2025
Endothelial CLEC5A drives barrier dysfunction and vascular leakage responsible for lung injury in bacterial pneumonia and sepsis
Zhang T, Huang X, Goodwin J, Wen R, Liu Y, Yang Y, Zhang T, Zheng Y, Chen A, Hao P, Tong X, Yang N, Liu C. Endothelial CLEC5A drives barrier dysfunction and vascular leakage responsible for lung injury in bacterial pneumonia and sepsis. Science Advances 2025, 11: eadt7589. PMID: 40498836, PMCID: PMC12154197, DOI: 10.1126/sciadv.adt7589.Peer-Reviewed Original ResearchConceptsVascular leakagePuncture (CLP)-induced polymicrobial sepsisRegulating endothelial barrier functionCLP-challenged miceEndothelial barrier dysfunctionTrans-endothelial electrical resistanceEndothelial barrier functionLipopolysaccharide (LPS)-induced endotoxemiaVascular endothelial cellsPattern recognition receptorsSurvival benefitMultiorgan failurePolymicrobial sepsisTrans-endothelial migrationCecal ligationBacterial pneumoniaLung injuryBarrier dysfunctionVascular injurySingle-cell RNA sequencingDecreased mortalityInflammatory stormBacterial infectionsHeterogeneity of vascular endothelial cellsSepsisPulmonary Infections in People with HIV
Grammatico M, Shenoi S, Lemieux S, Akgün K. Pulmonary Infections in People with HIV. 2025, 793-819. DOI: 10.1007/978-3-031-77335-8_31.Peer-Reviewed Original Research
2023
Uncommon histopathological features of cytomegalovirus encephalitis and measles inclusion body encephalitis on autopsy in two patients with primary immunodeficiency.
Jindal A, Suri D, Gupta K, Kumar A, Pandiarajan V, Pilania R, Guleria S, Rawat A, Vyas S, Bhatia A, Singh S, Radotra B. Uncommon histopathological features of cytomegalovirus encephalitis and measles inclusion body encephalitis on autopsy in two patients with primary immunodeficiency. Clinical Neuropathology 2023, 42: 15-25. PMID: 36278299, DOI: 10.5414/np301476.Peer-Reviewed Original ResearchConceptsMeasles inclusion body encephalitisSevere combined immunodeficiencyInclusion body encephalitisPrimary immunodeficiencyCombined immunodeficiencyViral encephalitisCase 2Primary immunodeficiency diseasesFeatures of viral encephalitisWhole-exome sequencingRare giant cellsFatal viral encephalitisCytomegalovirus encephalitisImmunodeficiency diseaseMicroglial nodulesCystic encephalomalaciaHistopathological featuresBacterial pneumoniaHistological featuresAlveolar damageExtracranial organsPathogenic variantsImmunodeficiencyGenetic testingExome sequencingNonutility of procalcitonin for diagnosing bacterial pneumonia in patients with severe COVID-19
Cohen A, Glick L, Lee S, Kunitomo Y, Tsang D, Pitafi S, Toro P, Ristic N, Zhang E, Carey G, Datta R, Dela Cruz C, Gautam S. Nonutility of procalcitonin for diagnosing bacterial pneumonia in patients with severe COVID-19. European Clinical Respiratory Journal 2023, 10: 2174640. PMID: 36815942, PMCID: PMC9930745, DOI: 10.1080/20018525.2023.2174640.Peer-Reviewed Original ResearchSevere COVID-19Bacterial superinfectionBacterial pneumoniaCOVID-19Lower respiratory culturesSuperimposed bacterial pneumoniaUtility of procalcitoninProcalcitonin measurementImmune biomarkersClinical resemblanceRespiratory culturesImmunomodulatory agentsProcalcitoninPatientsBacterial infectionsSuperinfectionCurve analysisSignificant riskCharacteristic curvePneumoniaTime of cultureDiagnosisInfectionBiomarkers
2020
Added Diagnostic Utility of Clinical Metagenomics for the Diagnosis of Pneumonia in Immunocompromised Adults
