2025
The Impact of Enhanced Behavioral Health Services on Total Healthcare Costs Among US Employers: A Site-Level Analysis of 19 Cohort Studies
Hawrilenko M, Smolka C, Ward E, Kavelaars R, Brown M, Chekroud A. The Impact of Enhanced Behavioral Health Services on Total Healthcare Costs Among US Employers: A Site-Level Analysis of 19 Cohort Studies. Journal Of Health Economics And Outcomes Research 2025, 12: 246-251. PMID: 40546793, PMCID: PMC12182909, DOI: 10.36469/001c.138634.Peer-Reviewed Original ResearchBehavioral health benefitsComprehensive mental health programMedical spendingMental health programsMental health careBehavioral health servicesHealthcare decision-makingReturn-on-investment estimatesRetrospective matched cohort designMeta-analysisHealth benefitsDifference-in-differences analysisUS employersMatched cohort designMedical claims dataEmployer-sponsored health plansMedication management sessionsHealth programsHealth servicesHealth careHealth plansCohort designInverse varianceDifference-in-differences modelReturn on investmenthe Impact of Enhanced Behavioral Health Services on Total Healthcare Costs Among US Employers: A Site-Level Analysis of 19 Cohort Studies
Hawrilenko M, Smolka C, Ward E, Kavelaars R, Brown M, Chekroud A. he Impact of Enhanced Behavioral Health Services on Total Healthcare Costs Among US Employers: A Site-Level Analysis of 19 Cohort Studies. Journal Of Health Economics And Outcomes Research 2025, 246-251. DOI: 10.36469/jheor.2025.138634.Peer-Reviewed Original ResearchBehavioral health benefitsComprehensive mental health programMedical spendingMental health programsMental health careBehavioral health servicesHealthcare decision-makingReturn-on-investment estimatesRetrospective matched cohort designMeta-analysisHealth benefitsDifference-in-differences analysisUS employersMatched cohort designMedical claims dataEmployer-sponsored health plansMedication management sessionsHealth programsHealth servicesHealth careHealth plansInverse varianceCohort designDifference-in-differences modelReturn on investmentThe validity of test-negative design for assessment of typhoid conjugate vaccine protection: comparison of estimates by different study designs using data from a cluster-randomised controlled trial
Feng S, Zhang Y, Khanam F, Voysey M, Pitzer V, Qadri F, Clemens J, Pollard A, Liu X. The validity of test-negative design for assessment of typhoid conjugate vaccine protection: comparison of estimates by different study designs using data from a cluster-randomised controlled trial. The Lancet Global Health 2025, 13: e1122-e1131. PMID: 40252689, PMCID: PMC12095117, DOI: 10.1016/s2214-109x(25)00056-7.Peer-Reviewed Original ResearchConceptsTyphoid Conjugate VaccineCluster randomised controlled trialJapanese encephalitis vaccineAge-eligible childrenCohort designTest-negative controlsStudy designTyphoid feverVaccine effectivenessHealth care seeking behaviorNon-vaccineesIncreased riskBlood culture-confirmed typhoid feverSalmonella enterica serotype TyphiCase-control study designNon-typhoidal infectionsVaccine protectionBlood culture specimensExperimental study designMiddle-income countriesObservational study designPublic health challengeChildren aged 9 monthsIncreased risk of typhoid feverRisk of typhoid feverLateralization and Distalization Shoulder Angles May Not Predict Clinical Outcomes in Reverse Total Shoulder Arthroplasty: A Systematic Review and Meta-Analysis
