissionTransitions of careImprovement of patientsAdvanced practice nursesFamily-centered carePerson-centred careUnit admissionICU carePalliative supportPalliative carePractice nursesPalliative principlesMedicine teamPatientsICUAtorvastatin versus Placebo in ICU Patients with COVID-19: Ninety-day Results of the INSPIRATION-S Trial
Talasaz A, Sadeghipour P, Bakhshandeh H, Sharif-Kashani B, Rashidi F, Beigmohammadi M, Moghadam K, Rezaian S, Dabbagh A, Sezavar S, Farrokhpour M, Abedini A, Aliannejad R, Riahi T, Yadollahzadeh M, Lookzadeh S, Rezaeifar P, Matin S, Tahamtan O, Mohammadi K, Zoghi E, Rahmani H, Hosseini S, Mousavian S, Abri H, Sadeghipour P, Baghizadeh E, Rafiee F, Jamalkhani S, Amin A, Mohebbi B, Parhizgar S, Soleimanzadeh M, Aghakouchakzadeh M, Eslami V, Payandemehr P, Khalili H, Talakoob H, Tojari T, Shafaghi S, Tabrizi S, Kakavand H, Kashefizadeh A, Najafi A, Jimenez D, Gupta A, Madhavan M, Sethi S, Parikh S, Monreal M, Hadavand N, Hajighasemi A, Ansarin K, Maleki M, Sadeghian S, Barco S, Siegerink B, Spatz E, Piazza G, Kirtane A, Tassell B, Lip G, Klok F, Goldhaber S, Stone G, Krumholz H, Bikdeli B. Atorvastatin versus Placebo in ICU Patients with COVID-19: Ninety-day Results of the INSPIRATION-S Trial. Thrombosis And Haemostasis 2023, 123: 723-733. PMID: 36944357, DOI: 10.1055/a-2059-4844.Peer-Reviewed Original ResearchConceptsExtracorporeal membrane oxygenationArterial thrombosisMAIN OUTCOMEAtorvastatin 20Symptom onsetICU patientsFunctional statusIntensive care unit patientsCOVID-19Double-blind multicenterAdult ICU patientsCare unit patientsThrombo-inflammatory responseCoronavirus disease 2019Meaningful treatment effectPrespecified studyCause mortalityAtorvastatin useUnit patientsMembrane oxygenationFunctional outcomeDisease 2019Functional scalesPlaceboPatients
2022
Imaging in the Intensive Care Unit
Toy D, Siegel M, Rubinowitz A. Imaging in the Intensive Care Unit. Seminars In Respiratory And Critical Care Medicine 2022, 43: 899-923. PMID: 36442475, DOI: 10.1055/s-0042-1750041.Peer-Reviewed Original ResearchConceptsICU patientsIll patientsPathologic disease statesInterstitial lung diseaseIntensive care unitCT pulmonary angiographySpecific clinical scenariosModality of choicePortable chest radiographsHospital courseRadiologic manifestationsCare unitPleural effusionPulmonary angiographyLung diseaseICU settingChest radiographsSmall pneumothoracesRadiographic examinationAdditional abnormalitiesPatientsClinical scenariosPatient careInvasive devicesDiagnostic accuracySWEAT ICU—An Observational Study of Physician Workload and the Association of Physician Outcomes in Academic ICUs
Agarwal A, Chen JT, Coopersmith CM, Denson JL, Dickert NW, Ferrante LE, Gershengorn HB, Gosine AD, Hayward BJ, Kaur N, Khan A, Lamberton C, Landsittel D, Lyons PG, Mikkelsen ME, Nadig NR, Pietropaoli AP, Poole BR, Viglianti EM, Sevransky JE, Network O. SWEAT ICU—An Observational Study of Physician Workload and the Association of Physician Outcomes in Academic ICUs. Critical Care Explorations 2022, 4: e0774. PMID: 36259061, PMCID: PMC9575792, DOI: 10.1097/cce.0000000000000774.Peer-Reviewed Original ResearchPatient mortalityICU physiciansObservational studyStudy daysPhysician workloadCross-sectional observational studyMultivariable logistic regression modelAdult ICU patientsSecondary outcome measuresPhysician burnoutNumber of patientsOptimal staffing modelLogistic regression modelsMedian patientICU patientsPrimary outcomeWell-Being IndexPrimary exposurePhysician careOverall prevalencePatient outcomesAcademic ICUsOutcome measuresDay 28Binomial mixed effects modelsPsychological Attachment Orientation and Long-Term Posttraumatic Stress Symptoms Among Family Members of ICU Patients
