2023
A novel homozygous nonsense variant of AK7 is associated with multiple morphological abnormalities of the sperm flagella
Chang T, Tang H, Zhou X, He J, Liu N, Li Y, Xiang W, Yao Z. A novel homozygous nonsense variant of AK7 is associated with multiple morphological abnormalities of the sperm flagella. Reproductive BioMedicine Online 2023, 48: 103765. PMID: 38492416, DOI: 10.1016/j.rbmo.2023.103765.Peer-Reviewed Original ResearchConceptsHomozygous nonsense variantMultiple morphological abnormalitiesWhole-exome sequencingSperm flagellaAssociated with multiple morphological abnormalitiesMitochondrial function of spermatozoaFlagella-associated proteinsFunction of spermatozoaPotential gene variantsMitochondrial metabolic dysfunctionSperm ultrastructureFlagellar assemblyPatient's spermatozoaFlagellar defectsRate of apoptosisConcentration of reactive oxygen speciesMale infertilitySanger sequencingReactive oxygen speciesMitochondrial functionSpermSpermatozoaMutated genesFunctional associationDisease phenotype
2022
Chapter 4 The impact of erectile dysfunction on infertility and its treatment
Khan A, Lindelof J, Honig S. Chapter 4 The impact of erectile dysfunction on infertility and its treatment. 2022, 57-76. DOI: 10.1016/b978-0-12-822288-1.00008-7.Peer-Reviewed Original Research
2021
Infertility, in vitro fertilization, and fertility preservation
Inhorn M. Infertility, in vitro fertilization, and fertility preservation. 2021, 217-232. DOI: 10.4324/9781003216452-17.Peer-Reviewed Original ResearchIntracytoplasmic sperm injectionFertility preservationMale infertilityReproductive health conditionsReproductive age couplesReproductive health challengesYears of ageAge-related infertilitySperm injectionInfertility problemsOocyte cryopreservationInfertilityHealth challengesSocial burdenHealth conditionsWomenRelated interventionsInvoluntary childlessnessWoman’s eggInterventionFuture motherhoodGlobal spreadSingle womenIVFPreventionThe relationship of plasma antioxidant levels to semen parameters: the Males, Antioxidants, and Infertility (MOXI) randomized clinical trial
Knudtson JF, Sun F, Coward RM, Hansen KR, Barnhart KT, Smith J, Legro RS, Diamond MP, Krawetz SA, Zhang H, Usadi R, Baker VL, Santoro N, Steiner AZ. The relationship of plasma antioxidant levels to semen parameters: the Males, Antioxidants, and Infertility (MOXI) randomized clinical trial. Journal Of Assisted Reproduction And Genetics 2021, 38: 3005-3013. PMID: 34455507, PMCID: PMC8609082, DOI: 10.1007/s10815-021-02301-2.Peer-Reviewed Original ResearchConceptsPlasma antioxidant levelsLive birthsClinical trialsSemen parametersAntioxidant levelsVitamin ERank sum testSecondary analysisClinical outcomesNormal rangeBaseline plasma valuesVitamin E levelsWilcoxon rank sum testMale fertilityConclusionsAmong menPrimary endpointDNA fragmentationResultsAt baselineSerum levelsFertility centerE levelsMethodsThis studyMale infertilityFertility outcomesPlasma valuesPhysiologically detectable bisphenol A impairs human sperm functions by reducing protein-tyrosine phosphorylation
Li N, Kang H, Peng Z, Wang H, Weng S, Zeng X. Physiologically detectable bisphenol A impairs human sperm functions by reducing protein-tyrosine phosphorylation. Ecotoxicology And Environmental Safety 2021, 221: 112418. PMID: 34146982, DOI: 10.1016/j.ecoenv.2021.112418.Peer-Reviewed Original ResearchConceptsHuman sperm viabilityHuman sperm functionHuman spermExposure of BPASperm functionProgesterone-induced acrosome reactionProtein tyrosine phosphorylationProtein tyrosine phosphorylation levelsAcrosome reactionMale infertilityHealthy peopleMouse sperm motilitySperm viabilityCalcium signalingPhosphorylation levelsTyrosine phosphorylation levelsBisphenol ASperm motilityProgressive motilityHyperactivationMotilityDetectable concentrationRemarkable declineTyrosine phosphorylationPlastic monomersGenetic Defects in DNAH2 Underlie Male Infertility With Multiple Morphological Abnormalities of the Sperm Flagella in Humans and Mice
