2′-Fucosyllactose mitigates cognitive deficits in Alzheimer models: targeting amyloid pathology, oxidative stress, and synaptic plasticity
Munni Y, Tran K, Jeon S, Hwang M, Yoon J, Song Y, Oh T, Gum S, Yang I. 2′-Fucosyllactose mitigates cognitive deficits in Alzheimer models: targeting amyloid pathology, oxidative stress, and synaptic plasticity. Frontiers In Pharmacology 2025, 16: 1598030. DOI: 10.3389/fphar.2025.1598030.Peer-Reviewed Original ResearchPrimary hippocampal neuronsY-maze testWater mazeY-mazeCognitive performanceSynaptic vesicle protein 2Synaptic vesicle recyclingMouse model of ADAlzheimer's diseaseHuman milk oligosaccharidesRelevant to ADDisorder complexitySynaptic plasticityCytokine levels in vivoMouse modelModel of ADOxidative stressAD-related cognitive declineMorris water mazeInterleukin (IL)-6 levelsTumor necrosis factor (TNF)-aBrain-derived neurotrophic factorShortened escape latencyVesicle recyclingPostsynaptic density protein 95
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