2024
Integrative multiomic analysis identifies distinct molecular subtypes of NAFLD in a Chinese population
Ding J, Liu H, Zhang X, Zhao N, Peng Y, Shi J, Chen J, Chi X, Li L, Zhang M, Liu W, Zhang L, Ouyang J, Yuan Q, Liao M, Tan Y, Li M, Xu Z, Tang W, Xie C, Li Y, Pan Q, Xu Y, Cai S, Byrne C, Targher G, Ouyang X, Zhang L, Jiang Z, Zheng M, Sun F, Chai J. Integrative multiomic analysis identifies distinct molecular subtypes of NAFLD in a Chinese population. Science Translational Medicine 2024, 16: eadh9940. PMID: 39504356, DOI: 10.1126/scitranslmed.adh9940.Peer-Reviewed Original ResearchConceptsNonalcoholic fatty liver diseaseWhole-genome sequencingHepatocellular carcinomaMolecular subtypesLiver cirrhosisChinese cohort of patientsInfiltration of M1Risk of liver cirrhosisSerum metabolic analysisClinical diagnosisSubtype of nonalcoholic fatty liver diseaseCohort of patientsDevelopment of liver cirrhosisHepatocellular carcinoma developmentIntegrative multiomic analysisHealth care burdenFatty liver diseaseExpression of CYP1A2Urine specimensTreatment strategiesChinese cohortImpaired outcomeM2 macrophagesIntegrative multiomicsLiver diseaseCytomorphological characteristics of low‐grade papillary urothelial carcinoma in voided urine samples: Distinction from benign and high‐grade papillary urothelial carcinoma
Takeda K, Adeniran A, Levi A, Tang H, Cai G. Cytomorphological characteristics of low‐grade papillary urothelial carcinoma in voided urine samples: Distinction from benign and high‐grade papillary urothelial carcinoma. Cytopathology 2024, 35: 724-732. PMID: 38992916, DOI: 10.1111/cyt.13413.Peer-Reviewed Original ResearchHigh-grade papillary urothelial carcinomaLow-grade papillary urothelial carcinomaPapillary urothelial carcinomaUrothelial carcinomaVoided urine samplesCytomorphologic featuresBenign casesUrine samplesUrine specimensNuclear enlargementVoided urine specimensHigh-grade transformationNuclear-to-cytoplasmic (N/CIrregular nuclear membranesUrine cytologyRetrospective reviewHistopathological diagnosisCytomorphologic characteristicsCytomorphological distinctionFrequent recurrenceCytologic featuresCarcinomaBenign conditionsAccurate diagnosisHigh N/C ratio
2022
Urinary phenol concentrations and fecundability and early pregnancy loss
Vollmar A, Weinberg C, Baird D, Wilcox A, Calafat A, Deziel N, Johnson C, Jukic A. Urinary phenol concentrations and fecundability and early pregnancy loss. Human Reproduction 2022, 38: 139-155. PMID: 36346334, PMCID: PMC10089295, DOI: 10.1093/humrep/deac230.Peer-Reviewed Original ResearchConceptsEarly pregnancy lossPregnancy lossUrinary phenol concentrationsIntraclass correlation coefficientMenstrual cycleNational InstituteDaily first-morning urine specimensPhenol exposureEnvironmental Health SciencesFirst morning urine specimensLogistic regressionSTUDY FUNDING/COMPETINGMultivariable logistic regressionPARTICIPANTS/MATERIALSROLE OF CHANCEIntramural Research ProgramClinical miscarriageProspective cohortIncreased oddsLive birthsEpidemiologic studiesUrine specimensHealth SciencesEndocrine-disrupting potentialReproductive functionBupivacaine Metabolite Can Interfere with Norfentanyl Measurement by LC–MS/MS
Mahowald G, Khaliq T, Basu S, Griggs D, Siegel M, Leffert L, Bernstein S, Flood JG, Uljon S. Bupivacaine Metabolite Can Interfere with Norfentanyl Measurement by LC–MS/MS. The Journal Of Applied Laboratory Medicine 2022, 7: 854-862. PMID: 35259249, DOI: 10.1093/jalm/jfac009.Peer-Reviewed Original Research
2020
Accounting for urinary dilution in peri-implantation samples: implications for creatinine adjustment and specimen pooling