Hwang JY, Nawaz S, Choi J, Wang H, Hussain S, Nawaz M, Lopez-Giraldez F, Jeong K, Dong W, Oh JN, Bilguvar K, Mane S, Lee CK, Bystroff C, Lifton RP, Ahmad W, Chung JJ. Genetic Defects in DNAH2 Underlie Male Infertility With Multiple Morphological Abnormalities of the Sperm Flagella in Humans and Mice. Frontiers In Cell And Developmental Biology 2021, 9: 662903. PMID: 33968937, PMCID: PMC8103034, DOI: 10.3389/fcell.2021.662903.Peer-Reviewed Original ResearchMultiple morphological abnormalitiesMale infertility casesMorphological abnormalitiesWhole-exome sequencingIrregular flagellaInfertility casesSperm flagella formationMMAF phenotypeSevere formMale infertilityAsthenozoospermic patientsMutant miceNon-synonymous variantsAbnormalitiesRecessive variantsCellular mechanismsGenetic factorsMMAFGenetic defectsPatientsMiceHeavy chain domainSperm morphologyAsthenozoospermiaSperm motility
2019
Evaluation of different testing tools for the identification of non-gonococcal Neisseria spp. isolated from Lebanese male semen: a strong and significant association with infertility
Khoder M, Osman M, Diene S, Okdah L, Lalaoui R, Al Achkar M, Mallat H, Hamze M, Rolain J. Evaluation of different testing tools for the identification of non-gonococcal Neisseria spp. isolated from Lebanese male semen: a strong and significant association with infertility. Journal Of Medical Microbiology 2019, 68: 1012-1020. PMID: 31172907, DOI: 10.1099/jmm.0.000990.Peer-Reviewed Original ResearchConceptsNeisseria sppSignificant associationRetrospective study designCross-sectional retrospective study designCritical treatment decisionsSymptoms of infertilityLarge-scale epidemiological investigationsAntimicrobial susceptibility testingStrains of NeisseriaUrogenital infectionsInfertile patientsNeisseria infectionsTreatment decisionsNormal seminogramMale infertilityControl groupLebanese menEpidemiological investigationsInfertilitySusceptibility testingLebanese populationAPI NHPatientsStudy designAnalytical profile indexA novel copy number variation in CATSPER2 causes idiopathic male infertility with normal semen parameters
Luo T, Chen H, Zou Q, Wang T, Cheng Y, Wang H, Wang F, Jin Z, Chen Y, Weng S, Zeng X. A novel copy number variation in CATSPER2 causes idiopathic male infertility with normal semen parameters. Human Reproduction 2019, 34: 414-423. PMID: 30629171, DOI: 10.1093/humrep/dey377.Peer-Reviewed Original ResearchConceptsIdiopathic male infertilityNormal semen parametersWhole-cell patch-clamp techniqueMale infertilityPatch-clamp techniqueSemen parametersCatSper currentsIdiopathic infertilitySTUDY FUNDING/COMPETINGGenetic abnormalitiesCatSper genesChild Health HospitalReproductive medical centerNovel copy number variationsPARTICIPANTS/MATERIALSROLE OF CHANCEHuman male infertilityHealthy male donorsCopy number variationsHuman CatSperPrinciple Ca2Progesterone responseCase reportProvincial MaternalHealth Hospital
2017
Ubiquitination-Deficient Mutations in Human Piwi Cause Male Infertility by Impairing Histone-to-Protamine Exchange During Spermiogenesis
Gou L, Kang J, Dai P, Wang X, Li F, Zhao S, Zhang M, Hua M, Lu Y, Zhu Y, Li Z, Chen H, Wu L, Li D, Fu X, Li J, Shi H, Liu M. Ubiquitination-Deficient Mutations in Human Piwi Cause Male Infertility by Impairing Histone-to-Protamine Exchange During Spermiogenesis. Obstetrical & Gynecological Survey 2017, 72: 540-541. DOI: 10.1097/ogx.0000000000000482.Peer-Reviewed Original Research
2016
The poly(A)-binding protein genes, EPAB, PABPC1, and PABPC3 are differentially expressed in infertile men with non-obstructive azoospermia
Ozturk S, Sozen B, Uysal F, Bassorgun I, Usta M, Akkoyunlu G, Demir N. The poly(A)-binding protein genes, EPAB, PABPC1, and PABPC3 are differentially expressed in infertile men with non-obstructive azoospermia. Journal Of Assisted Reproduction And Genetics 2016, 33: 335-348. PMID: 26843391, PMCID: PMC4785164, DOI: 10.1007/s10815-016-0654-z.Peer-Reviewed Original ResearchConceptsPoly(A)-binding proteinNon-obstructive azoospermiaPoly(A)-binding protein geneSertoli cell-only syndromeTesticular biopsy samplesRound spermatidsPABP expressionExpression levelsIsolated spermatocytesTranslational controlProtein geneInfertile menPABPC1Male infertilitySpermatocytesPABPC3MRNA expressionArrest groupEPABSco groupBiopsy samplesMolecular backgroundProteinAzoospermiaEvaluate expression levels
2013
Extra-renal manifestations of autosomal dominant polycystic kidney disease (ADPKD): considerations for routine screening and management
Luciano RL, Dahl NK. Extra-renal manifestations of autosomal dominant polycystic kidney disease (ADPKD): considerations for routine screening and management. Nephrology Dialysis Transplantation 2013, 29: 247-254. PMID: 24215018, DOI: 10.1093/ndt/gft437.Peer-Reviewed Educational MaterialsConceptsAutosomal dominant polycystic kidney diseaseEnd-stage renal diseaseChronic kidney diseaseExtra-renal manifestationsKidney diseasePolycystic kidney diseaseDisease burdenRenal cystsBilateral renal cystsCurrent screening recommendationsDominant polycystic kidney diseaseExtra-renal diseaseDiverticular diseaseRenal diseaseScreening recommendationsSystemic diseaseADPKD patientsRoutine screeningMale infertilityDiseaseProgressive increasePatientsCystsManifestationsBurden
2011
Recruitment challenges of a multicenter randomized controlled varicocelectomy trial
Trussell JC, Christman GM, Ohl DA, Legro RS, Krawetz SA, Snyder PJ, Patrizio P, Polotsky AJ, Diamond MP, Casson PR, Coutifaris C, Barnhart K, Brzyski RG, Schlaff WD, Meacham R, Shin D, Thomas T, Zhang M, Santoro N, Eisenberg E, Zhang H, Network R. Recruitment challenges of a multicenter randomized controlled varicocelectomy trial. Fertility And Sterility 2011, 96: 1299-1305. PMID: 22130101, PMCID: PMC3243664, DOI: 10.1016/j.fertnstert.2011.10.025.Peer-Reviewed Original ResearchConceptsReproductive Medicine NetworkPlacebo armInfertility evaluationIntrauterine inseminationMedicine NetworkSuboptimal recruitmentClinical trial enrollmentMale infertility studiesAscertain reasonsIUI cyclesInfertile womenTrial enrollmentSurgical interventionPatient educationMAIN OUTCOMEStudy recruitmentInfertile menMale infertilityStudy participantsInfertility studiesMale partnersRecruitment challengesTrialsInadequate recruitmentFertility interventionsImplantation Rate Remains Unaffected in Women with Endometriosis Compared to Tubal Factor Infertility
Matalliotakis I, Sakkas D, Illuzzi J, Matalliotaki C, Arici A. Implantation Rate Remains Unaffected in Women with Endometriosis Compared to Tubal Factor Infertility. Journal Of Endometriosis And Pelvic Pain Disorders 2011, 3: 86-92. DOI: 10.5301/je.2011.8528.Peer-Reviewed Original ResearchTubal factor infertilityMale infertilityTubal infertilityInfertility groupEndometriosis groupFactor infertilityImplantation rateAge-matched control groupMale infertility groupTubal infertility groupICSI treatment cyclesReduced pregnancy rateMethods Five hundredDelivery rateNumber of embryosConsecutive IVFIVF treatmentIVF programPregnancy rateUterine receptivityEndometriosisTreatment cyclesControl groupInfertilityPatients
2009
Masculinity and Marginality
Birenbaum-Carmeli D, Inhorn M. Masculinity and Marginality. Journal Of Middle East Women's Studies 2009, 5: 23-52. DOI: 10.2979/mew.2009.5.2.23.Peer-Reviewed Original ResearchPalestinian menStigma of infertilityIsraeli citizenshipEthnographic interviewsSocietal levelMinority statusMiddle EastCommunity levelInfertility experienceDaily experiencesCitizenshipMarginalityDisclosure practicesFertility treatmentAdvanced fertility treatmentsPositive experiencesLebanonLife domainsInfertility-related informationIsraelTreatment placesExperienceGlobal spreadInfertility casesMale infertilityMale Infertility and Consanguinity in Lebanon: The Power of Ethnographic Epidemiology
Inhorn M, Kobeissi L, Abu-Musa A, Awwad J, Fakih M, Hammoud N, Hannoun A, Lakkis D, Nassar Z. Male Infertility and Consanguinity in Lebanon: The Power of Ethnographic Epidemiology. 2009, 165-195. DOI: 10.1093/acprof:oso/9780195374643.003.0007.Peer-Reviewed Original ResearchReproductive health problemsMale infertilityConsanguineous marriagesHealth problemsPublic health education programsCases of subfertilityMale infertility casesHealth education programsInfertility casesSignificant associationStrong genetic componentInfertilityFamily clusteringGenetic formsGenetic counselingConsanguinityGenetic componentSubfertilityEducation programsEpidemiology
2007
Occupational and environmental exposures to heavy metals: Risk factors for male infertility in Lebanon?
