2025
Altered brain activation during memory retrieval mediates the relationship between developmental trauma and psychotic symptom severity
Mason A, Palmer W, Cao H, Addington J, Bearden C, Cadenhead K, Cornblatt B, Perkins D, Mathalon D, Walker E, Woods S, Cannon T. Altered brain activation during memory retrieval mediates the relationship between developmental trauma and psychotic symptom severity. Schizophrenia Research 2025, 281: 115-121. PMID: 40328092, DOI: 10.1016/j.schres.2025.04.034.Peer-Reviewed Original ResearchConceptsInferior parietal lobe activityPsychotic symptom severityParietal lobe activityDevelopmental traumaDelusion severityHallucination severityMemory taskNeurocognitive measuresMemory processesMemory performanceSymptom severityScale of Psychosis-risk SymptomsNorth American Prodrome Longitudinal StudyPoorer episodic memory performanceRisk of psychotic symptomsPaired-associate memory taskAssociated with memory processingMemory-associated regionsTrauma-exposed individualsEpisodic memory processesEpisodic memory tasksPsychosis-risk symptomsClinical high riskEpisodic memory performanceSubclinical delusionsHigh rates of suicidality and parasuicidal behavior in individuals at clinical high-risk for psychosis: Implications for suicide risk assessment and suicide prevention
Trujillo T, Mirzakhanian H, Addington J, Bearden C, Cannon T, Cornblatt B, Keshavan M, Mathalon D, Perkins D, Stone W, Walker E, Woods S, Cadenhead K. High rates of suicidality and parasuicidal behavior in individuals at clinical high-risk for psychosis: Implications for suicide risk assessment and suicide prevention. Schizophrenia Research 2025, 281: 1-9. PMID: 40300257, DOI: 10.1016/j.schres.2025.04.030.Peer-Reviewed Original ResearchConceptsClinical high riskCalgary Depression Scale for SchizophreniaClinical high-risk youthSuicide risk assessmentParasuicidal behaviorSuicidal ideationLife eventsSelf-harmNorth American Prodrome Longitudinal StudyClinical high-risk participantsStructured Assessment of Violence RiskAssessment of Violence RiskClinical high-risk groupHealthy controlsRates of suicidal ideationHistory of self-harmHistory of SILevels of suicidalityStressful life eventsPredictors of SIRates of suicideAssociated with worse symptomsCHR participantsPsychotic conversionDSM diagnosesCultural variables influence performance on the MATRICS Consensus Cognitive Battery among people at clinical high risk for psychosis
Guest R, Aberizk K, Addington J, Bearden C, Cadenhead K, Cannon T, Cornblatt B, Keshavan M, Mathalon D, Perkins D, Stone W, Woods S, Walker E. Cultural variables influence performance on the MATRICS Consensus Cognitive Battery among people at clinical high risk for psychosis. Schizophrenia Research 2025, 280: 60-68. PMID: 40250131, PMCID: PMC12169887, DOI: 10.1016/j.schres.2025.04.019.Peer-Reviewed Original ResearchConceptsMATRICS Consensus Cognitive BatteryConsensus Cognitive BatteryClinical high riskCognitive batteryCHR-PHopkins Verbal Learning Test-RevisedNorth American Prodrome Longitudinal StudyEnglish speakersHealthy controlsLetter-Number SpanPsychosis-Risk SyndromesMultigroup structural equation modelingInfluence cognitive performanceCultural variablesNative English speakersSample of peopleLetter-NumberNeuropsychological measuresVariables influencing performanceTest-RevisedCognitive performanceStructural equation modelingAnimal namesDiagnostic groupsCanadian sampleDelineating Empirically Plausible Causal Pathways to Suicidality Among People at Clinical High Risk for Psychosis