Surucu S, Okutan A, Lee M, MacLeod J, Kodra J, Fong S, Moran J, Donohue K, Graf A, Jimenez A. Lateralization and Distalization Shoulder Angles May Not Predict Clinical Outcomes in Reverse Total Shoulder Arthroplasty: A Systematic Review and Meta-Analysis. JSES International 2025 DOI: 10.1016/j.jseint.2025.04.004.Peer-Reviewed Original ResearchDistalization shoulder anglesLateralization shoulder angleRange of motionReverse total shoulder arthroplastyRandom-effects modelSystematic reviewMeta-analysisShoulder angleInclusion criteriaTotal shoulder arthroplastyPreferred Reporting ItemsClinical outcomesRetrospective cohort designFollow-upShoulder arthroplastyCohort designReporting ItemsStudy qualityCochrane CenterNon-randomized studiesCorrelation coefficientMeta-analysesOutcome scoresControlled TrialsQ testProfile of non-invasive physical health indicators associated with cognitive performance in Chinese older adults: evidence from the China Health and Retirement Longitudinal Study
Wei X, Li C, Liu D, Chen J, Ju Y, Liu J, Liu B, Zhang Y. Profile of non-invasive physical health indicators associated with cognitive performance in Chinese older adults: evidence from the China Health and Retirement Longitudinal Study. BMC Public Health 2025, 25: 420. PMID: 39894807, PMCID: PMC11789399, DOI: 10.1186/s12889-025-21479-z.Peer-Reviewed Original ResearchConceptsPhysical health indicatorsHealth indicatorsMild cognitive impairmentOlder adultsChina HealthCognitive performanceRight grip strengthChinese older adultsScreening of cognitive declineCognitive domainsLongitudinal cohort designCognitive performance domainsSubgroup analysisDomains of cognitive performancePhysical functionBackgroundExisting studiesGrip strengthCohort designLinear regression modelsMultiple linear regression modelStandardised interviewMethodsThe present studyResultsPulmonary functionSex-specific factorsGeneral cognition
2024
Biases in COVID-19 vaccine effectiveness studies using cohort design
Agampodi S, Tadesse B, Sahastrabuddhe S, Excler J, Kim J. Biases in COVID-19 vaccine effectiveness studies using cohort design. Frontiers In Medicine 2024, 11: 1474045. PMID: 39540039, PMCID: PMC11557388, DOI: 10.3389/fmed.2024.1474045.Peer-Reviewed Original ResearchCohort designHealth-promoting behaviorsObservational studyPublic health strategiesPublic health policiesMiddle-income countriesPre-existing data sourcesHealthy user biasHealthy vaccinee effectSociodemographic disparitiesHealth strategiesHealth policyOutcome misclassificationSustaining public trustMisclassification biasHealth statusHealthcare systemVaccinee effectSusceptibility biasDiverse populationsCOVID-19Vaccine effectiveness studiesFrailty biasVaccine effectivenessCOVID-19 pandemicResidential Relocation of Community-Dwelling Older Adults: The Role of Physical Function and the Housing Environment.
Jensen-Battaglia M, Loh K, Wang Y, Block R, Mohile S, Agree E, Seplaki C. Residential Relocation of Community-Dwelling Older Adults: The Role of Physical Function and the Housing Environment. Journal Of Aging And Health 2024, 8982643241293585. PMID: 39437448, PMCID: PMC12012160, DOI: 10.1177/08982643241293585.Peer-Reviewed Original ResearchNational Health and Aging Trends StudyOlder adultsAssociated with relocationDifficulty with mobilityEstimate adjusted associationsProspective cohort designAssociated with movesPhysical functionTrends StudyEnvironmental barriersAdjusted associationsStudy staffCohort designSelf-ReportResidential relocationLogistic regressionCurrent housingPermanent addressHousing environmentHousingAdultsUnited StatesRelocationAssociationCluster correction
2023
Comparison of the Test-negative Design and Cohort Design With Explicit Target Trial Emulation for Evaluating COVID-19 Vaccine Effectiveness
Li G, Gerlovin H, Muñiz M, Wise J, Madenci A, Robins J, Aslan M, Cho K, Gaziano J, Lipsitch M, Casas J, Hernán M, Dickerman B. Comparison of the Test-negative Design and Cohort Design With Explicit Target Trial Emulation for Evaluating COVID-19 Vaccine Effectiveness. Epidemiology 2023, 35: 137-149. PMID: 38109485, PMCID: PMC11022682, DOI: 10.1097/ede.0000000000001709.Peer-Reviewed Original ResearchTest-negative designTarget trial emulationVaccine effectivenessCohort designTrial emulationResidual confoundingCOVID-19 vaccine effectivenessHealth care-seeking behaviorBNT162b2 vaccine effectivenessCare-seeking behaviorCOVID-19 outcomesVA healthcare systemCOVID-19 vaccineBNT162b2 vaccineAbsolute riskObservational studyNationwide dataVeterans AffairsTarget trialsEffect estimatesHealthcare systemVaccineCohortNegative controlTrialsA scoping review described diversity in methods of randomization and reporting of baseline balance in stepped-wedge cluster randomized trials
