2018
Allostatic load, a measure of chronic physiological stress, is associated with pregnancy outcomes, but not fertility, among women with unexplained infertility
Barrett ES, Vitek W, Mbowe O, Thurston SW, Legro RS, Alvero R, Baker V, Bates GW, Casson P, Coutifaris C, Eisenberg E, Hansen K, Krawetz S, Robinson R, Rosen M, Usadi R, Zhang H, Santoro N, Diamond M. Allostatic load, a measure of chronic physiological stress, is associated with pregnancy outcomes, but not fertility, among women with unexplained infertility. Human Reproduction 2018, 33: 1757-1766. PMID: 30085177, PMCID: PMC6454470, DOI: 10.1093/humrep/dey261.Peer-Reviewed Original ResearchConceptsAdverse pregnancy outcomesOvarian stimulationPreterm birthPregnancy outcomesLive birthsUnexplained infertilityLipoprotein cholesterolBlood pressureBirth outcomesLow birthweightAllostatic loadSpontaneous abortionReproductive outcomesHigh-density lipoprotein cholesterolLow-density lipoprotein cholesterolAL scoreSTUDY FUNDING/COMPETINGChronic physiological stressMulti-variable logistic regression modelAdvanced Reproductive CareMultiple Intrauterine GestationsDiastolic blood pressureNon-pregnant stateSystolic blood pressureType of infertility
2016
Mitochondrial gene expression profiles are associated with intrahepatic cholestasis of pregnancy
Mella MT, Kohari K, Jones R, Peña J, Ferrara L, Stone J, Lambertini L. Mitochondrial gene expression profiles are associated with intrahepatic cholestasis of pregnancy. Placenta 2016, 45: 16-23. PMID: 27577705, DOI: 10.1016/j.placenta.2016.07.002.Peer-Reviewed Original ResearchConceptsOxidative stress statusIntrahepatic cholestasisHepatic bile acid accumulationHigher maternal serum levelsMaternal serum levelsSpontaneous preterm birthNon-pregnant stateBile acid levelsBile acid concentrationsBile acid accumulationStress statusPathophysiology of ICPOxidative stress ratePreterm birthClinical courseFetal demiseSerum levelsFetal effectsPregnant womenHigh oxidative stressReal-time PCRLong-term effectsMitochondrial activityPlacenta samplesBile acids
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply