2025
A high proportion of immature oocytes in a cycle cohort does not compromise embryo development or live birth rates after ICSI
Sripada V, Sakkas D, Vaughan D, Morse B, Fouks Y. A high proportion of immature oocytes in a cycle cohort does not compromise embryo development or live birth rates after ICSI. Human Reproduction 2025, deaf167. PMID: 40912262, DOI: 10.1093/humrep/deaf167.Peer-Reviewed Original ResearchLive birth rateProportion of immature oocytesIVF-ICSI cyclesGonadotropin dosageBirth rateIVF-ICSIEmbryo transferAnti-Mullerian hormone levelsPropensity score matchingOvarian stimulation protocolsMetaphase-IIImmature oocytesFresh embryo transferProportion of mature oocytesPGT-AFertility clinicsIVF outcomesMature oocytesLower pregnancyEmbryo developmentFertilization rateLower blastocyst formationOocyte quality markersMetaphase-II oocytesPreimplantation genetic testingEffect of hCG day’s estradiol levels on pregnancy outcomes following GnRH antagonist protocol: a retrospective study of 3192 fresh embryo transfer cycles
Zeng H, Chang Y, Liu N, Li S. Effect of hCG day’s estradiol levels on pregnancy outcomes following GnRH antagonist protocol: a retrospective study of 3192 fresh embryo transfer cycles. BMC Pregnancy And Childbirth 2025, 25: 836. PMID: 40797168, PMCID: PMC12341211, DOI: 10.1186/s12884-025-07929-x.Peer-Reviewed Original ResearchPregnancy outcomesAntagonist protocolPregnancy rateHigher pregnancy rateEstradiol levelsRetrospective studyEmbryo transferFresh embryo transfer cyclesEmbryo transfer cyclesFresh embryo transferFresh ET cyclesGnRH antagonist protocolMethodsThe retrospective studyFresh ETHCG dayET cyclesTransfer cyclesXiangya HospitalPregnancyAntagonistOutcomesSegment regressionCPRDoes endometrial thickness impact live birth rate following a frozen embryo transfer: outcomes of 30 676 euploid single embryo transfers
Genovese H, Mayo C, Kalafat E, Fatemi H, Ata B, Garcia-Velasco J, Seli E. Does endometrial thickness impact live birth rate following a frozen embryo transfer: outcomes of 30 676 euploid single embryo transfers. Human Reproduction 2025, deaf129. PMID: 40639807, DOI: 10.1093/humrep/deaf129.Peer-Reviewed Original ResearchLive birth rateFrozen embryo transferEndometrial thicknessReceiver operating characteristic curveEmbryo transferBirth ratePrognostic valueLive birthsInternational multicenter retrospective cohort studyOdds of live birth ratePredictor of live birth rateEuploid frozen embryo transferFrozen embryo transfer protocolsFrozen embryo transfer cyclesMulticenter retrospective cohort studyAdjusted effect estimatesEuploid FET cyclesMultivariate logistic regression analysisEndometrial preparation protocolsSingle embryo transferProgramming cycleModified natural cycleStudy funding/competing interest(sRetrospective cohort studyRegression analysisDoes the weekend matter? evaluating the weekend effect on pregnancy outcomes in first-cycle fresh IVF/ICSI embryo transfers: a retrospective study
Yang T, Yang Y, Hou Z, Chang T, Liu N, Liu D, Li Y, Zhao J, Zhang Q, Yao Z, Tian F, Li Y. Does the weekend matter? evaluating the weekend effect on pregnancy outcomes in first-cycle fresh IVF/ICSI embryo transfers: a retrospective study. BMC Pregnancy And Childbirth 2025, 25: 708. PMID: 40610925, PMCID: PMC12224509, DOI: 10.1186/s12884-025-07783-x.Peer-Reviewed Original ResearchConceptsClinical pregnancy rateDay of oocyte retrievalFresh ET cyclesIntracytoplasmic sperm injectionOocyte retrievalIn vitro fertilizationEmbryo transferAssisted Reproductive TechnologyET cyclesXiangya Hospital of Central South UniversityIVF/ICSI-embryo transferMultivariate logistic regression analysisFresh embryo transferLive birth rateReproductive Medicine CenterRetrospective cohort studyPregnancy success rateLogistic regression analysisCentral South UniversityWeekend groupWeekend retrievalsSperm injectionFresh cyclesPregnancy outcomesRetrospective studyImpact of spring festival on pregnancy outcomes in patients undergoing first embryo transfer: a retrospective cohort study
