2025
Use of targeted therapy in patients with advanced non-small cell lung cancer in response to broad genomic profiling.
Wang X, Long J, Rothen J, Huang S, Soulos P, Robinson T, Presley C, Goldberg S, Mamtani R, Ma S, Wang S, Kunst N, Dinan M, Gross C. Use of targeted therapy in patients with advanced non-small cell lung cancer in response to broad genomic profiling. Journal Of Clinical Oncology 2025, 43: 11155-11155. DOI: 10.1200/jco.2025.43.16_suppl.11155.Peer-Reviewed Original ResearchAdvanced non-small cell lung cancerNon-small cell lung cancerCell lung cancerTargeted therapyLung cancerTargetable alterationsGenomic profilingUsefulness of targeted therapyUS cancer clinicsFirst-line treatmentCohort of patientsClinico-genomic databaseNCCN guidelinesIdentified patientsPatient populationFDA approvalTreatment selectionPatientsCancer clinicClinical guidelinesTherapyCancerLimited dataTT useFDA approval statusMorphometric analysis of the inferior petrosal sinus and cerebellopontine angle cistern to assess feasibility of endovascular shunting in pediatric patients
Colasurdo M, Chen K, Chen H, McIntyre M, Matouk C, Selim M, Whitehead W, Heilman C, Malek A, Kan P. Morphometric analysis of the inferior petrosal sinus and cerebellopontine angle cistern to assess feasibility of endovascular shunting in pediatric patients. Journal Of NeuroInterventional Surgery 2025, jnis-2025-023137. PMID: 40169197, DOI: 10.1136/jnis-2025-023137.Peer-Reviewed Original ResearchInferior petrosal sinusCerebellopontine angle cisternShunt placementPetrosal sinusAnatomical criteriaHigh-resolution brain MRISurgical shunt placementYears of ageConsecutive patientsPediatric patientsMultivariable adjustmentBrain MRIAdult criteriaPatientsPediatric hospitalEndovascular shuntYounger ageLeft sidePediatric applicationsLimited dataSinusAssociated with differencesRegression analysisAgeSchool age
2024
Chapter 39 Role in reproductive biology and dysfunction in women
Pal L, Taylor H. Chapter 39 Role in reproductive biology and dysfunction in women. 2024, 873-888. DOI: 10.1016/b978-0-323-91386-7.00036-2.Peer-Reviewed Original ResearchVitamin DMaternal vitamin D statusVitamin D inadequacyVitamin D deficiencyVitamin D statusActive hormonal formReproductive physiologyBeneficial roleVitamin D signalingSpectrum of disordersFemale reproductive functionHuman reproductive physiologyD deficiencyD statusDihydroxyvitamin DFemale reproductive physiologyInsulin resistanceCardiovascular diseaseHormonal formMetabolic milieuD signalingReproductive functionPleotropic effectsPathological processesLimited data
2023
Drug use, drug use disorders, and treatment services in the Eastern Mediterranean region: a systematic review
Rostam-Abadi Y, Gholami J, Jobehdar M, Ardeshir M, Aghaei A, Olamazadeh S, Taj M, Saeed K, Mojtabai R, Rahimi-Movaghar A. Drug use, drug use disorders, and treatment services in the Eastern Mediterranean region: a systematic review. The Lancet Psychiatry 2023, 10: 282-295. PMID: 36848914, DOI: 10.1016/s2215-0366(22)00435-7.Peer-Reviewed Original ResearchConceptsDrug use disordersEastern Mediterranean RegionDrug useTreatment servicesUse disorderIncreasing global public health concernCost-effective carePrevalence of drug use disordersGlobal public health concernPublic health concernPrevalence of drug useGrey literaturePatterns of drug useOpioid agonist treatmentEvidence-basedSystematic reviewTreatment coverageHealth concernAgonist treatmentRegional levelYoung peoplePrevalenceOnline databasesDrugLimited data
2022
Evaluation and management of orthostatic hypotension: Limited data, limitless opportunity
Peixoto AJ. Evaluation and management of orthostatic hypotension: Limited data, limitless opportunity. Cleveland Clinic Journal Of Medicine 2022, 89: 36-45. PMID: 34983800, DOI: 10.3949/ccjm.89gr.22001.Peer-Reviewed Original Research
2021
Emergency department‐initiated buprenorphine protocols: A national evaluation
