2025
ACR Appropriateness Criteria® Acute Respiratory Illness in Immunocompetent Patients: 2024 Update
Imaging P, Batra K, Walker C, Little B, Bang T, Bartel T, Brixey A, Christensen J, Cox C, Hanak M, Khurana S, Madan R, Merchant N, Moore W, Pandya S, Sanchez L, Shroff G, Zagurovskaya M, Chung J. ACR Appropriateness Criteria® Acute Respiratory Illness in Immunocompetent Patients: 2024 Update. Journal Of The American College Of Radiology 2025, 22: s14-s35. PMID: 40409874, DOI: 10.1016/j.jacr.2025.02.014.Peer-Reviewed Original ResearchConceptsAcute respiratory illnessRespiratory illnessManagement of acute respiratory illnessesAmerican College of Radiology Appropriateness CriteriaRAND/UCLA Appropriateness Method User ManualSelf-limiting viral infectionEvidence-based guidelinesEstablished methodology principlesImmunocompetent adult patientsChronic obstructive pulmonary disease exacerbationsAppropriateness of imagingPublic health issuePeer-reviewed journalsFollow-up imagingMultidisciplinary expert panelSuspected pneumonia casesPeer-reviewed literatureGuideline developmentRecommendations AssessmentImmunocompetent patientsOccult malignancyHealth issuesExpert panelAdult patientsAppropriateness CriteriaVaccine Effectiveness Against Influenza A(H1N1), A(H3N2), and B-Associated Hospitalizations, United States, 1 September 2023 to 31 May 2024
Lewis N, Harker E, Cleary S, Zhu Y, Grijalva C, Chappell J, Rhoads J, Baughman A, Casey J, Blair P, Jones I, Johnson C, Halasa N, Lauring A, Martin E, Gaglani M, Ghamande S, Columbus C, Steingrub J, Duggal A, Felzer J, Prekker M, Peltan I, Brown S, Hager D, Gong M, Mohamed A, Exline M, Khan A, Ferguson S, Mosier J, Qadir N, Chang S, Ginde A, Zepeski A, Mallow C, Harris E, Johnson N, Gibbs K, Kwon J, Vaughn I, Ramesh M, Safdar B, Surie D, Dawood F, Ellington S, Self W. Vaccine Effectiveness Against Influenza A(H1N1), A(H3N2), and B-Associated Hospitalizations, United States, 1 September 2023 to 31 May 2024. The Journal Of Infectious Diseases 2025, jiaf185. PMID: 40198276, DOI: 10.1093/infdis/jiaf185.Peer-Reviewed Original ResearchAcute respiratory illnessVaccine effectivenessInfluenza virusDays prior to illness onsetInfluenza-associated hospitalizationsTest-negative designSentinel Surveillance NetworkImmunocompetent patientsInfluenza BInfluenza seasonImmunocompromised patientsInfluenza casesB virusInfluenzaIllness onsetPatientsRespiratory illnessMedical CenterSARS-CoV-2VaccineSurveillance networkElevated activityHospitalDaysVirus
2024
Severe Clinical Outcomes Due to Human Adenoviral Respiratory Infections in Hospitalized Immunocompetent Adults
Legakis L, Nguyen D, Bandaranayake T. Severe Clinical Outcomes Due to Human Adenoviral Respiratory Infections in Hospitalized Immunocompetent Adults. Infectious Diseases In Clinical Practice 2024, 32: e1412. DOI: 10.1097/ipc.0000000000001412.Peer-Reviewed Original ResearchSevere adenoviral infectionAdenoviral infectionImmunocompetent patientsClinical outcomesSmoking historyPulmonary diseaseRisk factorsSevere diseaseAdenoviral respiratory infectionUpper respiratory tract infectionRespiratory viral panelAbsence of feverAdult immunocompetent patientsExtracorporeal membrane oxygenationRespiratory tract infectionsSevere clinical outcomesChronic obstructive pulmonary diseasePresence of coinfectionObstructive pulmonary diseasePotential risk factorsCritical careImmunocompetent adultsImmunocompromised patientsImmunocompetent hostsTract infections
2023
Acute cytomegalovirus proctitis and epididymitis acquired via sexual transmission in an immunocompetent patient: a case report