Rosen Vollmar AK, Johnson CH, Weinberg CR, Deziel NC, Baird DD, Wilcox AJ, Jukic AMZ. Accounting for urinary dilution in peri-implantation samples: implications for creatinine adjustment and specimen pooling. Journal Of Exposure Science & Environmental Epidemiology 2020, 31: 356-365. PMID: 32424331, PMCID: PMC7671945, DOI: 10.1038/s41370-020-0227-1.Peer-Reviewed Original ResearchConceptsCreatinine adjustmentCreatinine concentrationUrinary dilutionUrinary estrogen metabolitesEffect of pregnancyUrinary creatinine concentrationCreatinine levelsWeeks' gestationEarly pregnancyCreatinine excretionEstrogen metabolitesCreatinine measuresUrine specimensPooled measureBiomarker measurementsPooled specimensEnvironmental exposuresExposure measuresLinear mixed modelsBiomonitoring resultsPregnancyT-testKappa coefficientMixed modelsPerson sample
2019
Double‐Blind Placebo‐Controlled Trial of Galantamine for Methadone‐Maintained Individuals With Cocaine Use Disorder: Secondary Analysis of Effects on Illicit Opioid Use
Carroll KM, DeVito EE, Yip SW, Nich C, Sofuoglu M. Double‐Blind Placebo‐Controlled Trial of Galantamine for Methadone‐Maintained Individuals With Cocaine Use Disorder: Secondary Analysis of Effects on Illicit Opioid Use. American Journal On Addictions 2019, 28: 238-245. PMID: 31165574, PMCID: PMC9078084, DOI: 10.1111/ajad.12904.Peer-Reviewed Original ResearchConceptsMethadone-maintained individualsOpioid useSecondary analysisMultiple drugsConcurrent cocaine dependenceTrial of galantaminePlacebo-controlled trialDouble-blind placeboIllicit opioid useRandomized clinical trialsCocaine use disorderGalantamine's effectFuture trialsClinical trialsUrine specimenUrine specimensUse disordersOpioidsCholinesterase inhibitorsMaintenance settingCocaine useCocaine dependencePlaceboConcurrent useGalantamineBladder urothelial BK channel activity is a critical mediator for innate immune response in urinary tract infection pathogenesis
Yeh J, Lu M, Alvarez-Lugo L, Chai TC. Bladder urothelial BK channel activity is a critical mediator for innate immune response in urinary tract infection pathogenesis. American Journal Of Physiology. Renal Physiology 2019, 316: f617-f623. PMID: 30648906, DOI: 10.1152/ajprenal.00554.2018.Peer-Reviewed Original ResearchConceptsUrinary tract infectionInnate immune responseImmune responseBK channel activityUrinary tract infection pathogenesisChannel activityFemale C57BL/6 miceInflammatory protein-2Voltage-gated potassium channelsUropathogenic Escherichia coliInhibitor iberiotoxinUPEC exposureUTI pathogenesisInflammatory biomarkersTract infectionsC57BL/6 miceIL-6Urinary biomarkersUrinary changesBiomarker levelsInfection pathogenesisUrine specimensProtein 10LPS inoculationSame biomarkers
2017
Prevalence and antibiotic susceptibility patterns of bacteria causing urinary tract infections in Youssef Hospital Center: first report from Akkar governorate, North of Lebanon
Hamze M, Osman M, Mallat H, Raad E. Prevalence and antibiotic susceptibility patterns of bacteria causing urinary tract infections in Youssef Hospital Center: first report from Akkar governorate, North of Lebanon. The International Arabic Journal Of Antimicrobial Agents 2017, 7 DOI: 10.3823/0802.Peer-Reviewed Original ResearchUrinary tract infectionAntibiotic susceptibility patternHospital CenterSusceptibility patternsSusceptibility testingTract infectionsBacterial uropathogensAntibiotic resistance ratesCommon uropathogenic bacteriaAntibiotic susceptibility testingAntimicrobial susceptibility testingUTI symptomsInfected patientsRisk factorsAntibiotic resistance levelsResistance ratesEpidemiological dataUrine specimensHealthcare centersAntibiotic susceptibilityUropathogenic bacteriaProteus sppUropathogensEnterobacter sppPatients
2016
Interim Buprenorphine vs. Waiting List for Opioid Dependence
Sigmon SC, Ochalek TA, Meyer AC, Hruska B, Heil SH, Badger GJ, Rose G, Brooklyn JR, Schwartz RP, Moore BA, Higgins ST. Interim Buprenorphine vs. Waiting List for Opioid Dependence. New England Journal Of Medicine 2016, 375: 2504-2505. PMID: 28002704, PMCID: PMC5373028, DOI: 10.1056/nejmc1610047.Peer-Reviewed Original ResearchA Novel Rapid Bedside Test for Rupture of Membranes [25I]
