2022
Early life body mass index trajectories and albuminuria in midlife: A 30-year prospective cohort study
Wang Y, Li F, Chu C, Zhang X, Zhang X, Liao Y, Du M, Zou T, Ma Q, Chen C, Wang D, Wang K, Yan Y, Sun Y, Hu G, Jia H, Li H, Niu Z, Yan R, Man Z, Wang L, Luo W, Zhang J, Li C, Lu W, Chang J, Safirstein R, Lu Y, Mu J. Early life body mass index trajectories and albuminuria in midlife: A 30-year prospective cohort study. EClinicalMedicine 2022, 48: 101420. PMID: 35516445, PMCID: PMC9065297, DOI: 10.1016/j.eclinm.2022.101420.Peer-Reviewed Original ResearchBody mass indexDistinct BMI trajectoriesFirst Affiliated HospitalBMI trajectoriesOdds ratioXi'an Jiaotong UniversityAffiliated HospitalCardiovascular diseaseBody mass index (BMI) trajectoriesClinical Research AwardHigher BMI trajectoriesProspective cohort studySystolic blood pressureRisk of albuminuriaUnadjusted odds ratioNon-communicable disease preventionHigher UACRCohort studyBlood pressureCreatinine ratioRenal diseaseUrinary albuminVascular dysfunctionBMI groupsStudy cohortMultiparameter analysis of vascular remodeling in post-acute sequelae of COVID-19
Fetita C, Maury M, Justet A, Dindart J, Richeux J, Sese L, Aide N, Gille T, Nunes H, Bernaudin J, Brillet P. Multiparameter analysis of vascular remodeling in post-acute sequelae of COVID-19. Progress In Biomedical Optics And Imaging 2022, 12033: 120330a-120330a-11. DOI: 10.1117/12.2611461.Peer-Reviewed Original ResearchPost-acute sequelae of COVID-19Sequelae of COVID-19Remodeling biomarkersVascular alterationsVascular remodelingAssociated with vascular dysfunctionPerfusion lung scintigraphyVascular perfusionBlood volume ratioGround-glass opacitiesPost-acute sequelaeInvestigate possible associationsVascular remodeling indexCT attenuationDLCO valuesLung scintigraphyRadiological featuresGlass opacitiesCT scanLarge-caliber vesselsCOVID-19 infectionFibrotic patternInterstitial thickeningVascular densityVascular dysfunction
2021
Blockade of the CD93 pathway normalizes tumor vasculature to facilitate drug delivery and immunotherapy
Sun Y, Chen W, Torphy RJ, Yao S, Zhu G, Lin R, Lugano R, Miller EN, Fujiwara Y, Bian L, Zheng L, Anand S, Gao F, Zhang W, Ferrara SE, Goodspeed AE, Dimberg A, Wang XJ, Edil BH, Barnett CC, Schulick RD, Chen L, Zhu Y. Blockade of the CD93 pathway normalizes tumor vasculature to facilitate drug delivery and immunotherapy. Science Translational Medicine 2021, 13 PMID: 34321321, PMCID: PMC8749958, DOI: 10.1126/scitranslmed.abc8922.Peer-Reviewed Original ResearchConceptsInsulin-like growth factor binding protein 7Vascular dysfunctionAnti-programmed death-1/Intratumoral effector T cellsTumor vasculatureTumor microenvironmentGrowth factor binding protein 7Tumor-associated endothelial cellsImproved antitumor responsesEffector T cellsDeath-1/Immune checkpoint therapyImmune cell infiltrationFavorable tumor microenvironmentMouse tumor modelsBinding protein 7Checkpoint therapyAntitumor responseCell infiltrationPoor responseT cellsHypoxic tumor microenvironmentTumor perfusionSolid tumorsTherapeutic interventions
2020
New Insights Into Blood-Brain Barrier Maintenance: The Homeostatic Role of β-Amyloid Precursor Protein in Cerebral Vasculature
Ristori E, Donnini S, Ziche M. New Insights Into Blood-Brain Barrier Maintenance: The Homeostatic Role of β-Amyloid Precursor Protein in Cerebral Vasculature. Frontiers In Physiology 2020, 11: 1056. PMID: 32973564, PMCID: PMC7481479, DOI: 10.3389/fphys.2020.01056.Peer-Reviewed Original ResearchCerebral amyloid angiopathyΒ-amyloid precursor proteinBlood-brain barrierCentral nervous systemAlzheimer's diseaseBlood-brain barrier maintenanceΒ-amyloid accumulationPeripheral blood circulationPrecursor proteinEndothelial cell homeostasisCAA pathogenesisBBB dysfunctionBBB functionAmyloid angiopathyVascular dysfunctionAD onsetCerebrovascular homeostasisCerebral vasculatureVascular endotheliumPathological outcomesNervous systemHomeostatic roleBrain vasculatureNeurodegenerative disordersBarrier maintenance
