2025
O-149 No effect of maternal age on embryo implantation and live birth rates after preimplantation genetic testing for aneuploidies: retrospective analysis of 11,855 single blastocyst transfers
Gayete-Mor B, Miguel-Escalada I, Kalafat E, Zamora M, Pujol A, Lledó B, Stoop D, Lorenzon A, Rodriguez-Aranda A, Sakkas D, Popovic M. O-149 No effect of maternal age on embryo implantation and live birth rates after preimplantation genetic testing for aneuploidies: retrospective analysis of 11,855 single blastocyst transfers. Human Reproduction 2025, 40: deaf097.149. DOI: 10.1093/humrep/deaf097.149.Peer-Reviewed Original ResearchEuploid embryo transferAge-related fertility declineAdvanced maternal ageLive birth ratePreimplantation genetic testingEmbryo qualityMaternal ageLive birthsEuploid embryosFertility declineEmbryo transferClinical outcomesClinical pregnancyEffect of maternal agePGT-AAssociated with poor embryo qualityBirth rateOlder patientsGenetic testingReproductive outcomesEuploid blastocyst transferGood-quality blastocystsReduced oocyte yieldPoor embryo qualityPoor-quality embryos
2024
Reproductive outcomes following insemination in same-sex female couples, unpartnered female patients, and heterosexual couples
Heyward Q, Vaughan D, Dodge L, Duvall D, Sakkas D, Sabbagh R, Korkidakis A, Penzias A. Reproductive outcomes following insemination in same-sex female couples, unpartnered female patients, and heterosexual couples. Fertility And Sterility 2024, 123: 173-175. PMID: 39128673, DOI: 10.1016/j.fertnstert.2024.08.319.Peer-Reviewed Original ResearchMitochondria as therapeutic targets in assisted reproduction
Yildirim R, Seli E. Mitochondria as therapeutic targets in assisted reproduction. Human Reproduction 2024, 39: 2147-2159. PMID: 39066614, DOI: 10.1093/humrep/deae170.Peer-Reviewed Original ResearchMitochondrial replacement therapyClinical trialsAssisted reproductionImprove oocyte qualityTherapeutic targetAssisted reproductive outcomesImprove assisted reproductive outcomesMitochondrial quality control mechanismsDevelopmental competenceOocyte qualityReplacement therapyProgrammed Cell DeathQuality control mechanismsPharmacological agentsTargeting mitochondrial functionCalcium homeostasisReproductive outcomesInhibitor rapamycinMammalian targetMaternal spindle transferAntioxidant coenzyme Q10Mitochondrial populationEmbryo developmentCoenzyme Q10Cell deathThe impact of implementing a non-invasive preimplantation genetic testing for aneuploidies (niPGT-A) embryo culture protocol on embryo viability and clinical outcomes
Sakkas D, Navarro-Sánchez L, Ardestani G, Barroso G, Bisioli C, Boynukalin K, Cimadomo D, Frantz N, Kopcow L, Andrade G, Ozturk B, Rienzi L, Weiser A, Valbuena D, Simón C, Rubio C. The impact of implementing a non-invasive preimplantation genetic testing for aneuploidies (niPGT-A) embryo culture protocol on embryo viability and clinical outcomes. Human Reproduction 2024, 39: 1952-1959. PMID: 39059790, DOI: 10.1093/humrep/deae156.Peer-Reviewed Original ResearchNon-invasive preimplantation genetic testingEmbryo culture protocolsNiPGT-ADay of biopsyPreimplantation genetic testingPGT-APregnancy outcomesPregnancy rateIVF clinicsClinical outcomesControl groupStudy groupGenetic testingReproductive outcomesConcordance rateDay 6Clinical pregnancy rateOverall pregnancy outcomeClinical reproductive outcomesBiopsy stepBlastocyst mediumBlastocyst viabilityBlastocyst developmentCulture protocolMiscarriage rate
2023
Food, nutrition, and fertility: from soil to fork
