2025
Amino acid patterns predict white matter integrity measures in the brain in patients across the Alzheimer’s disease continuum
Goharmanesh F, Masmoie M, Nasiri H, Sadat-Madani S, Namin S, Damizadeh M, Shakeri S, Sodeifian F, Rajabpour-Sanati A, Bahrainian B, Mohammadi Y, Shushtari A, Mayeli M. Amino acid patterns predict white matter integrity measures in the brain in patients across the Alzheimer’s disease continuum. Metabolic Brain Disease 2025, 40: 227. PMID: 40531346, DOI: 10.1007/s11011-025-01647-1.Peer-Reviewed Original ResearchConceptsWhite matter integrityMean diffusivityDiffusion tensor imagingFractional anisotropyAlzheimer's Disease Neuroimaging InitiativeAxial diffusivityAA metabolic pathwaysReduced white matter integrityDisease continuumDTI-derived metricsWhite matter integrity measuresWhite matter microstructural integrityAD patientsCross-sectional studyUltra-high performance liquid chromatographyPotential therapeutic targetRadial diffusivityDecreased FAIncreased MDStudy groupEarly diagnosisProgression markersAlzheimer's disease continuumAmino acidsMild cognitive impairmentElevated serum leucine levels are associated with cognitive impairment and reduced gray matter and cerebral volume across the Alzheimer’s disease continuum
Nasiri H, Azargoonjahromi A, Nouri Z, Azimi S, Zand H, Shourideh A, Heydari S, Mahmoudvand B, Barabadi S, Samadpour N, Mohamadhosseini A, Khodadadi A, Shakeri S, Mayeli M, Initiative F. Elevated serum leucine levels are associated with cognitive impairment and reduced gray matter and cerebral volume across the Alzheimer’s disease continuum. Neuroscience 2025, 577: 47-53. PMID: 40348165, DOI: 10.1016/j.neuroscience.2025.05.013.Peer-Reviewed Original ResearchConceptsCognitive performanceBrain volumeMediation analysisAlzheimer's Disease Assessment Scale-cognitive subscaleReduced gray matterGray matter volumeStructural brain volumesAssociated with cognitive impairmentAlzheimer's diseaseGray matterMagnetic resonance imagingPoor cognitive outcomesAlzheimer's disease continuumMatter volumeT1-weighted magnetic resonance imagingBrain structuresCognitive outcomesCerebral volumeCognitive impairmentCognitive declineBrain atrophyAD continuumBrainSerum leucine levelsAD pathologyPotential Mediating Role of Polygenic Hazard Score in the Association Between Neurofilament Light Chain and Default Mode Network Connectivity Across the Alzheimer's Disease Continuum
Saberian P, Nasiri H, Kaffashian F, Nasiriansari P, Nasab F, Mehrvarz N, Talebizadeh F, Shakeri S, Mayeli M, Initiative F. Potential Mediating Role of Polygenic Hazard Score in the Association Between Neurofilament Light Chain and Default Mode Network Connectivity Across the Alzheimer's Disease Continuum. IBRO Neuroscience Reports 2025, 18: 732-738. PMID: 40476223, PMCID: PMC12139489, DOI: 10.1016/j.ibneur.2025.04.018.Peer-Reviewed Original ResearchPolygenic hazard scoreDMN connectivityMild cognitive impairmentAlzheimer's diseaseAlzheimer's Disease Neuroimaging InitiativeDefault mode network connectivityNo significant indirect effectsAD groupLight chainMode network connectivityGenetic risk burdenResting-state fMRIBrain network connectivityMild cognitive impairment groupPlasma NfL levelsPotential mediator roleHazard scoreAlzheimer's disease continuumProgressive cognitive declineMediation modelRs-fMRIMediation analysisPlasma NfLCognitive stagesDMNMultimodal MRI accurately identifies amyloid status in unbalanced cohorts in Alzheimer’s disease continuum
Dolci G, Ellis C, Cruciani F, Brusini L, Abrol A, Galazzo I, Menegaz G, Calhoun V, Initiative F. Multimodal MRI accurately identifies amyloid status in unbalanced cohorts in Alzheimer’s disease continuum. Network Neuroscience 2025, 9: 259-279. PMID: 40161995, PMCID: PMC11949592, DOI: 10.1162/netn_a_00423.Peer-Reviewed Original ResearchNeuropathological hallmarks of Alzheimer's diseaseHallmarks of Alzheimer's diseaseHyperphosphorylated tau proteinAmyloid-bTau proteinNeurofibrillary tanglesNeuropathological hallmarksAmyloid accumulationAlzheimer's diseaseAb accumulationDepositional signatureIdentification of individualsAmyloid statusAccumulationAmyloidShed lightTanglesAlzheimer's disease continuumProteinUncovering cerebral blood flow patterns corresponding to Amyloid-beta accumulations in patients across the Alzheimer’s disease continuum using the arterial spin labeling
Daneshpour A, Nasiri H, Motamed A, Heidarzadeh N, Fard A, Koleini S, Fakhimi F, Abiri L, Mayeli M, Sadeghi M. Uncovering cerebral blood flow patterns corresponding to Amyloid-beta accumulations in patients across the Alzheimer’s disease continuum using the arterial spin labeling. Neurological Sciences 2025, 46: 2081-2090. PMID: 39838256, DOI: 10.1007/s10072-025-07992-4.Peer-Reviewed Original ResearchConceptsMild cognitive impairmentSubjective memory complaintsMethodsWe analyzed dataAmyloid-betaDisease continuumAD participantsLinear regression modelsMultiple linear regression modelMemory complaintsRight inferior parietal cortexUnadjusted analysisCaudal middle frontal cortexRight lateral occipital cortexEducation levelAlzheimer's disease continuumCerebral blood flowAmyloid-beta accumulationArterial spin labelingLeft pars triangularisMiddle frontal cortexInferior parietal cortexAD dementiaLateral occipital cortexHigher cognitive functionsCognitive decline
2024
Polygenic hazard score predicts synaptic and axonal degeneration and cognitive decline in Alzheimer's disease continuum
Farhadieh M, Mozafar M, Sanaaee S, Sodeifi P, Kousha K, Zare Y, Zare S, Rad N, Jamshidi-Goharrizi F, Allahverdloo M, Rahimi A, Sadeghi M, Shafie M, Mayeli M, Initiative F. Polygenic hazard score predicts synaptic and axonal degeneration and cognitive decline in Alzheimer's disease continuum. Archives Of Gerontology And Geriatrics 2024, 127: 105576. PMID: 39096557, DOI: 10.1016/j.archger.2024.105576.Peer-Reviewed Original ResearchConceptsPolygenic hazard scoreMild cognitive impairmentCognitive declineCognitive impairmentLevel of cognitive impairmentFollow-up cognitive assessmentHazard scoreMCI patientsFollow-up cognitive testingCognitive measuresAssociated with cognitive declineFollow-up pointsAlzheimer's diseaseAlzheimer's disease continuumCognitive AssessmentAssociated with specific biomarkersCognitively normal controlsCognitive testsCompared to low-risk patientsLongitudinal analysisHigh riskLow riskLow-risk patientsDisease continuumCognitive outcomesDiffusion MRI Allows Capturing the Amyloid-β and τ Proteins Status in Alzheimer’s Disease Continuum
Dolci G, Cruciani F, Brusini L, Pini L, Galazzo I, Calhoun V, Menegaz G. Diffusion MRI Allows Capturing the Amyloid-β and τ Proteins Status in Alzheimer’s Disease Continuum. 2024, 00: 1-5. DOI: 10.1109/isbi56570.2024.10635105.Peer-Reviewed Original Research
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply