2025
A minimum data standard for wildlife disease research and surveillance
Schwantes C, Sánchez C, Stevens T, Zimmerman R, Albery G, Becker D, Brookson C, Kading R, Keiser C, Khandelwal S, Kramer-Schadt S, Krut-Landau R, McKee C, Montecino-Latorre D, O’Donoghue Z, Olson S, O’Shea M, Poisot T, Robertson H, Ryan S, Seifert S, Simons D, Vicente-Santos A, Wood C, Graeden E, Carlson C. A minimum data standard for wildlife disease research and surveillance. Scientific Data 2025, 12: 1054. PMID: 40544158, PMCID: PMC12182584, DOI: 10.1038/s41597-025-05332-x.Peer-Reviewed Original ResearchEarly Release - Ehrlichia chaffeensis DNA in Haemaphysalis longicornis Ticks, Connecticut, USA - Volume 31, Number 6—June 2025 - Emerging Infectious Diseases journal - CDC
Molaei G, Mohapatra A, Khalil N, Cozens D, Bonilla D. Early Release - Ehrlichia chaffeensis DNA in Haemaphysalis longicornis Ticks, Connecticut, USA - Volume 31, Number 6—June 2025 - Emerging Infectious Diseases journal - CDC. Emerging Infectious Diseases 2025, 31: 1260-1262. PMID: 40439594, PMCID: PMC12123906, DOI: 10.3201/eid3106.250034.Peer-Reviewed Original ResearchThe five senses of immunity
Nixon D, Bachtel N, Hupert N, Eleftherianos I. The five senses of immunity. Trends In Immunology 2025, 46: 361-363. PMID: 40251093, PMCID: PMC12172028, DOI: 10.1016/j.it.2025.03.005.Peer-Reviewed Original ResearchIntegrating genomic and spatial analyses to describe tuberculosis transmission: a scoping review
Lan Y, Rancu I, Chitwood M, Sobkowiak B, Nyhan K, Lin H, Wu C, Mathema B, Brown T, Colijn C, Warren J, Cohen T. Integrating genomic and spatial analyses to describe tuberculosis transmission: a scoping review. The Lancet Microbe 2025, 101094. PMID: 40228509, DOI: 10.1016/j.lanmic.2025.101094.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsGenome sequencing approachGenetic similarityGenomic dataSequencing approachGenotyping methodsPathogen geneticsGenetic methodsPathogen sequencesSampling completenessTuberculosis isolatesTransmission patternsTuberculosis casesPathogensTuberculosis transmissionM tuberculosis isolatesInfection-related mortalityEnvironmental factorsTuberculosis transmission dynamicsSpatial proximityTransmission clustersGenomeSpatial patternsTuberculosisTransmission dynamicsGeneticsWild Florida mottled ducks demonstrate strong heterogeneity in their humoral innate immune response.
Ayala A, Cheng M, Hellinger T, McBride K, Webb J, Fanning A, Snyder P, Ferragamo M, Garcia S, Sterner N, Bischoff K, Almagro-Moreno S, Ogbunugafor C. Wild Florida mottled ducks demonstrate strong heterogeneity in their humoral innate immune response. PLOS ONE 2025, 20: e0312653. PMID: 40096078, PMCID: PMC11913296, DOI: 10.1371/journal.pone.0312653.Peer-Reviewed Original ResearchConceptsFlorida mottled ducksAmerican Type Culture CollectionMottled ducksHumoral innate immune responseType Culture CollectionInnate immune responseVibrio sppEndemic subspeciesHabitat conversionInnate immune systemEco-immunologyCulture CollectionE. coliAnas platyrhynchosSubspeciesPeninsular FloridaConservation needsEffects of climate changeEcological covariatesHumoral innate immune systemBactericidal assayDucksResponse to agingWaterborne pathogensPathogensRNA cytidine acetyltransferase NAT10 maintains T cell pathogenicity in inflammatory bowel disease
Li H, Cai X, Xu C, Yang X, Song X, Kong Y, Yang M, Wu Q, Zheng S, Shao Y, Wang P, Zhou J, Li H. RNA cytidine acetyltransferase NAT10 maintains T cell pathogenicity in inflammatory bowel disease. Cell Discovery 2025, 11: 19. PMID: 40038243, PMCID: PMC11880361, DOI: 10.1038/s41421-025-00781-5.Peer-Reviewed Original ResearchAccelerated rate of apoptosisPost-transcriptional gene regulationBcl2-associated athanogene 3N-acetyltransferase 10Apoptosis-related genesUpregulation of apoptosis-related genesAcetyltransferase NAT10T cell developmentRate of apoptosisGene regulationApoptotic pathwayAc4C modificationN4-acetylcytidineCD4+ T cellsAcetylation modificationNAT10Inflammatory bowel diseaseMRNA stabilityNAT10 expressionDiminished stabilityT cellsN-acetyltransferaseRNAPathogensNaive CD4+ T cellsModeling thoracic aortic genetic variants in the zebrafish: useful for predicting clinical pathogenicity?
