2025
Circulating Tissue Specific Extracellular Vesicles for Noninvasive Monitoring of Acute Cellular Rejection in Clinical Heart Transplantation.
Korutla L, Hu R, Liu Y, Romano C, Habertheuer A, Abedi P, Wang H, Molugu S, Rostami S, Naji A, Nuqali A, Beasley M, Maulion C, Hahn S, Ahmad T, Wang Z, Sen S, Vallabhajosyula P. Circulating Tissue Specific Extracellular Vesicles for Noninvasive Monitoring of Acute Cellular Rejection in Clinical Heart Transplantation. Transplantation 2025 PMID: 40238644, DOI: 10.1097/tp.0000000000005369.Peer-Reviewed Original ResearchModerate acute cellular rejectionAcute cellular rejectionT cellsHeart transplantationSmall extracellular vesiclesCellular rejectionAntibody-mediated rejectionEndomyocardial biopsy samplesHeart transplant patientsWilcoxon rank sum testExtracellular vesiclesClinical heart transplantationRank sum testCardiac allograftsExternal validation studyCTnT proteinTransplant patientsPostoperative dayDiagnostic accuracyBiopsy samplesSuccessful treatmentCargo of small extracellular vesiclesTransplantationPatientsDiagnostic potential
2024
WCN24-2555 AN UNUSUAL CASE OF ACUTE KIDNEY INJURY DUE TO SULFADIAZINE CRYSTAL NEPHROPATHY AND SUCCESSFUL TREATMENT WITH URINE ALKALINIZATION
Hoteit M, Ghaddar M, Kfoury H, Abu-Alfa A. WCN24-2555 AN UNUSUAL CASE OF ACUTE KIDNEY INJURY DUE TO SULFADIAZINE CRYSTAL NEPHROPATHY AND SUCCESSFUL TREATMENT WITH URINE ALKALINIZATION. Kidney International Reports 2024, 9: s643-s644. DOI: 10.1016/j.ekir.2024.02.1354.Peer-Reviewed Original ResearchCurrent and Future Approaches to Pediatric Anxiety Disorder Treatment
Zugman A, Winkler A, Qamar P, Pine D. Current and Future Approaches to Pediatric Anxiety Disorder Treatment. American Journal Of Psychiatry 2024, 181: 189-200. PMID: 38425255, PMCID: PMC11256210, DOI: 10.1176/appi.ajp.20231037.Peer-Reviewed Original Research
2023
Complex pathologies in a patient referred for varicose veins
Ali S, Pinto P, Huber S, Perez-Lozada J, Attaran R, Chaar C. Complex pathologies in a patient referred for varicose veins. Journal Of Vascular Surgery Cases And Innovative Techniques 2023, 9: 101107. PMID: 36852313, PMCID: PMC9958068, DOI: 10.1016/j.jvscit.2023.101107.Peer-Reviewed Original ResearchVenous pathologyVaricose veinsOvarian vein embolizationSuperficial venous refluxSaphenous vein refluxIliac vein compressionCross-sectional imagingVenous ablationPelvic painVenous refluxLeg symptomsOvarian veinVein embolizationVein refluxPelvic symptomsVein compressionDuplex examinationIliac veinLeg varicositiesSuccessful treatmentComplex pathologyPathologyVeinSymptomsReflux
2022
Reinfection and Risk Behaviors After Treatment of Hepatitis C Virus Infection in Persons Receiving Opioid Agonist Therapy : A Cohort Study.