Mor A, Tal R, Irani M, Sabharwal A, Kalgi B, Minkoff H. A Novel Rapid Bedside Test for Rupture of Membranes [25I]. Obstetrics And Gynecology 2016, 127: 79s-80s. DOI: 10.1097/01.aog.0000483729.29770.4b.Peer-Reviewed Original ResearchRupture of membranesNormal vaginal dischargeAmniotic fluid leakageBedside testAlpha-fetoproteinPregnant womenVaginal dischargeFluid leakageUrine pregnancy testProspective cohort studyReliable bedside testQualitative immunoassayRapid bedside testNegative resultsIntact membranesVaginal bleedingCohort studyInfertility clinicPregnancy testStudy groupUrine specimensHome testWomenPositive resultsImmunoassay
2015
Urinary Concentrations of Phthalate Metabolites and Bisphenol A and Associations with Follicular-Phase Length, Luteal-Phase Length, Fecundability, and Early Pregnancy Loss
Jukic AM, Calafat AM, McConnaughey DR, Longnecker MP, Hoppin JA, Weinberg CR, Wilcox AJ, Baird DD, Calafat A, McConnaughey D, Longnecker M, Hoppin J, Weinberg C, Wilcox A, Baird D. Urinary Concentrations of Phthalate Metabolites and Bisphenol A and Associations with Follicular-Phase Length, Luteal-Phase Length, Fecundability, and Early Pregnancy Loss. Environmental Health Perspectives 2015, 124: 321-328. PMID: 26161573, PMCID: PMC4786975, DOI: 10.1289/ehp.1408164.Peer-Reviewed Original ResearchConceptsEarly pregnancy lossLuteal phase lengthShort luteal phaseFollicular phase lengthPregnancy lossMonocarboxyoctyl phthalatePhthalate metabolitesLuteal phaseMenstrual cycleDaily first-morning urine specimensFirst morning urine specimensUrinary bisphenol AFuture human studiesHuman chorionic gonadotropinVaginal bleedingDEHP metabolitesUrinary concentrationsHuman ovulationProgesterone metabolitesChorionic gonadotropinUrine specimensDetrimental alterationsHuman studiesAnimal studiesPregnancy
2012
Combining cognitive behavioral therapy and contingency management to enhance their effects in treating cannabis dependence: less can be more, more or less
Carroll KM, Nich C, LaPaglia DM, Peters EN, Easton CJ, Petry NM. Combining cognitive behavioral therapy and contingency management to enhance their effects in treating cannabis dependence: less can be more, more or less. Addiction 2012, 107: 1650-1659. PMID: 22404223, PMCID: PMC3509418, DOI: 10.1111/j.1360-0443.2012.03877.x.Peer-Reviewed Original ResearchConceptsCognitive behavioral therapyContingency managementHomework completionTime-line follow-back methodTreatment-seeking young adultsCannabis dependenceAddition of CBTSession attendanceOut-patient treatment programDays of cannabisCannabis treatment outcomesCBT outcomeBehavioral therapyAbstinence conditionSkills trainingRandom effects regression analysisAlone conditionCriminal justice systemUrine specimensTreatment programYoung adultsWeekly urineEffects regression analysisJustice systemAbstinence
2011
Adverse Outcomes in Nursing Home Residents with Increased Episodes of Observed Bacteriuria
Das R, Towle V, Ness P, Juthani-Mehta M. Adverse Outcomes in Nursing Home Residents with Increased Episodes of Observed Bacteriuria. Infection Control And Hospital Epidemiology 2011, 32: 84-86. PMID: 21091203, PMCID: PMC3089439, DOI: 10.1086/657664.Peer-Reviewed Original ResearchAdverse Outcomes in Nursing Home Residents with Increased Episodes of Observed Bacteriuria
Das R, Towle V, Ness P, Juthani-Mehta M. Adverse Outcomes in Nursing Home Residents with Increased Episodes of Observed Bacteriuria. Infection Control And Hospital Epidemiology 2011, 32: 84-86. DOI: 10.1086/657592.Peer-Reviewed Original Research
2009
High-risk behaviours among juvenile prison inmates in Pakistan
Altaf A, Janjua NZ, Kristensen S, Zaidi NA, Memon A, Hook EW, Vermund SH, Shah SA. High-risk behaviours among juvenile prison inmates in Pakistan. Public Health 2009, 123: 470-475. PMID: 19615706, DOI: 10.1016/j.puhe.2009.06.001.Peer-Reviewed Original ResearchConceptsHuman immunodeficiency virusCross-sectional studyHigh-risk behaviorsRisk behaviorsMultivariate logistic regression analysisHIV risk behaviorsLogistic regression analysisMean knowledge scoreMultiple sexual partnersUse of condomsMode of transmissionMale juvenile detaineesImmunodeficiency virusHigh riskRisk scoreChlamydia trachomatisUrine specimensLigase chain reactionCondom useKnowledge scoreNeisseria gonorrhoeaePrison inmatesSexual partnersBiological markersSexual activity