Guo CZ, D'Onofrio G, Fiellin DA, Edelman EJ, Hawk K, Herring A, McCormack R, Perrone J, Cowan E. Emergency department‐initiated buprenorphine protocols: A national evaluation. Journal Of The American College Of Emergency Physicians Open 2021, 2: e12606. PMID: 34877567, PMCID: PMC8630357, DOI: 10.1002/emp2.12606.Peer-Reviewed Original ResearchClinical Opiate Withdrawal ScaleEmergency departmentBUP initiationBUP doseCOWS scoresEmergency department-initiated buprenorphineTreatment-eligible patientsOpioid use disorderOpiate Withdrawal ScaleBUP administrationDischarge careBUP treatmentEvidence-based practiceWithdrawal symptomsNaloxone prescriptionsPatient outcomesWithdrawal ScaleBuprenorphineUse disordersClinician judgmentReal-world settingClinical diagnosisDiagnosis checklistDoseLimited dataSpatial Characteristics of Colonic Mucosa-Associated Gut Microbiota in Humans
Jiao L, Kourkoumpetis T, Hutchinson D, Ajami N, Hoffman K, White D, Graham D, Hair C, Shah R, Kanwal F, Jarbrink-Sehgal M, Husain N, Hernaez R, Hou J, Cole R, Velez M, Ketwaroo G, Kramer J, El-Serag H, Petrosino J. Spatial Characteristics of Colonic Mucosa-Associated Gut Microbiota in Humans. Microbial Ecology 2021, 83: 811-821. PMID: 34223947, DOI: 10.1007/s00248-021-01789-6.Peer-Reviewed Original ResearchConceptsAmplicon sequence variantsBacterial community compositionCommunity compositionMucosa-associated gut microbiotaTaxonomic structureSignificant differencesRelative abundanceColonic biopsiesEscherichia/ShigellaInter-individual variabilityColonic segmentsColon segmentsFunctional capacityGut microbiotaLarge intestineFree adultsColonic bacteriaRRNA geneCompositional dissimilarityMajor phylaFecal bacteriaSequencing dataLimited dataHyperimmune plasma infusion in an immunocompromised Covid-19 patient previously treated for follicular lymphoma
Levi G, Rocchetti C, Magri R, Uccelli S, Bottone D, Quadri F, Novali M, Santin AD, Bezzi M. Hyperimmune plasma infusion in an immunocompromised Covid-19 patient previously treated for follicular lymphoma. Monaldi Archives For Chest Disease 2021, 91 PMID: 34121379, DOI: 10.4081/monaldi.2021.1867.Peer-Reviewed Original ResearchConceptsPlasma infusionFollicular lymphomaHyperimmune plasmaCOVID-19COVID-19 patientsStandard of careInflammatory indexFirst doseImmunocompetent patientsRadiological findingsSecond doseNasopharyngeal swabsPoor prognosisCaucasian womenImproved outcomesPositive testPatientsSubsequent onsetLimited dataFeverLymphomaInfusionDoseDaysObinutuzumabTrends in 30- and 90-Day Readmission Rates for Heart Failure
Khan MS, Sreenivasan J, Lateef N, Abougergi MS, Greene SJ, Ahmad T, Anker SD, Fonarow GC, Butler J. Trends in 30- and 90-Day Readmission Rates for Heart Failure. Circulation Heart Failure 2021, 14: e008335. PMID: 33866827, DOI: 10.1161/circheartfailure.121.008335.Peer-Reviewed Original ResearchConceptsHospital Readmissions Reduction ProgramHF readmission ratesIndex HF hospitalizationLow-volume hospitalsReadmission ratesHF hospitalizationPayer sourceHeart failure outcomesNational Readmission DatabaseReadmissions Reduction ProgramNon-Medicare insuranceCause 30Cause readmissionEjection fractionHeart failureSubgroup analysisReadmissionLinear regression analysisPrimary analysisSecondary analysisHospitalizationFailure outcomesHF volumeLimited dataRegression analysisMetabolic syndrome and insulin resistance in pre-pubertal children with psoriasis
Caroppo F, Galderisi A, Ventura L, Belloni Fortina A. Metabolic syndrome and insulin resistance in pre-pubertal children with psoriasis. European Journal Of Pediatrics 2021, 180: 1739-1745. PMID: 33483797, PMCID: PMC8105196, DOI: 10.1007/s00431-020-03924-w.Peer-Reviewed Original ResearchConceptsPre-pubertal childrenMetabolic syndromeInsulin resistanceMetabolic diseasesMetabolic syndrome risk factorsSingle-center prospective studyHomeostatic model assessmentAge-specific percentilesCardiometabolic comorbiditiesChildhood psoriasisProspective studyRisk factorsHigh prevalencePsoriasisModel assessmentSyndromePrevalenceLimited dataYoung childrenChildrenAdultsDiseaseComorbiditiesHOMADiagnosis
2020
Outpatient Opioid Use After Cesarean Delivery.
Emerson J, Danilack V, Kulkarni A, Kesselring C, Brousseau E, Matteson K. Outpatient Opioid Use After Cesarean Delivery. Rhode Island Medical Journal 2020, 103: 68-74. PMID: 32752572.Peer-Reviewed Original ResearchConceptsMorphine equivalent dosesCesarean deliveryOpioid needsOpioid useOpioid prescribingOutpatient opioid prescribingOutpatient opioid useAvailability of opioidsPatient-specific factorsOpioid patientsPrescribe opioidsClinical characteristicsPatient characteristicsPsychiatric comorbidityMedical recordsOpioid abuseOpiate useInpatient needsOpioidsEquivalent dosesLimited dataPearson correlation coefficientPrescribingPatientsT-test
2019
Antidepressants for Anxiety Disorders in Late-Life: A Systematic Review
Balasubramaniam M, Joshi P, Alag P, Gupta S, Maher S, Tampi D, Gupta A, Young J, Tampi RR. Antidepressants for Anxiety Disorders in Late-Life: A Systematic Review. Annals Of Clinical Psychiatry 2019, 31: 277-291. PMID: 31369663, DOI: 10.1177/154733251903100413.Peer-Reviewed Educational MaterialsConceptsLate-life anxietyAnxiety disordersRCTs of antidepressantsCochrane Central RegisterTolerability of antidepressantsBibliographic databases PubMedGeneralized anxiety disorderLong-term useCentral RegisterControlled TrialsAntidepressantsElectronic searchDatabases PubMedSystematic reviewOlder adultsStudy periodTrialsDisordersAnxiety symptomsLater lifeLimited dataSignificant reductionAnxietyReviewTolerabilityHow do grandparents influence child health and development? A systematic review
Sadruddin AFA, Ponguta LA, Zonderman AL, Wiley KS, Grimshaw A, Panter-Brick C. How do grandparents influence child health and development? A systematic review. Social Science & Medicine 2019, 239: 112476. PMID: 31539783, DOI: 10.1016/j.socscimed.2019.112476.Peer-Reviewed Original ResearchConceptsChild healthSystematic reviewPhysical healthPathways of careType of careQuality of studiesMore robust dataStudy designBehavioral healthEvidence baseCare provisionGrandparent involvementCustodial careCarePotential mechanismsLimited dataOutcomesSubstantial heterogeneityRobust dataHealthChild outcomesReviewInvolvementSample characteristics
2018
Dolutegravir/rilpivirine for the treatment of HIV-1 infection
Dowers E, Zamora F, Barakat LA, Ogbuagu O. Dolutegravir/rilpivirine for the treatment of HIV-1 infection. HIV/AIDS - Research And Palliative Care 2018, 10: 215-224. PMID: 30464642, PMCID: PMC6220428, DOI: 10.2147/hiv.s157855.Peer-Reviewed Original ResearchHIV-1 infectionDolutegravir/rilpivirineAntiretroviral therapyImportant drug-drug interactionsClinical trial efficacyDrug-drug interactionsImproved safety profileLong-term toxicityDrug package insertsRegimen simplificationMaintenance therapyCombination regimensMedication adherenceSafety profileSafety dataTrial efficacyConference abstractsPackage insertsDrug AdministrationUS FoodPharmacokinetic propertiesGoogle ScholarInfectionLimited dataRilpivirineRelationships of Musculoskeletal Symptoms, Sociodemographics, and Body Mass Index With Leisure-Time Physical Activity Among Nurses
Nam S, Song M, Lee SJ. Relationships of Musculoskeletal Symptoms, Sociodemographics, and Body Mass Index With Leisure-Time Physical Activity Among Nurses. Workplace Health & Safety 2018, 66: 577-587. PMID: 29792132, PMCID: PMC8161463, DOI: 10.1177/2165079918771987.Peer-Reviewed Original ResearchConceptsLeisure-time physical activityRegular aerobic physical activityBody mass indexAerobic physical activityHigher Body Mass IndexMusculoskeletal symptomsMass indexPhysical activityMuscle-strengthening physical activityPhysical activity promotion interventionsPatient handling tasksMultiple logistic regressionEmployment-related barriersCalifornia nursesPromotion interventionsHigh prevalenceSymptomsStatewide random sampleLogistic regressionNursesCross-sectional dataSociodemographicsLimited dataRegular engagementWhite nursesHow to investigate and adjust for selection bias in cohort studies
Nohr EA, Liew Z. How to investigate and adjust for selection bias in cohort studies. Acta Obstetricia Et Gynecologica Scandinavica 2018, 97: 407-416. PMID: 29415329, DOI: 10.1111/aogs.13319.Peer-Reviewed Original ResearchConceptsCohort studyDanish National Birth CohortSelection biasLong-term followNational Birth CohortLongitudinal cohort studyCase-control studySubsequent follow upsExposure-outcome associationsTraditional epidemiological approachesPreventable causeFollow-upInverse probability weightingBirth cohortInitial participation rateStudy designEpidemiological approachLimited dataCohortDiseaseBias analysisProbability weightingParticipation ratesParticipantsLess diseaseTranscatheter Pulmonary Valve Replacement With the Melody Valve in Small Diameter Expandable Right Ventricular Outflow Tract Conduits
Shahanavaz S, Qureshi AM, Levi DS, Boudjemline Y, Peng LF, Martin MH, Bauser-Heaton H, Keeshan B, Asnes JD, Jones TK, Justino H, Aboulhosn JA, Gray RG, Nguyen H, Balzer DT, McElhinney DB. Transcatheter Pulmonary Valve Replacement With the Melody Valve in Small Diameter Expandable Right Ventricular Outflow Tract Conduits. JACC Cardiovascular Interventions 2018, 11: 554-564. PMID: 29566801, DOI: 10.1016/j.jcin.2018.01.239.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAngiographyBlood Vessel ProsthesisBlood Vessel Prosthesis ImplantationCardiac CatheterizationChildChild, PreschoolFeasibility StudiesFemaleGraft Occlusion, VascularHeart Valve ProsthesisHeart Valve Prosthesis ImplantationHemodynamicsHumansMalePreliminary DataProsthesis DesignPulmonary ValveRetrospective StudiesTime FactorsTreatment OutcomeUnited StatesVentricular Outflow ObstructionYoung AdultConceptsTranscatheter pulmonary valve replacementRight ventricular outflow tractPulmonary valve replacementMelody valveValve replacementDysfunctional right ventricular outflow tractsPercutaneous transcatheter pulmonary valve replacementSuccessful transcatheter pulmonary valve replacementSignificant hemodynamic improvementSignificant pulmonary regurgitationVentricular outflow tractCases of endocarditisRVOT reinterventionHemodynamic improvementPulmonary regurgitationHemodynamic outcomesOutflow tractProcedural characteristicsPreliminary experiencePatientsSmall diameter conduitsLimited dataOutcomesSmall conduitsReinterventionThe Psychosocial Impact of Withdrawing from Living Kidney Donation
Thiessen C, Kulkarni S. The Psychosocial Impact of Withdrawing from Living Kidney Donation. Current Transplantation Reports 2018, 5: 64-71. DOI: 10.1007/s40472-018-0185-x.Peer-Reviewed Original ResearchPsychosocial impactSignificant emotional distressEmotional distressLong-term negative impactExperiences of peopleLiving Kidney DonationPurpose of ReviewWeKidney donationFurther researchNegative impactDistressNon-medical reasonsRelationshipDecisionsCenter strategyIndividualsPeopleExperienceLimited dataSupportResearchImpact
2017
Contingency Management Interventions for Tobacco and Other Substance Use Disorders in Pregnancy
Hand DJ, Ellis JD, Carr MM, Abatemarco DJ, Ledgerwood DM. Contingency Management Interventions for Tobacco and Other Substance Use Disorders in Pregnancy. Psychology Of Addictive Behaviors 2017, 31: 907-921. PMID: 28639813, PMCID: PMC5714659, DOI: 10.1037/adb0000291.Peer-Reviewed Original ResearchConceptsSubstance use disordersPregnant womenCM interventionContingency managementInfant outcomesUse disordersEffective interventionsIllicit substancesEffectiveness of CMUse of tobaccoUse of licitNicotine abstinenceEfficacious treatmentPregnancyMajority of studiesSecondary analysisVariety of populationsVulnerable populationsMultiple studiesInterventionLimited dataWomenDisordersUnderlying mechanismPrimary studiesTreatment Outcomes for Metastatic Melanoma of Unknown Primary in the New Era: A Single-Institution Study and Review of the Literature
Utter K, Goldman C, Weiss SA, Shapiro RL, Berman RS, Wilson MA, Pavlick AC, Osman I. Treatment Outcomes for Metastatic Melanoma of Unknown Primary in the New Era: A Single-Institution Study and Review of the Literature. Oncology 2017, 93: 249-258. PMID: 28746931, PMCID: PMC5617794, DOI: 10.1159/000478050.Peer-Reviewed Original ResearchConceptsMUP patientsProspective melanoma databaseSystemic therapyUnknown primaryMetastatic melanomaClinical trialsSingle-institution studyMKP patientsTreatment guidelinesPoor outcomeMelanoma databaseWorse outcomesTreatment outcomesPatientsBetter outcomesTherapyPatient dataMelanomaGoogle ScholarUnique populationSurvival dataOutcomesLimited dataImmunotherapyTrials
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