Yang Y, Hou Z, Qiu H, Chang T, Liu N, Liu D, Li Y, Zhao J, Zhang Q, Yao Z, Tian F, Yang T, Li Y. Impact of spring festival on pregnancy outcomes in patients undergoing first embryo transfer: a retrospective cohort study. Scientific Reports 2025, 15: 23339. PMID: 40604013, PMCID: PMC12222965, DOI: 10.1038/s41598-025-05029-6.Peer-Reviewed Original ResearchConceptsPropensity score matchingRetrospective cohort studyEmbryo transferPregnancy outcomesCohort studyPregnancy rateIn vitro fertilization/intracytoplasmic sperm injectionClinical pregnancy rateFertilization/intracytoplasmic sperm injectionLive birth rateOutcomes of patientsPropensity Score Matching AnalysisMultivariate logistic regressionMultivariate regression analysisUniversity-affiliated hospitalSperm injectionET cyclesImplantation ratePoor prognosisRisk factorsPatientsPregnancyScore matchingBirth rateLogistic regressionModified Versions of Natural Frozen Embryo Transfers Do Not Impact Live Births
Hargreaves C, Craig W, Sakkas D, Toth T, Vaughan D. Modified Versions of Natural Frozen Embryo Transfers Do Not Impact Live Births. Fertility And Sterility 2025 PMID: 40588150, DOI: 10.1016/j.fertnstert.2025.06.036.Peer-Reviewed Original ResearchFrozen embryo transferVaginal progesterone supplementationHuman chorionic gonadotropinLive birthsProgesterone supplementationEmbryo transferNatural frozen embryo transferFrozen embryo transfer cyclesHuman chorionic gonadotropin triggerIncidence of live birthPercentage of live birthsNatural FET cyclesReference groupUniversity-affiliated fertility clinicCohort of patientsRetrospective cohort studyFET cyclesNatural cyclesAromatase inhibitorsChorionic gonadotropinCohort studyIndividual patientsPatientsStudy protocolBirthRevitalizing reproductive health: innovations and future frontiers in restorative medicine
Bulletti F, Giacomucci E, Guido M, Palagiano A, Coccia M, Bulletti C. Revitalizing reproductive health: innovations and future frontiers in restorative medicine. Therapeutic Advances In Reproductive Health 2025, 19: 26334941251345844. PMID: 40546415, PMCID: PMC12182620, DOI: 10.1177/26334941251345844.Peer-Reviewed Original ResearchFertility careThyroid dysfunctionReproductive medicineFactors affecting infertilityLive birth rateMedically Assisted ReproductionNewcastle-Ottawa ScaleCochrane risk of bias toolAssisted Reproductive TechnologyRisk of bias toolMulticenter trialPublic health challengeSurgical correctionReproductive-aged individualsEmbryo transferFertility outcomesART successSystem abnormalitiesBirth ratePregnancy rateAssisted reproductionNewcastle-OttawaWeb of ScienceReproductive technologyInclusion criteriaUtilization and Fertility Preservation Outcomes in Women Undergoing Embryo Cryopreservation Before Breast Cancer Treatment: A Meta-Analysis
Turan V, Oktem O, Bang H, Oktay K. Utilization and Fertility Preservation Outcomes in Women Undergoing Embryo Cryopreservation Before Breast Cancer Treatment: A Meta-Analysis. Clinical Breast Cancer 2025, 25: 617-624.e1. PMID: 40603132, DOI: 10.1016/j.clbc.2025.06.003.Peer-Reviewed Original ResearchBreast cancer treatmentFertility preservation rateLive birth rateClinical pregnancyCancer treatmentFertility preservationEmbryo transferPreservation rateBirth rateFertility preservation outcomesFrozen embryo transferCochrane Library databasesRandom-effects modelSecondary outcome measuresPregnancy outcomesEmbryo cryopreservationBreast cancerPreservation outcomesLibrary databasesPregnancyBreastMeta-analysisOutcome measuresWomenTreatmentSerum estradiol and progesterone levels at different time points in the menstrual cycle as predictors of outcome in frozen embryo transfer cycles
