2025
Fetal exposure to a mixture of endocrine‐disrupting chemicals and biomarkers of male fecundity: A population‐based cohort study
Hull S, Hougaard K, Toft G, Petersen K, Flachs E, Lindh C, Ramlau‐Hansen C, Wise L, Wilcox A, Liew Z, Bonde J, Tøttenborg S. Fetal exposure to a mixture of endocrine‐disrupting chemicals and biomarkers of male fecundity: A population‐based cohort study. Andrology 2025 PMID: 40220336, DOI: 10.1111/andr.70039.Peer-Reviewed Original ResearchExposure to endocrine-disrupting chemicalsFetal exposureEndocrine-disrupting chemicalsPolyfluoroalkyl substancesTesticular volumeFetal exposure to endocrine-disrupting chemicalsChemical mixturesSperm concentrationPhthalate metabolitesDanish National Birth CohortSemen Quality CohortTotal sperm countMaternal blood samplesPopulation-based cohort studyAssociated with several biomarkersLower sperm concentrationPFAS mixtureConfidence intervalsNational Birth CohortReproductive hormone levelsOne-quartile increaseMale fecundityConcentrations of per-Fetal programmingSperm count
2024
Size matters: Total testicular volume predicts sperm count in Tanner V varicocele patients
Fang A, Franco I, Pizzuti J, Boroda J, Friedman S, Fine R, Horowitz M, Schlussel R, Landau-Dyer L, Zelkovic P, Freyle J, Sommer J, Gitlin J. Size matters: Total testicular volume predicts sperm count in Tanner V varicocele patients. Journal Of Pediatric Urology 2024, 20: 960-966. PMID: 38876892, DOI: 10.1016/j.jpurol.2024.05.012.Peer-Reviewed Original ResearchNegative predictive valueSemen analysisAbnormal SAPredictive valueSperm countSurgical interventionTesticular volumeRetrospective single-center chart reviewSingle-center chart reviewOdds ratioAppropriateness of surgical interventionLeft-sided varicoceleMotile sperm countAbnormal semen analysisReceiver operating characteristic analysisPrevalence of varicoceleMultivariate logistic regressionTotal testicular volumeYouden's J statisticVaricocele gradeMedian ageChart reviewUltrasound resultsYounger patientsRisk stratification
2023
Sperm Selection in the Laboratory
Sakkas D, Vaughan D. Sperm Selection in the Laboratory. 2023, 197-203. DOI: 10.1017/9781009197533.026.Peer-Reviewed Original Research
2022
Biomarkers of Stress and Male Fertility
Spitzer TL, Trussell JC, Coward RM, Hansen KR, Barnhart KT, Cedars MI, Diamond MP, Krawetz SA, Sun F, Zhang H, Santoro N, Steiner AZ. Biomarkers of Stress and Male Fertility. Reproductive Sciences 2022, 29: 1262-1270. PMID: 35106743, PMCID: PMC9078052, DOI: 10.1007/s43032-022-00853-x.Peer-Reviewed Original ResearchConceptsLive birth rateSemen parametersSalivary levelsSperm countPregnancy/live birth rateBirth rateTotal motile sperm countMale factor infertilityMotile sperm countDNA fragmentationTotal sperm countSalivary cortisol levelsMale fertilityStress-related biomarkersChi-square testingSalivary alpha-amylaseInfertility trialsCohort studyHighest quintileIntrauterine inseminationPregnancy rateUpper quintileInfertile menPhysiologic measuresBiomarkers of stress
2020
Intrauterine insemination performance characteristics and post-processing total motile sperm count in relation to live birth for couples with unexplained infertility in a randomised, multicentre clinical trial