Grebely J, Dore GJ, Altice FL, Conway B, Litwin AH, Norton BL, Dalgard O, Gane EJ, Shibolet O, Nahass R, Luetkemeyer AF, Peng CY, Iser D, Gendrano IN, Kelly MM, Hwang P, Asante-Appiah E, Haber BA, Barr E, Robertson MN, Platt H. Reinfection and Risk Behaviors After Treatment of Hepatitis C Virus Infection in Persons Receiving Opioid Agonist Therapy : A Cohort Study. Annals Of Internal Medicine 2022, 175: 1221-1229. PMID: 35939812, DOI: 10.7326/m21-4119.Peer-Reviewed Original ResearchConceptsOpioid agonist therapyLong-term extension studyHCV reinfectionDrug useExtension studyAgonist therapySuccessful treatmentHepatitis C virus (HCV) reinfectionHepatitis C virus infectionBenefits of cureC virus infectionChronic HCV infectionRate of reinfectionUrine drug screeningOngoing drug useClinical trial sitesSubsidiary of MerckHCV infectionCohort studyVirus reinfectionDohme Corp.Treatment completionGenotype 1Virus infectionHigh riskCardiac crises: Cardiac arrhythmias and cardiomyopathy during TANGO2 deficiency related metabolic crises
Miyake CY, Lay EJ, Beach CM, Ceresnak SR, Delauz CM, Howard TS, Janson CM, Jardine K, Kannankeril PJ, Kava M, Kim JJ, Liberman L, Macicek SL, Pham TD, Robertson T, Valdes SO, Webster G, Stephens SB, Milewicz DM, Azamian M, Ehsan SA, Houck KM, Soler-Alfonso C, Glinton KE, Tosur M, Li N, Xu W, Lalani SR, Zhang L. Cardiac crises: Cardiac arrhythmias and cardiomyopathy during TANGO2 deficiency related metabolic crises. Heart Rhythm 2022, 19: 1673-1681. PMID: 35568137, PMCID: PMC10642301, DOI: 10.1016/j.hrthm.2022.05.009.Peer-Reviewed Original ResearchConceptsVentricular tachycardiaCardiac crisisCardiac arrestMetabolic crisisIntravenous magnesiumAtrial pacingCardiac arrhythmiasRetrospective multicenter chart reviewType I Brugada patternInitiation of feedsMulticenter chart reviewMembrane oxygenation supportCurrent treatment optionsAutosomal recessive diseaseLethal cardiac arrhythmiasBrugada patternOxygenation supportCardiac manifestationsChart reviewQTc prolongationAntiarrhythmic drugsHeart blockSupraventricular tachycardiaTreatment optionsSuccessful treatmentEvolution of Surgical Management of Metastatic Disease of the Pelvis.
Benevenia J, Guinand LA, Ippolito J, Neilson JC, Fabbri N, Lee FY, Yang R, Kurland AM. Evolution of Surgical Management of Metastatic Disease of the Pelvis. Instructional Course Lectures 2022, 71: 185-201. PMID: 35254782.Peer-Reviewed Original ResearchConceptsSurgical managementSignificant pain reliefMetastatic bone diseaseRestoration of ambulationStandardized modalityPain reliefSevere painMetastatic diseasePostoperative periodSurgical treatmentMinimal complicationsSuccessful treatmentSurgical methodsSurgical reconstructionBone diseasePelvic lesionsInterventional methodsPatientsFrail stateMultidisciplinary approachDiseaseWound healingComplicationsLesionsLimited life span
2021
Direct antiviral agents for chronic hepatitis C virus infection improve health-related quality of life significantly in the long term
Atamla M, Khoury J, Dabbah I, Kramsky R, Yaacob A, Veitsman E, Saadi T. Direct antiviral agents for chronic hepatitis C virus infection improve health-related quality of life significantly in the long term. Clinical And Experimental Hepatology 2021, 7: 258-263. PMID: 34712826, PMCID: PMC8527337, DOI: 10.5114/ceh.2021.109192.Peer-Reviewed Original ResearchDirect antiviral agentsChronic hepatitis C virus (HCV) infectionHepatitis C virus infectionQuality of lifeC virus infectionHealth-related qualitySuccessful treatmentVirus infectionAntiviral agentsChronic HCV infectionDAA treatmentExtrahepatic manifestationsHCV infectionLiver diseaseLong termLiver fibrosisObservational studyProfound negative impactNew drugsInfectionHRQLTreatmentAverage timePatientsDrugsEmergent and Non-Emergent Agitation in the Older Adult: Evaluation and Management
