2024
Metabolic imaging of human embryos is predictive of ploidy status but is not associated with clinical pregnancy outcomes: a pilot trial
Sakkas D, Gulliford C, Ardestani G, Ocali O, Martins M, Talasila N, Shah J, Penzias A, Seidler E, Sanchez T. Metabolic imaging of human embryos is predictive of ploidy status but is not associated with clinical pregnancy outcomes: a pilot trial. Human Reproduction 2024, 39: 516-525. PMID: 38195766, DOI: 10.1093/humrep/dead268.Peer-Reviewed Original ResearchGood quality blastocystsPilot trialPregnancy outcomesMetabolic imagingPloidy statusNon-invasive metabolic imagingLogistic regressionSTUDY FUNDING/COMPETINGClinical pregnancy outcomesFlavin adenine dinucleotide concentrationsPARTICIPANTS/MATERIALSROLE OF CHANCEMetabolic imaging parametersHuman blastocystsMitochondrial metabolismBoston IVFDay 6 blastocystsRobust AUCIVF couplesStudy protocolImaging assessmentHuman embryosMetabolic parametersFrozen blastocystsDay 5
2023
Intra-patient analysis of individual weight gain or loss between IVF cycles: cycle now and transfer later
Fouks Y, Vaughan D, Neuhausser W, Cohen Y, Penzias A, Sakkas D. Intra-patient analysis of individual weight gain or loss between IVF cycles: cycle now and transfer later. Human Reproduction 2023, 39: 93-101. PMID: 38006233, DOI: 10.1093/humrep/dead244.Peer-Reviewed Original ResearchConceptsIVF cyclesNumber of oocytesWeight gainWeight lossObstetrical riskWeight changeReproductive outcomesBlastulation rateCumulative live birth rateSTUDY FUNDING/COMPETINGShort-term weight gainInitial IVF cycleGEE modelLive birth rateMarkers of obesityAdverse reproductive outcomesPARTICIPANTS/MATERIALSCycle outcome parametersROLE OF CHANCESignificant weight changePositive associationFertilization rateIntra-patient analysisIndividual weight gainObese patients
2022
Urinary phenol concentrations and fecundability and early pregnancy loss
Vollmar A, Weinberg C, Baird D, Wilcox A, Calafat A, Deziel N, Johnson C, Jukic A. Urinary phenol concentrations and fecundability and early pregnancy loss. Human Reproduction 2022, 38: 139-155. PMID: 36346334, PMCID: PMC10089295, DOI: 10.1093/humrep/deac230.Peer-Reviewed Original ResearchConceptsEarly pregnancy lossPregnancy lossUrinary phenol concentrationsIntraclass correlation coefficientMenstrual cycleNational InstituteDaily first-morning urine specimensPhenol exposureEnvironmental Health SciencesFirst morning urine specimensLogistic regressionSTUDY FUNDING/COMPETINGMultivariable logistic regressionPARTICIPANTS/MATERIALSROLE OF CHANCEIntramural Research ProgramClinical miscarriageProspective cohortIncreased oddsLive birthsEpidemiologic studiesUrine specimensHealth SciencesEndocrine-disrupting potentialReproductive functionTranscriptomic landscape of granulosa cells and peripheral blood mononuclear cells in women with PCOS compared to young poor responders and women with normal response
Cozzolino M, Herraiz S, Titus S, Roberts L, Romeu M, Peinado I, Scott RT, Pellicer A, Seli E. Transcriptomic landscape of granulosa cells and peripheral blood mononuclear cells in women with PCOS compared to young poor responders and women with normal response. Human Reproduction 2022, 37: 1274-1286. PMID: 35451009, PMCID: PMC9156844, DOI: 10.1093/humrep/deac069.Peer-Reviewed Original ResearchConceptsPeripheral blood mononuclear cellsYoung poor respondersPolycystic ovary syndromePoor ovarian responseGCs of PCOSOvarian granulosa cellsBlood mononuclear cellsGranulosa cellsMature folliclesPoor respondersMononuclear cellsRNA expression profilesNormal responseAge groupsSTUDY FUNDING/COMPETINGHigher menopausal ageRotterdam diagnostic criteriaOvarian hyperstimulation syndromeInstituto de Salud Carlos IIIPARTICIPANTS/MATERIALSAntral follicular countROLE OF CHANCEOvarian follicular dynamicsSame study groupIngenuity Pathway Analysis
2021
Body mass index and subfertility: multivariable regression and Mendelian randomization analyses in the Norwegian Mother, Father and Child Cohort Study
Hernáez Á, Rogne T, Skåra KH, Håberg SE, Page CM, Fraser A, Burgess S, Lawlor DA, Magnus MC. Body mass index and subfertility: multivariable regression and Mendelian randomization analyses in the Norwegian Mother, Father and Child Cohort Study. Human Reproduction 2021, 36: 3141-3151. PMID: 34668019, PMCID: PMC8600658, DOI: 10.1093/humrep/deab224.Peer-Reviewed Original ResearchConceptsCohort studyBMI valuesMendelian randomization analysisMultivariable regressionGreater oddsMultivariable logistic regression modelSTUDY FUNDING/COMPETINGProject number 262700Risk of subfertilityRandomization analysisBody mass indexChild Cohort StudyPARTICIPANTS/MATERIALSUK National InstituteNational InstituteROLE OF CHANCELogistic regression modelsSelf-reported informationAssisted reproduction technologyObese menObese womenHigher BMILower BMIMass indexUS National Institutes
2020
Factors associated with study protocol adherence and bio banking participation in reproductive medicine clinical trials and their relationship to live birth
Engmann L, Sun F, Legro RS, Diamond MP, Zhang H, Santoro N, Bartlebaugh C, Dodson W, Estes S, Ober J, Brzyski R, Easton C, Hernandez A, Leija M, Pierce D, Robinson R, Awonuga A, Cedo L, Cline A, Collins K, Krawetz S, Puscheck E, Singh M, Yoscovits M, Barnhart K, Coutifaris C, Lecks K, Martino L, Marunich R, Snyder P, Alvero R, Comfort A, Crow M, Schlaff W, Casson P, Hohmann A, Mallette S, Christman G, Ohl D, Ringbloom M, Tang J, Bates G, Mason S, DiMaria N, Usadi R, Lucidi R, Rhea M, Baker V, Turner K, Trussell J, DelBasso D, Huang H, Li Y, Makuch R, Patrizio P, Sakai L, Scahill L, Taylor H, Thomas T, Tsang S, Yan Q, Zhang M, Haisenleder D, Lamar C, DePaolo L, Herring A, Redmond J, Thomas M, Turek P, Wactawski-Wende J, Rebar R, Cato P, Dukic V, Lewis V, Schlegel P, Witter F. Factors associated with study protocol adherence and bio banking participation in reproductive medicine clinical trials and their relationship to live birth. Human Reproduction 2020, 35: 2819-2831. PMID: 33190149, PMCID: PMC8453415, DOI: 10.1093/humrep/deaa232.Peer-Reviewed Original ResearchConceptsPolycystic ovary syndromeClinical trial protocolMedicine clinical trialsU10 HD055942U10 HD38998Baseline characteristicsTrial protocolClinical trialsLive birthsPolycystic Ovary Syndrome IIU10 HD38992U10 HD39005U10 HD27049STUDY FUNDING/COMPETINGMultiple Intrauterine GestationsStudy protocol adherenceUS multicenter trialRegular ovulatory cyclesClinical trial findingsPolycystic ovarian morphologyPARTICIPANTS/MATERIALSROLE OF CHANCELower household incomeAfrican AmericansAspects of adherenceYoung women with poor ovarian response exhibit epigenetic age acceleration based on evaluation of white blood cells using a DNA methylation-derived age prediction model