Hansen KR, Peck JD, Coward RM, Wild RA, Trussell JC, Krawetz SA, Diamond MP, Legro RS, Coutifaris C, Alvero R, Robinson RD, Casson P, Christman GM, Santoro N, Zhang H. Intrauterine insemination performance characteristics and post-processing total motile sperm count in relation to live birth for couples with unexplained infertility in a randomised, multicentre clinical trial. Human Reproduction 2020, 35: 1296-1305. PMID: 32432326, PMCID: PMC7316499, DOI: 10.1093/humrep/deaa027.Peer-Reviewed Original ResearchConceptsTotal motile sperm countLive birth rateHigher total motile sperm countUnexplained infertilityMulticentre clinical trialMotile sperm countClinical trialsLive birthsOvarian stimulationHCG injectionBirth ratePatient discomfortSperm countTreatment cyclesSecondary analysisEunice Kennedy Shriver National InstituteSTUDY FUNDING/COMPETINGLive birth successMultiple Intrauterine GestationsDuration of infertilityIUI treatment cyclesLive birth outcomesPARTICIPANTS/MATERIALSROLE OF CHANCEYears of ageThe Association Between Race, Obesity, and Sperm Quality Among Men Attending a University Physician Practice in Washington, DC
McCray N, Young H, Irwig M, Frankfurter D, Schwartz A, Witmyer J, Hynes M, Jayanthi V, Marcus M, Patel M, Perry M. The Association Between Race, Obesity, and Sperm Quality Among Men Attending a University Physician Practice in Washington, DC. American Journal Of Men's Health 2020, 14: 1557988320925985. PMID: 32602769, PMCID: PMC7328221, DOI: 10.1177/1557988320925985.Peer-Reviewed Original ResearchConceptsBody mass indexSperm healthPhysician practicesAssociated with low sperm motilitySperm countWorld Health OrganizationLow sperm motilitySample of U.S. menMen of colorLow sperm countNon-Hispanic menStudy sample sizeSperm motilitySperm concentrationSperm qualitySemen samplesSperm parametersSemen qualityObesity ratesSpermEpidemiological literatureU.S. menHispanic menMass indexAndrological health
2016
Matrine compromises mouse sperm functions by a [Ca2+]i-related mechanism
Luo T, Zou Q, He Y, Wang H, Wang T, Liu M, Chen Y, Wang B. Matrine compromises mouse sperm functions by a [Ca2+]i-related mechanism. Reproductive Toxicology 2016, 60: 69-75. PMID: 26867864, DOI: 10.1016/j.reprotox.2016.02.003.Peer-Reviewed Original ResearchConceptsMouse sperm functionSperm functionDaily dosesIntraperitoneal injectionMale miceSperm countTestis weightReproductive toxicityMiceChinese medicineCatSper channelsMatrineProgressive motilityAcrosome reactionKey regulatorMouse spermTotal motilitySperm viabilityGene expressionTestis sizeMotilitySpermDoses
2003
Postmortem Sperm Retrieval: The Effect of Instituting Guidelines
TASH J, APPLEGARTH L, KERR S, FINS J, ROSENWAKS Z, SCHLEGEL P. Postmortem Sperm Retrieval: The Effect of Instituting Guidelines. Journal Of Urology 2003, 170: 1922-1925. PMID: 14532808, DOI: 10.1097/01.ju.0000092832.37190.94.Peer-Reviewed Original ResearchMeSH KeywordsAdultCryopreservationDeath, SuddenEthics CommitteesEthics Committees, ResearchEthics, InstitutionalFemaleHumansInformed ConsentInsemination, Artificial, HomologousMalePractice Guidelines as TopicSemen PreservationSpecimen HandlingSperm Injections, IntracytoplasmicSperm MotilitySpermatozoaTissue DonorsUnited StatesConceptsPostmortem sperm retrievalSperm retrievalInstitutional review board-approved chart reviewIn vitro fertilization cyclesVasal aspirationSperm countChart reviewFertilization cyclesPost-thaw motilityProcurement proceduresInstitutional guidelinesDeceased menPatientsDeathEthical concernsSpermConsentMenSpecimen volumeMotilityGuidelinesInstitutions
1990
Association of cocaine use with sperm concentration, motility, and morphology
Bracken M, Eskenazi B, Sachse K, McSharry J, Hellenbrand K, Leo-Summers L. Association of cocaine use with sperm concentration, motility, and morphology. Fertility And Sterility 1990, 53: 315-322. PMID: 2298313, DOI: 10.1016/s0015-0282(16)53288-9.Peer-Reviewed Original ResearchConceptsCocaine useRisk factorsMale subfertilityMajor risk factorGeneral male populationFirst semen analysisUse of cocaineHigh prevalenceLow sperm motilitySperm countDiagnostic InterviewMale populationSemen analysisHistory of useSperm concentrationAbnormal formsSubfertilityMore yearsSperm motilityCocaineMenAssociationLarge proportionMotilityYears
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