2023
Metabolic fitness of IgA+ plasma cells in the gut requires DOCK8
Zhang B, Chen S, Yin X, McBride C, Gertie J, Yurieva M, Bielecka A, Hoffmann B, Hinson J, Grassmann J, Xu L, Siniscalco E, Soldatenko A, Hoyt L, Joseph J, Norton E, Uthaman G, Palm N, Liu E, Eisenbarth S, Williams A. Metabolic fitness of IgA+ plasma cells in the gut requires DOCK8. Mucosal Immunology 2023, 17: 431-449. PMID: 38159726, PMCID: PMC11571232, DOI: 10.1016/j.mucimm.2023.12.001.Peer-Reviewed Original ResearchPlasma cellsLamina propriaT cell-dependent antigensCytokinesis 8 (DOCK8) mutationsDOCK8-deficient miceMucosal IgA productionRecurrent gastrointestinal infectionGut lamina propriaPoor antibody responseIgA class switchingAntigen-specific IgAEarly B cell activationLong-term survivalB cell activationGut IgAFood antigensAntibody responseIgA productionImmune homeostasisGastrointestinal infectionsPrimary immunodeficiencyT cellsPC compartmentB cellsCell activationUncommon histopathological features of cytomegalovirus encephalitis and measles inclusion body encephalitis on autopsy in two patients with primary immunodeficiency.
Jindal A, Suri D, Gupta K, Kumar A, Pandiarajan V, Pilania R, Guleria S, Rawat A, Vyas S, Bhatia A, Singh S, Radotra B. Uncommon histopathological features of cytomegalovirus encephalitis and measles inclusion body encephalitis on autopsy in two patients with primary immunodeficiency. Clinical Neuropathology 2023, 42: 15-25. PMID: 36278299, DOI: 10.5414/np301476.Peer-Reviewed Original ResearchConceptsMeasles inclusion body encephalitisSevere combined immunodeficiencyInclusion body encephalitisPrimary immunodeficiencyCombined immunodeficiencyViral encephalitisCase 2Primary immunodeficiency diseasesFeatures of viral encephalitisWhole-exome sequencingRare giant cellsFatal viral encephalitisCytomegalovirus encephalitisImmunodeficiency diseaseMicroglial nodulesCystic encephalomalaciaHistopathological featuresBacterial pneumoniaHistological featuresAlveolar damageExtracranial organsPathogenic variantsImmunodeficiencyGenetic testingExome sequencing
2019
Potential role of regulatory B cells in immunological diseases
Valizadeh A, Sanaei R, Rezaei N, Azizi G, Fekrvand S, Aghamohammadi A, Yazdani R. Potential role of regulatory B cells in immunological diseases. Immunology Letters 2019, 215: 48-59. PMID: 31442542, DOI: 10.1016/j.imlet.2019.08.004.Peer-Reviewed Original ResearchConceptsRegulatory B cellsB cellsImmune systemChronic infectious diseasePotential therapeutic strategyMechanism of actionCytokine productionImmunomodulatory effectsPrimary immunodeficiencyTherapeutic strategiesImmunological diseasesTherapeutic effortsInfectious diseasesExact phenotypeDiseaseFindings of humanPotential roleBregsDiverse diseasesCellsCellular interactionsOngoing investigationAutoimmunityAllergyMalignancy
2016
PI3Kδ and primary immunodeficiencies
Lucas CL, Chandra A, Nejentsev S, Condliffe AM, Okkenhaug K. PI3Kδ and primary immunodeficiencies. Nature Reviews Immunology 2016, 16: 702-714. PMID: 27616589, PMCID: PMC5291318, DOI: 10.1038/nri.2016.93.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell DifferentiationCellular SenescenceEnzyme ActivationGene Expression RegulationHumansImmune SystemImmunityImmunologic Deficiency SyndromesLymphocyte ActivationLymphocytesMolecular Targeted TherapyMutationPhosphatidylinositol 3-KinasesPhosphoinositide-3 Kinase InhibitorsProtein SubunitsSignal TransductionConceptsPrimary immunodeficiencyT cellsHeterozygous mutationsAntibody replacement therapyStructural lung damageRegulatory T cellsT cell senescencePI3Kδ inhibitor idelalisibRecurrent sinopulmonary infectionsB-cell malignanciesHerpes family virusesMTOR inhibitor rapamycinPI3Kδ syndromeMost patientsLung damageLymphoma trialsReplacement therapyLymphoproliferative diseaseSinopulmonary infectionsAntibody responseP110δ catalytic subunitCell malignanciesB cellsImmune systemPatientsFacial manifestations of Epstein–Barr virus‐related lymphoproliferative disease in childhood acute lymphoblastic leukemia in remission: Two atypical presentations
Lu B, Kojima L, Huang M, Friedmann A, Ferry J, Weinstein H. Facial manifestations of Epstein–Barr virus‐related lymphoproliferative disease in childhood acute lymphoblastic leukemia in remission: Two atypical presentations. Pediatric Blood & Cancer 2016, 63: 2042-2045. PMID: 27392033, DOI: 10.1002/pbc.26102.Peer-Reviewed Case Reports and Technical NotesConceptsAcute lymphoblastic leukemiaLymphoblastic leukemiaLymphoproliferative diseaseB-cell acute lymphoblastic leukemiaRight-sided facial swellingT-cell acute lymphoblastic leukemiaChildhood acute lymphoblastic leukemiaHematopoietic transplantationMaintenance chemotherapyPrimary immunodeficiencyBilateral dacryoadenitisAtypical presentationFacial swellingLip lesionsNeither patientLymphoplasmacytic infiltrationT cellsFacial manifestationsFacial lesionsB cellsPatientsDe-EscalationRemissionLeukemiaLesions
2015
Munc18‐2 is required for Syntaxin 11 Localization on the Plasma Membrane in Cytotoxic T‐Lymphocytes
Dieckmann N, Hackmann Y, Aricò M, Griffiths G. Munc18‐2 is required for Syntaxin 11 Localization on the Plasma Membrane in Cytotoxic T‐Lymphocytes. Traffic 2015, 16: 1330-1341. PMID: 26771955, PMCID: PMC4791091, DOI: 10.1111/tra.12337.Peer-Reviewed Original ResearchConceptsCytotoxic T lymphocytesPlasma membraneMunc18-2Granule secretionT lymphocytesMunc18Syntaxin-11Fusion eventsFamilial haemophagocytic lymphohistiocytosisEndogenous localizationSyntaxinImmunological synapseSTX11Cytolytic granulesFHL4Loss of proteinHaemophagocytic lymphohistiocytosisPrimary immunodeficiencyProteinFHL5MembraneSecretionPlasmaLocalizationCytotoxicity
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