Azar MM, Schlaberg R, Malinis MF, Bermejo S, Schwarz T, Xie H, Dela Cruz CS. Added Diagnostic Utility of Clinical Metagenomics for the Diagnosis of Pneumonia in Immunocompromised Adults. CHEST Journal 2020, 159: 1356-1371. PMID: 33217418, DOI: 10.1016/j.chest.2020.11.008.Peer-Reviewed Original ResearchConceptsFinal clinical diagnosisDiagnostic yieldFungal pneumoniaImmunocompromised adultsMicrobiologic diagnosisAntimicrobial stewardshipMicrobiologic testingClinical diagnosisClinical metagenomicsCommunity-acquired pneumoniaStandard of careDiagnosis of pneumoniaAdult patientsRadiologic findingsBacterial pneumoniaBAL fluidProspective studyViral pneumoniaBacterial causePneumoniaDiagnostic utilityStudy designDiagnosisAdultsHypothetical impactSevere respiratory viral infection induces procalcitonin in the absence of bacterial pneumonia
Gautam S, Cohen AJ, Stahl Y, Toro P, Young GM, Datta R, Yan X, Ristic NT, Bermejo SD, Sharma L, Restrepo M, Dela Cruz CS. Severe respiratory viral infection induces procalcitonin in the absence of bacterial pneumonia. Thorax 2020, 75: 974-981. PMID: 32826284, DOI: 10.1136/thoraxjnl-2020-214896.Peer-Reviewed Original ResearchConceptsPure viral infectionBacterial coinfectionViral infectionInfluenza infectionSevere respiratory viral infectionsAbility of procalcitoninRetrospective cohort studyViral respiratory infectionsRespiratory viral infectionsMarker of severityRespiratory viral illnessSevere viral infectionsSpecificity of procalcitoninCharacteristic curve analysisCellular modelHigher procalcitoninProcalcitonin expressionElevated procalcitoninCohort studyViral illnessRespiratory infectionsAntibiotic administrationBacterial pneumoniaSevere diseaseProcalcitoninResidual endotoxin induces primary graft dysfunction through ischemia-reperfusion-primed alveolar macrophages
Akbarpour M, Lecuona E, Chiu S, Wu Q, Querrey M, Fernandez R, Nunez-Santana F, Sun H, Ravi S, Kurihara C, Walter JM, Joshi N, Ren Z, Roberts SC, Hauser A, Kreisel D, Li W, Chandel N, Misharin AV, Mohanakumar T, Budinger GRS, Bharat A. Residual endotoxin induces primary graft dysfunction through ischemia-reperfusion-primed alveolar macrophages. Journal Of Clinical Investigation 2020, 130: 4456-4469. PMID: 32692317, PMCID: PMC7410086, DOI: 10.1172/jci135838.Peer-Reviewed Original ResearchConceptsTissue-resident alveolar macrophagesPrimary graft dysfunctionHuman donor lungsNeutrophil recruitmentGraft dysfunctionDonor lungsBacterial pneumoniaAlveolar macrophagesBone marrow chimeric miceDonor lung injuryActivation of TLR4Blockade of TLR4MyD88-dependent mannerResidual endotoxinCoreceptor CD14Lung transplantationLung injuryNeutrophil infiltrationFatal syndromeSuccessful treatmentMouse modelChimeric miceBacterial endotoxinTLR4Endotoxin
2019
A rare presentation of Austrian syndrome with septic arthritis in an immunocompetent female
Battisha A, Madoukh B, Altibi A, Sheikh O. A rare presentation of Austrian syndrome with septic arthritis in an immunocompetent female. The Egyptian Heart Journal 2019, 71: 9. PMID: 31659532, PMCID: PMC6821411, DOI: 10.1186/s43044-019-0010-6.Peer-Reviewed Original ResearchSternoclavicular septic arthritisAustrian syndromeSeptic arthritisImmunocompetent patientsMedical history of hypertensionSternoclavicular joint septic arthritisCase presentationA caseHistory of hypertensionOsler's triadAortic vegetationsRare presentationAggressive pathologyCase reportBacterial pneumoniaStreptococcus pneumoniaeDrastic complicationsMedical historyRisk factorsViral influenzaSyndromeArthritisEndocarditisComplicationsMeningitisPatients
2014
Endothelin-1 and its role in the pathogenesis of infectious diseases