Inhorn M, King L, Nriagu J, Kobeissi L, Hammoud N, Awwad J, Abu-Musa A, Hannoun A. Occupational and environmental exposures to heavy metals: Risk factors for male infertility in Lebanon? Reproductive Toxicology 2007, 25: 203-212. PMID: 18093800, DOI: 10.1016/j.reprotox.2007.10.011.Peer-Reviewed Original ResearchConceptsMale infertilityRisk factorsBlood concentrationsFertile controlsRisk Factor InterviewEnvironmental exposuresImportant risk factorCase-control studyHigher whole-blood concentrationsWhole blood concentrationsUnexposed menInfertile casesReferent populationOccupational exposureInfertile menHealthy individualsFertility clinicsSemen analysisBlood collectionInfertilityMultiple regression analysisRegression analysisMenExposureClinicCivil war and male infertility in Lebanon
Kobeissi L, Inhorn M, Hannoun A, Hammoud N, Awwad J, Abu-Musa A. Civil war and male infertility in Lebanon. Fertility And Sterility 2007, 90: 340-345. PMID: 17919611, DOI: 10.1016/j.fertnstert.2007.06.061.Peer-Reviewed Original ResearchRing chromosome 12 and severe oligospermia: a case report
Martin JR, Wold A, Taylor HS. Ring chromosome 12 and severe oligospermia: a case report. Fertility And Sterility 2007, 90: 443.e13-443.e15. PMID: 17880954, PMCID: PMC3107849, DOI: 10.1016/j.fertnstert.2007.07.1347.Peer-Reviewed Original ResearchConceptsSevere oligospermiaCase reportMale infertilityTertiary care hospitalFull-term pregnancySpectrum of findingsChromosome 12 abnormalitiesRing chromosome 12Severe azoospermiaPrimary infertilityCare hospitalFertilization centerUnusual presentationMAIN OUTCOMEUnexplained azoospermiaDonor spermInfertilityOligospermiaPreimplantation genetic diagnosisGenetic diagnosisAzoospermiaChromosome 12ReportPregnancyIVFHealth issues in the Arab American community. Male infertility in Lebanon: a case-controlled study.
Kobeissi L, Inhorn M. Health issues in the Arab American community. Male infertility in Lebanon: a case-controlled study. Ethnicity & Disease 2007, 17: s3-33-s3-38. PMID: 17985448.Peer-Reviewed Original ResearchConceptsCase-control studyMale infertilityRisk factorsReproductive illnessesWar exposureMale reproductive health problemsSemen analysisFamilial clusteringMultivariate logistic regression analysisLaboratory blood testingMale reproductive healthSignificant risk factorsImportant risk factorMale infertility casesReproductive health problemsLogistic regression analysisControl of confoundersWorld Health Organization guidelinesHealth Organization guidelinesInfertile womenLifestyle factorsBlood testingInfertility casesEffect modificationCaffeine intake
2005
Anabolic Steroid-Associated Infertility: A Potentially Treatable and Reversible Cause of Male Infertility
Cohen J, Honig S. Anabolic Steroid-Associated Infertility: A Potentially Treatable and Reversible Cause of Male Infertility. Fertility And Sterility 2005, 84: s223. DOI: 10.1016/j.fertnstert.2005.07.570.Peer-Reviewed Original Research
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