Yuceturk A, Karaosmanoglu O, Aslan I, Kopuk S, Korun Z, Yazicioglu C, Seli E, Cakiroglu Y, Tiras B. Serum estradiol and progesterone levels at different time points in the menstrual cycle as predictors of outcome in frozen embryo transfer cycles. European Journal Of Obstetrics & Gynecology And Reproductive Biology 2025, 312: 114509. PMID: 40505433, DOI: 10.1016/j.ejogrb.2025.114509.Peer-Reviewed Original ResearchDay of progesterone initiationFrozen embryo transfer cyclesDay of embryo transferPredicting clinical pregnancyEmbryo transfer cyclesSerum estradiolEmbryo transferProgesterone levelsProgesterone initiationClinical pregnancyTransfer cyclesFrozen single blastocyst transferAssociated with higher clinical pregnancy ratesHigher clinical pregnancy ratesTime pointsSingle blastocyst transferSerum estradiol levelsClinical pregnancy rateFrozen embryo transferWomen aged <Prospective cohort studySerum progesterone >Predictors of outcomeBlastocyst transferOral estradiolRecommendation to improve the rigor and impact of non-randomized studies of interventions in fertility treatment research
Schwarze J, Tennant P, Barnhart K, Platt R, Gupta S, Venetis C, D'Hooghe T, Schisterman E. Recommendation to improve the rigor and impact of non-randomized studies of interventions in fertility treatment research. Fertility And Sterility 2025 PMID: 40467028, DOI: 10.1016/j.fertnstert.2025.05.168.Peer-Reviewed Original ResearchAssisted Reproductive TechnologyNonrandomized studies of interventionsRandomized Controlled TrialsNonrandomized studiesStudies of interventionsClinical practiceOvarian stimulationNon-randomized Studies of InterventionsMultidisciplinary expert consensusSelection biasAssisted reproductive technology researchReproductive technologyMethodological rigorStudy designEvidence-based clinical practiceEmbryo transferIntervention study designPatient populationTreatment outcomesDiverse patient populationsClinical decision makingGold standardControlled TrialsStudy protocolExpert consensusP-450 Two for the Price of One: Twins and Multiple Births Following a Natural vs. Programmed Single Frozen Blastocyst Transfer Cycle
Meyers A, Mensah V, Morse B, Sakkas D, Vaughan D. P-450 Two for the Price of One: Twins and Multiple Births Following a Natural vs. Programmed Single Frozen Blastocyst Transfer Cycle. Human Reproduction 2025, 40: deaf097.756. DOI: 10.1093/humrep/deaf097.756.Peer-Reviewed Original ResearchFrozen embryo transferMultiple pregnanciesHigher-order multiplesEmbryo transferNatural frozen embryo transferRisk of monozygotic twinningRisk of multiple pregnancyNatural cycle groupPregnancy outcome dataRetrospective cohort studyElectronic medical record databaseNatural cyclesLikelihood of pregnancySingleton pregnanciesMedical record databaseTwin pregnanciesChi-square testFetal sacMethods PatientsOvulated oocytesUnassisted conceptionWider implicationsCohort studyPregnancyTheoretical riskP-682 A high proportion of immature oocytes in a cycle cohort does not impair embryo development or live birth rates following ICSI
Sakkas D, Sripada V, Vaughan D, Morse B, Fouks Y. P-682 A high proportion of immature oocytes in a cycle cohort does not impair embryo development or live birth rates following ICSI. Human Reproduction 2025, 40: deaf097.988. DOI: 10.1093/humrep/deaf097.988.Peer-Reviewed Original ResearchLive birth rateIntracytoplasmic sperm injectionProportion of immature oocytesBirth rateGonadotropin dosageIn vitro fertilizationPropensity score matchingMetaphase IIImmature oocytesPresence of immature oocytesEmbryo transferFresh embryo transferAssociated with fertilization rateCryopreserved embryo transferCycle cohortPGT-ABlastocyst formationRatio groupFewer blastocystsPoor oocyte qualityGroups propensity score matchingGerminal vesicleOocyte maturationEmbryo developmentOvarian stimulationO-267 PGT-A provider strategies influence embryo selection and live birth rates: a multicenter analysis of 40,308 blastocyst biopsy results and 8,491 euploid embryo transfers