Freeman BD, Machado FS, Tanowitz HB, Desruisseaux MS. Endothelin-1 and its role in the pathogenesis of infectious diseases. Life Sciences 2014, 118: 110-119. PMID: 24780317, PMCID: PMC4538933, DOI: 10.1016/j.lfs.2014.04.021.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsEndothelin-1Isoforms of endothelinRole of endothelinRickettsia conorii infectionPathogenesis of sepsisPro-inflammatory cytokinesVascular smooth muscle cellsLeukocyte adhesion moleculesSmooth muscle cellsSevere malariaVascular dysfunctionBacterial pneumoniaInflammatory mediatorsVascular tonePotent vasoconstrictorImmunomodulatory propertiesInfectious processAlveolar macrophagesPlatelet aggregationInfectious diseasesMuscle cellsEndothelinAdhesion moleculesPathogenesisChagas disease
2013
Role of Tissue Protection in Lethal Respiratory Viral-Bacterial Coinfection
Jamieson AM, Pasman L, Yu S, Gamradt P, Homer RJ, Decker T, Medzhitov R. Role of Tissue Protection in Lethal Respiratory Viral-Bacterial Coinfection. Science 2013, 340: 1230-1234. PMID: 23618765, PMCID: PMC3933032, DOI: 10.1126/science.1233632.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCaspase 1CoinfectionDisease Models, AnimalHost-Pathogen InteractionsInterleukin-1betaLegionella pneumophilaLegionnaires' DiseaseLungMiceMice, Inbred C57BLOrthomyxoviridaeOrthomyxoviridae InfectionsPneumonia, BacterialToll-Like Receptor 2Toll-Like Receptor 3Toll-Like Receptor 4Tumor Necrosis Factor-alphaConceptsHost defenseInfluenza virusImmune resistance mechanismsSecondary bacterial pneumoniaInfluenza virus infectionViral-bacterial coinfectionsBacterial coinfectionBacterial pneumoniaVirus infectionMouse modelTissue protectionImmune systemTissue damagePathogen burdenDisease severityBacterial infectionsImpaired abilityInfectionCoinfectionResistance mechanismsVirusLegionella pneumophilaMorbidityPneumoniaFailure
2012
HIV as an independent risk factor for incident lung cancer
Sigel K, Wisnivesky J, Gordon K, Dubrow R, Justice A, Brown ST, Goulet J, Butt AA, Crystal S, Rimland D, Rodriguez-Barradas M, Gibert C, Park LS, Crothers K. HIV as an independent risk factor for incident lung cancer. AIDS 2012, 26: 1017-1025. PMID: 22382152, PMCID: PMC3580210, DOI: 10.1097/qad.0b013e328352d1ad.Peer-Reviewed Original ResearchConceptsIncidence rate ratiosIndependent risk factorUninfected patientsLung cancerSimilar HIVHIV infectionSurveillance biasRisk factorsIncidence rateVeterans Aging Cohort Study Virtual CohortVeterans Affairs Central Cancer RegistryChronic obstructive pulmonary diseaseIncident lung cancerObstructive pulmonary diseaseCentral Cancer RegistryLung cancer stageSimilar stage distributionRace/ethnicityExcess smokingMultivariable adjustmentAnalytic cohortPulmonary diseaseBacterial pneumoniaCancer RegistryPotential confounders
2011
Lung Disease in Older Patients with HIV
Akgün K, Crothers K. Lung Disease in Older Patients with HIV. Respiratory Medicine 2011, 227-252. PMCID: PMC7120014, DOI: 10.1007/978-1-60761-727-3_12.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsNoninfectious pulmonary diseasesChronic obstructive pulmonary diseasePneumocystis jirovecii pneumoniaPulmonary arterial hypertensionPulmonary diseaseOpportunistic infectionsAntiretroviral therapyBacterial pneumoniaLung diseasePulmonary opportunistic infectionsCombination antiretroviral therapyObstructive pulmonary diseaseArterial hypertensionJirovecii pneumoniaOlder patientsLung cancerSuccessful treatmentHIVPatientsDisease accountDiseaseLimited dataPneumoniaSignificant proportionTreatmentAre We Ready for Novel Detection Methods to Treat Respiratory Pathogens in Hospital-Acquired Pneumonia?