2019
Loss of Endothelial FTO Antagonizes Obesity-Induced Metabolic and Vascular Dysfunction
Krüger N, Biwer L, Good M, Ruddiman C, Wolpe A, DeLalio L, Murphy S, Macal E, Ragolia L, Serbulea V, Best A, Leitinger N, Harris T, Sonkusare S, Gödecke A, Isakson B. Loss of Endothelial FTO Antagonizes Obesity-Induced Metabolic and Vascular Dysfunction. Circulation Research 2019, 126: 232-242. PMID: 31801409, PMCID: PMC7007767, DOI: 10.1161/circresaha.119.315531.Peer-Reviewed Original ResearchConceptsMyogenic toneProstaglandin DResistance arteriesDeficient miceHigh-fat diet-induced glucose intoleranceDiet-induced glucose intoleranceObesity-induced hypertensionImpact of obesityPrevalence of obesityNew treatment optionsDevelopment of obesityHigh-fat dietRegulation of obesityDifferent cell typesCell typesGlucose intoleranceVascular alterationsVascular changesVascular dysfunctionControl miceInsulin resistanceTreatment optionsCardiovascular diseaseObesityArteryRight Ventricular-Arterial Uncoupling During Exercise in Heart Failure With Preserved Ejection Fraction Role of Pulmonary Vascular Dysfunction
Singh I, Rahaghi FN, Naeije R, Oliveira RKF, Systrom DM, Waxman AB. Right Ventricular-Arterial Uncoupling During Exercise in Heart Failure With Preserved Ejection Fraction Role of Pulmonary Vascular Dysfunction. CHEST Journal 2019, 156: 933-943. PMID: 31103695, DOI: 10.1016/j.chest.2019.04.109.Peer-Reviewed Original ResearchConceptsEes/EaRV-PA uncouplingPulmonary vascular dysfunctionResistive afterloadHeart failureVascular dysfunctionRight ventricular-pulmonary artery couplingLower pulmonary artery complianceRight ventricular-arterial uncouplingInvasive pulmonary hemodynamicsPulmonary arterial elastanceRV contractile reserveRV pressure waveformsVentricular-arterial uncouplingRight ventricular dysfunctionExercise-induced decreasePulmonary artery complianceExercise-induced increaseGroup of patientsLower peak VOLower stroke volumePeak oxygen consumptionSingle-beat analysisEnd-systolic elastancePVR response
2018
MicroRNAs in endothelial cell homeostasis and vascular disease
Fernández-Hernando C, Suárez Y. MicroRNAs in endothelial cell homeostasis and vascular disease. Current Opinion In Hematology 2018, 25: 227-236. PMID: 29547400, PMCID: PMC6175704, DOI: 10.1097/moh.0000000000000424.Peer-Reviewed Original ResearchConceptsVascular diseaseVascular disease preventionPotential therapeutic targetEndothelial cell homeostasisEndothelial cell functionEndothelial dysfunctionEndothelial functionVascular dysfunctionTherapeutic applicationsPotential therapeutic applicationsInvolvement of miRNAsDysregulation of miRNAsEndothelial homeostasisTherapeutic targetDisease preventionDiseaseCell functionRegulatory circuitsCritical modulatorUnanticipated roleTarget genesCell homeostasisDysfunctionMiRNAsHomeostasis
2017
Two Pools of Epoxyeicosatrienoic Acids in Humans
Elijovich F, Milne GL, Brown NJ, Laniado-Schwartzman M, Laffer CL. Two Pools of Epoxyeicosatrienoic Acids in Humans. Hypertension 2017, 71: 346-355. PMID: 29279315, PMCID: PMC5764817, DOI: 10.1161/hypertensionaha.117.10392.Peer-Reviewed Original ResearchConceptsSalt-resistant subjectsDihydroxyeicosatrienoic acidsEpoxyeicosatrienoic acidsBlood pressurePlasma epoxyeicosatrienoic acidsRegulation of natriuresisSalt-sensitive subjectsUrine sodium excretionPotential therapeutic implicationsRenal poolSodium excretionInpatient protocolNormotensive subjectsFractional excretionVascular dysfunctionVascular toneSystemic originTherapeutic implicationsTotal poolNatriuresisSalt loadingExcretionUrine poolsAldosteroneCatecholaminesDeterminants of mortality in systemic sclerosis: a focused review
Poudel DR, Jayakumar D, Danve A, Sehra ST, Derk CT. Determinants of mortality in systemic sclerosis: a focused review. Rheumatology International 2017, 38: 1847-1858. PMID: 29116439, DOI: 10.1007/s00296-017-3826-y.Peer-Reviewed Original ResearchConceptsHigh morbidityMortality rateAutoimmune rheumatic disordersDisease-related complicationsNon-clinical factorsDeterminants of mortalitySystemic sclerosisVascular dysfunctionAutoantibody productionRheumatic disordersScleroderma patientsObservational studyEpidemiological dataGeneral populationVisceral organsPubMed databaseMortalitySclerodermaHigher likelihoodMorbidityRelated determinantsFocused reviewAvailable literaturePopulationComplicationsShear Stress Induces Change in Extracellular Signal-Regulated Kinase 5 Levels with Sustained Activation under Disturbed and Continuous Laminar Flow
Shalaby SY, Chitragari G, Sumpio BJ, Sumpio BE. Shear Stress Induces Change in Extracellular Signal-Regulated Kinase 5 Levels with Sustained Activation under Disturbed and Continuous Laminar Flow. International Journal Of Angiology 2017, 26: 109-115. PMID: 28566937, PMCID: PMC5446257, DOI: 10.1055/s-0037-1599057.Peer-Reviewed Original ResearchExtracellular signal-regulated kinase 5Pathogenesis of atherosclerosisExposure of HUVECERK5 activationVascular dysfunctionPattern of activationFro flowVascular remodelingConfluent HUVECsHours of exposurePhospho-ERK5Endothelial integrityActivation of ERK5Kinase 5Sustained activationEnd of experimentationERK5 phosphorylationHUVECActivationHoursExposureTransient phosphorylationCell lysatesDisturbed flow conditionsParallel plate flow chamber
2016
Endothelin-1 Treatment Induces an Experimental Cerebral Malaria–Like Syndrome in C57BL/6 Mice Infected with Plasmodium berghei NK65
Martins YC, Freeman BD, Ndunge O, Weiss LM, Tanowitz HB, Desruisseaux MS. Endothelin-1 Treatment Induces an Experimental Cerebral Malaria–Like Syndrome in C57BL/6 Mice Infected with Plasmodium berghei NK65. American Journal Of Pathology 2016, 186: 2957-2969. PMID: 27640146, PMCID: PMC5222963, DOI: 10.1016/j.ajpath.2016.07.020.Peer-Reviewed Original ResearchConceptsExperimental cerebral malariaEndothelin-1ET-1 treatmentC57BL/6 miceBerghei NK65Pathogenesis of ECMBlood-brain barrier leakagePlasmodium berghei ANKA infectionBlood-brain barrier permeabilitySevere malarial diseasePlasmodium berghei ANKABerghei ANKA infectionP. berghei NK65Plasmodium berghei NK65Functional capillary densityEndothelin-1 treatmentCerebral malariaMicrovascular alterationsANKA infectionBerghei ANKARed blood cellsVascular dysfunctionCerebral microvasculatureNeurological signsBarrier leakageUse of hyperspectral imaging to assess endothelial dysfunction in peripheral arterial disease
Sumpio BJ, Citoni G, Chin JA, Sumpio BE. Use of hyperspectral imaging to assess endothelial dysfunction in peripheral arterial disease. Journal Of Vascular Surgery 2016, 64: 1066-1073. PMID: 27266597, DOI: 10.1016/j.jvs.2016.03.463.