Oyeyemi D, Chan E, Montano M, Belzer A, Ogbuagu O, Zapata H, Tuan J. Acute cytomegalovirus proctitis and epididymitis acquired via sexual transmission in an immunocompetent patient: a case report. Journal Of Medical Case Reports 2023, 17: 489. PMID: 37946248, PMCID: PMC10636986, DOI: 10.1186/s13256-023-04216-1.Peer-Reviewed Original ResearchConceptsCytomegalovirus proctitisCase reportAcute primary cytomegalovirus infectionPrimary cytomegalovirus infectionHealthy Caucasian individualsImmunocompetent personsTesticular painCytomegalovirus infectionImmunocompetent patientsRare causeImmunocompetent hostsSexual transmissionDiagnostic workupRectal pathologyConclusionsThis reportProctitisEpididymitisCaucasian individualsReportPainPatientsBackgroundWeSerologyWorkupInfectionSubdural empyema secondary to pansinusitis after coronavirus disease 2019 infection in an immunocompetent patient: illustrative case
Hong C, Prust M, Manes R, Rimmer R, Omay S. Subdural empyema secondary to pansinusitis after coronavirus disease 2019 infection in an immunocompetent patient: illustrative case. Journal Of Neurosurgery Case Lessons 2023, 5: case22525. PMID: 36806010, PMCID: PMC10550626, DOI: 10.3171/case22525.Peer-Reviewed Original ResearchIntracranial infectionSubdural empyemaAntimicrobial therapyCoronavirus disease 2019 (COVID-19) infectionPolymerase chain reaction testingMultidisciplinary surgical managementRapid clinical improvementAggressive surgical approachDisease 2019 infectionFull clinical recoveryTime of presentationCoronavirus disease 2019COVID-19Clinical improvementClinical recoveryImmunocompetent patientsImmunocompetent maleSurgical managementSignificant complicationsSurgical approachDisease 2019Negative culturesPositive culturesHealthy individualsReaction testingEpstein-Barr virus–associated primary intracranial leiomyosarcoma in an immunocompetent patient: illustrative case
Tabor J, Lei H, Morales-Valero S, O’Brien J, Gopal P, Erson-Omay E, Fulbright R, Moliterno J. Epstein-Barr virus–associated primary intracranial leiomyosarcoma in an immunocompetent patient: illustrative case. Journal Of Neurosurgery Case Lessons 2023, 5: case22532. PMID: 36692065, PMCID: PMC10550697, DOI: 10.3171/case22532.Peer-Reviewed Original ResearchEpstein-Barr virusPrimary intracranial leiomyosarcomaHuman immunodeficiency virusImmunocompetent statusImmunocompetent patientsIntracranial leiomyosarcomaMainstay of treatmentGross total resectionLeft-sided headacheSmooth muscle tumorsLeft middle cranial fossaMagnetic resonance imagingMiddle cranial fossaDura-based massUncomplicated resectionPrompt diagnosisTotal resectionAssociated edemaImmunodeficiency virusPoor prognosisMuscle tumorsRare diagnosisRare tumorImmunocompromised individualsPatients
2022
Borrelia miyamotoi Meningoencephalitis in an Immunocompetent Patient
Gandhi S, Narasimhan S, Workineh A, Mamula M, Yoon J, Krause PJ, Farhadian SF. Borrelia miyamotoi Meningoencephalitis in an Immunocompetent Patient. Open Forum Infectious Diseases 2022, 9: ofac295. PMID: 35873293, PMCID: PMC9301576, DOI: 10.1093/ofid/ofac295.Peer-Reviewed Original ResearchHuman herpesvirus 8-negative effusion-based large B-cell lymphoma: a distinct entity with unique clinicopathologic characteristics
Gisriel SD, Yuan J, Braunberger RC, Maracaja DLV, Chen X, Wu X, McCracken J, Chen M, Xie Y, Brown LE, Li P, Zhou Y, Sethi T, McHenry A, Hauser RG, Paulson N, Tang H, Hsi ED, Wang E, Zhang QY, Young KH, Xu ML, Pan Z. Human herpesvirus 8-negative effusion-based large B-cell lymphoma: a distinct entity with unique clinicopathologic characteristics. Modern Pathology 2022, 35: 1411-1422. PMID: 35562413, PMCID: PMC9926946, DOI: 10.1038/s41379-022-01091-x.Peer-Reviewed Original ResearchConceptsLarge B-cell lymphomaDistinct clinicopathologic characteristicsMedian overall survivalB-cell lymphomaOverall survivalClinicopathologic characteristicsPrimary effusion lymphomaHHV8 infectionLymphomatous effusionsNon-germinal center B-cell subtypeLonger median overall survivalUnique clinicopathologic characteristicsFavorable prognostic factorEpstein-Barr virusSeparate diagnostic criteriaHuman herpesvirus 8B-cell subtypeMulti-institutional studyNon-Japanese casesDiagnostic uniformityImmunocompetent patientsPericardial effusionPericardial involvementSelect patientsChemotherapy administration
