2025
Updates in Pregnancy in Individuals with Obesity and After Bariatric Surgery
Espinal M, Hairston J, Kominiarek M. Updates in Pregnancy in Individuals with Obesity and After Bariatric Surgery. Obstetrics And Gynecology Clinics Of North America 2025, 52: 413-430. PMID: 40769654, DOI: 10.1016/j.ogc.2025.05.001.Peer-Reviewed Original ResearchConceptsGestational diabetesBariatric surgeryRisk of gestational diabetesAnti-obesity medicationsEarly pregnancy lossCesarean deliveryPostpartum hemorrhagePreterm birthDelivery complicationsSurgical complicationsSurgical infectionsCongenital anomaliesPregnancy lossPregnancy planningPregnancyNutritional deficienciesSurgeryLong-term effectsObesityReproductive healthComplicationsDiabetesAnti-obesitySafety concernsRiskBiallelic variants in the conserved ribosomal protein chaperone gene PDCD2 are associated with hydrops fetalis and early pregnancy loss
Landry-Voyer A, Holling T, Mis E, Hassani Z, Alawi M, Ji W, Jeffries L, Kutsche K, Bachand F, Lakhani S. Biallelic variants in the conserved ribosomal protein chaperone gene PDCD2 are associated with hydrops fetalis and early pregnancy loss. Proceedings Of The National Academy Of Sciences Of The United States Of America 2025, 122: e2426078122. PMID: 40208938, PMCID: PMC12012559, DOI: 10.1073/pnas.2426078122.Peer-Reviewed Original ResearchConceptsRibosomal RNA processingRNA processingNonimmune hydrops fetalisRibosomal biogenesis disordersNext generation sequencingRibosome biogenesisPregnancy lossPatient variantsMolecular chaperonesExome sequencingGeneration sequencingPDCD2Biallelic variantsGenetic variantsHydrops fetalisIndependent familiesIn vivo approachesAffected fetusMolecular causesPrimary fibroblastsDevelopmental defectsMonogenic disordersAssociated with hydrops fetalisUS5Early pregnancy loss
2022
Comparison of Early Pregnancy Loss Management Between States With Restrictive and Supportive Abortion Policies
Tal E, Paul R, Dorsey M, Madden T. Comparison of Early Pregnancy Loss Management Between States With Restrictive and Supportive Abortion Policies. Women's Health Issues 2022, 33: 126-132. PMID: 36379879, DOI: 10.1016/j.whi.2022.10.001.Peer-Reviewed Original ResearchConceptsEarly pregnancy loss managementEarly pregnancy lossUterine aspirationMifepristone-misoprostolPregnancy lossAbortion careAbortion trainingRestrictive abortion policiesMultivariable logistic regressionAcademic medical centerPractice patternsMedical CenterInternet-based surveyLoss managementLogistic regressionCost-effective strategyCareAspirationManagementConfoundersOBGYNPhysiciansAbortion policyUrinary phenol concentrations and fecundability and early pregnancy loss
Vollmar A, Weinberg C, Baird D, Wilcox A, Calafat A, Deziel N, Johnson C, Jukic A. Urinary phenol concentrations and fecundability and early pregnancy loss. Human Reproduction 2022, 38: 139-155. PMID: 36346334, PMCID: PMC10089295, DOI: 10.1093/humrep/deac230.Peer-Reviewed Original ResearchConceptsEarly pregnancy lossPregnancy lossUrinary phenol concentrationsIntraclass correlation coefficientMenstrual cycleNational InstituteDaily first-morning urine specimensPhenol exposureEnvironmental Health SciencesFirst morning urine specimensLogistic regressionSTUDY FUNDING/COMPETINGMultivariable logistic regressionPARTICIPANTS/MATERIALSROLE OF CHANCEIntramural Research ProgramClinical miscarriageProspective cohortIncreased oddsLive birthsEpidemiologic studiesUrine specimensHealth SciencesEndocrine-disrupting potentialReproductive function
2021
