2025
Impact of age-related changes in buccal epithelial cells on pediatric epigenetic biomarker research
Merrill S, Konwar C, Fatima F, Dever K, MacIsaac J, Letourneau N, Giesbrecht G, Dewey D, England-Mason G, Lewis C, Wang D, Teh A, Meaney M, Gonzalez A, Noll J, De Weerth C, Bush N, O’Donnell K, Stewart S, Kobor M. Impact of age-related changes in buccal epithelial cells on pediatric epigenetic biomarker research. Nature Communications 2025, 16: 609. PMID: 39800776, PMCID: PMC11725590, DOI: 10.1038/s41467-025-55909-8.Peer-Reviewed Original ResearchConceptsBuccal epithelial cellsAge-related changesObsessive-compulsive disorderEpithelial cellsDiurnal cortisol slopeCheek swabsImpact of age-related changesCortisol slopeAssociated with ageOral cellsDevelopmental rangeAge accelerationDNA methylation studiesHeterogeneous sampleNeutrophil proportionBiomarker researchMethylation studiesAgeSwabsWeak associationEpigenetic age
2024
The Cerebellum Plays a Protective Role in Cognitive Aging and Disease: Insights from a Multi‐Cohort Study
Uquillas F, Sefik E, Seidlitz J, Merriman J, Zhang V, Kislin M, Cohen J, Alexander‐Bloch A, Bethlehem R, Sepulcre J, Wang S, Vannini P, Gomez J, Initiative T. The Cerebellum Plays a Protective Role in Cognitive Aging and Disease: Insights from a Multi‐Cohort Study. Alzheimer's & Dementia 2024, 20: e085743. PMCID: PMC11716736, DOI: 10.1002/alz.085743.Peer-Reviewed Original ResearchMontreal Cognitive AssessmentEstimated intracranial volumeBrain reserveCognitive declineMontreal Cognitive Assessment scoreCerebellar volumePattern of cognitive declineUK BiobankAging-related cognitive declineCerebellar tissue volumesPosterior cerebellar cortexAmyloid burdenAPOE genotypeAlzheimer's diseaseCerebellar associationsMild cognitive impairmentExecutive functionCognitive agingAmyloid-beta burdenVentral attentionPosterior cerebellumCrus IAge-related changesDiagnostic groupsProcessing speedSleep Deficiency in the Elderly
Pappas J, Miner B. Sleep Deficiency in the Elderly. Sleep Medicine Clinics 2024, 19: 593-606. PMID: 39455180, DOI: 10.1016/j.jsmc.2024.07.007.Peer-Reviewed Original ResearchConceptsOlder adultsSleep deficiencyAge-related changesConsequences of sleep deficiencyPsychosocial/behavioral factorsHealth-relatedSleep physiologyAge-related outcomesNonpharmacological interventionsReview treatmentEffective nonpharmacological interventionAdultsCircadian rhythmicitySleepPhysical functionDeficiencyCognitionDepressionCommon and unique brain aging patterns between females and males quantified by large‐scale deep learning
Du Y, Yuan Z, Sui J, Calhoun V. Common and unique brain aging patterns between females and males quantified by large‐scale deep learning. Human Brain Mapping 2024, 45: e70005. PMID: 39225381, PMCID: PMC11369911, DOI: 10.1002/hbm.70005.Peer-Reviewed Original ResearchConceptsBrain functional changesFunctional connectivityCognitive controlBrain agingBrain functionPatterns of brain agingResting-state brain functional connectivityBrain functional interactionsBrain functional connectivityHuman brain functionBrain aging patternsGender commonalitiesAge-related changesDeep learningHealthy participantsNormal agingNegative connectionFunctional changesBrainPositive connectionDeep learning modelsFunctional domainsAge effectsFunctional interactionsCross-validation schemeGyrification across psychotic disorders: A bipolar-schizophrenia network of intermediate phenotypes study
Rychagov N, Del Re E, Zeng V, Oykhman E, Lizano P, McDowell J, Yassin W, Clementz B, Gershon E, Pearlson G, Sweeney J, Tamminga C, Keshavan M. Gyrification across psychotic disorders: A bipolar-schizophrenia network of intermediate phenotypes study. Schizophrenia Research 2024, 271: 169-178. PMID: 39032429, PMCID: PMC11384321, DOI: 10.1016/j.schres.2024.07.009.Peer-Reviewed Original ResearchBipolar-Schizophrenia NetworkPsychotic disordersDSM-IVIntermediate Phenotypes studyGyrification changesSchizophrenia compared to controlsBipolar I disorderRight cingulate cortexSchizoaffective disorder probandsBipolar disorder probandsDisorders compared to controlsAge-related differencesSchizoaffective disorderCingulate cortexVerbal memoryBipolar disorderAge-related changesFalse discovery rate correctionSchizophreniaCortical gyrificationHypogyriaFrontal lobeGyrificationDisordersHealthy controlsAge-related reduction in anxiety and neural encoding of negative emotional memory