Bronstein M, Kummerfeld E, Bearden C, Cornblatt B, Walker E, Woods S, Mathalon D, Perkins D, Cadenhead K, Addington J, Cannon T, Vinogradov S. Delineating Empirically Plausible Causal Pathways to Suicidality Among People at Clinical High Risk for Psychosis. Journal Of Psychopathology And Clinical Science 2025, 134: 239-250. PMID: 39913476, DOI: 10.1037/abn0000969.Peer-Reviewed Original ResearchConceptsClinical high riskNorth American Prodrome Longitudinal StudyClinical high-risk samplesAttenuated psychosis symptomsPathways to suicideSuicide risk reductionPsychosis symptomsCausal pathwaysDepressed moodPsychosisIntervention effortsSelf-deprecationSuicideLongitudinal studyMeasurement time pointsStudy timepointsHigh riskSymptomsInterventionHopelessnessMoodTime pointsDepressionIndividualsDirect causesRelations of temporoparietal connectivity with neighborhood social fragmentation in youth at clinical high-risk for psychosis
Aberizk K, Sefik E, Yuan Q, Cao H, Addington J, Bearden C, Cadenhead K, Cannon T, Cornblatt B, Keshavan M, Mathalon D, Perkins D, Stone W, Woods S, Walker E, Ku B. Relations of temporoparietal connectivity with neighborhood social fragmentation in youth at clinical high-risk for psychosis. Schizophrenia Research 2025, 277: 151-158. PMID: 40068446, PMCID: PMC11970632, DOI: 10.1016/j.schres.2025.02.012.Peer-Reviewed Original ResearchConceptsClinical high riskCHR-PCHR-P.Functional connectivityNorth American Prodrome Longitudinal StudyPatterns of brain connectivitySchizophrenia spectrum conditionsSocial engagementAutobiographical memory recallTemporoparietal brain regionsSuperior temporal poleBrain functional correlatesHippocampal functional connectivityTemporoparietal brain areasNeighbourhood social fragmentationArea-level characteristicsTemporal lobe abnormalitiesSocial fragmentationHealthy comparisonPsychotic disordersNeurobiological mechanismsHigh riskTemporal poleMemory recallBrain areasEmergence and dynamics of delusions and hallucinations across stages in early psychosis
Mourgues-Codern C, Benrimoh D, Gandhi J, Farina E, Vin R, Zamorano T, Parekh D, Malla A, Joober R, Lepage M, Iyer S, Addington J, Bearden C, Cadenhead K, Cornblatt B, Keshavan M, Stone W, Mathalon D, Perkins D, Walker E, Cannon T, Woods S, Shah J, Powers A. Emergence and dynamics of delusions and hallucinations across stages in early psychosis. Biological Psychiatry 2025 PMID: 40020853, DOI: 10.1016/j.biopsych.2025.02.891.Peer-Reviewed Original ResearchFirst-episode psychosis patientsSymptom patternsNorth American Prodrome Longitudinal StudyPositive symptoms of psychosisSymptoms of psychosisCHR-P samplesEarly intervention programsPositive symptomsDelusional ideationPsychosis patientsEarly psychosisCHR-PNeural mechanismsDelusionsHallucination onsetHallucinationsPsychosisBaseline assessmentLongitudinal studyIntervention programsSymptomsTime courseParticipantsIdeationOnset
2024
Mismatch Negativity as an Index of Auditory Short-Term Plasticity: Associations with Cortisol, Inflammation, and Gray Matter Volume in Youth at Clinical High Risk for Psychosis
Hamilton H, Roach B, Bachman P, Belger A, Carrión R, Duncan E, Johannesen J, Light G, Niznikiewicz M, Addington J, Bearden C, Cadenhead K, Cornblatt B, Perkins D, Tsuang M, Walker E, Woods S, Cannon T, Mathalon D. Mismatch Negativity as an Index of Auditory Short-Term Plasticity: Associations with Cortisol, Inflammation, and Gray Matter Volume in Youth at Clinical High Risk for Psychosis. Clinical EEG And Neuroscience 2024, 56: 46-59. PMID: 39552576, DOI: 10.1177/15500594241294035.Peer-Reviewed Original ResearchNMDAR-dependent plasticityClinical high riskGray matter volumeMismatch negativityMagnetic