2025
Moderating effect of insulin resistance on the relationship between cortical surface area and cognitive function in patients with first-episode schizophrenia
Lin C, Gou M, Pan S, Tong J, Zhou Y, Xie T, Yu T, Li Y, Cui Y, Tian B, Tan S, Wang Z, Luo X, Zhang P, Huang J, Chen S, Yin Y, Tan Y. Moderating effect of insulin resistance on the relationship between cortical surface area and cognitive function in patients with first-episode schizophrenia. Psychiatry Research Neuroimaging 2025, 352: 112048. PMID: 40829289, DOI: 10.1016/j.pscychresns.2025.112048.Peer-Reviewed Original ResearchConceptsCortical surface areaMCCB composite scoreFirst-episode schizophreniaCognitive functionCognitive deficitsPositive and Negative Symptom ScaleSchizophrenia Consensus Cognitive BatteryCognitive impairmentLeft middle temporal gyrusCaudal anterior cingulate gyrusConsensus Cognitive BatteryNegative Symptom ScaleComposite scoreMiddle temporal gyrusAnterior cingulate gyrusMechanism of cognitive impairmentModerating effectMCCB domainsCognitive batteryVerbal learningTemporal gyrusTreatment researchCingulate gyrusSchizophreniaBrain structuresImmunosenescence-related T cell phenotypes, structural brain imaging, and cognitive impairment in patients with schizophrenia: a moderated mediation analysis
Li N, Li Y, Yu T, Chen W, Gou M, Zheng W, Liu Z, Wang X, Fang J, Tong J, Chen S, Tian B, Li C, Tian L, Tan Y. Immunosenescence-related T cell phenotypes, structural brain imaging, and cognitive impairment in patients with schizophrenia: a moderated mediation analysis. Schizophrenia 2025, 11: 101. PMID: 40681520, PMCID: PMC12274616, DOI: 10.1038/s41537-025-00650-w.Peer-Reviewed Original ResearchCognitive impairmentSCZ patientsCognitive deficitsAssociated with working memory deficitsPositive and Negative Syndrome ScaleMATRICS Consensus Cognitive BatteryRight inferior parietal lobuleBiomarker of cognitive deficitsConsensus Cognitive BatteryNegative Syndrome ScaleWorking Memory scoresInferior parietal lobuleT cell subsetsStructural brain imagingModerated mediation analysisIL-1b levelsMemory T cell subsetsModerated Mediation ModelT-cell phenotypeSyndrome ScaleCognitive batteryMemory deficitsParietal lobuleSubcortical volumesT1-weighted magnetic resonance imagingCultural variables influence performance on the MATRICS Consensus Cognitive Battery among people at clinical high risk for psychosis
Guest R, Aberizk K, Addington J, Bearden C, Cadenhead K, Cannon T, Cornblatt B, Keshavan M, Mathalon D, Perkins D, Stone W, Woods S, Walker E. Cultural variables influence performance on the MATRICS Consensus Cognitive Battery among people at clinical high risk for psychosis. Schizophrenia Research 2025, 280: 60-68. PMID: 40250131, PMCID: PMC12169887, DOI: 10.1016/j.schres.2025.04.019.Peer-Reviewed Original ResearchConceptsMATRICS Consensus Cognitive BatteryConsensus Cognitive BatteryClinical high riskCognitive batteryCHR-PHopkins Verbal Learning Test-RevisedNorth American Prodrome Longitudinal StudyEnglish speakersHealthy controlsLetter-Number SpanPsychosis-Risk SyndromesMultigroup structural equation modelingInfluence cognitive performanceCultural variablesNative English speakersSample of peopleLetter-NumberNeuropsychological measuresVariables influencing performanceTest-RevisedCognitive performanceStructural equation modelingAnimal namesDiagnostic groupsCanadian sampleFunctional Remediation Improves Serum BDNF and TrkB Levels in Euthymic Patients with Bipolar Disorder: A Randomized Trial Study
Li R, Li J, Ji S, Li D, Chu L, Zhang J, Sun X, Luo X, Zhang Y. Functional Remediation Improves Serum BDNF and TrkB Levels in Euthymic Patients with Bipolar Disorder: A Randomized Trial Study. Neuropsychiatric Disease And Treatment 2025, 21: 115-128. PMID: 39882559, PMCID: PMC11776513, DOI: 10.2147/ndt.s502176.Peer-Reviewed Original ResearchYoung Mania Rating ScaleSerum brain-derived neurotrophic factorBrain-derived neurotrophic factorYoung Mania Rating Scale scoresBipolar disorderHDRS-17Functional remediationTrkB levelsEuthymic patientsConsensus Cognitive BatteryMania Rating ScaleEuthymic bipolar disorderEmotional Intelligence TestNo group differencesSerum BDNF levelsTyrosine kinase receptor BFR groupCognitive batteryAffective symptomsTreatment researchIntelligence testsTAU groupBDNF levelsMaze testCognitive function