Diagnosis of dengue fever in a patient with early pregnancy loss
Adjei NN, Lynn AY, Topran E, Adeyemo OO. Diagnosis of dengue fever in a patient with early pregnancy loss. BMJ Case Reports 2021, 14: e243968. PMID: 34404662, PMCID: PMC8375744, DOI: 10.1136/bcr-2021-243968.Peer-Reviewed Original ResearchConceptsInfluenza-like illnessEarly pregnancy lossConsistent clinical evidenceHistory of travelMosquito-borne virusDengue-endemic areasAbdominal crampingDengue serologyOrbital painVaginal bleedingMultiparous womenPreterm birthWeeks' gestationNeonatal deathClinical evidenceIntravenous fluidsPregnant womenAdverse outcomesPregnancy lossDengue feverDengueFeverGestationMiscarriageWomen
2020
Developmental potential of aneuploid human embryos cultured beyond implantation
Shahbazi MN, Wang T, Tao X, Weatherbee BAT, Sun L, Zhan Y, Keller L, Smith GD, Pellicer A, Scott RT, Seli E, Zernicka-Goetz M. Developmental potential of aneuploid human embryos cultured beyond implantation. Nature Communications 2020, 11: 3987. PMID: 32778678, PMCID: PMC7418029, DOI: 10.1038/s41467-020-17764-7.Peer-Reviewed Original ResearchMeSH KeywordsAneuploidyAntigens, CDCadherinsCell AdhesionCell Cycle CheckpointsCell LineageChromosome SegregationChromosomes, Human, Pair 16Chromosomes, Human, Pair 21Embryo ImplantationEmbryo, MammalianEmbryonic DevelopmentFemaleGenes, erbB-1Genetic TestingHumansMonosomyMosaicismPregnancyStem CellsTrisomyConceptsEarly pregnancy lossAneuploid human embryosPre-implantation genetic testingHuman embryosPost-implantation developmentTrisomy 16 embryosPregnancy lossCell cycle arrestGenetic testingTrisomy 15Major causeCases of mosaicismCycle arrestE-cadherinTrisomy 21 embryosProtein E-cadherinHigh rateCommon aneuploidiesStem cellsPremature differentiationAbnormal numberAneuploidyCell adhesion protein E-cadherinDevelopmental potentialArrestOR11-04 Effect of Preconception Intensive vs. Standard Lifestyle Intervention on Birth Outcomes in Obese Women With Unexplained Infertility: A Multicenter Randomized Trial
Legro R, Hansen K, Diamond M, Steiner A, Mersereau J, Sarwer D, Kris-Etherton P, Wild R, Krawetz S, Hoeger K, Usadi R, Johnstone E, Hao H, Eisenberg E, Santoro N, Zhang H. OR11-04 Effect of Preconception Intensive vs. Standard Lifestyle Intervention on Birth Outcomes in Obese Women With Unexplained Infertility: A Multicenter Randomized Trial. Journal Of The Endocrine Society 2020, 4: or11-04. PMCID: PMC7209215, DOI: 10.1210/jendso/bvaa046.2149.Peer-Reviewed Original ResearchStandard lifestyle modificationBetter birth outcomesUnexplained infertilityLive birthsObese womenBirth outcomesPregnancy lossLifestyle modificationLifestyle interventionWeight lossPhysical activityIL groupLow perinatal morbidityMajor pregnancy complicationsPreconception lifestyle interventionStandard lifestyle interventionGI side effectsKey secondary outcomesMulticenter randomized trialUse of orlistatMajor congenital anomaliesModerate weight lossPregnancy complication rateEarly pregnancy lossGestational DMLooking beyond the ovary for oncofertility care in women: uterine injury as a potential target for fertility-preserving treatments
Garg D, Johnstone E, Lomo L, Fair D, Rosen M, Taylor R, Silver B, Letourneau J. Looking beyond the ovary for oncofertility care in women: uterine injury as a potential target for fertility-preserving treatments. Journal Of Assisted Reproduction And Genetics 2020, 37: 1467-1476. PMID: 32342270, PMCID: PMC7311602, DOI: 10.1007/s10815-020-01792-9.Peer-Reviewed Original ResearchConceptsCancer survivorsPregnancy complicationsObstetrical outcomesFertility-preserving treatmentLow birth weightPoor obstetrical outcomesFemale cancer survivorsImpact of chemotherapyEarly pregnancy lossOncofertility carePregnancy implantationLate complicationsPregnancy outcomesPreterm birthRadiation fibrosisEndometrial receptivityGonadotoxic effectsUterine injuryBirth weightPregnancy lossPregnant uterusBlood supplyUterine functionChemotherapyComplications
2018
Vitamin D Deficiency Is Associated With Poor Ovarian Stimulation Outcome in PCOS but Not Unexplained Infertility
Butts SF, Seifer DB, Koelper N, Senapati S, Sammel MD, Hoofnagle AN, Kelly A, Krawetz SA, Santoro N, Zhang H, Diamond MP, Legro RS, Network E. Vitamin D Deficiency Is Associated With Poor Ovarian Stimulation Outcome in PCOS but Not Unexplained Infertility. The Journal Of Clinical Endocrinology & Metabolism 2018, 104: 369-378. PMID: 30085176, PMCID: PMC6300410, DOI: 10.1210/jc.2018-00750.Peer-Reviewed Original ResearchConceptsVitamin D deficiencyPolycystic ovary syndromeD deficiencyEarly pregnancy lossOvarian stimulationUnexplained infertilityLive birthsPregnancy lossDiagnosis of PCOSMultiple Intrauterine GestationsOvarian stimulation outcomesRetrospective cohort studyInvestigation of womenBanked seraPPCOS IICohort studyIntrauterine gestationOvary syndromeInfertile womenInfertility diagnosisPregnant subjectsElevated riskImportant treatmentReproductive outcomesTrial data
2017
Mechanisms of Antiphospholipid Antibody-Mediated Pregnancy Morbidity
Salmon J, Mineo C, Giles I, Chamley L, Meroni P, Abrahams V. Mechanisms of Antiphospholipid Antibody-Mediated Pregnancy Morbidity. 2017, 117-143. DOI: 10.1007/978-3-319-55442-6_6.Peer-Reviewed Original ResearchIntrauterine growth restrictionPregnancy complicationsAntiphospholipid syndromeAntiphospholipid antibodiesRecurrent early pregnancy lossImpaired placental functionLate obstetrical complicationsNon-thrombotic eventsPartial beneficial effectEarly pregnancy lossMaternal-fetal interfacePregnancy morbidityAPS patientsObstetrical complicationsThrombotic eventsTrophoblast functionsPregnancy lossGrowth restrictionPlacental functionHigh riskComplicationsPathogenic mechanismsComplement activationBeneficial effectsPatients
2015
Urinary Concentrations of Phthalate Metabolites and Bisphenol A and Associations with Follicular-Phase Length, Luteal-Phase Length, Fecundability, and Early Pregnancy Loss
Jukic AM, Calafat AM, McConnaughey DR, Longnecker MP, Hoppin JA, Weinberg CR, Wilcox AJ, Baird DD, Calafat A, McConnaughey D, Longnecker M, Hoppin J, Weinberg C, Wilcox A, Baird D. Urinary Concentrations of Phthalate Metabolites and Bisphenol A and Associations with Follicular-Phase Length, Luteal-Phase Length, Fecundability, and Early Pregnancy Loss. Environmental Health Perspectives 2015, 124: 321-328. PMID: 26161573, PMCID: PMC4786975, DOI: 10.1289/ehp.1408164.Peer-Reviewed Original ResearchConceptsEarly pregnancy lossLuteal phase lengthShort luteal phaseFollicular phase lengthPregnancy lossMonocarboxyoctyl phthalatePhthalate metabolitesLuteal phaseMenstrual cycleDaily first-morning urine specimensFirst morning urine specimensUrinary bisphenol AFuture human studiesHuman chorionic gonadotropinVaginal bleedingDEHP metabolitesUrinary concentrationsHuman ovulationProgesterone metabolitesChorionic gonadotropinUrine specimensDetrimental alterationsHuman studiesAnimal studiesPregnancy
2012
What is the Mechanism(s) of Antiphospholipid Antibody-Mediated Pregnancy Morbidity?