Zhang Q, Knies AK, Pach J, Kimbrough T, Martinez A, Juthani P, Tu S, Monin JK, Vranceanu AM, Hwang DY. Psychological Attachment Orientation and Long-Term Posttraumatic Stress Symptoms Among Family Members of ICU Patients. Critical Care Explorations 2022, 4: e0753. PMID: 36050994, PMCID: PMC9426807, DOI: 10.1097/cce.0000000000000753.Peer-Reviewed Original ResearchICU patientsPTSD symptomsICU dischargeHispanic ethnicityFamily meetingsFamily membersICU patients' family membersProspective cohort studyMultiple logistic regressionLong-term PTSD symptomsPatients' family membersHigh-risk categoryLonger-term posttraumatic stress symptomsPosttraumatic stress disorder (PTSD) symptomsNeuroscience ICUEvent Scale-RevisedCohort studyIndependent predictorsPatient characteristicsRisk factorsPatient deathUnivariate analysisPatient covariatesSignificant symptomsPsychologic outcomesSleep Disruption and its Relationship to ICU Outcomes
Tobias L, Pisani M, D’Ambrosio C. Sleep Disruption and its Relationship to ICU Outcomes. 2022, 175-190. DOI: 10.1007/978-3-031-06447-0_11.Peer-Reviewed Original ResearchCritical illnessSleep disruptionSleep deprivationDevelopment of deliriumImpairs glucose metabolismAdverse patient outcomesPoor quality sleepCircadian rhythm disturbancesPatient care interventionsImportant clinical consequencesAcute sleep deprivationICU morbidityICU populationICU patientsICU outcomesVentilator weaningRhythm disturbancesPatient outcomesCare interventionsSleep architectureClinical consequencesImmune functionNeurocognitive impairmentGlucose metabolismQuality sleepBest Practice for Improving Sleep in the ICU. Part I: Non-pharmacologic
Korwin A, Knauert M. Best Practice for Improving Sleep in the ICU. Part I: Non-pharmacologic. 2022, 231-248. DOI: 10.1007/978-3-031-06447-0_14.ChaptersIntensive care unitICU patientsNormal sleepCritical care treatmentNon-pharmacologic therapiesNon-pharmacologic interventionsMost ICU patientsAbnormal circadian rhythmPoor quality sleepCircadian functionAcute illnessCritical illnessPatient characteristicsIll adultsCare unitChronotherapeutic interventionsCare treatmentSleep preferenceCurrent evidencePatient careCircadian disruptionSleepPatientsFuture interventionsPractice changeLong-term recovery after critical illness in older adults
Kaushik R, Ferrante LE. Long-term recovery after critical illness in older adults. Current Opinion In Critical Care 2022, 28: 572-580. PMID: 35950731, PMCID: PMC9458622, DOI: 10.1097/mcc.0000000000000981.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsOlder ICU patientsPost-ICU recoveryCritical illnessGeriatric syndromesLong-term recoveryOlder adultsICU patientsRisk factorsIncidence of frailtyOlder ICU survivorsTransitional care programLong-term outcomesContinuum of careSocial isolationRecent epidemiologic workSocial risk factorsICU survivorsRecent literature pertainingUnique needsRecent longitudinal studiesNew disabilityWorse outcomesFunctional declineCare programSyndromeEffects of Ketamine Infusion on Breathing and Encephalography in Spontaneously Breathing ICU Patients