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overBiomarkersBrachial ArteryCase-Control StudiesCoronary Artery DiseaseCross-Sectional StudiesEndothelium, VascularFemaleHemoglobinsHumansHyperemiaMaleMicrocirculationMiddle AgedMolecular ImagingOxyhemoglobinsPeripheral Arterial DiseasePilot ProjectsPredictive Value of TestsProspective StudiesReproducibility of ResultsSeverity of Illness IndexSkinSpectrum AnalysisUpper ExtremityVasodilationConceptsPeripheral artery diseaseCoronary artery diseaseCuff occlusionUpper armArtery diseaseVascular dysfunctionArterial diseasePresence of PADArterial disease patientsPeripheral arterial diseaseSystemic vascular dysfunctionAdvanced diseaseEndothelial dysfunctionVascular clinicProspective studySurgical historyControl cohortDisease patientsMedical recordsUpper extremityVascular bedHealthy volunteersPatientsHemoglobin concentrationDemographic data
2014
Characterization of Extracellular Signal-Regulated Kinase 5 Levels in Human Umbilical Vein Endothelial Cells Exposed to Disturbed and Uniform Flow
Shalaby S, Chitragari G, Sumpio BJ, Sumpio BE. Characterization of Extracellular Signal-Regulated Kinase 5 Levels in Human Umbilical Vein Endothelial Cells Exposed to Disturbed and Uniform Flow. International Journal Of Angiology 2014, 23: 187-192. PMID: 25317031, PMCID: PMC4169104, DOI: 10.1055/s-0034-1378136.Peer-Reviewed Original ResearchEndothelin-1 and its role in the pathogenesis of infectious diseases
Freeman BD, Machado FS, Tanowitz HB, Desruisseaux MS. Endothelin-1 and its role in the pathogenesis of infectious diseases. Life Sciences 2014, 118: 110-119. PMID: 24780317, PMCID: PMC4538933, DOI: 10.1016/j.lfs.2014.04.021.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsEndothelin-1Isoforms of endothelinRole of endothelinRickettsia conorii infectionPathogenesis of sepsisPro-inflammatory cytokinesVascular smooth muscle cellsLeukocyte adhesion moleculesSmooth muscle cellsSevere malariaVascular dysfunctionBacterial pneumoniaInflammatory mediatorsVascular tonePotent vasoconstrictorImmunomodulatory propertiesInfectious processAlveolar macrophagesPlatelet aggregationInfectious diseasesMuscle cellsEndothelinAdhesion moleculesPathogenesisChagas disease
2013
Androgens influence microvascular dilation in PCOS through ET-A and ET-B receptors
Wenner MM, Taylor HS, Stachenfeld NS. Androgens influence microvascular dilation in PCOS through ET-A and ET-B receptors. AJP Endocrinology And Metabolism 2013, 305: e818-e825. PMID: 23921139, PMCID: PMC3798701, DOI: 10.1152/ajpendo.00343.2013.Peer-Reviewed Original ResearchConceptsPolycystic ovary syndromeET-B receptorsMicrovascular dilationHeat-induced vasodilationReceptor inhibitionET-B receptor antagonistGonadotropin-releasing hormone antagonistLaser Doppler flowmetryAndrogen suppressionOvary syndromeVascular dysfunctionHealthy womenT administrationEnhanced vasodilationHormone antagonistReceptor antagonistCutaneous microdialysisDoppler flowmetryTestosterone effectsSubtype receptorsVasodilationDay 8WomenDilationGnRHant
2011
Testosterone lowers microvascular ET‐B receptor responsiveness in women with PCOS
Wenner M, Taylor H, Stachenfeld N. Testosterone lowers microvascular ET‐B receptor responsiveness in women with PCOS. The FASEB Journal 2011, 25: lb559-lb559. DOI: 10.1096/fasebj.25.1_supplement.lb559.Peer-Reviewed Original ResearchPolycystic ovary syndromeHeat-induced vasodilationT administrationCutaneous vascular conductance responsesET-1 plasma concentrationsET-B receptor antagonistImpaired microvascular functionET-B receptorsVascular conductance responsesEndogenous sex hormonesLaser Doppler flowmetryPCOS showOvary syndromeGnRH antagonistMicrovascular functionVascular dysfunctionReceptor antagonistReceptor responsivenessMicrodialysis infusionSex hormonesPlasma concentrationsDoppler flowmetryReceptor sensitivityT exposureTestosterone exposure
2004
ATP-Induced Modulation of Norepinephrine Exocytosis in Human and Porcine Heart: Role of E-NTPDase1/CD39.