Chaudhary S, Zhang S, Chen Y, Dominguez J, Chao H, Li C. Age-related reduction in anxiety and neural encoding of negative emotional memory. Frontiers In Aging Neuroscience 2024, 16: 1375435. PMID: 39021704, PMCID: PMC11252031, DOI: 10.3389/fnagi.2024.1375435.Peer-Reviewed Original ResearchNegative emotional memoriesSpielberger State-Trait Anxiety InventoryEmotional memoryAge-related reductionSpielberger State-Trait Anxiety Inventory scoresWhole-brain regressionNegative emotional imagesState-Trait Anxiety InventoryTrait Anxiety InventoryAge-related differencesSignal detection theoryMemory taskNeutral imagesAge-related changesEmotional imagesAnxiety InventoryMediation analysisAnxietyPost-scanCortical activityNeural encodingState scoresMemoryOlder adultsDetection theoryInfant Social Attention Associated with Elevated Likelihood for Autism Spectrum Disorder: A Multi-Method Comparison
Fu X, Platt E, Shic F, Bradshaw J. Infant Social Attention Associated with Elevated Likelihood for Autism Spectrum Disorder: A Multi-Method Comparison. Journal Of Autism And Developmental Disorders 2024, 55: 2337-2349. PMID: 38678515, PMCID: PMC11911713, DOI: 10.1007/s10803-024-06360-z.Peer-Reviewed Original ResearchMeasures of attentionAutism spectrum disorderEye trackingEL infantsAtypical social attentionAnalysis of attentionNonsocial attentionSatisfactory success rateNonsocial informationMonths of ageAge-related changesSpectrum disorderGroup differencesSocial attentionAttention patternsFamilial likelihoodGaze allocationElevated likelihoodInfantsEarly markersLongitudinal studyInfant ageManual codingMulti-method comparisonSuccess rate0717 Ageism and Insomnia: Examining the Relationship Between Negative Aging Stereotypes and Insomnia in Older Adults
Boyle J, Fischer I, Bashian H, Moye J, Pietrzak R. 0717 Ageism and Insomnia: Examining the Relationship Between Negative Aging Stereotypes and Insomnia in Older Adults. Sleep 2024, 47: a307-a307. DOI: 10.1093/sleep/zsae067.0717.Peer-Reviewed Original ResearchNegative age stereotypesAge stereotypesClinical insomniaInsomnia symptomsClinical insomnia symptomsEmotional agingU.S. veteransNationally Representative SampleNegative stereotypesNational Health and ResilienceSleep disturbancePoor sleepEndorsement of negative stereotypesOlder veteransTraumatic life eventsPsychotropic medication useDaytime dysfunctionRates of sleep disturbancesImproving overall sleep qualityRepresentative sampleCognitive agingInsomnia severityOverall sleep qualityVeterans StudyAge-related changesThe Assessment and Management of Insomnia in Older Adults
Johnson C, Srinivasan S, Dix E, Tampi R. The Assessment and Management of Insomnia in Older Adults. American Journal Of Geriatric Psychiatry 2024, 32: s21. DOI: 10.1016/j.jagp.2024.01.074.Peer-Reviewed Original ResearchCBT-IBehavioral therapyOlder adultsCognitive Behavioral Therapy for InsomniaBehavioral treatment of insomniaSleep disordersCognitive behavioral therapyClasses of pharmacological interventionsTreatment of insomniaManagement of insomniaEvaluation of insomniaMaintenance of sleepREM sleep behavior disorderTerminal insomniaPersistent insomniaSleep behavior disorderAge-related changesBehavioral disordersSleep concernsNon-pharmacological interventionsInsomniaSleep architectureObstructive sleep apneaRestless legs syndromeAdjunctive treatmentDevelopmentally sensitive multispectral cortical connectivity profiles serving visual selective attention
Son J, Killanin A, Arif Y, Johnson H, Okelberry H, Weyrich L, Wang Y, Calhoun V, Stephen J, Taylor B, Wilson T. Developmentally sensitive multispectral cortical connectivity profiles serving visual selective attention. Developmental Cognitive Neuroscience 2024, 66: 101371. PMID: 38582064, PMCID: PMC11004069, DOI: 10.1016/j.dcn.2024.101371.Peer-Reviewed Original ResearchBrain regionsConnectivity profilesSensitive to developmental changesWhole-brain connectivity analysisMultiple cognitive domainsVisual selective attentionOscillatory brain responsesNeural oscillatory dynamicsYouth aged 6Pubertal transition periodPrefrontal cortexExecutive functionTemporoparietal junctionCognitive domainsBrain responsesSelective attentionDevelopmental sensitivityAge-related changesConnectivity analysisPeak voxelsCortical connectivity profilesDevelopmental changesGamma rangeCerebellar cortexBrainA Method to Estimate Longitudinal Change Patterns in Functional Network Connectivity of the Developing Brain Relevant to Psychiatric Problems, Cognition, and Age