Prendergast A, Sheppard M, Famulski J, Nicoli S, Mukherjee S, Sips P, Elefteriades J. Modeling thoracic aortic genetic variants in the zebrafish: useful for predicting clinical pathogenicity? Frontiers In Cardiovascular Medicine 2025, 12: 1480407. PMID: 40066353, PMCID: PMC11892108, DOI: 10.3389/fcvm.2025.1480407.Peer-Reviewed Original ResearchPathogenicity of VUSProportion of variantsMedical genetic testingCausal genesPathogenicity assessmentClinical pathogensTested pathogensGenetic variantsCausative genesTAAD casesGenesGenetic defectsGenetic testingThoracic aortic aneurysmHeritable genetic defectsImpact cardiovascular morbidityPathogensVUSAortic aneurysmCardiovascular morbidityVariantsZebrafishTAADClinical applicationEnhance patient carePublic health significance of the white-tailed deer (Odocoileus virginianus) and its role in the eco-epidemiology of tick- and mosquito-borne diseases in North America
Rochlin I, Kenney J, Little E, Molaei G. Public health significance of the white-tailed deer (Odocoileus virginianus) and its role in the eco-epidemiology of tick- and mosquito-borne diseases in North America. Parasites & Vectors 2025, 18: 43. PMID: 39915849, PMCID: PMC11803971, DOI: 10.1186/s13071-025-06674-6.Peer-Reviewed Original ResearchConceptsWhite-tailed deerOdocoileus virginianusMosquito-borne diseasesEco-epidemiologyNorth AmericaMosquito-borne pathogensPopulation dynamicsPathogensEffective disease managementDeerPathogen transmissionEastern United StatesReproductive potentialPublic health significanceTick-borneVector-borne diseasesOdocoileusBiological adaptationTicksMosquito vectorsBiological characteristicsSoutheastern CanadaTransmission cycleHealth significanceMosquitoesA new method for detecting mixed Mycobacterium tuberculosis infection and reconstructing constituent strains provides insights into transmission
Sobkowiak B, Cudahy P, Chitwood M, Clark T, Colijn C, Grandjean L, Walter K, Crudu V, Cohen T. A new method for detecting mixed Mycobacterium tuberculosis infection and reconstructing constituent strains provides insights into transmission. Genome Medicine 2025, 17: 8. PMID: 39871355, PMCID: PMC11771024, DOI: 10.1186/s13073-025-01430-y.Peer-Reviewed Original ResearchConceptsShort-read WGS dataWhole-genome sequencingStrain sequencesWGS dataMultiple strainsStrain proportionsMycobacterium tuberculosis populationMixed infectionGenome sequenceBioinformatics pipelineClustering allele frequenciesDownstream analysisAllele frequenciesEvidence of mixed infectionSequenceTuberculosis populationStrainIsolatesIn vitroTransmission clustersMixed samplesAllelesInfectionMycobacterium tuberculosis infectionPathogensRNA sensing at the crossroads of autoimmunity and autoinflammation
Williams S, Sim S, Wolin S. RNA sensing at the crossroads of autoimmunity and autoinflammation. RNA 2025, 31: rna.080304.124. PMID: 39779213, PMCID: PMC11874990, DOI: 10.1261/rna.080304.124.Peer-Reviewed Original ResearchConceptsRNA sensorsInnate immune system's abilityImmune systemAutoinflammatory diseasesHost defense systemRNA homeostasisForeign RNAHost RNAType I interferon-stimulated genesPathogen recognitionInnate immune systemI interferon-stimulated genesRNA sensingImmune-mediated diseasesImmune system's abilityRNAAdaptive immune systemHuman immune systemTumor surveillanceViral counterpartsSenescent cellsGenesHomeostatic processesViral infectionPathogensAn Extraordinary Case of Prosthetic Joint Infection by Listeria monocytogenes and Histoplasma capsulatum