2024
The associations between duration of untreated psychosis, growth factors, and neurocognition in patients with drug-naïve schizophrenia
Su Q, Xuekelaiti Z, Ma H, Qiu Y, Sun X, Bi F, Li M, Li J. The associations between duration of untreated psychosis, growth factors, and neurocognition in patients with drug-naïve schizophrenia. Schizophrenia Research 2024, 274: 113-120. PMID: 39288474, DOI: 10.1016/j.schres.2024.09.011.Peer-Reviewed Original ResearchDuration of untreated psychosisBrain-derived neurotrophic factorMATRICS Consensus Cognitive BatterySpeed of processingVascular endothelial growth factorUntreated psychosisEpidermal growth factorAssociated with speed of processingDuration of untreated psychosis groupGrowth factorConsensus Cognitive BatteryDrug-naive schizophreniaPlasma concentrations of vascular endothelial growth factorPlasma concentrationsConcentrations of vascular endothelial growth factorCognitive batteryVerbal learningAssociated with speedEndothelial growth factorNeurocognitionVisual learningCognitive impairmentEnzyme-linked immunosorbent assayBiological mechanismsNeurotrophic factorCONNEX, a Phase III Randomized Trial Program Assessing Efficacy and Safety of Iclepertin in Schizophrenia: Recruitment and Baseline Characteristics
Blahova Z, Ikezawa S, Falkai P, Krystal J, Rangan T. CONNEX, a Phase III Randomized Trial Program Assessing Efficacy and Safety of Iclepertin in Schizophrenia: Recruitment and Baseline Characteristics. BJPsych Open 2024, 10: s72-s73. PMCID: PMC11738127, DOI: 10.1192/bjo.2024.230.Peer-Reviewed Original ResearchVirtual Reality Functional Capacity Assessment ToolComposite T-scoreSchizophrenia Cognition Rating ScaleSchizophrenia Consensus Cognitive BatteryCognitive impairmentGlycine transporter-1 inhibitorStable antipsychotic treatmentN-methyl-d-aspartate receptor signallingConsensus Cognitive BatteryCognitive remediation therapyIncrease synaptic levelsCognition Rating ScaleT-scoreDuration of illnessCo-agonist glycineAntipsychotic treatmentAntipsychotic medicationSchizophrenia treatmentCognitive batteryRemediation therapyCognitive symptomsTreatment researchSchizophreniaImprove cognitionPlacebo-controlled parallel-group trialRight superior frontal gyrus: A potential neuroimaging biomarker for predicting short-term efficacy in schizophrenia
Yang Y, Jin X, Xue Y, Li X, Chen Y, Kang N, Yan W, Li P, Guo X, Luo B, Zhang Y, Liu Q, Shi H, Zhang L, Su X, Liu B, Lu L, Lv L, Li W. Right superior frontal gyrus: A potential neuroimaging biomarker for predicting short-term efficacy in schizophrenia. NeuroImage Clinical 2024, 42: 103603. PMID: 38588618, PMCID: PMC11015154, DOI: 10.1016/j.nicl.2024.103603.Peer-Reviewed Original ResearchSuperior frontal gyrusPositive and Negative Syndrome ScaleMATRICS Consensus Cognitive BatteryRight superior frontal gyrusAntipsychotic drug treatmentStructural magnetic resonance imagingInferior temporal gyrusSZ patientsFunctional connectivityWM densityFrontal gyrusEffect of antipsychotic drug treatmentTarget of antipsychotic drugsSecond-generation antipsychotic treatmentRight medial superior frontal gyrusMedial superior frontal gyrusRight inferior temporal gyrusConsensus Cognitive BatteryNegative Syndrome ScaleResting-state functional MRIRight anterior cingulateMeasure psychiatric symptomsRegional gray matterAssociated with treatment outcomeRight cingulate gyrusDoes Baseline Cognitive Function Predict the Reduction Rate in HDRS-17 Total Scores in First-Episode, Drug-Naïve Patients with Major Depressive Disorder?