Maitin-Shepard M, Werner E, Feig L, Chavarro J, Mumford S, Wylie B, Rando O, Gaskins A, Sakkas D, Arora M, Kudesia R, Lujan M, Braun J, Mozaffarian D. Food, nutrition, and fertility: from soil to fork. American Journal Of Clinical Nutrition 2023, 119: 578-589. PMID: 38101699, DOI: 10.1016/j.ajcnut.2023.12.005.Peer-Reviewed Original ResearchNutrition-related factorsDietary patternsEvidence gapsBirth outcomesMale fertilityLow-quality evidenceHealthy dietary patternBody weight statusHigh-quality evidenceSemen qualityFemale reproductive outcomesFemale fertilityEffects of nutritionOvulation disordersClinical outcomesQuality evidenceZinc supplementationFemale infertilityWeight statusReproductive outcomesFertility treatmentDietary supplementsDietary effectsFolic acidEnvironmental exposuresIntra-patient analysis of individual weight gain or loss between IVF cycles: cycle now and transfer later
Fouks Y, Vaughan D, Neuhausser W, Cohen Y, Penzias A, Sakkas D. Intra-patient analysis of individual weight gain or loss between IVF cycles: cycle now and transfer later. Human Reproduction 2023, 39: 93-101. PMID: 38006233, DOI: 10.1093/humrep/dead244.Peer-Reviewed Original ResearchConceptsIVF cyclesNumber of oocytesWeight gainWeight lossObstetrical riskWeight changeReproductive outcomesBlastulation rateCumulative live birth rateSTUDY FUNDING/COMPETINGShort-term weight gainInitial IVF cycleGEE modelLive birth rateMarkers of obesityAdverse reproductive outcomesPARTICIPANTS/MATERIALSCycle outcome parametersROLE OF CHANCESignificant weight changePositive associationFertilization rateIntra-patient analysisIndividual weight gainObese patients
2022
Endometrial Cancer in Reproductive Age: Fertility-Sparing Approach and Reproductive Outcomes
Mutlu L, Manavella D, Gullo G, McNamara B, Santin A, Patrizio P. Endometrial Cancer in Reproductive Age: Fertility-Sparing Approach and Reproductive Outcomes. Cancers 2022, 14: 5187. PMID: 36358604, PMCID: PMC9656291, DOI: 10.3390/cancers14215187.Peer-Reviewed Original ResearchFertility-preserving approachEndometrial cancerLow-grade endometrial cancerFertility sparing approachStandard surgical treatmentCommon gynecologic malignancyGynecologic malignanciesOncologic outcomesSurgical treatmentPatient goalsReproductive ageReproductive outcomesClose monitoringCancerYoung womenConservative approachFertility goalsReproductive technologiesPatientsWomenAgeOutcomesEarly stagesHysterectomyMalignancyRelationship Between Dating Violence and Contraceptive Use Among Texas Adolescents
Srikanth N, Weerakoon S, Mathew M, Xie L, Messiah S. Relationship Between Dating Violence and Contraceptive Use Among Texas Adolescents. Journal Of Interpersonal Violence 2022, 38: 4852-4876. PMID: 36000420, DOI: 10.1177/08862605221119519.Peer-Reviewed Original ResearchConceptsDating violenceTexas adolescentsContraceptive useUnplanned pregnancyYouth Risk Behavior Surveillance System dataSexual dating violenceSexually transmitted infectionsDating violence preventionImpact reproductive healthLogistic regression analysisNoncontraceptive useAntiabortion lawsHormonal contraceptionViolence preventionSurveillance System dataViolenceCondom useReproductive outcomesMultinomial logistic regression analysisReproductive healthAge groupsLawPregnancyContraceptionRegression analysisFollicular activation in women previously diagnosed with poor ovarian response: a randomized, controlled trial
Díaz-García C, Herraiz S, Pamplona L, Subirá J, Soriano MJ, Simon C, Seli E, Pellicer A. Follicular activation in women previously diagnosed with poor ovarian response: a randomized, controlled trial. Fertility And Sterility 2022, 117: 747-755. PMID: 35367015, DOI: 10.1016/j.fertnstert.2021.12.034.Peer-Reviewed Original ResearchConceptsPoor ovarian responseAntral follicle countOvarian reserve markersLive birth rateOvarian fragmentationFollicular activationFollicle countOvarian responseReserve markersHormone levelsPregnancy rateReproductive outcomesEmbryo transferTotal antral follicle countMII oocytesSerum antimüllerian hormoneAntimüllerian hormone levelsBirth rateMetaphase II oocytesEmbryology (ESHRE) criteriaHippo pathway inhibitionAntimüllerian hormoneSecondary outcomesFertilization cyclesIVF outcomes