2021
Magic Dr.T? Tuberculous brain lesions in an immunocompetent patient-A case report
Saleh MA, Tu L, Mango M, Jacob M, Minja F. Magic Dr.T? Tuberculous brain lesions in an immunocompetent patient-A case report. Radiology Case Reports 2021, 17: 581-586. PMID: 34976263, PMCID: PMC8688167, DOI: 10.1016/j.radcr.2021.11.074.Peer-Reviewed Original ResearchCentral nervous system tuberculosisNervous system tuberculosisImmunocompetent patientsBrain lesionsPatient - A Case ReportSpecific antibiotic combinationsRespiratory tract infectionsRing-enhancing brain lesionsSerious neurological sequelaeSolid organ transplantationHealth care workersCNS tuberculomasNeurological sequelaeClinical suspicionTract infectionsHIV infectionActive infectionCase reportAntibiotic combinationsDifferential considerationsOrgan transplantationEarly diagnosisEndemic areasCare workersPatientsHyperimmune plasma infusion in an immunocompromised Covid-19 patient previously treated for follicular lymphoma
Levi G, Rocchetti C, Magri R, Uccelli S, Bottone D, Quadri F, Novali M, Santin AD, Bezzi M. Hyperimmune plasma infusion in an immunocompromised Covid-19 patient previously treated for follicular lymphoma. Monaldi Archives For Chest Disease 2021, 91 PMID: 34121379, DOI: 10.4081/monaldi.2021.1867.Peer-Reviewed Original ResearchConceptsPlasma infusionFollicular lymphomaHyperimmune plasmaCOVID-19COVID-19 patientsStandard of careInflammatory indexFirst doseImmunocompetent patientsRadiological findingsSecond doseNasopharyngeal swabsPoor prognosisCaucasian womenImproved outcomesPositive testPatientsSubsequent onsetLimited dataFeverLymphomaInfusionDoseDaysObinutuzumab
2020
Identifying a Kidney Transplant Recipient COVID Phenotype to Aid Test Utilization in the Setting of Limited Testing Availability—Does One Exist?
Virmani S, Gleeson SE, Girone GF, Malhotra D, Cohen EA, Klarman SE, Asch WS. Identifying a Kidney Transplant Recipient COVID Phenotype to Aid Test Utilization in the Setting of Limited Testing Availability—Does One Exist? Transplantation Proceedings 2020, 52: 2584-2591. PMID: 32711848, PMCID: PMC7305913, DOI: 10.1016/j.transproceed.2020.05.033.Peer-Reviewed Original ResearchConceptsKidney transplant recipientsSARS-CoV-2BK viremiaLimited testing availabilityTesting availabilitySevere acute respiratory syndrome 2 virusImmunosuppressed kidney transplant recipientsOutpatient testing centerPolyoma BK viremiaCOVID-19 infectionPositive predictive valueTransplant recipientsImmunocompetent patientsSymptomatic patientsImmunosuppressed patientsTransplant centersHigh morbidityEmergency departmentInpatient treatmentGeneral populationHigh incidencePatientsCenter deliveriesPredictive valueTest utilizationCurrent Concepts in the Epidemiology, Diagnosis, and Management of Histoplasmosis Syndromes
Azar MM, Loyd JL, Relich RF, Wheat LJ, Hage CA. Current Concepts in the Epidemiology, Diagnosis, and Management of Histoplasmosis Syndromes. Seminars In Respiratory And Critical Care Medicine 2020, 41: 013-030. PMID: 32000281, DOI: 10.1055/s-0039-1698429.Peer-Reviewed Original ResearchConceptsDisseminated diseaseCurrent evidence-based approachesProgressive disseminated diseaseCommon clinical presentationCommunity-acquired pneumoniaChronic pulmonary diseaseSelf-limiting diseaseLiposomal amphotericin BManagement of histoplasmosisEvidence-based approachHistoplasmosis syndromeImmunocompetent patientsPulmonary diseaseClinical presentationCrohn's diseasePreferred agentClinical manifestationsCommon conditionMilder casesAmphotericin BHistoplasmosisAmphotericin B.DiseaseEpidemiologyGlobal diseaseInvasive pseudomembranous upper airway and tracheal Aspergillosis refractory to systemic antifungal therapy and serial surgical debridement in an Immunocompetent patient