resonance imagingGray matter lossShort-term plasticityMMN amplitudeMatter volumeN-methyl-D-aspartateHigh riskCHR-PPro-inflammatory cytokine levelsPathogenesis of schizophreniaModel of schizophreniaBiomarkers of schizophreniaMismatch negativity amplitudeCHR-P individualsNorth American Prodrome Longitudinal StudyEvent-related potentialsAberrant neurodevelopmental processesInfluence of psychosisSubcortical gray matter volumesTotal gray matter volumeNMDAR hypofunctionNeighborhood ethnoracial diversity and positive psychotic symptoms among youth at high-risk and healthy comparisons
Ku B, Yuan Q, Haardörfer R, Addington J, Bearden C, Cadenhead K, Cannon T, Cornblatt B, Keshavan M, Mathalon D, Perkins D, Stone W, Woods S, Druss B, Walker E, Anglin D. Neighborhood ethnoracial diversity and positive psychotic symptoms among youth at high-risk and healthy comparisons. Psychiatry Research 2024, 342: 116222. PMID: 39378539, PMCID: PMC11617269, DOI: 10.1016/j.psychres.2024.116222.Peer-Reviewed Original ResearchHealthy comparisonPositive symptomsCHR-PPeer victimizationNorth American Prodrome Longitudinal StudyScale of Prodromal SymptomsAttenuated positive symptomsPositive psychotic symptomsClinical high riskFewer life eventsAssociated with schizophreniaEthnoracial diversityPsychotic symptomsHigh riskPrevent psychosisDepressive symptomsStructural equation modelingLife eventsProdromal symptomsPsychosisDiscriminatory experiencesEthnoracial minoritiesSocial determinantsNeighborhood povertyEthnoracial groupsSleep disturbance, suicidal ideation and psychosis-risk symptoms in individuals at clinical high risk for psychosis
Cohen S, Goldsmith D, Ning C, Addington J, Bearden C, Cadenhead K, Cannon T, Cornblatt B, Keshavan M, Mathalon D, Perkins D, Seidman L, Stone W, Tsuang M, Woods S, Walker E, Miller B. Sleep disturbance, suicidal ideation and psychosis-risk symptoms in individuals at clinical high risk for psychosis. Psychiatry Research 2024, 341: 116147. PMID: 39197223, DOI: 10.1016/j.psychres.2024.116147.Peer-Reviewed Original ResearchPsychosis-risk symptomsClinical high riskSuicidal ideationCHR-P individualsCHR-PSleep disturbanceTerminal insomniaNorth American Prodrome Longitudinal StudyAssociated with conversion to psychosisSleep problemsConversion to psychosisTreatment of sleep disturbancesAssociated with SIIndices of sleep disturbanceMultiple indicesPsychosisIdeationLongitudinal intervention studyInsomniaLongitudinal studySchizophreniaSymptomsSleepSymptom scoresInvestigate relationshipsOccasional cannabis use is associated with higher premorbid functioning and IQ in youth at clinical high-risk (CHR) for psychosis: Parallel findings to psychosis cohorts
Kennedy L, Ku B, Addington J, Amir C, Bearden C, Cannon T, Carrión R, Cornblatt B, Keshavan M, Perkins D, Mathalon D, Stone W, Walker E, Woods S, Cadenhead K. Occasional cannabis use is associated with higher premorbid functioning and IQ in youth at clinical high-risk (CHR) for psychosis: Parallel findings to psychosis cohorts. Schizophrenia Research 2024, 271: 319-331. PMID: 39084107, PMCID: PMC11955428, DOI: 10.1016/j.schres.2024.07.032.Peer-Reviewed Original ResearchClinical high riskCannabis use frequencyPremorbid functioningCannabis usePsychosis cohortSocial functioningCannabis usersAssociated with greater symptom severityAssociated with better neurocognitionNorth American Prodrome Longitudinal StudyClinical high-risk participantsClinical high-risk youthClinical high-risk populationsUse groupRates of cannabis useCannabis use groupsMeasures of IQCannabis use patternsGreater symptom severityHigher premorbid functioningFollow-up analysisPsychosis sampleHigher IQNeurocognitive domainsFirst-episodeNeurocognition in adolescents and young adults at clinical high risk for psychosis: Predictive stability for social and role functioning