Nevins P, Davis-Plourde K, Pereira Macedo J, Ouyang Y, Ryan M, Tong G, Wang X, Meng C, Ortiz-Reyes L, Li F, Caille A, Taljaard M. A scoping review described diversity in methods of randomization and reporting of baseline balance in stepped-wedge cluster randomized trials. Journal Of Clinical Epidemiology 2023, 157: 134-145. PMID: 36931478, PMCID: PMC10546924, DOI: 10.1016/j.jclinepi.2023.03.010.Peer-Reviewed Original ResearchConceptsStepped-wedge clusterIndividual-level characteristicsMethod of randomizationCross-sectional designControl armBaseline imbalancesCohort designMedian numberElectronic searchPrimary analysisBaseline balanceStudy designPrimary reportsBaselineTrialsIntervention conditionSW-CRTsRandomizationReporting
2022
Characteristics and Gender Differences of Headache in the Veterans Health Administration
Sico JJ, Seng E, Wang K, Skanderson M, Schindler E, Ney JP, Lorenze N, Kimber A, Lindsey H, Grinberg AS, Kuruvilla D, Higgins D, Graham G, Sandbrink F, Scholten J, Shapiro RE, Lipton RB, Fenton B. Characteristics and Gender Differences of Headache in the Veterans Health Administration. Neurology 2022, 99: e1993-e2005. PMID: 36100437, PMCID: PMC9651459, DOI: 10.1212/wnl.0000000000200905.Peer-Reviewed Original ResearchConceptsVeterans Health AdministrationHeadache diagnosisHealthcare utilizationIncidence rateHeadache careHeadache typesHealth AdministrationSociodemographic characteristicsMilitary-related exposuresAge-adjusted incidenceEmergency department utilizationElectronic health record dataRetrospective cohort designType of headacheHigh incidence rateTraumatic brain injuryUnited States veteransHealth record dataPost-traumatic stress disorderGender differencesMilitary sexual traumaHeadache disordersBrain injuryHeadache specialistsCohort designIn-hospital complications after cervical fusion in cases with versus without cerebral palsy
Galivanche AR, Gillinov SM, Mercier MR, Schneble CA, Varthi AG, Grauer JN, Frumberg DB. In-hospital complications after cervical fusion in cases with versus without cerebral palsy. North American Spine Society Journal (NASSJ) 2022, 12: 100167. PMID: 36132746, PMCID: PMC9483629, DOI: 10.1016/j.xnsj.2022.100167.Peer-Reviewed Original ResearchMinor adverse eventsCerebral palsyHospital complicationsAdverse eventsCervical fusionNational Inpatient Sample databaseMultiple logistic regression modelHospital adverse eventsCervical spine pathologyCervical fusion surgeryRetrospective cohort designMultiple logistic regressionLogistic regression modelsHospital mortalityMore comorbiditiesHospital morbidityHospital stayPerioperative outcomesPreoperative variablesPropensity matchingSurgical interventionFusion surgeryCohort designSpine pathologyCervical pathology
2021
swdpwr: A SAS macro and an R package for power calculations in stepped wedge cluster randomized trials
Chen J, Zhou X, Li F, Spiegelman D. swdpwr: A SAS macro and an R package for power calculations in stepped wedge cluster randomized trials. Computer Methods And Programs In Biomedicine 2021, 213: 106522. PMID: 34818620, PMCID: PMC8665077, DOI: 10.1016/j.cmpb.2021.106522.Peer-Reviewed Original ResearchConceptsWedge clusterIntracluster correlation coefficientContinuous outcomesCross-sectional cohortBinary outcomesExchangeable correlation structureWedge designPublic health intervention evaluationsHealth services researchClosed cohort designPower calculationCohort designClosed cohortStudy designIntracluster correlationIntervention evaluationNeeds of investigatorsOutcomesTrialsCohortServices researchInvestigatorsPrevious studiesSWD