Suleiman A, Santer P, Munoz-Acuna R, Hammer M, Schaefer MS, Wachtendorf LJ, Rumyantsev S, Berra L, Chamadia S, Johnson-Akeju O, Baedorf-Kassis EN, Eikermann M. Effects of Ketamine Infusion on Breathing and Encephalography in Spontaneously Breathing ICU Patients. Journal Of Intensive Care Medicine 2022, 38: 299-306. PMID: 35934953, DOI: 10.1177/08850666221119716.Peer-Reviewed Original ResearchConceptsSpontaneous breathing trialKetamine infusionMcg/Inspiratory flowInspiratory workKey secondary endpointProspective interventional studyEnd-expiratory pressurePre-specified time pointsKetamine 10Breathing trialSecondary endpointsPrimary outcomeICU patientsIll patientsMechanical ventilationEsophageal pressureInfusion regimenInterventional studyPropofol sedationRespiratory timingResistive workAirway flowPreclinical studiesElectroencephalographic patternsDurable functional limitation in patients with coronavirus disease-2019 admitted to intensive care and the effect of intermediate-dose vs standard-dose anticoagulation on functional outcomes
INVESTIGATORS I, Sadeghipour P, Talasaz A, Barco S, Bakhshandeh H, Rashidi F, Rafiee F, Rezaeifar P, Jamalkhani S, Matin S, Baghizadeh E, Tahamtan O, Sharif-Kashani B, Beigmohammadi M, Farrokhpour M, Sezavar S, Payandemehr P, Dabbagh A, Moghadam K, Jimenez D, Monreal M, Maleki M, Siegerink B, Spatz E, Piazza G, Parikh S, Kirtane A, Van Tassell B, Lip G, Goldhaber S, Klok F, Krumholz H, Bikdeli B. Durable functional limitation in patients with coronavirus disease-2019 admitted to intensive care and the effect of intermediate-dose vs standard-dose anticoagulation on functional outcomes. European Journal Of Internal Medicine 2022, 103: 76-83. PMID: 35879217, PMCID: PMC9212871, DOI: 10.1016/j.ejim.2022.06.014.Peer-Reviewed Original ResearchConceptsStandard-dose prophylactic anticoagulationPatient Health Questionnaire-2Proportion of patientsProphylactic anticoagulationIntermediate doseFunctional limitationsDepressive symptomsFunctional outcomeCOVID-19Intensive care unit hospitalizationCritically ill patientsMultiple organ failureSevere functional limitationsFunctional Status ScaleCoronavirus disease 2019Open labelExercise limitationAirway diseaseICU patientsOrgan failureIntensive careStatus ScaleClinical trialsGrade 3AnticoagulationTrends in Geriatric Conditions Among Older Adults Admitted to US ICUs Between 1998 and 2015
Cobert J, Jeon SY, Boscardin J, Chapman AC, Ferrante LE, Lee S, Smith AK. Trends in Geriatric Conditions Among Older Adults Admitted to US ICUs Between 1998 and 2015. CHEST Journal 2022, 161: 1555-1565. PMID: 35026299, PMCID: PMC9248079, DOI: 10.1016/j.chest.2021.12.658.Peer-Reviewed Original ResearchConceptsICU admissionPre-existing disabilityGeriatric conditionsOlder adultsSelf-reported chronic diseasesPatients 65 yearsRate of dementiaICU patientsAdverse outcomesICU settingChronic diseasesAdjusted proportionDaily livingMultimorbidityICUAdmissionGeriatric principlesFrailtyDementiaUS ICUsFunctional measuresStudy designDisabilityAdultsTime trends
2021
Association of Surge Conditions with Mortality Among Critically Ill Patients with COVID-19