Abrahams V, Borghi M, Meroni P, Rand J, Raschi E, Salmon J, Tedesco F, Tincani A. What is the Mechanism(s) of Antiphospholipid Antibody-Mediated Pregnancy Morbidity? 2012, 79-101. DOI: 10.1007/978-1-4614-3194-7_5.Peer-Reviewed Original ResearchPregnancy complicationsAntiphospholipid syndromeAntiphospholipid antibodiesRecurrent early pregnancy lossImpaired placental functionLate obstetrical complicationsNon-thrombotic eventsPartial beneficial effectIntrauterine growth restrictionEarly pregnancy lossMaternal-fetal interfacePregnancy morbidityAPS patientsObstetrical complicationsThrombotic eventsTrophoblast functionsPregnancy lossGrowth restrictionPlacental functionHigh riskComplicationsPathogenic mechanismsComplement activationBeneficial effectsPatients
2007
Clomiphene, Metformin, or Both for Infertility in the Polycystic Ovary Syndrome
Legro R, Barnhart H, Schlaff W, Carr B, Diamond M, Carson S, Steinkampf M, Coutifaris C, McGovern P, Cataldo N, Gosman G, Nestler J, Giudice L, Leppert P, Myers E. Clomiphene, Metformin, or Both for Infertility in the Polycystic Ovary Syndrome. Obstetrical & Gynecological Survey 2007, 62: 386-388. DOI: 10.1097/01.ogx.0000265909.61668.01.Peer-Reviewed Original ResearchPolycystic ovary syndromeExtended-release metforminMetformin groupLive birthsTreatment groupsClomiphene citrateOvary syndromeInfertile womenPregnancy lossSex hormone-binding globulin levelsAbstract Polycystic ovary syndromeHormone-binding globulin levelsFirst trimester pregnancy lossClomiphene-treated patientsDose of clomipheneMetformin-treated womenPlacebo-controlled trialSerious adverse eventsFirst-line treatmentFree androgen indexLive birth rateGastrointestinal side effectsBody mass indexEarly pregnancy lossSingle drug group
2006
Inherited Thrombophilias and Early Pregnancy Loss
Langhoff-Roos J, Paidas M, Ku D, Arkel Y, Loekwood C. Inherited Thrombophilias and Early Pregnancy Loss. Medical Intelligence Unit 2006, 229-243. DOI: 10.1007/0-387-34944-8_20.Peer-Reviewed Original ResearchFactor V LeidenThrombophilic conditionsPregnancy complicationsClinical manifestationsV LeidenFirst trimester pregnancy outcomeHeterozygous factor V LeidenIntrauterine growth restrictionLate fetal lossEarly pregnancy lossMaternal thromboembolismThrombogenic mutationsAbruptio placentaePregnancy outcomesProthrombotic conditionsPregnancy lossFetal lossGrowth restrictionAntithrombin deficiencyClinical practiceHeterogeneous groupComplicationsThrombophiliaDominant conditionCurrent knowledge
1998
Spontaneous Abortion and Exposure to Electric Blankets and Heated Water Beds
Belanger K, Leaderer B, Hellenbrand K, Holford T, McSharry J, Power M, Bracken M. Spontaneous Abortion and Exposure to Electric Blankets and Heated Water Beds. Epidemiology 1998, 9: 36-42. PMID: 9430266, DOI: 10.1097/00001648-199801000-00009.Peer-Reviewed Original ResearchConceptsElectric blanket useSpontaneous abortionPregnancy lossBlanket useEarly pregnancy lossHeated water bedsTime of conceptionMonth of conceptionWire code categoriesWeeks' gestationProspective studyEarly pregnancyUnadjusted analysesBed useGreater riskPregnancyAbortionDose responseWomenRiskElectric bedElectric blanketExposureSlight increaseGestation
1996
Endometrial Receptivity
Arici A, Attar E. Endometrial Receptivity. 1996, 27-44. DOI: 10.1007/978-3-642-60961-9_3.Peer-Reviewed Original ResearchEndometrial receptivityDisorders of implantationFertilization-embryo transferCause of infertilityEarly pregnancy lossHigher pregnancy rateHuman reproductive processTrue incidencePregnancy lossPregnancy rateSuccessful implantationMost clinicsClinical researchImplantationInfertilitySignificant numberReproductive processesClinicIncidenceReceptivity
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