Saha R, Saha D, Rahaman A, Fu Z, Liu J, Calhoun V. A Method to Estimate Longitudinal Change Patterns in Functional Network Connectivity of the Developing Brain Relevant to Psychiatric Problems, Cognition, and Age. Brain Connectivity 2024, 14: 130-140. PMID: 38308475, PMCID: PMC10954605, DOI: 10.1089/brain.2023.0040.Peer-Reviewed Original ResearchFunctional network connectivityFunctional connectivityPsychiatric problemsFunctional network connectivity matricesNetwork connectivityMultivariate patternsWhole-brain functional networksIntrinsic functional connectivityPattern of functional changesBrain functional connectivityIntrinsic functional relationshipLongitudinal changesAdolescent brainAge-related changesBrain networksStudy developmental changesScanning sessionBrain functionAssociated with longitudinal changesCognitive scoresDevelopmental changesBrain developmentFunctional changesCognitionLongitudinal change patterns
2023
The regional pattern of age-related synaptic loss in the human brain differs from gray matter volume loss: in vivo PET measurement with [11C]UCB-J
Toyonaga T, Khattar N, Wu Y, Lu Y, Naganawa M, Gallezot J, Matuskey D, Mecca A, Pittman B, Dias M, Nabulsi N, Finnema S, Chen M, Arnsten A, Radhakrishnan R, Skosnik P, D’Souza D, Esterlis I, Huang Y, van Dyck C, Carson R. The regional pattern of age-related synaptic loss in the human brain differs from gray matter volume loss: in vivo PET measurement with [11C]UCB-J. European Journal Of Nuclear Medicine And Molecular Imaging 2023, 51: 1012-1022. PMID: 37955791, DOI: 10.1007/s00259-023-06487-8.Peer-Reviewed Original ResearchSynaptic densityAge-related decreaseMagnetic resonance imagingBlood flowAge-related synaptic lossGray matter volume lossSynaptic density lossPositron emission tomography (PET) ligandSynaptic vesicle glycoprotein 2AVivo PET measurementsMedial occipital cortexGray matter volumeAge-related neurodegenerationGray matter regionsCognitive normal subjectsAge-related changesSynaptic lossNerve terminalsWide age rangeOccipital cortexTomography ligandNormal subjectsGM volumeAge-related functional lossesMatter volumeThe Effects of Aging on Rod Bipolar Cell Ribbon Synapses
Shrestha A, Rameshkumar N, Boff J, Rajmanna R, Chandrasegaran T, Frederick C, Zenisek D, Vaithianathan T. The Effects of Aging on Rod Bipolar Cell Ribbon Synapses. Cells 2023, 12: 2385. PMID: 37830599, PMCID: PMC10572008, DOI: 10.3390/cells12192385.Peer-Reviewed Original ResearchConceptsRod bipolar cellsRibbon synapsesSynaptic ribbonsCalcium currentBipolar cellsRetinal ganglion cellsAge-related morphological changesBipolar cell ribbon synapsesBipolar cell terminalsGlobal health concernAge-related visual impairmentAge-related changesPlexiform layerGanglion cellsInner nuclearCochlear cellsSensory alterationsCell terminalsVisual impairmentFunctional changesHealth concernCalcium signalsSynapsesCalcium dynamicsRetinaHigh-throughput single-cell profiling of B cell responses following inactivated influenza vaccination in young and older adults
Wang M, Jiang R, Mohanty S, Meng H, Shaw A, Kleinstein S. High-throughput single-cell profiling of B cell responses following inactivated influenza vaccination in young and older adults. Aging 2023, 15: 9250-9274. PMID: 37367734, PMCID: PMC10564424, DOI: 10.18632/aging.204778.Peer-Reviewed Original ResearchConceptsB cellsActivated B cellsB cell receptorOlder adultsInfluenza vaccinationAge groupsPeripheral blood B cellsYoung adultsInactivated influenza vaccineB cell responsesSubstantial disease burdenBlood B cellsMemory B cellsInfluenza vaccination responsesStrong antibody responseAge-related changesInfluenza vaccineVaccination responseSeasonal influenzaAntibody responseHospital visitsDisease burdenSomatic hypermutation frequenciesVaccinationCell responsesAge-related Changes in Structure, Function, and Transcriptomics of the Human Proximal Pulmonary Artery