Endimiani A, Hujer K, Hujer A, Kurz S, Jacobs M, Perlin D, Bonomo R. Are We Ready for Novel Detection Methods to Treat Respiratory Pathogens in Hospital-Acquired Pneumonia? Clinical Infectious Diseases 2011, 52: s373-s383. PMID: 21460299, PMCID: PMC3106236, DOI: 10.1093/cid/cir054.Peer-Reviewed Original ResearchConceptsHospital-acquired pneumoniaGenetic determinants of antimicrobial resistanceDeterminants of antimicrobial resistanceAntimicrobial susceptibility testingAntibiotic-resistant pathogensHospital-acquired bacterial pneumoniaPathogen-directed therapyDifficult treatment challengeCharacterize pathogensResults of cultureSusceptibility testingDiagnosis of pneumoniaEmpirical therapyAntimicrobial resistancePathogensHospital-AcquiredPulmonary microbiomeBacterial pneumoniaMolecular diagnosticsPolymerase chain reactionTreatment challengesMolecular testingRespiratory pathogensPneumoniaChain reaction
2010
HIV Infection and Risk for Incident Pulmonary Diseases in the Combination Antiretroviral Therapy Era
Crothers K, Huang L, Goulet JL, Goetz MB, Brown ST, Rodriguez-Barradas MC, Oursler KK, Rimland D, Gibert CL, Butt AA, Justice AC. HIV Infection and Risk for Incident Pulmonary Diseases in the Combination Antiretroviral Therapy Era. American Journal Of Respiratory And Critical Care Medicine 2010, 183: 388-395. PMID: 20851926, PMCID: PMC3266024, DOI: 10.1164/rccm.201006-0836oc.Peer-Reviewed Original ResearchConceptsChronic obstructive pulmonary diseaseObstructive pulmonary diseaseCombination antiretroviral therapy eraAntiretroviral therapy eraPulmonary diseaseTherapy eraPulmonary infectionHIV infectionVeterans Aging Cohort Study Virtual CohortIncident chronic obstructive pulmonary diseaseLower HIV RNA levelsVirtual cohortVeterans Affairs Healthcare SystemAssociation of HIVMost pulmonary diseasesHIV RNA levelsRates of asthmaIncidence rate ratiosSelf-reported smokingLarge Health SurveyPulmonary hypertensionUninfected patientsComorbid diseasesOpportunistic pneumoniaBacterial pneumoniaPulmonary pathologic findings of fatal 2009 pandemic influenza A/H1N1 viral infections.
Gill JR, Sheng ZM, Ely SF, Guinee DG, Beasley MB, Suh J, Deshpande C, Mollura DJ, Morens DM, Bray M, Travis WD, Taubenberger JK. Pulmonary pathologic findings of fatal 2009 pandemic influenza A/H1N1 viral infections. Archives Of Pathology & Laboratory Medicine 2010, 134: 235-43. PMID: 20121613, PMCID: PMC2819217, DOI: 10.5858/134.2.235.Peer-Reviewed Original ResearchConceptsPulmonary pathologic findingsPathologic findingsCardiorespiratory diseaseInfluenza A/H1N1 virusNovel pandemic influenza virusH1N1 viral infectionInfluenza viral antigensFirst influenza pandemicPandemic influenza virusReverse transcription-polymerase chain reactionTranscription-polymerase chain reactionAlveolar epithelial cellsChief Medical ExaminerWorld Health OrganizationAlveolar damageClinicopathologic characteristicsAutopsy evidenceBacterial pneumoniaPathology findingsH1N1 virusMedical recordsMicrobiologic studiesRespiratory tractViral antigensInfluenza pandemic
2006
Medical Disease and Alcohol Use Among Veterans With Human Immunodeficiency Infection
Justice AC, Lasky E, McGinnis KA, Skanderson M, Conigliaro J, Fultz SL, Crothers K, Rabeneck L, Rodriguez-Barradas M, Weissman SB, Bryant K. Medical Disease and Alcohol Use Among Veterans With Human Immunodeficiency Infection. Medical Care 2006, 44: s52-s60. PMID: 16849969, DOI: 10.1097/01.mlr.0000228003.08925.8c.Peer-Reviewed Original ResearchConceptsICD-9 diagnostic codesICD-9 codesChart reviewMedical diseasesDiagnostic codesAlcohol useHepatitis CLevel of exposureHIV infectionAlcohol exposureMultivariate modelGreater exposure levelsCD4 cell countHIV-positive patientsIntravenous drug useObstructive lung diseaseHuman immunodeficiency infectionCurrent alcohol useNonlinearity of associationsDiagnosis of abuseCohort studyBacterial pneumoniaPast drinkersViral loadLung disease