Jiao Q, Dong Y, Ma X, Ji S, Liu X, Zhang J, Sun X, Li D, Luo X, Zhang Y. Does Baseline Cognitive Function Predict the Reduction Rate in HDRS-17 Total Scores in First-Episode, Drug-Naïve Patients with Major Depressive Disorder? Neuropsychiatric Disease And Treatment 2024, 20: 353-361. PMID: 38415074, PMCID: PMC10898600, DOI: 10.2147/ndt.s453447.Peer-Reviewed Original ResearchHDRS-17 total scoreFunctioning Assessment Short TestMATRICS Consensus Cognitive BatteryMajor depressive disorderHDRS-17Fed patientsCPT-IPCognitive functionBaseline cognitive functionTotal scoreDepressive disorderFirst-episodeDrug-naivePatients' responses to antidepressant treatmentFunctioning Assessment Short Test total scoreResponse to antidepressant treatmentHamilton Depression Rating ScaleFunctioning Assessment Short Test scoreConsensus Cognitive BatteryDepression Rating ScaleAssociated with worse cognitive functionSpeed of processingHamilton Anxiety ScaleDrug-naive patientsInterpersonal relationship domainThe relationship between serum prolactin levels and cognitive function in drug-naïve schizophrenia patients: a cross-sectional study
Luo G, Bai F, Qu X, Jing Y, Wang S, Xuekelaiti Z, Yao C, Li M, Li J. The relationship between serum prolactin levels and cognitive function in drug-naïve schizophrenia patients: a cross-sectional study. Journal Of Neural Transmission 2024, 131: 385-391. PMID: 38277043, DOI: 10.1007/s00702-024-02748-4.Peer-Reviewed Original ResearchSerum prolactin levelsSchizophrenia patientsCognitive functionProlactin levelsCognitive deficitsHealthy controlsPatients serum prolactin levelsConsensus Cognitive BatterySignificant cognitive deficitsSevere cognitive deficitsCognitive batteryTreatment researchPsychiatric symptomsSchizophreniaCognitionMCCBDeficitsCross-sectional studyProlactinClinical symptomsClinical dataClinical severitySymptomsPatientsSymptomatology
2023
73 Identification of 24-Month Cognitive Trajectories Among Clinical High Risk for Psychosis (CHR-P) Using Latent Class Mixture Modeling
Guest R, Addington J, Bearden C, Cadenhead K, Cornblatt B, Mathalon D, Perkins D, Tsuang M, Woods S, Cannon T, Keshavan M, Stone W, Walker E. 73 Identification of 24-Month Cognitive Trajectories Among Clinical High Risk for Psychosis (CHR-P) Using Latent Class Mixture Modeling. Journal Of The International Neuropsychological Society 2023, 29: 857-858. DOI: 10.1017/s1355617723010597.Peer-Reviewed Original ResearchMATRICS Consensus Cognitive BatterySpeed of processingVerbal learningCognitive batteryCognitive trajectoriesCognitive deficitsWide Range Achievement TestDomain-specific deficitsConsensus Cognitive BatteryWechsler Abbreviated ScalePre-morbid IQHigher cognitive skillsFull Scale IQLower premorbid IQAge-based normsMild cognitive deficitsClinical high riskMCCB domainsCognitive remediationMemory domainCognitive skillsGeneral cognitionReading subtestCognitive performanceNorth American Prodromal Longitudinal Study
2022
The relationship between TLR4/NF-κB/IL-1β signaling, cognitive impairment, and white-matter integrity in patients with stable chronic schizophrenia