Hanson BM, Tao X, Zhan Y, Jenkins TG, Morin SJ, Scott RT, Seli EU. Young women with poor ovarian response exhibit epigenetic age acceleration based on evaluation of white blood cells using a DNA methylation-derived age prediction model. Human Reproduction 2020, 35: 2579-2588. PMID: 33049778, DOI: 10.1093/humrep/deaa206.Peer-Reviewed Original ResearchConceptsPoor ovarian responseWhite blood cellsPolycystic ovary syndromeOvarian responseOvarian stimulationChronologic ageWBC samplesEpigenetic age accelerationCumulus cellsAge accelerationYoung womenSTUDY FUNDING/COMPETINGBlood cellsProspective cohort studyGood responder groupCommon clinical challengePeripheral blood samplesPARTICIPANTS/MATERIALSROLE OF CHANCEYears of agePatient's chronologic ageGeneral health consequencesCC samplesAge-related changesAge prediction modelVarying levels of serum estradiol do not alter the timing of the early endometrial secretory transformation
Osman E, Wang T, Zhan Y, Juneau C, Morin S, Seli E, Scott R, Franasiak J. Varying levels of serum estradiol do not alter the timing of the early endometrial secretory transformation. Human Reproduction 2020, 35: 1637-1647. PMID: 32613240, DOI: 10.1093/humrep/deaa135.Peer-Reviewed Original ResearchConceptsEndometrial secretory transformationWindow of implantationSecretory transformationE2 levelsPg/IVF cyclesEndometrial biopsyEndometrial responseStimulation cyclesE2 concentrationsStudy designSTUDY FUNDING/COMPETINGSupraphysiologic E2 levelsSupraphysiologic estradiol levelsClinical pregnancy rateControlled ovarian stimulationEndometrial biopsy specimensFresh embryo transferHistory of infertilityPARTICIPANTS/MATERIALSROLE OF CHANCEEmbryonic competenceE2 riseEndometrial assessmentIntramuscular P4Intrauterine insemination performance characteristics and post-processing total motile sperm count in relation to live birth for couples with unexplained infertility in a randomised, multicentre clinical trial
Hansen KR, Peck JD, Coward RM, Wild RA, Trussell JC, Krawetz SA, Diamond MP, Legro RS, Coutifaris C, Alvero R, Robinson RD, Casson P, Christman GM, Santoro N, Zhang H. Intrauterine insemination performance characteristics and post-processing total motile sperm count in relation to live birth for couples with unexplained infertility in a randomised, multicentre clinical trial. Human Reproduction 2020, 35: 1296-1305. PMID: 32432326, PMCID: PMC7316499, DOI: 10.1093/humrep/deaa027.Peer-Reviewed Original ResearchConceptsTotal motile sperm countLive birth rateHigher total motile sperm countUnexplained infertilityMulticentre clinical trialMotile sperm countClinical trialsLive birthsOvarian stimulationHCG injectionBirth ratePatient discomfortSperm countTreatment cyclesSecondary analysisEunice Kennedy Shriver National InstituteSTUDY FUNDING/COMPETINGLive birth successMultiple Intrauterine GestationsDuration of infertilityIUI treatment cyclesLive birth outcomesPARTICIPANTS/MATERIALSROLE OF CHANCEYears of age
2019
A novel copy number variation in CATSPER2 causes idiopathic male infertility with normal semen parameters
Luo T, Chen H, Zou Q, Wang T, Cheng Y, Wang H, Wang F, Jin Z, Chen Y, Weng S, Zeng X. A novel copy number variation in CATSPER2 causes idiopathic male infertility with normal semen parameters. Human Reproduction 2019, 34: 414-423. PMID: 30629171, DOI: 10.1093/humrep/dey377.Peer-Reviewed Original ResearchConceptsIdiopathic male infertilityNormal semen parametersWhole-cell patch-clamp techniqueMale infertilityPatch-clamp techniqueSemen parametersCatSper currentsIdiopathic infertilitySTUDY FUNDING/COMPETINGGenetic abnormalitiesCatSper genesChild Health HospitalReproductive medical centerNovel copy number variationsPARTICIPANTS/MATERIALSROLE OF CHANCEHuman male infertilityHealthy male donorsCopy number variationsHuman CatSperPrinciple Ca2Progesterone responseCase reportProvincial MaternalHealth Hospital
2018