Keene A, Admon A, Brenner S, Gupta S, Lazarous D, Leaf D, Gershengorn H, Walther C, Anumudu S, Arunthamakun J, Kopecky K, Milligan G, McCullough P, Nguyen T, Shaefi S, O’Gara B, Krajewski M, Baskin S, Shankar S, Valencia J, Pannu A, Hayes M, Grandin E, Waikar S, Kibbelaar Z, Athavale A, Hart P, Upadhyay S, Vohra I, Oyintayo A, Green A, Rachoin J, Schorr C, Shea L, Edmonston D, Mosher C, Shehata A, Cohen Z, Allusson V, Bambrick-Santoyo G, ul aain Bhatti N, Mehta B, Williams A, Brenner S, Walters P, Go R, Rose K, Hernán; M, Lisk R, Chan L, Mathews K, Coca S, Altman D, Saha A, Soh H, Wen H, Bose S, Leven E, Wang J, Mosoyan G, Nadkarni G, Pattharanitima P, Gallagher E, Friedman A, Guirguis J, Kapoor R, Meshberger C, Kelly K, Parikh C, Garibaldi B, Corona-Villalobos C, Wen Y, Menez S, Malik R, Elena Cervantes C, Gautam S, Mallappallil M, Ouyang J, John S, Yap E, Melaku Y, Mohamed I, Bajracharya S, Puri I, Thaxton M, Bhattacharya J, Wagner J, Boudourakis L, Nguyen H, Ahoubim A, Thomas L, Sirganagari D, Guru P, Kashani K, Tehranian S, Zhou Y, Bergl P, Rodriguez J, Shah J, Gupta M, Kumar P, Lazarous D, Kassaye S, Melamed M, Johns T, Mocerino R, Prudhvi K, Zhu D, Levy R, Azzi Y, Fisher M, Yunes M, Sedaliu K, Golestaneh L, Brogan M, Kumar N, Chang M, Thakkar J, Raichoudhury R, Athreya A, Farag M, Schenck E, Jung Cho S, Plataki M, Alvarez-Mulett S, Gomez-Escobar L, Pan D, Lee S, Krishnan J, Whalen W, Charytan D, Macina A, Chaudhry S, Wu B, Modersitzki F, Srivastava A, Leidner A, Martinez C, Kruser J, Wunderink R, Hodakowski A, Velez J, Price-Haywood E, Matute-Trochez L, Hasty A, Mohamed M, Avasare R, Zonies D, Leaf D, Gupta S, Sise M, Newman E, Abu Omar S, Pokharel K, Sharma S, Singh H, Correa S, Shaukat T, Kamal O, Wang W, Yang H, Boateng J, Lee M, Strohbehn I, Li J, Mueller A, Redfern R, Cairl N, Naimy G, Abu-Saif A, Hall D, Bickley L, Rowan C, Madhani-Lovely F, Peev V, Reiser J, Byun J, Vissing A, Kapania E, Post Z, Patel N, Hermes J, Sutherland A, Patrawalla A, Finkel D, Danek B, Arikapudi S, Paer J, Cangialosi P, Liotta M, Radbel J, Puri S, Sunderram J, Scharf M, Ahmed A, Berim I, Vatson J, Anand S, Levitt J, Garcia P, Boyle S, Song R, Arif A, Zhang J, Woo S, Deng X, Katz-Greenberg G, Senter K, Sharshir M, Rusnak V, Imran Ali M, Peters T, Hughes K, Bansal A, Podoll A, Chonchol M, Sharma S, Burnham E, Rashidi A, Hejal R, Judd E, Latta L, Tolwani A, Albertson T, Adams J, Chang S, Beutler R, Schulze C, Macedo E, Rhee H, Liu K, Jotwani V, Koyner J, Kunczt A, Shah C, Jaikaransingh V, Toth-Manikowski S, Joo M, Lash J, Neyra J, Chaaban N, Elias M, Ahmad Y, Dy R, Iardino A, Au E, Sharma J, Anne Sosa M, Taldone S, Contreras G, De La Zerda D, Fornoni A, Gershengorn H, Hayek S, Blakely P, Berlin H, Azam T, Shadid H, Pan M, O” Hayer P, Meloche C, Feroze R, Padalia K, Bitar A, Leya J, Donnelly J, Admon A, Flythe J, Tugman M, Chang E, Brown B, Leonberg-Yoo A, Spiardi R, Miano T, Roche M, Vasquez C, Bansal A, Ernecoff N, Kapoor S, Verma S, Chen H, Kovesdy C, Molnar M, Azhar A, Susan Hedayati S, Nadamuni M, Shastri S, Willett D, Short S, Renaghan A, Enfield K, Bhatraju P, Bilal Malik A, Semler M, Vijayan A, Mariyam Joy C, Li T, Goldberg S, Kao P, Schumaker G, Goyal N, Faugno A, Schumaker G, Hsu C, Tariq A, Meyer L, Kshirsagar R, Jose A, Weiner D, Christov M, Chugh S, Griffiths J, Gupta S, Kapoor A, Chugh S, Wilson P, Arora T, Ugwuowo U. Association of Surge Conditions with Mortality Among Critically Ill Patients with COVID-19. Journal Of Intensive Care Medicine 2021, 37: 500-509. PMID: 34939474, PMCID: PMC8926920, DOI: 10.1177/08850666211067509.Peer-Reviewed Original ResearchConceptsOdds of deathCOVID-19Multicenter cohort studySubstantial excess mortalityHospital mortalityCohort studyConsecutive adultsICU patientsIll patientsSurge periodMultivariable differenceU.S. ICUsExcess mortalityMAIN OUTCOMEHigh incidenceICUHospitalMortalityPatientsInverse probabilityU.S. hospitalsAdmissionCohortDeathOddsProteomic Profiles in Patients with Thrombosis Due to COVID-19 Are Distinct from Non-COVID-19 Thrombosis