Li H, Chen W, Gou M, Li W, Tong J, Zhou Y, Xie T, Yu T, Feng W, Li Y, Chen S, Tian B, Tan S, Wang Z, Pan S, Li N, Luo X, Zhang P, Huang J, Tian L, Li CR, Tan Y. The relationship between TLR4/NF-κB/IL-1β signaling, cognitive impairment, and white-matter integrity in patients with stable chronic schizophrenia. Frontiers In Psychiatry 2022, 13: 966657. PMID: 36051545, PMCID: PMC9424630, DOI: 10.3389/fpsyt.2022.966657.Peer-Reviewed Original ResearchStable chronic schizophreniaNF-κB/ILWhite matter integrityHealthy controlsMATRICS Consensus Cognitive BatteryFractional anisotropyChronic schizophreniaCortical thicknessCognitive impairmentInnate immunityCognitive functionToll-like receptor 4Higher TLR4 levelsLevels of TLR4Subcortical gray matter volumesWhite matter fractional anisotropyNegative Syndrome ScaleGray matter volumeTLR4 expressionTLR4 levelsWhite matter microstructureReceptor 4Cognitive deteriorationConsensus Cognitive BatteryLPS stimulationSerum hyperhomocysteine and cognitive impairment in first-episode patients with schizophrenia: Moderated by brain cortical thickness
Lin C, Gou M, Pan S, Tong J, Zhou Y, Xie T, Yu T, Feng W, Li Y, Chen S, Tian B, Tan S, Wang Z, Luo X, Li CR, Zhang P, Huang J, Hong L, Tan Y. Serum hyperhomocysteine and cognitive impairment in first-episode patients with schizophrenia: Moderated by brain cortical thickness. Neuroscience Letters 2022, 788: 136826. PMID: 35944595, DOI: 10.1016/j.neulet.2022.136826.Peer-Reviewed Original ResearchConceptsBrain cortical thicknessCognitive impairmentCognitive deficitsGray matter thicknessSchizophrenia (MATRICS) Consensus Cognitive BatteryAttention/vigilanceConsensus Cognitive BatteryCortical thicknessSerum Hcy levelsFirst-episode patientsHealthy controlsHigh homocysteineWorking memoryHcy levelsCognitive batteryNegative Symptom ScaleCognitive functionTreatment researchHigh-resolution magnetic resonance imagingSymptom ScaleSandwich enzyme-linked immunosorbentSchizophreniaHigher cortical thicknessImpairmentEnzyme-linked immunosorbentAssociation between plasma levels of BDNF and GDNF and the diagnosis, treatment response in first-episode MDD
Liu X, Li P, Ma X, Zhang J, Sun X, Luo X, Zhang Y. Association between plasma levels of BDNF and GDNF and the diagnosis, treatment response in first-episode MDD. Journal Of Affective Disorders 2022, 315: 190-197. PMID: 35908604, DOI: 10.1016/j.jad.2022.07.041.Peer-Reviewed Original ResearchConceptsAntidepressant treatmentPlasma levelsGDNF levelsMATRICS Consensus Cognitive BatteryMDD patientsHealthy controlsDepression severityWeeks antidepressant treatmentFirst-episode depressionPeripheral plasma levelsPeripheral venous bloodWeeks of treatmentDiagnosis of MDDDecreased plasma levelsHAMA-14Plasma BDNFAntidepressant medicationClinical symptomsHDRS-17Venous bloodCognitive dysfunctionPlasma concentrationsTreatment responseConsensus Cognitive BatteryPatientsChildhood trauma and cognitive deficits in patients with schizophrenia: mediation by orbitofrontal cortex H-shaped sulci volume
Wang L, Yin Y, Feng W, Zhou Y, Huang J, Zhang P, Chen S, Fan H, Cui Y, Luo X, Tan S, Wang Z, Tian B, Tian L, Li CR, Tan Y. Childhood trauma and cognitive deficits in patients with schizophrenia: mediation by orbitofrontal cortex H-shaped sulci volume. Journal Of Psychiatry And Neuroscience 2022, 47: e209-e217. PMID: 35654451, PMCID: PMC9177195, DOI: 10.1503/jpn.210178.Peer-Reviewed Original ResearchConceptsFirst-episode schizophreniaCTQ total scoresHealthy controlsCognitive functionChildhood Trauma QuestionnaireTotal scoreCognitive deficitsChildhood trauma experiencesMATRICS Consensus Cognitive BatteryChildhood traumaOrbitofrontal cortexWorse cognitive functionTrauma experiencesHigh-resolution MRIRetrospective designPatientsConsensus Cognitive BatterySchizophreniaTraumaSubscoresSmall sample sizeTrauma QuestionnaireComposite scoreLines of evidenceScoresDysfunctional monocytic toll-like receptor 4 signaling pathway and cognitive deficits in chronic schizophrenia patients with tardive dyskinesia