2020
Ethical challenges for women’s healthcare highlighted by the COVID-19 pandemic
Bruno B, Shalowitz D, Arora K. Ethical challenges for women’s healthcare highlighted by the COVID-19 pandemic. Journal Of Medical Ethics 2020, 47: 69-72. PMID: 33046589, DOI: 10.1136/medethics-2020-106646.Peer-Reviewed Original ResearchConceptsWomen's healthcareMaternal health outcomesDeferral of elective surgeryCOVID-19 pandemicHealth outcomesCommunity healthDisadvantaged womenHealthcare policyHealthcareCOVID-19Increasing disparityInfectious exposuresEthical challengesRates of violenceWomenRefinement of policiesElective surgeryPreliminary recommendationsOutcomesTreatment of COVID-19HealthPandemicReproductive outcomesDisparitiesPreventionMitochondrial DNA content is not predictive of reproductive competence in euploid blastocysts
Scott RT, Sun L, Zhan Y, Marin D, Tao X, Seli E. Mitochondrial DNA content is not predictive of reproductive competence in euploid blastocysts. Reproductive BioMedicine Online 2020, 41: 183-190. PMID: 32600944, DOI: 10.1016/j.rbmo.2020.04.011.Peer-Reviewed Original ResearchConceptsRelative mtDNA copy numberSingle embryo transferMitochondrial DNA copy numberMtDNA copy numberEmbryo transferSuccessful single embryo transferDNA copy numberRelative mtDNA levelsHuman blastocystsReal-time polymerase chain reactionQuantitative real-time polymerase chain reactionReproductive competenceIVF outcomesMaternal ageOngoing implantationPolymerase chain reactionEuploid blastocystsMitochondrial DNA contentReproductive outcomesSame patientClinical decisionTrophectoderm biopsySame cohortAmount of mtDNACopy numberPrior and novel coronaviruses, Coronavirus Disease 2019 (COVID-19), and human reproduction: what is known?
Segars J, Katler Q, McQueen DB, Kotlyar A, Glenn T, Knight Z, Feinberg EC, Taylor HS, Toner JP, Kawwass JF, Force A. Prior and novel coronaviruses, Coronavirus Disease 2019 (COVID-19), and human reproduction: what is known? Fertility And Sterility 2020, 113: 1140-1149. PMID: 32482250, PMCID: PMC7161522, DOI: 10.1016/j.fertnstert.2020.04.025.Peer-Reviewed Original ResearchMeSH KeywordsBetacoronavirusCoronavirus InfectionsCOVID-19FemaleFertilityHost-Pathogen InteractionsHumansInfertility, FemaleInfertility, MaleMaleOrchitisPandemicsPneumonia, ViralPregnancyPregnancy Complications, InfectiousPregnancy OutcomeReproductionRisk AssessmentRisk FactorsSARS-CoV-2Sperm CountSperm MotilityConceptsCoronavirus disease 2019 (COVID-19) infectionDisease 2019 infectionMiddle East respiratory syndromeSevere acute respiratory syndrome coronavirus 1Maternal case fatality rateSARS-CoV-2 infectionCase fatality rateGerm cell destructionCOVID-19 infectionCoronavirus disease 2019SARS coronavirus 2Human reproductionNeonatal complicationsNeonatal transmissionPreterm deliveryPregnancy outcomesAsymptomatic womenPregnant womenHuman ovarySevere orchitisDisease 2019Enzyme 2Respiratory syndromeMAIN OUTCOMEReproductive outcomes
2019
Critical window variable selection: estimating the impact of air pollution on very preterm birth
Warren JL, Kong W, Luben TJ, Chang HH. Critical window variable selection: estimating the impact of air pollution on very preterm birth. Biostatistics 2019, 21: 790-806. PMID: 30958877, PMCID: PMC7422642, DOI: 10.1093/biostatistics/kxz006.Peer-Reviewed Original ResearchConceptsHierarchical Bayesian frameworkBayesian frameworkStatistical modelVariable selectionImproved estimationCritical windowPreterm birthRisk parametersVery preterm birthAdverse birth outcomesControl analysisExposure-disease relationshipsDifferent reproductive outcomesBirth outcomesPregnant womenReproductive outcomesCase/control analysis