Carrión R, Ku B, Dorvil S, Auther A, McLaughlin D, Addington J, Bearden C, Cadenhead K, Cannon T, Keshavan M, Mathalon D, Perkins D, Stone W, Tsuang M, Walker E, Woods S, Cornblatt B. Neurocognition in adolescents and young adults at clinical high risk for psychosis: Predictive stability for social and role functioning. Schizophrenia Research 2024, 271: 129-137. PMID: 39024961, PMCID: PMC12042140, DOI: 10.1016/j.schres.2024.06.054.Peer-Reviewed Original ResearchClinical high riskCHR-PNeurocognitive deficitsImpact of processing speedProcessing speedNorth American Prodrome Longitudinal StudyBaseline processing speedCHR-P participantsPoor social functioningCHR-P individualsYoung adultsDisorganized symptomsBaseline neurocognitionAttentional impairmentAttention deficitDevelopmental trajectoriesNeurocognitionPsychosisImpact of symptomsProdromal phaseSocial functioningIntervention issuesTreatment targetLongitudinal studyDeficitsDifferential expression of haptoglobin in individuals at clinical high risk of psychosis and its association with global functioning and clinical symptoms
Healy C, Byrne J, Raj Suasi S, Föcking M, Mongan D, Kodosaki E, Heurich M, Cagney G, Wynne K, Bearden C, Woods S, Cornblatt B, Mathalon D, Stone W, Cannon T, Addington J, Cadenhead K, Perkins D, Jeffries C, Cotter D. Differential expression of haptoglobin in individuals at clinical high risk of psychosis and its association with global functioning and clinical symptoms. Brain Behavior And Immunity 2024, 117: 175-180. PMID: 38219978, DOI: 10.1016/j.bbi.2023.12.018.Peer-Reviewed Original ResearchGlobal Assessment of Functioning ScaleNorth American Prodrome Longitudinal StudyClinical high riskPoor functionScale of Psychosis-risk SymptomsPsychosis-risk symptomsAssociated with poorer functioningFirst-episode psychosisTransition to psychosisGreater symptom severityFollow-upIndividuals at-riskClinical symptomsPsychotic disordersHigh riskSymptom severityPsychosocial functioningGlobal functioningPsychosisSubscale scoresFDR correctionAcute phase inflammatory responseLongitudinal studyGlobal assessmentFunctional scalesAttention Deficit Hyperactivity Disorder Among Youth at Clinical High Risk of Psychosis
Braun A, Liu L, Bearden C, Cadenhead K, Cornblatt B, Keshavan M, Mathalon D, Perkins D, Stone W, Tsuang M, Walker E, Woods S, Cannon T, Addington J. Attention Deficit Hyperactivity Disorder Among Youth at Clinical High Risk of Psychosis. Schizophrenia Bulletin Open 2024, 5: sgae028. PMID: 39583590, PMCID: PMC11584910, DOI: 10.1093/schizbullopen/sgae028.Peer-Reviewed Original ResearchClinical high riskCo-morbid ADHDClinical high risk of psychosisPredictors of transition to psychosisNorth American Prodrome Longitudinal StudySubstance useClinical high-risk individualsClinical high-risk participantsClinical high-risk youthHigh risk of psychosisAttention deficit hyperactivity disorderNegative psychotic symptomsTransition to psychosisCo-morbid disordersNon-ADHD groupRisk of psychosisDeficit hyperactivity disorderCo-morbidityIncreased substance useAssociated with numerous adverse outcomesPsychotic symptomsNumerous adverse outcomesPremorbid functioningSocial cognitionADHD group
2023
Relations of Lifetime Perceived Stress and Basal Cortisol With Hippocampal Volume Among Healthy Adolescents and Those at Clinical High Risk for Psychosis: A Structural Equation Modeling Approach
Aberizk K, Addington J, Bearden C, Cadenhead K, Cannon T, Cornblatt B, Keshavan M, Mathalon D, Perkins D, Stone W, Tsuang M, Woods S, Walker E, Ku B. Relations of Lifetime Perceived Stress and Basal Cortisol With Hippocampal Volume Among Healthy Adolescents and Those at Clinical High Risk for Psychosis: A Structural Equation Modeling Approach. Biological Psychiatry 2023, 96: 401-411. PMID: 38092185, PMCID: PMC11166888, DOI: 10.1016/j.biopsych.2023.11.027.Peer-Reviewed Original ResearchBilateral hippocampal volumeStructural equation modelingHealthy comparisonsHippocampal volumeBiological sexRelation of ageEquation modelingMultigroup structural equation modelingNorth American Prodrome Longitudinal StudyMeasures of stressNon-human animalsNonspecific risk factorClinical high riskStructural equation modeling approachAdolescent sampleBasal cortisolPerceived stressSmaller hippocampal volumesElevated basal cortisolAssociations Between Childhood Area-Level Social Fragmentation, Maladaptation to School, and Social Functioning Among Healthy Youth and Those at Clinical High Risk for Psychosis
Ku B, Addington J, Bearden C, Cadenhead K, Cannon T, Compton M, Cornblatt B, Druss B, Gülöksüz S, Mathalon D, Perkins D, Tsuang M, Walker E, Woods S, Carrión R. Associations Between Childhood Area-Level Social Fragmentation, Maladaptation to School, and Social Functioning Among Healthy Youth and Those at Clinical High Risk for Psychosis. Schizophrenia Bulletin 2023, 49: 1437-1446. PMID: 37358832, PMCID: PMC10686327, DOI: 10.1093/schbul/sbad093.Peer-Reviewed Original ResearchConceptsClinical high riskHealthy comparisonsSocial functioningHigh riskPoor social functioningNorth American Prodrome Longitudinal StudyImportant risk factorRisk factorsPsychotic disordersEffective interventionsHealthy youthChildhoodLongitudinal studyAdulthoodPsychosisAssociationAdultsMaladaptationRiskSocial deficitsFurther researchFunctioningCommunity level
2022
Accelerated cortical thinning precedes and predicts conversion to psychosis: The NAPLS3 longitudinal study of youth at clinical high-risk
Collins M, Ji J, Chung Y, Lympus C, Afriyie-Agyemang Y, Addington J, Goodyear B, Bearden C, Cadenhead K, Mirzakhanian H, Tsuang M, Cornblatt B, Carrión R, Keshavan M, Stone W, Mathalon D, Perkins D, Walker E, Woods S, Powers A, Anticevic A, Cannon T. Accelerated cortical thinning precedes and predicts conversion to psychosis: The NAPLS3 longitudinal study of youth at clinical high-risk. Molecular Psychiatry 2022, 28: 1182-1189. PMID: 36434057, PMCID: PMC10005940, DOI: 10.1038/s41380-022-01870-7.Peer-Reviewed Original ResearchConceptsCHR-NCPercent thickness changeCortical thinningPsychosis onsetHealth controlsProgressive grey matter lossNorth American Prodrome Longitudinal StudyClinical high-risk individualsGray matter lossHigh-risk individualsLongitudinal studyGreater percent decreaseNovel treatment targetsParietal cortical regionsTargeted early interventionsCortical thicknessCortical areasMRI scansCHR individualsTreatment targetsEarly interventionCortical regionsLeft hemisphere regionsROC analysisHC participants
2021
White matter changes in psychosis risk relate to development and are not impacted by the transition to psychosis