Machida T, Heerdt P, Reid A, Schaefer U, Silver R, Broekman M, Marcus A, Levi R. ATP-Induced Modulation of Norepinephrine Exocytosis in Human and Porcine Heart: Role of E-NTPDase1/CD39. Blood 2004, 104: 1869. DOI: 10.1182/blood.v104.11.1869.1869.Peer-Reviewed Original ResearchE-NTPDase1/CD39NE exocytosisSympathetic nerve terminalsNE releaseNovel therapeutic approachesMyocardial ischemiaNerve terminalsTherapeutic approachesCardiac sympathetic nerve terminalsCoronary vascular dysfunctionSympathetic nerve endingsIschemic heart diseaseActivation of ATPGuinea pig heartsImportant modulatory roleAnti-thrombotic agentsCause of dysfunctionDepolarization of synaptosomesRelease of ATPAdrenergic neurotransmissionCardiac neuronsIschemic complicationsSympathetic terminalsP2X purinoceptorsVascular dysfunctionBrachial artery reactivity in asymptomatic patients with type 2 diabetes mellitus and microalbuminuria (from the Detection of Ischemia in Asymptomatic Diabetics–Brachial Artery Reactivity study)
Papaioannou GI, Seip RL, Grey NJ, Katten D, Taylor A, Inzucchi SE, Young LH, Chyun DA, Davey JA, Wackers FJ, Iskandrian AE, Ratner RE, Robinson EC, Carolan S, Engel S, Heller GV. Brachial artery reactivity in asymptomatic patients with type 2 diabetes mellitus and microalbuminuria (from the Detection of Ischemia in Asymptomatic Diabetics–Brachial Artery Reactivity study). The American Journal Of Cardiology 2004, 94: 294-299. PMID: 15276091, DOI: 10.1016/j.amjcard.2004.04.022.Peer-Reviewed Original ResearchMeSH KeywordsAge FactorsAgedAlbuminuriaBrachial ArteryCoronary Artery DiseaseC-Reactive ProteinDiabetes Mellitus, Type 2Diabetic AngiopathiesEndothelium, VascularFemaleHumansLinear ModelsMaleMiddle AgedMultivariate AnalysisProspective StudiesReference ValuesRisk AssessmentSensitivity and SpecificitySeverity of Illness IndexSex FactorsUltrasonography, DopplerVasoconstrictionVasodilationConceptsEndothelium-independent vasodilationEndothelium-dependent vasodilationBrachial artery reactivityType 2 diabetes mellitusHormone replacement therapyDiabetes mellitusC-reactive proteinSystemic inflammationAsymptomatic patientsEndothelial dysfunctionIndependent predictorsReplacement therapyNovel atherosclerotic risk factorAsymptomatic Diabetics (DIAD) studyAtherosclerotic risk factorsPresence of microalbuminuriaFuture cardiovascular eventsSimilar baseline characteristicsDetection of ischemiaCardiovascular eventsBaseline characteristicsBrachial arteryVascular dysfunctionEntire cohortRisk factors
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