Li N, Li Y, Huang J, Zhang P, Tong J, Chen S, Cui Y, Tan S, Wang Z, Yang F, Hong E, Li CR, Tian L, Tan Y. Dysfunctional monocytic toll-like receptor 4 signaling pathway and cognitive deficits in chronic schizophrenia patients with tardive dyskinesia. Neuroscience Letters 2022, 777: 136581. PMID: 35337952, DOI: 10.1016/j.neulet.2022.136581.Peer-Reviewed Original ResearchConceptsToll-like receptor 4Abnormal Involuntary Movement ScaleTardive dyskinesiaChronic schizophrenia patientsSchizophrenia patientsMATRICS Consensus Cognitive BatteryReceptor 4TD patientsHigher toll-like receptor 4Cognitive deficitsSeverity of TDNegative Syndrome ScaleInnate immune systemNTD patientsTLR4 levelsHealthy controlsAIMS scoresMovement ScalePatientsConsensus Cognitive BatteryLPS stimulationTLR4 signalsPathway disturbancesLipopolysaccharide (LPS) stimulationSyndrome Scale
2021
Effects of microRNA-181b-5p on cognitive deficits in first-episode patients with schizophrenia: Mediated by BCL-2
Gou M, Pan S, Tong J, Zhou Y, Han J, Xie T, Yu T, Feng W, Li Y, Chen S, Cui Y, Tian B, Tan MDS, Wang Z, Luo X, Li CR, Zhang P, Huang J, Hong LE, Tan Y, Tian L. Effects of microRNA-181b-5p on cognitive deficits in first-episode patients with schizophrenia: Mediated by BCL-2. Journal Of Psychiatric Research 2021, 136: 358-365. PMID: 33636692, DOI: 10.1016/j.jpsychires.2021.02.003.Peer-Reviewed Original ResearchConceptsFirst-episode patientsBcl-2 mRNAEnzyme Linked Immunosorbent AssayMATRICS Consensus Cognitive BatteryQuantitative real-time PCRCognitive deficitsCognitive functionGender-matched healthy controlsBcl-2Pathogenesis of schizophreniaPeripheral whole bloodExpression levelsNegative Syndrome ScaleBcl-2 protein expressionLinked Immunosorbent AssayBcl-2 protein levelsPeripheral bloodHealthy controlsBcl-2 mRNA levelsReal-time PCRTarget genes Bcl-2Consensus Cognitive BatterySchizophrenia patientsSyndrome ScaleGene Bcl-2
2020
Altered brain function and clinical features in patients with first-episode, drug naïve major depressive disorder: A resting-state fMRI study
Liang S, Xue K, Wang W, Yu W, Ma X, Luo S, Zhang J, Sun X, Luo X, Liu F, Zhang Y. Altered brain function and clinical features in patients with first-episode, drug naïve major depressive disorder: A resting-state fMRI study. Psychiatry Research Neuroimaging 2020, 303: 111134. PMID: 32652482, DOI: 10.1016/j.pscychresns.2020.111134.Peer-Reviewed Original ResearchConceptsMajor depressive disorderDrug-naïve major depressive disorderAltered brain functionFunctioning Assessment Short TestMATRICS Consensus Cognitive BatteryMDD patientsDepressive disorderDefault mode networkBrain functionClinical featuresFunctional impairmentHealthy subjectsLow-frequency fluctuation (ALFF) valuesDrug-naïve MDD patientsResting-state fMRI studyAssessment Short TestTotal FAST scoresALFF valuesNeurocognitive impairmentPatientsConsensus Cognitive BatteryLingual gyrusOccupational functioningFAST scoreGlobal functioningPsychometric properties of the MATRICS Consensus Cognitive Battery (MCCB) in Chinese patients with major depressive disorder