Subramanian S, Fahed M, Dix E, Wilkins K. Emergent and Non-Emergent Agitation in the Older Adult: Evaluation and Management. Current Geriatrics Reports 2021, 10: 73-81. DOI: 10.1007/s13670-021-00358-6.Peer-Reviewed Original ResearchCohen-Mansfield Agitation InventoryElectroconvulsive therapyOlder adultsPsychiatric disordersNon-pharmacological managementAlcohol withdrawalDistressing symptomsBenzodiazepine usePharmacological treatmentTreatment optionsExcited catatoniaHeterogenous presentationSuccessful treatmentSignificant disabilitySubstance intoxicationNeuropsychiatric conditionsMotor behaviorCognitive enhancersPolypharmacyAdultsDeliriumPatientsCatatoniaReviewThis paperTreatmentDual therapeutic targeting of intra-articular inflammation and intracellular bacteria enhances chondroprotection in septic arthritis
Kwon HK, Lee I, Yu KE, Cahill SV, Alder KD, Lee S, Dussik CM, Back J, Choi J, Song L, Kyriakides TR, Lee FY. Dual therapeutic targeting of intra-articular inflammation and intracellular bacteria enhances chondroprotection in septic arthritis. Science Advances 2021, 7: eabf2665. PMID: 34172438, PMCID: PMC8232912, DOI: 10.1126/sciadv.abf2665.Peer-Reviewed Original ResearchConceptsIntra-articular inflammationSeptic arthritisBacterial infectionsDual therapeutic targetingKnee septic arthritisPromising new therapeutic strategyArticular cartilageChallenging clinical problemNovel treatment modalitiesIntracellular bacteriaNew therapeutic strategiesAdjuvant targetingTreatment modalitiesBacterial eradicationSuccessful treatmentHost inflammationCausative bacteriaMurine modelTherapeutic strategiesArthritisTherapeutic goalsClinical problemTherapeutic targetingInflammationVital organsNocardia thailandica Brain Abscess in an Immunocompromised Patient
Effendi M, Tirmizi S, McManus D, Huttner AJ, Peaper DR, Topal JE. Nocardia thailandica Brain Abscess in an Immunocompromised Patient. Case Reports In Infectious Diseases 2021, 2021: 6620049. PMID: 34234968, PMCID: PMC8216818, DOI: 10.1155/2021/6620049.Peer-Reviewed Original ResearchSuccessful treatmentCentral nervous system infectionRadiographic treatment successInitiation of therapyNervous system infectionCeftriaxone 2Ceftriaxone monotherapyRadiological improvementBrain abscessesSystem infectionMedical therapyTreatment successCNS penetrationPatientsMedical literatureInfectionBrainTherapyTreatmentMonthsMonotherapyAbscessCeftriaxoneCraniotomyThe role of social network support in treatment outcomes for medication for opioid use disorder: A systematic review
Kumar N, Oles W, Howell BA, Janmohamed K, Lee ST, Funaro MC, O'Connor PG, Alexander M. The role of social network support in treatment outcomes for medication for opioid use disorder: A systematic review. Journal Of Substance Use And Addiction Treatment 2021, 127: 108367. PMID: 34134871, PMCID: PMC9022048, DOI: 10.1016/j.jsat.2021.108367.Peer-Reviewed Original ResearchConceptsOpioid use disorderUse disordersTreatment outcomesMedication treatmentMOUD treatmentSystematic reviewOpioid use disorder treatmentSocial network supportPositive social support networksUse disorder treatmentPatients' oddsOpioid deathsPatient populationSuccessful treatmentOpioid epidemicInclusion criteriaResearch DatabaseElectronic research databasesHealthy behaviorsDisorder treatmentTools physiciansTargeted interventionsDisordersMedicationsTreatment