Manning E, Ramachandra A, Cavinato C, Schupp J, Justet A, Lee P, Heerdt P, Singh I, Murphy T, Gill T, Tellides G, Kaminski N, Humphrey J. Age-related Changes in Structure, Function, and Transcriptomics of the Human Proximal Pulmonary Artery. 2023, a4656-a4656. DOI: 10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a4656.Peer-Reviewed Original ResearchNav1.7 gain-of-function mutation I228M triggers age-dependent nociceptive insensitivity and C-LTMR dysregulation
Wimalasena N, Taub D, Shim J, Hakim S, Kawaguchi R, Chen L, El-Rifai M, Geschwind D, Dib-Hajj S, Waxman S, Woolf C. Nav1.7 gain-of-function mutation I228M triggers age-dependent nociceptive insensitivity and C-LTMR dysregulation. Experimental Neurology 2023, 364: 114393. PMID: 37003485, PMCID: PMC10171359, DOI: 10.1016/j.expneurol.2023.114393.Peer-Reviewed Original ResearchConceptsParoxysmal extreme pain disorderSmall fiber neuropathyFunction mutationsDRG neuron hyperexcitabilityYoung adult miceVoltage-gated sodium channel NaSodium conductanceAge-related changesNeuron hyperexcitabilityPain disordersCongenital insensitivitySodium channel NaExcitability changesFemale miceMouse DRGYoung miceNeuronal excitabilityNoxious heatSkin lesionsVoltage-gated channelsAdult miceNeuron subtypesNervous systemProfound insensitivityMiceThe Assessment and Management of Insomnia Among Older Adults
Johnson C, Srinivasan S, Dix E, Tampi R. The Assessment and Management of Insomnia Among Older Adults. American Journal Of Geriatric Psychiatry 2023, 31: s19. DOI: 10.1016/j.jagp.2022.12.301.Peer-Reviewed Original ResearchSleep disordersCognitive behavioral therapyOlder adultsBehavioral therapyREM sleep behavior disorderSimilar short-term outcomesBetter long-term outcomesFirst-line treatmentSleep behavior disorderObstructive sleep apneaNon-pharmacological interventionsShort-term outcomesLong-term outcomesRestless legs syndromeEvaluation of insomniaManagement of insomniaMaintenance of sleepVariety of treatmentsAge-related changesMechanism of actionElderly patientsAdjunctive treatmentLegs syndromeLine treatmentSleep apneaAffective Brain Development in Concert with Caregivers
Tottenham N. Affective Brain Development in Concert with Caregivers. 2023, 00: 1-1. DOI: 10.1109/aciiw59127.2023.10388104.Peer-Reviewed Original ResearchBrain developmentHuman brain developmentChildren's brain developmentDevelopmental sensitive periodsAffecting brain developmentAge-related changesCaregiving environmentAffective behaviorAffective learningEnvironmental influencesSensitive periodParent caregiversProlonged developmentSocial environmentCaregiversNeurocircuitryChildrenLearning
2022
Coordinated anatomical and functional variability in the human brain during adolescence
Bero J, Li Y, Kumar A, Humphries C, Nag S, Lee H, Ahn W, Hahn S, Constable R, Kim H, Lee D. Coordinated anatomical and functional variability in the human brain during adolescence. Human Brain Mapping 2022, 44: 1767-1778. PMID: 36479851, PMCID: PMC9921246, DOI: 10.1002/hbm.26173.Peer-Reviewed Original ResearchConceptsCortical thicknessCortical areasFunctional connectivityResting-state functional connectivityAssociation cortical areasMultiple cortical areasCortical information processingAge-related changesCortical myelinationAdult brainCytoarchitectural featuresBrain developmentInformation processingBrainDevelopmental changesHuman brainAdolescenceMyelinationPatterns of coordinationMeasuresRegional variationMyelinAge-related changes in Folliculogenesis and potential modifiers to improve fertility outcomes - A narrative review
Esencan E, Beroukhim G, Seifer D. Age-related changes in Folliculogenesis and potential modifiers to improve fertility outcomes - A narrative review. Reproductive Biology And Endocrinology 2022, 20: 156. PMID: 36397149, PMCID: PMC9670479, DOI: 10.1186/s12958-022-01033-x.Peer-Reviewed Original ResearchConceptsInsulin-like growth factor-1Vascular endothelial growth factorAge-related changesAntimullerian hormoneFertility outcomesIndividual studiesGrowth factor-1Endothelial growth factorObstetrical outcomesVitamin DOocyte quantityOvarian agingFollicular depletionFollicular fluidIntraovarian regulatorsRodent studiesHealthy oocytesNarrative reviewReproductive agingPotential modifiersCumulus cellsGrowth factorFactor 1Mitochondrial functionOutcomes
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