Allostatic load, a measure of chronic physiological stress, is associated with pregnancy outcomes, but not fertility, among women with unexplained infertility
Barrett ES, Vitek W, Mbowe O, Thurston SW, Legro RS, Alvero R, Baker V, Bates GW, Casson P, Coutifaris C, Eisenberg E, Hansen K, Krawetz S, Robinson R, Rosen M, Usadi R, Zhang H, Santoro N, Diamond M. Allostatic load, a measure of chronic physiological stress, is associated with pregnancy outcomes, but not fertility, among women with unexplained infertility. Human Reproduction 2018, 33: 1757-1766. PMID: 30085177, PMCID: PMC6454470, DOI: 10.1093/humrep/dey261.Peer-Reviewed Original ResearchConceptsAdverse pregnancy outcomesOvarian stimulationPreterm birthPregnancy outcomesLive birthsUnexplained infertilityLipoprotein cholesterolBlood pressureBirth outcomesLow birthweightAllostatic loadSpontaneous abortionReproductive outcomesHigh-density lipoprotein cholesterolLow-density lipoprotein cholesterolAL scoreSTUDY FUNDING/COMPETINGChronic physiological stressMulti-variable logistic regression modelAdvanced Reproductive CareMultiple Intrauterine GestationsDiastolic blood pressureNon-pregnant stateSystolic blood pressureType of infertilityDiminished ovarian reserve and poor response to stimulation in patients <38 years old: a quantitative but not qualitative reduction in performance
Morin SJ, Patounakis G, Juneau CR, Neal SA, Scott RT, Seli E. Diminished ovarian reserve and poor response to stimulation in patients <38 years old: a quantitative but not qualitative reduction in performance. Human Reproduction 2018, 33: 1489-1498. PMID: 30010882, DOI: 10.1093/humrep/dey238.Peer-Reviewed Original ResearchMeSH KeywordsAdultAge FactorsAneuploidyBlastomeresDatabases, FactualEmbryo Culture TechniquesEmbryo TransferFemaleFertility Agents, FemaleFertilization in VitroHumansInfertility, FemaleLive BirthOvarian ReserveOvaryOvulationOvulation InductionPregnancyPregnancy RateRetrospective StudiesTreatment OutcomeConceptsPoor oocyte qualityOvarian reserveLive birth rateDiminished ovarian reserveOocyte yieldOocyte qualityBlastulation rateAMH levelsPoor respondersPoor responseFollicular depletionBirth rateEmbryo transferAneuploidy rateLower live birth ratesYoung womenSTUDY FUNDING/COMPETINGGood prognosis patientsOvarian reserve parametersOvarian reserve testingYoung poor respondersPoor ovarian responseRetrospective cohort studyLower oocyte yieldInterquartile rangeEffect of exposure to second-hand smoke from husbands on biochemical hyperandrogenism, metabolic syndrome and conception rates in women with polycystic ovary syndrome undergoing ovulation induction
Li J, Wu Q, Wu XK, Zhou ZM, Fu P, Chen XH, Yan Y, Wang X, Yang ZW, Li WL, Stener-Victorin E, Legro RS, Ng EH, Zhang H, Mol BWJ, Wang CC, Group F. Effect of exposure to second-hand smoke from husbands on biochemical hyperandrogenism, metabolic syndrome and conception rates in women with polycystic ovary syndrome undergoing ovulation induction. Human Reproduction 2018, 33: 617-625. PMID: 29471520, DOI: 10.1093/humrep/dey027.Peer-Reviewed Original ResearchConceptsPolycystic ovary syndromeNon-exposed womenSHS exposure statusSHS exposureMetabolic syndromeBiochemical hyperandrogenismObstetric outcomesOvary syndromeOvulation inductionSex hormonesExposure statusHigher serum total testosteroneSecond-hand smoke exposureSTUDY FUNDING/COMPETINGConception rateLower sex hormoneFree androgen indexSerum total testosteroneUterine blood flowLive birth rateNon-exposed groupSecond-hand smokePARTICIPANTS/MATERIALSROLE OF CHANCEAndrogen index
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