2020
Successful Treatment of Guttate Psoriasis With Ixekizumab: A Case Series
Fogel A, Strober B. Successful Treatment of Guttate Psoriasis With Ixekizumab: A Case Series. Journal Of Psoriasis And Psoriatic Arthritis 2020, 6: 12-15. DOI: 10.1177/2475530320970538.Peer-Reviewed Original ResearchRisk factors for recurrent tuberculosis after successful treatment in a high burden setting: a cohort study
Cudahy PGT, Wilson D, Cohen T. Risk factors for recurrent tuberculosis after successful treatment in a high burden setting: a cohort study. BMC Infectious Diseases 2020, 20: 789. PMID: 33097000, PMCID: PMC7585300, DOI: 10.1186/s12879-020-05515-4.Peer-Reviewed Original ResearchConceptsM. tuberculosis infectionRecurrent tuberculosisSuccessful treatmentTuberculosis recurrenceHazard ratioSmear gradeTuberculosis infectionRisk factorsSmear-positive pulmonary tuberculosisCox proportional hazards modelSputum smear gradeRepetitive unit-variable number tandem repeat (MIRU-VNTR) typingHigh-burden settingsRisk of recurrenceProportional hazards modelSuccessful treatment completionRecurrent diseaseCohort studyPulmonary tuberculosisBurden settingsClinical presentationRecurrent episodesInitial episodeNumber tandem repeat typingTreatment completionPsoriasis With Eczematous Features: A Retrospective Clinicopathologic Study.
Noorily AR, Criscito MC, Cohen JM, Brinster NK. Psoriasis With Eczematous Features: A Retrospective Clinicopathologic Study. American Journal Of Dermatopathology 2020, 43: 112-118. PMID: 32618707, DOI: 10.1097/dad.0000000000001711.Peer-Reviewed Original ResearchMeSH KeywordsAdministration, CutaneousAdministration, OralAdultAgedAged, 80 and overBiological ProductsBiopsyDatabases, FactualDermatitis, Allergic ContactEczemaFemaleGlucocorticoidsHumansImmunosuppressive AgentsMaleMiddle AgedPredictive Value of TestsPsoriasisRemission InductionRetrospective StudiesSkinTreatment OutcomeYoung AdultConceptsAllergic contact dermatitisPsoriasis vulgarisClinical characteristicsHistopathological featuresEczematous changesDiagnostic workupSuccessful treatmentContact dermatitisOutcomes of patientsPercent of patientsHalf of patientsRetrospective chart reviewFeatures of psoriasisRetrospective clinicopathologic studyEczematous dermatosesEczematous featuresChart reviewClinicopathologic studyMost patientsSystemic therapyTopical glucocorticoidsHistopathologic featuresChallenging diagnosisClinicopathologic correlationTreatment modalitiesResidual endotoxin induces primary graft dysfunction through ischemia-reperfusion-primed alveolar macrophages
Akbarpour M, Lecuona E, Chiu S, Wu Q, Querrey M, Fernandez R, Nunez-Santana F, Sun H, Ravi S, Kurihara C, Walter JM, Joshi N, Ren Z, Roberts SC, Hauser A, Kreisel D, Li W, Chandel N, Misharin AV, Mohanakumar T, Budinger GRS, Bharat A. Residual endotoxin induces primary graft dysfunction through ischemia-reperfusion-primed alveolar macrophages. Journal Of Clinical Investigation 2020, 130: 4456-4469. PMID: 32692317, PMCID: PMC7410086, DOI: 10.1172/jci135838.Peer-Reviewed Original ResearchConceptsTissue-resident alveolar macrophagesPrimary graft dysfunctionHuman donor lungsNeutrophil recruitmentGraft dysfunctionDonor lungsBacterial pneumoniaAlveolar macrophagesBone marrow chimeric miceDonor lung injuryActivation of TLR4Blockade of TLR4MyD88-dependent mannerResidual endotoxinCoreceptor CD14Lung transplantationLung injuryNeutrophil infiltrationFatal syndromeSuccessful treatmentMouse modelChimeric miceBacterial endotoxinTLR4EndotoxinDigital Image Analysis of Heterogeneous Tuberculosis Pulmonary Pathology in Non-Clinical Animal Models using Deep Convolutional Neural Networks