Liang S, Yu W, Ma X, Luo S, Zhang J, Sun X, Luo X, Zhang Y. Psychometric properties of the MATRICS Consensus Cognitive Battery (MCCB) in Chinese patients with major depressive disorder. Journal Of Affective Disorders 2020, 265: 132-138. PMID: 32090734, DOI: 10.1016/j.jad.2020.01.052.Peer-Reviewed Original ResearchConceptsMajor depression disorderMATRICS Consensus Cognitive BatteryMDD patientsCognitive impairmentChinese patientsConsensus Cognitive BatteryBipolar disorderHamilton Depression Rating Scale-17Cognitive AssessmentChinese MDD patientsMajor depressive disorderSeverity of symptomsMontreal Cognitive AssessmentConcurrent validityMild cognitive impairmentCognitive batteryPsychometric propertiesGood concurrent validityMedication treatmentDepressive disorderHealthy controlsGood internal consistencyDepressive symptomsDepression disorderPatients
2019
Plasma total antioxidant status and cognitive impairments in first-episode drug-naïve patients with schizophrenia
Xie T, Li Q, Luo X, Tian L, Wang Z, Tan S, Chen S, Yang G, An H, Yang F, Tan Y. Plasma total antioxidant status and cognitive impairments in first-episode drug-naïve patients with schizophrenia. Cognitive Neurodynamics 2019, 13: 357-365. PMID: 31354881, PMCID: PMC6624222, DOI: 10.1007/s11571-019-09530-3.Peer-Reviewed Original ResearchAttention/vigilanceSpeed of processingTotal antioxidant statusFirst-episode drug-naïve patientsDrug-naïve patientsCognitive impairmentCognitive deficitsSchizophrenia (MATRICS) Consensus Cognitive BatteryMCCB total scoreConsensus Cognitive BatteryHealthy controlsAntioxidant statusPlasma total antioxidant statusSex-matched healthy controlsOxidative stressPlasma TAS levelsPathophysiology of schizophreniaCognitive batteryStroop testNegative Syndrome ScaleReactive oxygen species-induced oxidative damageTreatment researchPsychopathological symptomsFEDN patientsHealthy subjects
2018
The effects of cannabidiol (CBD) on cognition and symptoms in outpatients with chronic schizophrenia a randomized placebo controlled trial
Boggs DL, Surti T, Gupta A, Gupta S, Niciu M, Pittman B, Schnakenberg Martin AM, Thurnauer H, Davies A, D’Souza D, Ranganathan M. The effects of cannabidiol (CBD) on cognition and symptoms in outpatients with chronic schizophrenia a randomized placebo controlled trial. Psychopharmacology 2018, 235: 1923-1932. PMID: 29619533, DOI: 10.1007/s00213-018-4885-9.Peer-Reviewed Original ResearchMeSH KeywordsAdministration, OralAdultAffectAntipsychotic AgentsCannabidiolChronic DiseaseCognitionCognitive DysfunctionDouble-Blind MethodFemaleFollow-Up StudiesHumansMaleMental Status and Dementia TestsMiddle AgedOutpatientsPsychiatric Status Rating ScalesSchizophreniaSchizophrenic PsychologyTreatment OutcomeConceptsMATRICS Consensus Cognitive BatterySide effectsChronic schizophreniaAntipsychotic-treated patientsMovement side effectsFixed-dose studyPlacebo-treated subjectsWeeks of treatmentPANSS total scoreEffects of cannabidiolWorsening of moodNegative Syndrome ScaleAntipsychotic-treated outpatients× time effect× time interactionMCCB composite scoreOral cannabidiolCBD groupClinical trialsParallel groupPANSS scoresMethodsThis studyPsychotic symptomsConsensus Cognitive BatterySyndrome Scale
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