Di Biase MA, Cetin-Karayumak S, Lyall AE, Zalesky A, Cho KIK, Zhang F, Kubicki M, Rathi Y, Lyons MG, Bouix S, Billah T, Anticevic A, Schleifer C, Adkinson BD, Ji JL, Tamayo Z, Addington J, Bearden CE, Cornblatt BA, Keshavan MS, Mathalon DH, McGlashan TH, Perkins DO, Cadenhead KS, Tsuang MT, Woods SW, Stone WS, Shenton ME, Cannon TD, Pasternak O. White matter changes in psychosis risk relate to development and are not impacted by the transition to psychosis. Molecular Psychiatry 2021, 26: 6833-6844. PMID: 34024906, PMCID: PMC8611104, DOI: 10.1038/s41380-021-01128-8.Peer-Reviewed Original ResearchConceptsClinical high riskWhite matter changesWhite matter microstructureHigh riskMatter changesCHR individualsAge-related white matter changesNorth American Prodrome Longitudinal StudyEmergence of psychosisWhite matter abnormalitiesYears of ageImpact of ageIllness onsetExtracellular free waterHealthy controlsLongitudinal cohortCHR subjectsMagnetic resonance imaging dataProspective analysisRegional fatLinear mixed effects modelsHigh fatPsychosisFractional anisotropyBaseline measures
2019
Duration of the psychosis prodrome
Powers AR, Addington J, Perkins DO, Bearden CE, Cadenhead KS, Cannon TD, Cornblatt BA, Mathalon DH, Seidman LJ, Tsuang MT, Walker EF, McGlashan TH, Woods SW. Duration of the psychosis prodrome. Schizophrenia Research 2019, 216: 443-449. PMID: 31806523, PMCID: PMC7539292, DOI: 10.1016/j.schres.2019.10.051.Peer-Reviewed Original ResearchConceptsSyndrome onsetPsychosis prodromeNorth American Prodrome Longitudinal StudyCHR-P patientsClinical high-risk syndromeHigh-risk syndromePsychosis risk syndromeMedication exposureProdromal periodFrank psychosisRisk syndromeProdromePsychosisLongitudinal studySyndromeOnsetStructured interviewsDurationFirst descriptionThirdYearsFinal thirdPatientsMonths
2017
The Role of microRNA Expression in Cortical Development During Conversion to Psychosis
Zheutlin AB, Jeffries CD, Perkins DO, Chung Y, Chekroud AM, Addington J, Bearden CE, Cadenhead KS, Cornblatt BA, Mathalon DH, McGlashan TH, Seidman LJ, Walker EF, Woods SW, Tsuang M, Cannon TD. The Role of microRNA Expression in Cortical Development During Conversion to Psychosis. Neuropsychopharmacology 2017, 42: 2188-2195. PMID: 28186095, PMCID: PMC5603810, DOI: 10.1038/npp.2017.34.Peer-Reviewed Original ResearchConceptsNorth American Prodrome Longitudinal StudyCortical thinningDisease onsetClinical high-risk individualsProinflammatory cytokine levelsHigh-risk individualsGray matter reductionsOnset of psychosisCortical gray matter reductionMicroRNA expressionMicroglial actionCytokine levelsProinflammatory cytokinesCortical maturationImmune cellsHealthy controlsInflammatory responsePeripheral leukocytesCortical developmentHigh riskImmune functionSynaptic plasticityImmune systemConversion statusResident macrophages
2016
Multisite reliability of MR-based functional connectivity
Noble S, Scheinost D, Finn ES, Shen X, Papademetris X, McEwen SC, Bearden CE, Addington J, Goodyear B, Cadenhead KS, Mirzakhanian H, Cornblatt BA, Olvet DM, Mathalon DH, McGlashan TH, Perkins DO, Belger A, Seidman LJ, Thermenos H, Tsuang MT, van Erp TGM, Walker EF, Hamann S, Woods SW, Cannon TD, Constable RT. Multisite reliability of MR-based functional connectivity. NeuroImage 2016, 146: 959-970. PMID: 27746386, PMCID: PMC5322153, DOI: 10.1016/j.neuroimage.2016.10.020.Peer-Reviewed Original ResearchConceptsNorth American Prodrome Longitudinal StudyRight motor cortexIntrinsic connectivity distributionPosterior cingulate cortexFunctional connectivity studiesFunctional connectivity measurementsMultisite studyVoxel-wise connectivityConnectivity studiesConnectivity measuresSeed-based connectivityConnectivity analysisMotor cortexHealthy cohortCingulate cortexScan durationSingle-subject levelFcMRI dataFunctional connectivityConnectivity measurementsClinical populationsLittle dataLongitudinal studyMultisite reliabilityScanner manufacturers
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