Madeeva D, Borges K, Shallow M, Juthani P, Wang S, Gupta A, Chun H, Lee A, Pine A. Proteomic Profiles in Patients with Thrombosis Due to COVID-19 Are Distinct from Non-COVID-19 Thrombosis. Blood 2021, 138: 777. PMCID: PMC8701622, DOI: 10.1182/blood-2021-153959.Peer-Reviewed Original ResearchSerum amyloid ACOVID-19 patientsVenous thromboembolismCOVID-19 infectionLipocalin-2Thromboembolic eventsThromboembolic complicationsPentraxin 3Complement factors C2COVID-19Lower extremity Doppler ultrasoundTissue factorComplement activationCell adhesion molecule-1Pathogenesis of thromboembolismInstitutional review board approvalChest CT angiographyAdhesion molecule-1Endothelial cell adhesion molecule-1Novel therapeutic strategiesSodium citrate tubesReview board approvalClassical complement pathwayRadiologic confirmationICU patientsMachine Learning Prediction of Death in Critically Ill Patients With Coronavirus Disease 2019
Churpek MM, Gupta S, Spicer AB, Hayek SS, Srivastava A, Chan L, Melamed ML, Brenner SK, Radbel J, Madhani-Lovely F, Bhatraju PK, Bansal A, Green A, Goyal N, Shaefi S, Parikh CR, Semler MW, Leaf DE, Walther C, Anumudu S, Arunthamakun J, Kopecky K, Milligan G, McCullough P, Nguyen T, Shaefi S, Krajewski M, Shankar S, Pannu A, Valencia J, Waikar S, Kibbelaar Z, Athavale A, Hart P, Ajiboye O, Itteera M, Green A, Rachoin J, Schorr C, Shea L, Edmonston D, Mosher C, Shehata A, Cohen Z, Allusson V, Bambrick-Santoyo G, Bhatti N, Metha B, Williams A, Brenner S, Walters P, Go R, Rose K, Hernán M, Zhou A, Kim E, Lisk R, Chan L, Mathews K, Coca S, Altman D, Saha A, Soh H, Wen H, Bose S, Leven E, Wang J, Mosoyan G, Nadkarni G, Friedman A, Guirguis J, Kapoor R, Meshberger C, Parikh C, Garibaldi B, Corona-Villalobos C, Wen Y, Menez S, Malik R, Cervantes C, Gautam S, Chang C, Nguyen H, Ahoubim A, Thomas L, Guru P, Bergl P, Zhou Y, Rodriguez J, Shah J, Gupta M, Kumar P, Lazarous D, Kassaye S, Melamed M, Johns T, Mocerino R, Prudhvi K, Zhu D, Levy R, Azzi Y, Fisher M, Yunes M, Sedaliu K, Golestaneh L, Brogan M, Thakkar J, Kumar N, Ross M, Chang M, Raichoudhury R, Schenck E, Cho S, Plataki M, Alvarez-Mulett S, Gomez-Escobar L, Pan D, Lee S, Krishnan J, Whalen W, Charytan D, Macina A, Ross D, Srivastava A, Leidner A, Martinez C, Kruser J, Wunderink R, Hodakowski A, Velez J, Price-Haywood E, Matute-Trochez L, Hasty A, Mohamed M, Avasare R, Zonies D, Leaf D, Gupta S, Baron R, Sise M, Newman E, Abu Omar S, Pokharel K, Sharma S, Singh H, Gaviria S, Shaukat T, Kamal O, Wang W, Yang H, Boateng J, Lee M, Strohbehn I, Li J, Muhsin S, Mandel E, Mueller A, Cairl N, Madhani-Lovely F, Rowan C, Madhai-Lovely F, Peev V, Reiser J, Byun J, Vissing A, Kapania E, Post Z, Patel N, Hermes J, Sutherland A, Patrawalla A, Finkel D, Danek B, Arikapudi S, Paer J, Radbel J, Puri S, Sunderram J, Scharf M, Ahmed A, Berim I, Vatson J, Anand S, Levitt J, Garcia P, Boyle S, Song R, Zhang J, Sharshir M, Rusnak V, Bansal A, Podoll A, Chonchol M, Sharma S, Burnham E, Rashidi A, Hejal R, Judd E, Latta L, Tolwani A, Albertson T, Adams J, Chang S, Beutler R, Schulze C, Macedo E, Rhee H, Liu K, Jotwani V, Koyner J, Shah C, Jaikaransingh V, Toth-Manikowski S, Joo M, Lash J, Neyra J, Chaaban N, Iardino A, Au E, Sharma J, Sosa M, Taldone S, Contreras G, De