2025
Effect of Esketamine on Depressive Symptoms in Adolescents with Major Depressive Disorder at Imminent Suicide Risk: A Randomized Psychoactive-Controlled Study
Kosik-Gonzalez C, Fu D, Chen L, Lane R, Bloch M, DelBello M, Moreno C, Drevets W, Canuso C. Effect of Esketamine on Depressive Symptoms in Adolescents with Major Depressive Disorder at Imminent Suicide Risk: A Randomized Psychoactive-Controlled Study. Journal Of The American Academy Of Child & Adolescent Psychiatry 2025 PMID: 40058488, DOI: 10.1016/j.jaac.2025.02.015.Peer-Reviewed Original ResearchChildren's Depression Rating Scale-RevisedMajor depressive disorderDepressive disorderDepressive symptomsEsketamine dosesSymptoms of major depressive disorderCDRS-R total scoreEsketamine nasal sprayEvidenced-based psychotherapySeverity of suicidalityImprove depressive symptomsReducing depressive symptomsEffects of esketamineIntentional self-injuryImminent riskIntranasal esketamineOral antidepressantSelf-injurySuicidal ideationEnd-point changesAnalysis of covarianceScale-RevisedBetween-group differencesEsketamineTotal score
2024
Effect of Esketamine Nasal Spray on Cognition in Patients With Treatment-Resistant Depression: Results From Four Phase 3 Studies
Morrison R, Singh J, Daly E, Fedgchin M, Ochs-Ross R, Karcher K, Lane R, Cooper K, Sanacora G, Maruff P, Drevets W. Effect of Esketamine Nasal Spray on Cognition in Patients With Treatment-Resistant Depression: Results From Four Phase 3 Studies. The International Journal Of Neuropsychopharmacology 2024, 27: pyae046. PMID: 39514643, PMCID: PMC11561565, DOI: 10.1093/ijnp/pyae046.Peer-Reviewed Original ResearchEsketamine nasal sprayTreatment-resistant depressionLong-term maintenance treatmentMADRS scoreOral antidepressantHopkins Verbal Learning Test-RevisedMaintenance treatmentCognitive test batteryEffects of esketamineGroup mean performanceFollow-up assessmentMild to moderate impairmentDepression severityTest-RevisedCogState batteryCognitive performancePsychomotor functionTest batteryCognitive testsCognitionEsketamineNasal sprayEffect sizeDepressionEffects of short-term
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