Popovic M, Kalafat E, Miguel-Escalada I, Rodríguez-Aranda A, Sakkas D. O-267 PGT-A provider strategies influence embryo selection and live birth rates: a multicenter analysis of 40,308 blastocyst biopsy results and 8,491 euploid embryo transfers. Human Reproduction 2025, 40: deaf097.267. DOI: 10.1093/humrep/deaf097.267.Peer-Reviewed Original ResearchLive birth rateEuploid embryo transferPGT-AEuploid embryosEmbryo transferMaternal ageEmbryo selectionEuploidy rateBiopsy dayEmbryo qualityBirth rateCumulative live birth rateLower live birth ratesClinical IVF practicePGT-A cyclesChance of live birthPreimplantation genetic testingMulticenter cohort studyDiagnosis of mosaicismMaternal age groupsNext generation sequencingSuccess rateAge groupsProportion of embryosMultivariate logistic regressionO-149 No effect of maternal age on embryo implantation and live birth rates after preimplantation genetic testing for aneuploidies: retrospective analysis of 11,855 single blastocyst transfers
Gayete-Mor B, Miguel-Escalada I, Kalafat E, Zamora M, Pujol A, Lledó B, Stoop D, Lorenzon A, Rodriguez-Aranda A, Sakkas D, Popovic M. O-149 No effect of maternal age on embryo implantation and live birth rates after preimplantation genetic testing for aneuploidies: retrospective analysis of 11,855 single blastocyst transfers. Human Reproduction 2025, 40: deaf097.149. DOI: 10.1093/humrep/deaf097.149.Peer-Reviewed Original ResearchEuploid embryo transferAge-related fertility declineAdvanced maternal ageLive birth ratePreimplantation genetic testingEmbryo qualityMaternal ageLive birthsEuploid embryosFertility declineEmbryo transferClinical outcomesClinical pregnancyEffect of maternal agePGT-AAssociated with poor embryo qualityBirth rateOlder patientsGenetic testingReproductive outcomesEuploid blastocyst transferGood-quality blastocystsReduced oocyte yieldPoor embryo qualityPoor-quality embryosP-470 Endometrial immune cell profiles differ during fresh vs. frozen embryo transfer cycles: insights into the window of implantation
Strbo N, Rodriguez S, Padula L, Fisher E, Slater B, Gharagozloo A, Awadallah C, Ibrahim M, Rubino R, Paidas M, Attia G. P-470 Endometrial immune cell profiles differ during fresh vs. frozen embryo transfer cycles: insights into the window of implantation. Human Reproduction 2025, 40: deaf097.776. DOI: 10.1093/humrep/deaf097.776.Peer-Reviewed Original ResearchFrozen embryo transfer cyclesFrozen embryo transferImmune cell profilesTime of embryo transferEmbryo transferFrozen cyclesEndometrial milieuWindow of implantationT cellsAssisted reproductive technology cyclesEndometrial expressionFresh embryo transferImprove IVF outcomesCell profilesAcademic fertility centerImmune milieuImmune cellsExpression of CD8+ T cellsAntagonist protocolCD8+ T cellsExpression of B cellsGonadotropin doseCycle outcomesExpression of T cellsIVF outcomesO-147 Biochemical or clinical pregnancy loss following the first embryo frozen transfer does not increase the risk of pregnancy loss in the subsequent embryo transfer
Barrett F, Kalafat E, Margolis C, Werner M, Ata B, Seli E. O-147 Biochemical or clinical pregnancy loss following the first embryo frozen transfer does not increase the risk of pregnancy loss in the subsequent embryo transfer. Human Reproduction 2025, 40: deaf097.147. DOI: 10.1093/humrep/deaf097.147.Peer-Reviewed Original ResearchRisk of pregnancy lossEuploid embryosImplant failurePregnancy lossEndometrial thicknessEmbryo transferUltrasound evidenceSerum beta-hCG levelsIncreased risk of pregnancy lossDay of blastulationMedian endometrial thicknessBeta-hCG levelsRisk of aneuploidyClinical pregnancy lossRisk of recurrenceRetrospective cohort studyEvidence of pregnancyPearson chi-square testRate of livebirthsEmbryo-fetalEuploid transfersGestational sacFET cyclesBeta-hCGChi-square testP-332 Does endometrial thickness impact live birth rate following a frozen embryo transfer or is there a self-fulfilling prophecy: outcomes of 30,676 euploid single embryo transfers