La Zerda D, Gershengorn H, Hayek S, Blakely P, Berlin H, Azam T, Shadid H, Pan M, Hayer P, Meloche C, Feroze R, Padalia K, Leya J, Donnelly J, Admon A, Flythe J, Tugman M, Brown B, Leonberg-Yoo A, Spiardi R, Miano T, Roche M, Vasquez C, Bansal A, Ernecoff N, Kovesdy C, Molnar M, Hedayati S, Nadamuni M, Khan S, Willett D, Short S, Renaghan A, Bhatraju P, Malik A, Semler M, Vijayan A, Joy C, Li T, Goldberg S, Kao P, Schumaker G, Goyal N, Faugno A, Schumaker G, Hsu C, Tariq A, Meyer L, Christov M, Wilson F, Arora T, Ugwuowo U. Machine Learning Prediction of Death in Critically Ill Patients With Coronavirus Disease 2019. Critical Care Explorations 2021, 3: e0515. PMID: 34476402, PMCID: PMC8378790, DOI: 10.1097/cce.0000000000000515.Peer-Reviewed Original ResearchSequential Organ Failure Assessment scoreOrgan Failure Assessment scoreNational Early Warning ScoreCoronavirus disease 2019Early Warning ScoreDisease 2019CURB-65Warning ScoreIll patientsAssessment scoresModified Sequential Organ Failure Assessment scoreCharacteristic curveExternal validationCritically ill patientsClinical trial enrichmentPrognostic enrichmentICU admissionInhospital mortalityAdult patientsHighest areaICU patientsPrimary outcomeArterial pHTrial enrichmentU.S. ICUsThe Use of Aerosolized Medications in Adult Intensive Care Unit Patients: A Prospective, Multicenter, Observational, Cohort Study
Lyu S, Li J, Wu M, He D, Fu T, Ni F, Tan X, Wu G, Pan B, Li L, Wang H, Zeng G, Ni Z, Tan W, Zong Y, Chen L, Liu P, Qin H, He P, Zhang L, An Y, Liang Z, Xie L, Li Y, Zhou M, Li Q, Zhao J, Fang B, Ma Y, Huang R, Guo W, Dong X, Huang X, MO G, Xia J, Xiao K, Zhao H, Kong X, Zhao H, Ma J, Gao P, Yang W, Han F, Dong Y, Ye L, Chen C, Bao Z, Liu Y, Zheng C, Miao L, Yao M, Wang W, Wei S, Li H, Luo F, Liang G, Li J, Zhang C, Dai L, Song L, Wang C, Wang S. The Use of Aerosolized Medications in Adult Intensive Care Unit Patients: A Prospective, Multicenter, Observational, Cohort Study. Journal Of Aerosol Medicine And Pulmonary Drug Delivery 2021, 34: 383-391. PMID: 34129389, DOI: 10.1089/jamp.2021.0004.Peer-Reviewed Original ResearchConceptsIntensive care unitAerosol therapyAerosolized medicationsCohort studySide effectsShort-acting muscarinic antagonistsCombination of inhaled corticosteroidsChronic obstructive pulmonary disease exacerbationsIntensive care unit patientsSpontaneously breathing patientsAdult intensive care unit patientsAdult ICU patientsChinese ICUsBreathing patientsRespiratory supportMuscarinic antagonistInhaled CorticosteroidsAdult patientsClinical outcomesMechanical ventilationDisease exacerbationUnit patientsCare unitConclusion:</i></b>ICU patients
2020
Pilot Observational Study to Detect Diurnal Variation and Misalignment in Heart Rate Among Critically Ill Patients
Knauert MP, Murphy TE, Doyle MM, Pisani MA, Redeker NS, Yaggi HK. Pilot Observational Study to Detect Diurnal Variation and Misalignment in Heart Rate Among Critically Ill Patients. Frontiers In Neurology 2020, 11: 637. PMID: 32760341, PMCID: PMC7373742, DOI: 10.3389/fneur.2020.00637.Peer-Reviewed Original ResearchMedical ICU admissionIntensive care unitHeart rateIll patientsICU admissionCircadian alignmentMedical record chart abstractionsProspective observational cohort studyCircadian disruptionMedical ICU patientsObservational cohort studyCritical illness outcomesPilot observational studyContinuous telemetric monitoringChart abstractionExploratory analysisCohort studyCritical illnessHospital admissionICU patientsCare unitPatient interviewsFrequent bloodOdds ratioObservational studyEndotheliopathy in COVID-19-associated coagulopathy: evidence from a single-centre, cross-sectional study