Khan SN, Manur R, Brooks JS, Husson MA, Leahy K, Grant M. Invasive pseudomembranous upper airway and tracheal Aspergillosis refractory to systemic antifungal therapy and serial surgical debridement in an Immunocompetent patient. BMC Infectious Diseases 2020, 20: 13. PMID: 31906888, PMCID: PMC6945574, DOI: 10.1186/s12879-019-4744-2.Peer-Reviewed Case Reports and Technical NotesConceptsImmunocompetent patientsEndoscopic debridementLong-term antibiotic treatmentComplete disease resolutionSystemic antifungal therapySerial surgical debridementEfficacious treatment approachVoriconazole dosingRefractory symptomsSymptom controlAggressive treatmentBacterial sinusitisDisease resolutionRespiratory symptomsSurgical debridementRespiratory infectionsVoriconazole monotherapyTreatment regimensFungal infiltrationMechanical debridementUpper airwayAntibiotic treatmentAntifungal therapyDisease progressionSuch infections
2019
A rare presentation of Austrian syndrome with septic arthritis in an immunocompetent female
Battisha A, Madoukh B, Altibi A, Sheikh O. A rare presentation of Austrian syndrome with septic arthritis in an immunocompetent female. The Egyptian Heart Journal 2019, 71: 9. PMID: 31659532, PMCID: PMC6821411, DOI: 10.1186/s43044-019-0010-6.Peer-Reviewed Original ResearchSternoclavicular septic arthritisAustrian syndromeSeptic arthritisImmunocompetent patientsMedical history of hypertensionSternoclavicular joint septic arthritisCase presentationA caseHistory of hypertensionOsler's triadAortic vegetationsRare presentationAggressive pathologyCase reportBacterial pneumoniaStreptococcus pneumoniaeDrastic complicationsMedical historyRisk factorsViral influenzaSyndromeArthritisEndocarditisComplicationsMeningitisPatientsRetrospective cohort study of anatomic localization of cutaneous squamous cell carcinomas in solid organ transplant recipients compared with immunocompetent patients
Cheng JY, Li FY, Wang M, Colegio OR. Retrospective cohort study of anatomic localization of cutaneous squamous cell carcinomas in solid organ transplant recipients compared with immunocompetent patients. Journal Of The American Academy Of Dermatology 2019, 81: 1417-1419. PMID: 31150701, DOI: 10.1016/j.jaad.2019.05.054.Peer-Reviewed Original Research
2018
Very low rate of anti‐D development in male, primarily immunocompetent patients transfused with D‐mismatched platelets
Curtis G, Scott M, Orengo L, Hendrickson JE, Tormey CA. Very low rate of anti‐D development in male, primarily immunocompetent patients transfused with D‐mismatched platelets. Transfusion 2018, 58: 1568-1569. PMID: 29949189, DOI: 10.1111/trf.14614.Peer-Reviewed Original ResearchCutaneous Squamous Cell Carcinomas in Solid Organ Transplant Recipients Compared With Immunocompetent Patients
Cheng JY, Li FY, Ko CJ, Colegio OR. Cutaneous Squamous Cell Carcinomas in Solid Organ Transplant Recipients Compared With Immunocompetent Patients. JAMA Dermatology 2018, 154: 60-66. PMID: 29167858, PMCID: PMC5833573, DOI: 10.1001/jamadermatol.2017.4506.Peer-Reviewed Original ResearchMeSH KeywordsAcademic Medical CentersAge DistributionAgedCarcinoma, Squamous CellCohort StudiesFemaleHumansImmunocompetenceIncidenceMaleMiddle AgedNeoplasm InvasivenessNeoplasm StagingOrgan TransplantationPrognosisRetrospective StudiesRisk AssessmentSex DistributionSkin NeoplasmsTransplant RecipientsUnited StatesConceptsSolid organ transplant recipientsSquamous cell carcinomaImmunocompetent control groupOrgan transplant recipientsImmunocompetent patientsTransplant recipientsImmunocompetent individualsMean ageCell carcinomaOutcome measuresControl groupStudy participantsCutaneous squamous cell carcinomaAggressive squamous cell carcinomaAnnual biopsy rateImmunosuppressive medication regimenRetrospective cohort studyDisease-specific deathSecondary outcome measuresPrimary outcome measureAggressive behaviorCumulative followOverall deathCohort studyImmunocompetent group
2017
Case report of the patient source of the Babesia microti R1 reference strain and implications for travelers
Stahl P, Poinsignon Y, Pouedras P, Ciubotaru V, Berry L, Emu B, Krause PJ, Mamoun C, Cornillot E. Case report of the patient source of the Babesia microti R1 reference strain and implications for travelers. Journal Of Travel Medicine 2017, 25: tax073. PMID: 29394381, PMCID: PMC6927858, DOI: 10.1093/jtm/tax073.Peer-Reviewed Original ResearchConceptsIndirect immunofluorescence antibody testingBabesiosis casesB. microti antibodiesB. microtiTreatment of babesiosisImmunofluorescence antibody testingB. microti infectionNon-endemic areasDiagnosis of babesiosisMicroti antibodiesFebrile illnessImmunocompetent patientsRed blood cellsAntibody testingB. microti DNAPhysical examinationCase reportMedical historyMicroti infectionTick biteClinical informationEndemic areasPatient sourcePatientsBlood smears
2015
Methotrexate and temozolomide versus methotrexate, procarbazine, vincristine, and cytarabine for primary CNS lymphoma in an elderly population: an intergroup ANOCEF-GOELAMS randomised phase 2 trial
Omuro A, Chinot O, Taillandier L, Ghesquieres H, Soussain C, Delwail V, Lamy T, Gressin R, Choquet S, Soubeyran P, Huchet A, Benouaich-Amiel A, Lebouvier-Sadot S, Gyan E, Touitou V, Barrié M, del Rio M, Gonzalez-Aguilar A, Houillier C, Delgadillo D, Lacomblez L, Tanguy M, Hoang-Xuan K. Methotrexate and temozolomide versus methotrexate, procarbazine, vincristine, and cytarabine for primary CNS lymphoma in an elderly population: an intergroup ANOCEF-GOELAMS randomised phase 2 trial. The Lancet Haematology 2015, 2: e251-e259. PMID: 26688235, DOI: 10.1016/s2352-3026(15)00074-5.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overAntimetabolites, AntineoplasticAntineoplastic AgentsAntineoplastic Combined Chemotherapy ProtocolsCentral Nervous System NeoplasmsCytarabineDacarbazineDisease-Free SurvivalFemaleHumansLymphomaMaleMethotrexateMiddle AgedProcarbazineProspective StudiesQuality of LifeTemozolomideTreatment OutcomeVincristineConceptsPrimary CNS lymphomaProgression-free survivalKarnofsky Performance Scale scoreCytarabine groupPhase 2 trialCNS lymphomaPerformance Scale scoreTemozolomide groupElderly populationScale scoreMedian progression-free survivalPhase 2 trial designCommon grade 3Methotrexate-based regimensProphylactic G-CSFMedian overall survivalStandard chemotherapy regimenPoor prognosis patientsQuality of lifeChemotherapy regimenEfficacy endpointPrimary endpointPrognosis patientsElderly patientsImmunocompetent patientsFirst-line treatment and outcome of elderly patients with primary central nervous system lymphoma (PCNSL)—a systematic review and individual patient data meta-analysis
Kasenda B, Ferreri A, Marturano E, Forst D, Bromberg J, Ghesquieres H, Ferlay C, Blay J, Hoang-Xuan K, Pulczynski E, Fosså A, Okoshi Y, Chiba S, Fritsch K, Omuro A, O'Neill B, Bairey O, Schandelmaier S, Gloy V, Bhatnagar N, Haug S, Rahner S, Batchelor T, Illerhaus G, Briel M. First-line treatment and outcome of elderly patients with primary central nervous system lymphoma (PCNSL)—a systematic review and individual patient data meta-analysis. Annals Of Oncology 2015, 26: 1305-1313. PMID: 25701456, PMCID: PMC4735103, DOI: 10.1093/annonc/mdv076.Peer-Reviewed Original ResearchConceptsKarnofsky performance scoreElderly PCNSL patientsFirst-line therapyHD-MTXIndividual patient dataPCNSL patientsImproved survivalEligible studiesElderly primary central nervous system lymphoma (PCNSL) patientsPrimary central nervous system lymphoma (PCNSL) patientsPrimary central nervous system lymphomaSystematic reviewCentral nervous system lymphomaHigh-dose methotrexatePatient dataWhole brain radiotherapyFirst-line treatmentNervous system lymphomaStrong prognostic factorElderly patientsImmunocompetent patientsProspective trialMedian ageOral chemotherapyPrognostic factors
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