2020
Population neuroscience: challenges and opportunities for psychiatric research in low- and middle-income countries
Cirillo A, Diniz E, Gadelha A, Asevedo E, Axelrud L, Miguel E, Rohde L, Bressan R, Pan P, de J. Mari J. Population neuroscience: challenges and opportunities for psychiatric research in low- and middle-income countries. Brazilian Journal Of Psychiatry 2020, 42: 442-448. PMID: 32267341, PMCID: PMC7430393, DOI: 10.1590/1516-4446-2019-0761.Peer-Reviewed Original ResearchConceptsMiddle-income countriesHigh-income countriesPopulation neuroscienceLongitudinal cohort studyCohort studyCohort designPsychiatric disordersElectronic searchMEDLINE databaseSystematic reviewBrain functioningCohortPsychiatric researchLMICsPsychiatry researchSearch criteriaKey studiesEMBASEEpidemiologyStudy
2019
Towards precision medicine for stress disorders: diagnostic biomarkers and targeted drugs
Le-Niculescu H, Roseberry K, Levey D, Rogers J, Kosary K, Prabha S, Jones T, Judd S, McCormick M, Wessel A, Williams A, Phalen P, Mamdani F, Sequeira A, Kurian S, Niculescu A. Towards precision medicine for stress disorders: diagnostic biomarkers and targeted drugs. Molecular Psychiatry 2019, 25: 918-938. PMID: 30862937, PMCID: PMC7192849, DOI: 10.1038/s41380-019-0370-z.Peer-Reviewed Original ResearchMeSH KeywordsAdaptor Proteins, Signal TransducingAdultbeta 2-MicroglobulinBiomarkersDEAD-box RNA HelicasesFemaleGene ExpressionHumansMaleMental DisordersMiddle AgedMolecular Targeted TherapyNogo ProteinsPrecision MedicinePredictive Value of TestsProto-Oncogene ProteinsReceptors, ImmunologicStress, PsychologicalTacrolimus Binding ProteinsTelomere HomeostasisConceptsPredictive biomarkersGene expression biomarkersTelomere lengthBlood gene expression biomarkersPossible new drug candidateStress disorderPsychological stressFuture psychiatric hospitalizationsVisual analog scaleHigh-risk groupSimple visual analog scaleDrug repurposing analysisExpression biomarkersGene expression signaturesAnalog scaleAdverse outcomesCalcium folinateCohort designHormonal changesPsychiatric hospitalizationDecreased qualityBiomarker findingsPsychiatric disordersPsychiatric patientsPatient stratificationTowards precision medicine for pain: diagnostic biomarkers and repurposed drugs
Niculescu A, Le-Niculescu H, Levey D, Roseberry K, Soe K, Rogers J, Khan F, Jones T, Judd S, McCormick M, Wessel A, Williams A, Kurian S, White F. Towards precision medicine for pain: diagnostic biomarkers and repurposed drugs. Molecular Psychiatry 2019, 24: 501-522. PMID: 30755720, PMCID: PMC6477790, DOI: 10.1038/s41380-018-0345-5.Peer-Reviewed Original ResearchConceptsBlood gene expression biomarkersPossible new drug candidateFuture emergency department (ED) visitsEmergency department visitsHigh-risk groupDrug repurposing analysisCurrent opioid epidemicPerception of painSubjects longitudinal designGene expression signaturesPain statesDepartment visitsPain disordersTreatment dilemmaBlood biomarkersSC-560Opioid epidemicCohort designRisk groupsIndependent cohortPainGene expression biomarkersPsychiatric patientsDiagnostic biomarkersIndividual biomarkers
2000
Mortality among Homeless and Nonhomeless Mentally Ill Veterans
KASPROW W, ROSENHECK R. Mortality among Homeless and Nonhomeless Mentally Ill Veterans. The Journal Of Nervous And Mental Disease 2000, 188: 141-147. PMID: 10749278, DOI: 10.1097/00005053-200003000-00003.Peer-Reviewed Original ResearchConceptsMortality riskGeneral U.S. populationMental health programsIll veteransCohort membersMortality rateHealth programsRetrospective cohort designU.S. populationHealth care systemPrior hospitalizationAge 45Cohort designOlder veteransElevated riskGeneral populationMale veteransNonsignificant trendAge 55Medical problemsVeterans AffairsCare systemBaselineMortalityAlcohol problems
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