Luu T, Daddi L, Azar M, Trubin P, Molloy I, Spichler-Moffarah A. An Extraordinary Case of Prosthetic Joint Infection by Listeria monocytogenes and Histoplasma capsulatum. Cureus 2025, 17: e76901. PMID: 39906453, PMCID: PMC11791120, DOI: 10.7759/cureus.76901.Peer-Reviewed Original ResearchListeria monocytogenes</i>Gram-positive organismsProsthetic joint infectionListeria monocytogenesHistoplasma capsulatumHost conditionsImmunocompromised hostsTwo-stage exchange surgeryCases of prosthetic joint infectionJoint infectionCo-InfectionHostAntimicrobial treatmentSynovial fluid cultureEpidemiological risk factorsMonocytogenesComplication of hipFungiPathogensExchange surgeryBacteriaFluid cultureOrganizationBiofilmRemote historyPathogens and planetary change
Carlson C, Brookson C, Becker D, Cummings C, Gibb R, Halliday F, Heckley A, Huang Z, Lavelle T, Robertson H, Vicente-Santos A, Weets C, Poisot T. Pathogens and planetary change. Nature Reviews Biodiversity 2025, 1: 32-49. DOI: 10.1038/s44358-024-00005-w.Peer-Reviewed Original ResearchBiodiversity lossAnthropogenic environmental changesLand-use changeBiodiversity conservationWildlife healthLand-useEcological costsDie-offGlobal changeBiodiversityEnvironmental changesEcological interventionsLive animal marketsInfectious disease riskPathogen surveillanceHuman-animal contactPathogensVector-borne diseasesSpeciesEvolutionary principlesWildlifeHigh-risk virusesEcosystemGlobal gapConservation
2024
Microscopic phage adsorption assay: High-throughput quantification of virus particle attachment to host bacterial cells
Antani J, Ward T, Emonet T, Turner P. Microscopic phage adsorption assay: High-throughput quantification of virus particle attachment to host bacterial cells. Proceedings Of The National Academy Of Sciences Of The United States Of America 2024, 121: e2410905121. PMID: 39700139, PMCID: PMC11670125, DOI: 10.1073/pnas.2410905121.Peer-Reviewed Original ResearchConceptsBacterial cellsViruses of bacteriaHost bacterial cellsTarget bacterial strainsEnumeration of bacteriaPhage biologyPhage attachmentHigh-throughput quantificationPhage libraryBacterial pathogensHigh-throughput screeningPhageBacterial strainsSingle-virusVirus particlesIndividual virus particlesFluorescence microscopyBacteriaEarth's biosphereParticle trackingCellsLow throughputBacteriumRate constantsPathogensmRNA Vaccines Against Tick‐borne Diseases
Arora G, Fikrig E. mRNA Vaccines Against Tick‐borne Diseases. 2024, 285-301. DOI: 10.1002/9783527838394.ch10.Peer-Reviewed Original ResearchTick-borne diseasesMRNA vaccinesIxodes scapularis ticksCrimean-Congo hemorrhagic feverEffective memory responsesVector-borne diseasesIncreasing cost of developmentPowassan virusModified mRNA vaccineMRNA-based vaccinesTicksVaccine platformTurnover timeLipid nanoparticlesMemory responsesClinical trialsImmune systemEffective vaccineMultiple antigensPathogensSpreading virusArthropodsVaccineDiseaseHemorrhagic feverTapir Health
Ordonneau D, Fernandes-Santos R, Zimmerman D, Pukazhenthi B, Rojas-Jimenez J, Pérez Flores J, Navas Suarez P. Tapir Health. Fascinating Life Sciences 2024, 167-205. DOI: 10.1007/978-3-031-65311-7_11.Peer-Reviewed Original ResearchPhenotypic Heterogeneity in Pathogens
Sherry J, Rego E. Phenotypic Heterogeneity in Pathogens. Annual Review Of Genetics 2024, 58: 183-209. PMID: 39083846, DOI: 10.1146/annurev-genet-111523-102459.Peer-Reviewed Original ResearchPhenotypic heterogeneityGenetically identical populationSalmonella typhimurium</i>Genetic diversityPathogen diversityPathogen populationsBacterial pathogensPathogen subpopulationsGenetic heterogeneityInvading pathogensHost organismFluctuating environmentsInfectious disease progressionPathogensIdentical populationsTreatment escapeInfection outcomesHeterogeneous subpopulationsDisease progressionInfecting organismDiversityCausative linkGeneticsSubpopulationsPhenotypeA model of proximate protection against pathogenic infection through shared immunity
Nixon D, Kyza-Karavioti M, Mallick S, Daley L, Hupert N, Bachtel N, Eleftherianos I. A model of proximate protection against pathogenic infection through shared immunity. MBio 2024, 15: e03046-24. PMID: 39526781, PMCID: PMC11633142, DOI: 10.1128/mbio.03046-24.Peer-Reviewed Original ResearchDrosophila melanogaster</i>Host immune defenseTransforming biomedical researchMicrobial signalsPathogen infectionPathogen challengeAdult fliesImmunological primingInsect pathogensImmune defenseInfected hostsInnate immune primingImmune primingHostPathogensInfluence immunityBiomedical researchHealthy individualsFliesPrimed hostsProtective effectLethal doseImmunityBacteriaSpecific chemicalsDual roles for a tick protein disulfide isomerase during the life cycle of the Lyme disease agent
Tang X, Cui Y, Namarra U, Tian X, Rivas-Giorgi F, Fikrig E. Dual roles for a tick protein disulfide isomerase during the life cycle of the Lyme disease agent. MBio 2024, 15: e01754-24. PMID: 39470213, PMCID: PMC11633212, DOI: 10.1128/mbio.01754-24.Peer-Reviewed Original ResearchProtein disulfide isomeraseLyme disease agentDisulfide isomeraseBlood-feeding vectorsExtracellular pathogensGene expressionInvasion of host cellsThiol-disulfide oxidoreductasesDisease agentsGroup of enzymesStages of bacterial infectionVirulence factorsLife cycleChaperone activityMammalian hostsHost cellsBlood-feeding ticksIsomeraseMicrobial infectionsColonized ticksPathogensDiverse infectionsMicrobial invasionInfection of miceVector-borne diseasesFlaviviruses manipulate mitochondrial processes to evade the innate immune response
Boytz R, Keita K, Pawlak J, Laurent-Rolle M. Flaviviruses manipulate mitochondrial processes to evade the innate immune response. Npj Viruses 2024, 2: 47. PMID: 39371935, PMCID: PMC11452341, DOI: 10.1038/s44298-024-00057-x.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsMitochondrial processesAntiviral signaling proteinProgrammed Cell DeathRegulate various aspectsInnate immune response to viral infectionEukaryotic organellesResponse to viral infectionMitochondrial biologyInnate immune responseMitochondrial morphologyCellular processesSignaling proteinsCell deathImmune response to viral infectionInnate immunityMitochondriaCalcium homeostasisFlavivirusesViral infectionImmune responseOrganellesPathogensDynamic structureProteinHomeostasisInsights into the evolution, virulence and speciation of Babesia MO1 and Babesia divergens through multiomics analyses
Singh P, Vydyam P, Fang T, Estrada K, Gonzalez L, Grande R, Kumar M, Chakravarty S, Berry V, Ranwez V, Carcy B, Depoix D, Sánchez S, Cornillot E, Abel S, Ciampossin L, Lenz T, Harb O, Sanchez-Flores A, Montero E, Le Roch K, Lonardi S, Mamoun C. Insights into the evolution, virulence and speciation of Babesia MO1 and Babesia divergens through multiomics analyses. Emerging Microbes & Infections 2024, 13: 2386136. PMID: 39148308, PMCID: PMC11370697, DOI: 10.1080/22221751.2024.2386136.Peer-Reviewed Original ResearchLeveraging genomic informationHuman babesiosisTick-borne diseasesDiseases of significanceCases of human babesiosisGenomic divergenceGenome sequenceGenomic informationMultigene familyGene functionBabesia divergensMammalian hostsAnimal healthMultiomics analysisZoonotic pathogensBabesiosisProtozoan parasitesVirulent strainsPathogensVertebrate hostsEnvironmental changesVirulenceReplication rateAntiparasitic drugsParasites
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