Asay B, Edwards B, Andrews J, Ramey M, Richard J, Podell B, Gutiérrez J, Frank C, Magunda F, Robertson G, Lyons M, Ben-Hur A, Lenaerts A. Digital Image Analysis of Heterogeneous Tuberculosis Pulmonary Pathology in Non-Clinical Animal Models using Deep Convolutional Neural Networks. Scientific Reports 2020, 10: 6047. PMID: 32269234, PMCID: PMC7142129, DOI: 10.1038/s41598-020-62960-6.Peer-Reviewed Original ResearchConceptsConvolutional neural networkNeural networkDeep convolutional neural networkHistopathological image analysisPulmonary pathologyTesting of novel therapiesAnimal modelsSemi-quantitative histopathology scoresImage recognitionUser limitationsNon-clinical animal modelsHistopathological imagesSeverity of diseaseTreatment of tuberculosisSoftware toolsTreatment cohortsNovel therapiesPulmonary tissueDisease progressionHistopathological analysisMouse modelPreclinical evaluationHistopathological scoresSuccessful treatmentPathological features
2019
Cholangiolithiasis postliver transplantation: Successful treatment utilizing percutaneous transhepatic cholangioscopy and laser lithotripsy
Nezami N, Benchetrit L, Latich I, Schlachter T. Cholangiolithiasis postliver transplantation: Successful treatment utilizing percutaneous transhepatic cholangioscopy and laser lithotripsy. Radiology Case Reports 2019, 14: 1459-1466. PMID: 31641393, PMCID: PMC6796643, DOI: 10.1016/j.radcr.2019.09.020.Peer-Reviewed Original ResearchPercutaneous transhepatic cholangioscopyLiver transplantLaser lithotripsyMajor procedure-related complicationsProcedure-related complicationsExtrahepatic bile ductAbdominal CT scanDuctal calculiHepaticojejunal anastomosisPostliver transplantationNew onsetSelect patientsLiver biopsyPersistent painBile ductDuct calculiRisk factorsSuccessful treatmentRemoval of intraSuitable alternative optionCT scanEndoscopic techniquesBasket retrievalLarge calculiCholangioscopySuccessful Treatment of Primary Orthostatic Tremor Using Perampanel
Wadhwa A, Schaefer SM. Successful Treatment of Primary Orthostatic Tremor Using Perampanel. Tremor And Other Hyperkinetic Movements 2019, 9 PMID: 31413897, PMCID: PMC6691907, DOI: 10.7916/tohm.v0.681.Peer-Reviewed Original ResearchPredictors of Dropout From Residential Treatment for Posttraumatic Stress Disorder Among Military Veterans
Smith NB, Sippel LM, Rozek DC, Hoff RA, Harpaz-Rotem I. Predictors of Dropout From Residential Treatment for Posttraumatic Stress Disorder Among Military Veterans. Frontiers In Psychology 2019, 10: 362. PMID: 30873081, PMCID: PMC6401625, DOI: 10.3389/fpsyg.2019.00362.Peer-Reviewed Original ResearchPosttraumatic stress disorderTreatment dropoutResidential treatmentStress disorderSymptomatic patient populationResidential PTSD programsType of treatmentTrauma-focused psychotherapyVeterans Affairs programsTrauma-focused therapyResidential programsResidential PTSD treatmentPredictors of dropoutPatient populationSuccessful treatmentPhysical functioningSymptomatic individualsPsychiatric symptomsHigh riskPTSD treatmentReduced likelihoodFiscal year 2015PTSD programGreater PTSD symptomsGreater symptoms
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