2005
The impact of cigarette smoking on mortality, quality of life, and comorbid illness among HIV-positive veterans
Crothers K, Griffith TA, McGinnis KA, Rodriguez‐Barradas M, Leaf DA, Weissman S, Gibert CL, Butt AA, Justice AC. The impact of cigarette smoking on mortality, quality of life, and comorbid illness among HIV-positive veterans. Journal Of General Internal Medicine 2005, 20: 1142-1145. PMID: 16423106, PMCID: PMC1490270, DOI: 10.1111/j.1525-1497.2005.0255.x.Peer-Reviewed Original ResearchConceptsChronic obstructive pulmonary diseaseQuality of lifeHIV-positive patientsImpact of smokingPhysical component summaryHIV-positive veteransCurrent smokersRespiratory symptomsBacterial pneumoniaActive antiretroviral therapyCD4 cell countHIV RNA levelsProspective observational studyObstructive pulmonary diseaseShort Form-12National VA databasesRace/ethnicityAntiretroviral therapyComorbid illnessesComponent summaryHIV infectionPatient questionnairePulmonary diseaseChart extractionCigarette smoking
2000
HTLV-II and Bacterial Infections Among Injection Drug Users
Safaeian M, Wilson L, Taylor E, Thomas D, Vlahov D. HTLV-II and Bacterial Infections Among Injection Drug Users. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2000, 24: 483-487. DOI: 10.1097/00126334-200008150-00012.Peer-Reviewed Original ResearchHTLV-II infectionInjection drug usersHTLV-IIBacterial pneumoniaInfective endocarditisOdds ratioBacterial infectionsDrug usersChart reviewConditional logistic regression methodsSelf-reported skinStandardized chart reviewOngoing cohort studyCase-control studyEnzyme-linked immunosorbentCohort studyHIV statusSkin abscessesRisk factorsControl studyEndocarditisInfectionImmunofluorescent assayPneumoniaLogistic regression methodHTLV-II and Bacterial Infections Among Injection Drug Users
Safaeian M, Wilson L, Taylor E, Thomas D, Vlahov D. HTLV-II and Bacterial Infections Among Injection Drug Users. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2000, 24: 483-487. DOI: 10.1097/00042560-200008150-00014.Peer-Reviewed Original ResearchConceptsHTLV-II infectionInjection drug usersHTLV-IIBacterial pneumoniaInfective endocarditisOdds ratioBacterial infectionsDrug usersChart reviewConditional logistic regression methodsSelf-reported skinStandardized chart reviewOngoing cohort studyCase-control studyEnzyme-linked immunosorbentCohort studyHIV statusResults PrevalenceSkin abscessesRisk factorsControl studyEndocarditisInfectionImmunofluorescent assayPneumonia
1998
Approach to the Diagnosis of Pulmonary Disease in Patients Infected With the Human Immunodeficiency Virus
Haramati L, Jenny-Avital E. Approach to the Diagnosis of Pulmonary Disease in Patients Infected With the Human Immunodeficiency Virus. Journal Of Thoracic Imaging 1998, 13: 247-260. PMID: 9799133, DOI: 10.1097/00005382-199810000-00005.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsPneumocystis carinii pneumoniaHuman immunodeficiency virusPulmonary diseaseCarinii pneumoniaImmunodeficiency virusLung cancerKaposi's sarcomaBacterial pneumoniaImmunodeficiency syndromeRadiographic patternsClinical informationFungal infectionsConcurrent antimicrobial therapyNeoplastic pulmonary diseasesCD4 cell countChest radiographic patternsHuman immunodeficiency syndromeSpecific pulmonary diseasesPrior travel historyRisk of occurrenceMultifocal areasPulmonary conditionsAntimicrobial therapyInterstitial opacitiesMycobacterial infection
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply