2025
Dissecting causal relationships between cortical morphology and neuropsychiatric disorders: a bidirectional Mendelian randomization study
Lin B, Li Y, Goula A, Chang X, Grasby K, Medland S, Andreassen O, Rutten B, Guloksuz S, van der Meer D, Luykx J. Dissecting causal relationships between cortical morphology and neuropsychiatric disorders: a bidirectional Mendelian randomization study. Nature Mental Health 2025, 3: 613-625. PMID: 40855853, PMCID: PMC12372973, DOI: 10.1038/s44220-025-00397-4.Peer-Reviewed Original ResearchMean cortical thicknessCognitive performanceCortical morphologySchizophrenia riskBrain cortical surface areaEffects of cognitive performanceCortical surface areaImproving brain healthCortical morphological measuresNeuropsychiatric disordersNeuropsychiatric phenotypesBidirectional associationsBrain healthSchizophreniaNeuropsychiatric traitsCortical thicknessGlobal mean cortical thicknessSmoking initiationPositive causal effectTemporal thicknessInvestigate causal linksCausal effectsBrainCausal linkIntervention studies
2023
Mice lacking Ptprd exhibit deficits in goal-directed behavior and female-specific impairments in sensorimotor gating
Ho E, Welch A, Thompson S, Knowles J, Dulawa S. Mice lacking Ptprd exhibit deficits in goal-directed behavior and female-specific impairments in sensorimotor gating. PLOS ONE 2023, 18: e0277446. PMID: 37205689, PMCID: PMC10198499, DOI: 10.1371/journal.pone.0277446.Peer-Reviewed Original ResearchConceptsProtein tyrosine phosphatase receptor type DGenome-wide association studiesProtein tyrosine phosphatase familyTyrosine phosphatase familyReceptor type DPhosphatase familyAssociation studiesGenetic studiesCell adhesionPTPRDNest-building behaviorEffect of genotypeSynaptic specificationNeuropsychiatric phenotypesTraitsConstitutive lackKnockout miceKO miceGatingLociBuilding behaviorMicePhenotype
2001
Regional cortical white matter reductions in velocardiofacial syndrome: a volumetric MRI analysis
Kates W, Burnette C, Jabs E, Rutberg J, Murphy A, Grados M, Geraghty M, Kaufmann W, Pearlson G. Regional cortical white matter reductions in velocardiofacial syndrome: a volumetric MRI analysis. Biological Psychiatry 2001, 49: 677-684. PMID: 11313035, DOI: 10.1016/s0006-3223(00)01002-7.Peer-Reviewed Original ResearchConceptsWhite matter reductionLobar brain regionsVelocardiofacial syndromeWhite matterBrain regionsVolumetric MRI analysisWhite matter anomaliesWhite matter volumeMatter reductionCerebral lobesAxonal integrityPsychiatric disordersCardiac defectsMatter volumeSyndromeBrain tissueGray matterLobar volumesCSF compartmentMRI analysisBrain developmentCraniofacial anomaliesUnaffected childrenNeuropsychiatric phenotypesCoronal images
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