2025
Cerebrospinal Fluid Biomarkers and Cognition in Alzheimer Disease and Frontotemporal Dementia in a Memory Clinic Setting
Cayir S, Sadabad F, Mecca A, Matuskey D, Fesharaki-Zadeh A. Cerebrospinal Fluid Biomarkers and Cognition in Alzheimer Disease and Frontotemporal Dementia in a Memory Clinic Setting. Alzheimer Disease & Associated Disorders 2025, 39: 22-27. PMID: 40397510, DOI: 10.1097/wad.0000000000000656.Peer-Reviewed Original ResearchMoCA scoresMemory clinic settingHospital memory clinicCognitive performanceMontreal Cognitive AssessmentFrontotemporal dementiaAlzheimer's diseaseCognitive test scoresP-tauMemory clinicElectronic records of patientsRetrospective cohort studyT-tauCohort studyCognitive AssessmentElectronic recordsMoCACerebrospinal fluidRecords of patientsIndex scoreTau-related pathologyClinical settingDementiaConcentrations of T-tauScores
2024
Correlation between changes in apathy and cognition in Alzheimer’s disease associated apathy: analysis of the Apathy in Dementia Methylphenidate Trial 2 (ADMET 2)
Sankhe K, Tumati S, Perin J, Rivet L, Vieira D, Rosenberg P, Herrmann N, Shade D, Lerner A, Padala P, Brawman‐Mintzer O, van Dyck C, Porsteinsson A, Craft S, Levey A, Mintzer J, Lanctôt K. Correlation between changes in apathy and cognition in Alzheimer’s disease associated apathy: analysis of the Apathy in Dementia Methylphenidate Trial 2 (ADMET 2). Alzheimer's & Dementia 2024, 20: e091793. PMCID: PMC11710533, DOI: 10.1002/alz.091793.Peer-Reviewed Original ResearchMini-Mental State ExamBoston Naming TestDigit Span ForwardCategory fluencyWorsening apathyNPI-aCognitive testsAlzheimer's diseaseCognitive change scoresAssociated with cognitive impairmentBaseline cognitive test scoresCognitive test scoresMild to moderate ADAssociated with performanceNaming TestVerbal fluencyExecutive functionMethylphenidate treatmentMethylphenidate groupTrail MakingCognitive domainsCognitive changesMethylphenidatePlacebo-controlled trialNPI-apathy
2022
Assess the documentation of cognitive tests and biomarkers in electronic health records via natural language processing for Alzheimer’s disease and related dementias
Chen Z, Zhang H, Yang X, Wu S, He X, Xu J, Guo J, Prosperi M, Wang F, Xu H, Chen Y, Hu H, DeKosky S, Farrer M, Guo Y, Wu Y, Bian J. Assess the documentation of cognitive tests and biomarkers in electronic health records via natural language processing for Alzheimer’s disease and related dementias. International Journal Of Medical Informatics 2022, 170: 104973. PMID: 36577203, PMCID: PMC11325083, DOI: 10.1016/j.ijmedinf.2022.104973.Peer-Reviewed Original ResearchConceptsElectronic health recordsPatients' electronic health recordsCognitive testsCognitive test scoresFlorida health systemSeverity categoriesHealth recordsAD-related dementiaAD/ADRD researchAD/ADRDPatient levelAlzheimer's diseaseClinical narrativesHealth systemBiomarkersDifferent severityDiseaseSeverityPatientsADRD researchStandardized approachDementiaTest scoresPopulation characteristicsScores
2021
Network interdigitations of Tau and amyloid‐beta deposits define cognitive levels in aging
Kim C, Montal V, Diez I, Orwig W, Initiative A, Sepulcre J. Network interdigitations of Tau and amyloid‐beta deposits define cognitive levels in aging. Human Brain Mapping 2021, 42: 2990-3004. PMID: 33955621, PMCID: PMC8193537, DOI: 10.1002/hbm.25350.Peer-Reviewed Original ResearchConceptsCognitively normal older adultsAmyloid-betaPathological hallmarks of Alzheimer's diseaseHallmarks of Alzheimer's diseaseTau depositionPositron emission tomographyGeneral cognitive impairmentTau neurofibrillary tanglesAlzheimer's diseaseNormal older adultsOlder adultsAmyloid-beta depositionCognitive test scoresTau pathogenesisAD vulnerable areasNeurofibrillary tanglesHeteromodal areasTau accumulationCognitive changesCognitive deteriorationCognitive impairmentCognitive declinePathological hallmarkPreclinical ADCognitive level
2018
Cognition among individuals along a spectrum of increased risk for Parkinson’s disease
Chahine LM, Urbe L, Caspell-Garcia C, Aarsland D, Alcalay R, Barone P, Burn D, Espay AJ, Hamilton JL, Hawkins KA, Lasch S, Leverenz JB, Litvan I, Richard I, Siderowf A, Coffey CS, Simuni T, Weintraub D, Initiative T. Cognition among individuals along a spectrum of increased risk for Parkinson’s disease. PLOS ONE 2018, 13: e0201964. PMID: 30125297, PMCID: PMC6101368, DOI: 10.1371/journal.pone.0201964.Peer-Reviewed Original ResearchConceptsParkinson's diseaseIdiopathic REM sleep behavior disorderParkinson's Progression Markers Initiative (PPMI) studyDe novo Parkinson's diseaseREM sleep behavior disorderDopamine transporterNon-motor symptomsNovo Parkinson's diseaseSleep behavior disorderNon-motor featuresSymbol Digit Modalities TestBaseline neuropsychological performanceMontreal Cognitive AssessmentFuture neurodegenerationLewy bodiesInclusion criteriaSpectrum of riskMutation carriersInitiative studyCohortBehavior disorderCognitive functionCognitive test scoresModalities TestNeuropsychological performance
2010
Cognitive Engagement and Cognitive Aging: Is Openness Protective?
Sharp ES, Reynolds CA, Pedersen NL, Gatz M. Cognitive Engagement and Cognitive Aging: Is Openness Protective? Psychology And Aging 2010, 25: 60-73. PMID: 20230128, PMCID: PMC2853722, DOI: 10.1037/a0018748.Peer-Reviewed Original ResearchMeSH KeywordsActivities of Daily LivingAgedAged, 80 and overAlzheimer DiseaseCardiovascular DiseasesCognition DisordersDiseases in TwinsEducational StatusExploratory BehaviorFemaleHumansInterpersonal RelationsLeisure ActivitiesLongitudinal StudiesMaleMiddle AgedModels, PsychologicalMotivationSocial BehaviorStatistics as TopicSurveys and QuestionnairesTemperamentConceptsCognitive performanceSwedish Adoption/Twin StudyHigher cognitive test scoresLatent growth curve modelsCognitive test scoresGrowth curve modelsVerbal abilityCognitive agingCognitive domainsCognitive engagementCognitive testsSpatial abilityProcessing speedCognitive declineTest scoresLongitudinal trajectoriesHigh opennessTwin studiesCurve modelLongitudinal changesGlobal scoreOpennessDaily livingIndividualsMemory
2005
Stability of Cognitive Performance in Older Patients With Schizophrenia: An 8-Week Test-Retest Study
Harvey PD, Palmer BW, Heaton RK, Mohamed S, Kennedy J, Brickman A. Stability of Cognitive Performance in Older Patients With Schizophrenia: An 8-Week Test-Retest Study. American Journal Of Psychiatry 2005, 162: 110-117. PMID: 15625208, DOI: 10.1176/appi.ajp.162.1.110.Peer-Reviewed Original ResearchMeSH KeywordsAge FactorsAgedAlgorithmsAmbulatory CareAntipsychotic AgentsCognition DisordersFemaleFollow-Up StudiesHumansMaleMiddle AgedNeuropsychological TestsPsychiatric Status Rating ScalesPsychometricsPsychomotor PerformanceReproducibility of ResultsSchizophreniaSchizophrenic PsychologySeverity of Illness IndexConceptsCognitive measuresCognitive performancePractice effectsComprehensive neuropsychological test batteryTest scoresReliable change index methodCognitive-enhancing medicationsNeuropsychological test batteryCognitive test scoresSignificant test-retest correlationsModest cognitive improvementTest-retest correlationsTest-retest performanceCognitive improvementTest batterySecond-generation antipsychotic medicationsTest-retest errorSchizophrenia patientsRetest studyAntipsychotic medicationAlternate formsConventional antipsychotic medicationsSchizophreniaSpurious improvementPrior studies
1998
Cerebral blood flow velocity decreases during cognitive stimulation in Huntington's disease
Deckel A, Cohen D, Duckrow R. Cerebral blood flow velocity decreases during cognitive stimulation in Huntington's disease. Neurology 1998, 51: 1576-1583. PMID: 9855504, DOI: 10.1212/wnl.51.6.1576.Peer-Reviewed Original ResearchConceptsAnterior cerebral arteryAnterior cerebral artery flow velocityCerebral artery flow velocityBlood flow velocity changesMiddle cerebral arteryCerebral arteryArtery flow velocityHD patientsTranscranial Doppler ultrasonographyFlow velocity changesControl subjectsMaze testHuntington's diseaseCerebral blood flow velocity changesBlood flow velocity decreasesLeft anterior cerebral arteryMiddle cerebral artery velocityCognitive test scoresCerebral blood flow velocityBlood flow velocity increasePorteus Maze TestRating ScaleCognitive testingTrails TestAsymptomatic HD patients
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