Goshua G, Pine AB, Meizlish ML, Chang CH, Zhang H, Bahel P, Baluha A, Bar N, Bona RD, Burns AJ, Dela Cruz CS, Dumont A, Halene S, Hwa J, Koff J, Menninger H, Neparidze N, Price C, Siner JM, Tormey C, Rinder HM, Chun HJ, Lee AI. Endotheliopathy in COVID-19-associated coagulopathy: evidence from a single-centre, cross-sectional study. The Lancet Haematology 2020, 7: e575-e582. PMID: 32619411, PMCID: PMC7326446, DOI: 10.1016/s2352-3026(20)30216-7.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overBetacoronavirusBiomarkersBlood Coagulation DisordersCoronavirus InfectionsCOVID-19Critical IllnessCross-Sectional StudiesEndothelium, VascularFemaleFollow-Up StudiesHumansIntensive Care UnitsMaleMiddle AgedPandemicsPneumonia, ViralPrognosisSARS-CoV-2Vascular DiseasesYoung AdultConceptsCOVID-19-associated coagulopathyNon-ICU patientsIntensive care unitKaplan-Meier analysisSoluble P-selectinCross-sectional studyPlatelet activationHospital dischargeICU patientsSoluble thrombomodulinEndothelial cellsVWF antigenCOVID-19P-selectinSingle-center cross-sectional studyLaboratory-confirmed COVID-19Medical intensive care unitSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pathogenesisVon Willebrand factor antigenSoluble thrombomodulin concentrationsVWF antigen concentrationEndothelial cell injurySoluble CD40 ligandMicrovascular complicationsAdult patientsEvaluating the Clinical Impact of Rapid Response Electroencephalography: The DECIDE Multicenter Prospective Observational Clinical Study.
Vespa PM, Olson DM, John S, Hobbs KS, Gururangan K, Nie K, Desai MJ, Markert M, Parvizi J, Bleck TP, Hirsch LJ, Westover MB. Evaluating the Clinical Impact of Rapid Response Electroencephalography: The DECIDE Multicenter Prospective Observational Clinical Study. Critical Care Medicine 2020, 48: 1249-1257. PMID: 32618687, PMCID: PMC7735649, DOI: 10.1097/ccm.0000000000004428.Peer-Reviewed Original ResearchConceptsNonconvulsive seizuresSeizure diagnosisTreatment planProspective observational clinical studyDiagnostic assessmentObservational clinical studyAssessment of patientsCritical care settingSerious adverse effectsTherapeutic decision makingProspective multicenterSecondary outcomesICU patientsPrimary outcomeStatus epilepticusHigh suspicionElectroencephalography assessmentAcademic hospitalBedside assessmentClinical impactClinical studiesObservational studyCare settingsPhysician confidencePatientsComplement related pattern recognition molecules as markers of short-term mortality in intensive care patients
Hansen C, Bayarri-Olmos R, Kristensen M, Pilely K, Hellemann D, Garred P. Complement related pattern recognition molecules as markers of short-term mortality in intensive care patients. Journal Of Infection 2020, 80: 378-387. PMID: 31981636, DOI: 10.1016/j.jinf.2020.01.010.Peer-Reviewed Original ResearchConceptsIntensive care unitSeptic shockFicolin-2Ficolin-2 levelsIntensive care patientsShort-term mortalityPattern recognition moleculesPTX3 levelsCRP levelsCare patientsICU patientsAdjusted analysisCare unitChronic diseasesMBL levelsBlood samplesBaseline levelsPatientsDisease severityChances of survivalGood markerPTX3MortalityCRPSurvivors
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