Genovese H, Mayo C, Kalafat E, Ata B, Fatemi H, Garcia-Velasco J, Seli E. P-332 Does endometrial thickness impact live birth rate following a frozen embryo transfer or is there a self-fulfilling prophecy: outcomes of 30,676 euploid single embryo transfers. Human Reproduction 2025, 40: deaf097.640. DOI: 10.1093/humrep/deaf097.640.Peer-Reviewed Original ResearchLive birth rateModified natural cycleEndometrial thicknessReceiver operating characteristic curveBirth rateFET cyclesEmbryo transferInternational multicenter retrospective cohort studyOdds of live birth rateEuploid single embryo transfersPredictor of live birth rateMulticenter retrospective cohort studyEuploid FET cyclesEndometrial preparation protocolsIn vitro fertilization centerMultivariate logistic regression analysisSingle embryo transferFrozen embryo transferImpact of ETRetrospective cohort studyPredicting live birthLogistic regression analysisOperating characteristics curvePercentage of cyclesEuploid blastocystsEstablishment and application of an RNA-seq-based predictive model for the hourly precision window of implantation (WOI) in patients with recurrent implantation failure
He A, Yang T, Lu S, Zou Y, Wan C, Chen Y, Zhao J, Liu N, Liu D, Li Y, Wang Y, Xu B, Hao J, Fu J, Zhang Q, Wang B, Li Y. Establishment and application of an RNA-seq-based predictive model for the hourly precision window of implantation (WOI) in patients with recurrent implantation failure. Journal Of Assisted Reproduction And Genetics 2025, 42: 2067-2082. PMID: 40304883, PMCID: PMC12229385, DOI: 10.1007/s10815-025-03468-8.Peer-Reviewed Original ResearchRecurrent implantation failureIntrauterine pregnancy ratePersonalized embryo transferLive birth rateImplantation rateB-hCGEndometrial receptivity testPregnancy ratePropensity score matchingImplant failureB-human chorionic gonadotropinEarly spontaneous abortion rateSpontaneous abortion rateControl groupBirth rateIntrauterine pregnancyPregnancy outcomesEndometrial biopsyEmbryo transferChorionic gonadotropinPregnancyPatientsExperimental groupAbortion rateScore matchingPerinatal Outcomes Are Similar in Programmed and Modified Natural Frozen Embryo Transfer Cycles
Farrel A, Yuen M, Dodge L, Sakkas D, Vaughan D, Toth T. Perinatal Outcomes Are Similar in Programmed and Modified Natural Frozen Embryo Transfer Cycles. Obstetrical & Gynecological Survey 2025, 80: 235-236. DOI: 10.1097/ogx.0000000000001393.Peer-Reviewed Original ResearchFrozen embryo transfer cyclesEmbryo transfer cyclesFrozen embryo transferEmbryo transferTransfer cyclesOvarian hyperstimulation syndromeFresh embryo transferHyperstimulation syndromeUnited StatesPerinatal outcomesFertilizer treatmentsClinical outcomesGenetic testingReduced likelihoodLikelihood of successIncreased patient autonomyImproved likelihoodAutonomyMapping the way to successful euploid frozen embryo transfer: a prospective pilot study of uterine elastography
Margolis C, Garrido N, Roberts L, Reig A, Gill P, Willson S, Genovese H, Barrett F, Zuckerman C, Whitehead C, Bergh P, Seli E, Werner M. Mapping the way to successful euploid frozen embryo transfer: a prospective pilot study of uterine elastography. Human Reproduction 2025, 40: 895-903. PMID: 39999405, DOI: 10.1093/humrep/deaf029.Peer-Reviewed Original ResearchPredictive of clinical pregnancyClinical pregnancyClinical parametersPatient populationShear wave elastographyPosterior myometriumEmbryo transferDay prior to embryo transferElastography parametersEuploid frozen embryo transferLikelihood of clinical pregnancyPredictive valueAlternative patient populationsInfertile patient populationLower uterine segmentPredicting clinical pregnancyFrozen embryo transferLikelihood of conceptionProspective pilot studyMultivariate logistic regression modelReceiver operating characteristic curvePrediction of pregnancyShear wave elastography assessmentsUniversity-affiliated centerAssociated with increased likelihood
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