2018
Associations between maternal plasma measurements of inflammatory markers and urinary levels of phenols and parabens during pregnancy: A repeated measures study
Aung M, Ferguson K, Cantonwine D, Bakulski K, Mukherjee B, Loch-Caruso R, McElrath T, Meeker J. Associations between maternal plasma measurements of inflammatory markers and urinary levels of phenols and parabens during pregnancy: A repeated measures study. The Science Of The Total Environment 2018, 650: 1131-1140. PMID: 30308801, PMCID: PMC6236678, DOI: 10.1016/j.scitotenv.2018.08.356.Peer-Reviewed Original ResearchConceptsPlasma inflammatory markersInflammatory markersC-reactive proteinInterquartile range increaseFetal developmentImmunological biomarkersRange increaseTumor necrosis factor-aCase-control studyProspective birth cohortImmune system regulationHealthy pregnancyUrinary phenolSystemic inflammationImmunological mechanismsInterleukin-10Urinary levelsInterleukin-1bPregnancyStudy visitsMultivariate linear mixed modelReproductive outcomesMeasures of exposureInverse probability weightingUrine samplesVitamin D Deficiency Is Associated With Poor Ovarian Stimulation Outcome in PCOS but Not Unexplained Infertility
Butts SF, Seifer DB, Koelper N, Senapati S, Sammel MD, Hoofnagle AN, Kelly A, Krawetz SA, Santoro N, Zhang H, Diamond MP, Legro RS, Network E. Vitamin D Deficiency Is Associated With Poor Ovarian Stimulation Outcome in PCOS but Not Unexplained Infertility. The Journal Of Clinical Endocrinology & Metabolism 2018, 104: 369-378. PMID: 30085176, PMCID: PMC6300410, DOI: 10.1210/jc.2018-00750.Peer-Reviewed Original ResearchConceptsVitamin D deficiencyPolycystic ovary syndromeD deficiencyEarly pregnancy lossOvarian stimulationUnexplained infertilityLive birthsPregnancy lossDiagnosis of PCOSMultiple Intrauterine GestationsOvarian stimulation outcomesRetrospective cohort studyInvestigation of womenBanked seraPPCOS IICohort studyIntrauterine gestationOvary syndromeInfertile womenInfertility diagnosisPregnant subjectsElevated riskImportant treatmentReproductive outcomesTrial dataAllostatic load, a measure of chronic physiological stress, is associated with pregnancy outcomes, but not fertility, among women with unexplained infertility
Barrett ES, Vitek W, Mbowe O, Thurston SW, Legro RS, Alvero R, Baker V, Bates GW, Casson P, Coutifaris C, Eisenberg E, Hansen K, Krawetz S, Robinson R, Rosen M, Usadi R, Zhang H, Santoro N, Diamond M. Allostatic load, a measure of chronic physiological stress, is associated with pregnancy outcomes, but not fertility, among women with unexplained infertility. Human Reproduction 2018, 33: 1757-1766. PMID: 30085177, PMCID: PMC6454470, DOI: 10.1093/humrep/dey261.Peer-Reviewed Original ResearchConceptsAdverse pregnancy outcomesOvarian stimulationPreterm birthPregnancy outcomesLive birthsUnexplained infertilityLipoprotein cholesterolBlood pressureBirth outcomesLow birthweightAllostatic loadSpontaneous abortionReproductive outcomesHigh-density lipoprotein cholesterolLow-density lipoprotein cholesterolAL scoreSTUDY FUNDING/COMPETINGChronic physiological stressMulti-variable logistic regression modelAdvanced Reproductive CareMultiple Intrauterine GestationsDiastolic blood pressureNon-pregnant stateSystolic blood pressureType of infertility
2017
Preconceptional antithyroid peroxidase antibodies, but not thyroid-stimulating hormone, are associated with decreased live birth rates in infertile women