2008
Computer-Assisted Delivery of Cognitive-Behavioral Therapy for Addiction: A Randomized Trial of CBT4CBT
Carroll KM, Ball SA, Martino S, Nich C, Babuscio TA, Nuro KF, Gordon MA, Portnoy GA, Rounsaville BJ. Computer-Assisted Delivery of Cognitive-Behavioral Therapy for Addiction: A Randomized Trial of CBT4CBT. American Journal Of Psychiatry 2008, 165: 881-888. PMID: 18450927, PMCID: PMC2562873, DOI: 10.1176/appi.ajp.2008.07111835.Peer-Reviewed Original Research
2007
The cost‐effectiveness of four treatments for marijuana dependence
Olmstead TA, Sindelar JL, Easton CJ, Carroll KM. The cost‐effectiveness of four treatments for marijuana dependence. Addiction 2007, 102: 1443-1453. PMID: 17645430, PMCID: PMC2398724, DOI: 10.1111/j.1360-0443.2007.01909.x.Peer-Reviewed Original ResearchConceptsMET/CBTDrug counselingContingency managementPatient outcomesYoung adultsEffective treatmentMarijuana dependenceAcceptability curvesIncremental cost-effectiveness ratioRandomized clinical trialsCost of therapyPatient outcome measuresCost-effective dependsCost-effectiveness ratioSubstance abuse clinicsCost-effective treatmentCM procedureClinical trialsOutcome measuresUrine specimenUrine specimensAdditional weeksAdditional studiesMarijuana abstinenceLonger duration
2006
The Use of Contingency Management and Motivational/Skills-Building Therapy to Treat Young Adults With Marijuana Dependence
Carroll KM, Easton CJ, Nich C, Hunkele KA, Neavins TM, Sinha R, Ford HL, Vitolo SA, Doebrick CA, Rounsaville BJ. The Use of Contingency Management and Motivational/Skills-Building Therapy to Treat Young Adults With Marijuana Dependence. Journal Of Consulting And Clinical Psychology 2006, 74: 955-966. PMID: 17032099, PMCID: PMC2148500, DOI: 10.1037/0022-006x.74.5.955.Peer-Reviewed Original ResearchConceptsMET/CBTYoung adultsSkill-building interventionsDrug counselingSignificant main effectIndividual drug counselingUrine specimensMarijuana dependenceCriminal justice systemTreatment attendanceCBTMarijuana useContingency managementSession attendanceTreatment retentionJustice systemMain effectIncentives contingentTreatment conditionsAdultsParticipantsAttendanceInterventionContingentTherapyCounseling plus Buprenorphine–Naloxone Maintenance Therapy for Opioid Dependence
Fiellin DA, Pantalon MV, Chawarski MC, Moore BA, Sullivan LE, O'Connor PG, Schottenfeld RS. Counseling plus Buprenorphine–Naloxone Maintenance Therapy for Opioid Dependence. New England Journal Of Medicine 2006, 355: 365-374. PMID: 16870915, DOI: 10.1056/nejmoa055255.Peer-Reviewed Original ResearchConceptsStandard medical managementBuprenorphine-naloxone treatmentIllicit opioid useMedical managementOpioid dependenceWeekly medicationOpioid useIllicit opioidsWeekly counselingPrimary careUrine specimensConsecutive weeksProportion of patientsImproved treatment outcomesMaintenance therapyPrimary outcomeClinical trialsMedication distributionSimilar efficacyTreatment outcomesMedicationsSelf-reported frequencyPatientsFrequency of attendanceMean percentage
2004
Sex differences in cocaine-dependent individuals' response to disulfiram treatment
Nich C, McCance-Katz EF, Petrakis IL, Cubells JF, Rounsaville BJ, Carroll KM. Sex differences in cocaine-dependent individuals' response to disulfiram treatment. Addictive Behaviors 2004, 29: 1123-1128. PMID: 15236812, PMCID: PMC3680597, DOI: 10.1016/j.addbeh.2004.03.004.Peer-Reviewed Original ResearchConceptsDisulfiram treatmentDopamine-mediated responsesDrug-free urine specimensRandomized clinical trialsCocaine-dependent subjectsSex-based responsesDays of abstinenceSex differencesPrimary outcomeClinical trialsTreatment interactionUrine specimensBetter outcomesCocaine dependenceAlcohol useIntermediate outcomesDisulfiramSexOutcomesTreatmentSignificant sexIndividual responsesPossible mechanismResponseDifferential response
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