Seungdamrong A, Steiner AZ, Gracia CR, Legro RS, Diamond MP, Coutifaris C, Schlaff WD, Casson P, Christman GM, Robinson RD, Huang H, Alvero R, Hansen KR, Jin S, Eisenberg E, Zhang H, Santoro N, Network E. Preconceptional antithyroid peroxidase antibodies, but not thyroid-stimulating hormone, are associated with decreased live birth rates in infertile women. Fertility And Sterility 2017, 108: 843-850. PMID: 29102040, PMCID: PMC8129952, DOI: 10.1016/j.fertnstert.2017.08.026.Peer-Reviewed Original ResearchAnti-TPO antibodiesLive birth rateThyroid-stimulating hormoneAntithyroid peroxidase antibodiesMIU/LInfertile womenClinical pregnancyPeroxidase antibodiesLive birthsReproductive outcomesBirth rateEunice Kennedy Shriver National InstituteMultivariable logistic regression analysisMultivariable logistic regression modelReproductive Medicine NetworkMIU/L.Adverse reproductive outcomesHigher miscarriage ratePoor reproductive outcomesRisk of miscarriageLogistic regression analysisLogistic regression modelsSimilar conception ratesMiscarriage rateTSH levelsAberrant expression of epithelial leucine-rich repeat containing G protein–coupled receptor 5–positive cells in the eutopic endometrium in endometriosis and implications in deep-infiltrating endometriosis
Vallvé-Juanico J, Suárez-Salvador E, Castellví J, Ballesteros A, Taylor HS, Gil-Moreno A, Santamaria X. Aberrant expression of epithelial leucine-rich repeat containing G protein–coupled receptor 5–positive cells in the eutopic endometrium in endometriosis and implications in deep-infiltrating endometriosis. Fertility And Sterility 2017, 108: 858-867.e2. PMID: 28923287, DOI: 10.1016/j.fertnstert.2017.08.018.Peer-Reviewed Original ResearchConceptsG protein-coupled receptorsProtein-coupled receptorsEutopic endometriumEpithelial markersHealthy egg donorsHuman eutopic endometriumType of endometriosisEndometrium of womenMenstrual cycle phaseProspective experimental studyParaffin-embedded tissuesEndometriotic patientsInflammatory markersEndometrial samplesUterine aspiratesHuman endometriumLeucine-rich repeatsFluorescence-activated cell sortingPathologic endometriumMAIN OUTCOMEEndometriosisReproductive outcomesEndometriumFertility clinicsStromal compartmentVitamin D deficiency is associated with poor reproductive outcomes in PCOS but not unexplained infertility
Butts S, Seifer D, Senapati S, Koelper N, Legro R, Diamond M. Vitamin D deficiency is associated with poor reproductive outcomes in PCOS but not unexplained infertility. Fertility And Sterility 2017, 108: e69-e70. DOI: 10.1016/j.fertnstert.2017.07.220.Peer-Reviewed Original Research
2016
Vitamin D Status Relates to Reproductive Outcome in Women With Polycystic Ovary Syndrome: Secondary Analysis of a Multicenter Randomized Controlled Trial
Pal L, Zhang H, Williams J, Santoro NF, Diamond MP, Schlaff WD, Coutifaris C, Carson SA, Steinkampf MP, Carr BR, McGovern PG, Cataldo NA, Gosman GG, Nestler JE, Myers E, Legro RS, Network F. Vitamin D Status Relates to Reproductive Outcome in Women With Polycystic Ovary Syndrome: Secondary Analysis of a Multicenter Randomized Controlled Trial. The Journal Of Clinical Endocrinology & Metabolism 2016, 101: 3027-3035. PMID: 27186859, PMCID: PMC4971341, DOI: 10.1210/jc.2015-4352.Peer-Reviewed Original ResearchConceptsPolycystic ovary syndromeLive birthsVitD statusOvary syndromeSerum 25OHDIndependent predictorsSecondary analysisOvulation induction outcomesSerum 25OHD levelsVitamin D statusHealth diagnostic criteriaD statusNonpregnant populationRetrospective cohortControlled TrialsVitamin DPregnancy lossReproductive outcomesDiagnostic criteriaTrial dataProgressive improvementWomenInduction outcomeNational InstituteSyndrome
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