2024
Identification of FGFR4 as a regulator of myofibroblast differentiation in pulmonary fibrosis
Ghanem M, Justet A, Jaillet M, Vasarmidi E, Boghanim T, Hachem M, Vadel A, Joannes A, Mordant P, Balayev A, Adams T, Mal H, Cazes A, Poté N, Mailleux A, Crestani B. Identification of FGFR4 as a regulator of myofibroblast differentiation in pulmonary fibrosis. American Journal Of Physiology - Lung Cellular And Molecular Physiology 2024, 327: l818-l830. PMID: 39350729, DOI: 10.1152/ajplung.00184.2023.Peer-Reviewed Original ResearchWild type littermatesFibroblast growth factorMurine embryonic fibroblastsEndothelin-1Pulmonary fibrosisFGFR4 inhibitionBleomycin-Induced Pulmonary FibrosisIn vitroMyofibroblast differentiationBleomycin-induced lung fibrosisPulmonary fibrosis in vivoTGF-bLung fibroblastsPro-fibrotic propertiesProtein levelsIn vivoAnti-fibrotic propertiesFibrosis in vivoRegulation of myofibroblast differentiationDevelopment of bleomycin-induced lung fibrosisWT miceTherapeutic optionsHuman lung fibroblastsIPF lungsLung fibrosisSelective mural cell recruitment of pericytes to networks of assembling endothelial cell-lined tubes
Yrigoin K, Davis G. Selective mural cell recruitment of pericytes to networks of assembling endothelial cell-lined tubes. Frontiers In Cell And Developmental Biology 2024, 12: 1389607. PMID: 38961866, PMCID: PMC11219904, DOI: 10.3389/fcell.2024.1389607.Peer-Reviewed Original ResearchCoronary artery smooth muscle cellsVascular basement membrane matrix depositionVascular basement membrane matrix assemblyEC tubesBasement membrane depositionVascular smooth muscle cellsSmooth muscle cellsInvestigate functional differencesMuscle cellsMatrix assemblyArtery smooth muscle cellsMural cell recruitmentPDGF-DDPlatelet-derived growth factor (PDGF)-BBCollagen matrixMembrane depositionMural cellsHuman coronary artery smooth muscle cellsMinimal recruitmentFunctional differencesEC-derived factorsEndothelin-1CellsMatrix environmentMinimal invasiveness
2022
Relationship between endothelin-1, heart failure with reduced ejection fraction and dapagliflozin: findings from DAPA-HF
Yeoh S, Docherty K, Jhund P, Hammarstedt A, Inzucchi S, Kober L, Kosiborod M, Martinez F, Ponikowski P, Solomon S, Sattar N, Welsh P, Sabatine M, Morrow D, McMurray J. Relationship between endothelin-1, heart failure with reduced ejection fraction and dapagliflozin: findings from DAPA-HF. European Heart Journal 2022, 43: ehac544.833. DOI: 10.1093/eurheartj/ehac544.833.Peer-Reviewed Original ResearchBaseline ET-1 concentrationET-1 concentrationsBaseline ET-1Benefit of dapagliflozinSerum ET-1Kidney functionEndothelin-1Tertile 3NT-proBNPPrimary outcomeCirculating Endothelin-1DAPA-HF trialEfficacy of dapagliflozinET-1 measurementsHeart Failure TrialReduced ejection fractionWorse functional statusET-1 levelsHeart failure outcomesHeart failure severityHigh-sensitivity troponinDAPA-HFCardiovascular deathEGFR slopeLower eGFR
2019
Atmospheric nanoparticles affect vascular function using a 3D human vascularized organotypic chip
Li Y, Wu Y, Liu Y, Deng Q, Mak M, Yang X. Atmospheric nanoparticles affect vascular function using a 3D human vascularized organotypic chip. Nanoscale 2019, 11: 15537-15549. PMID: 31393488, DOI: 10.1039/c9nr03622a.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCalciumCell Culture TechniquesHuman Umbilical Vein Endothelial CellsHumansIntercellular Adhesion Molecule-1Lab-On-A-Chip DevicesMaleMiceMice, Inbred BALB CMicroscopy, ConfocalMicrovesselsModels, CardiovascularNanoparticlesNF-kappa BNitric OxideProtein CoronaTissue EngineeringVascular Endothelial Growth Factor AZonula Occludens-1 ProteinConceptsVascular endothelial growth factorEndothelin-1Vessel permeabilityVascular functionImbalance of nitric oxideHuman vascular functionLoss of tight junctionsEndothelial cell contractionAbnormal expressionIntercellular cell adhesion molecule 1Cell adhesion molecule 1Human vesselsNitric oxideEndothelial growth factorAdhesion molecule 1Expression of intercellular cell adhesion molecule 1Expression of nuclear factor-kBNuclear factor-KBPathological responseVascular toxicityICAM-1In vitro resultsTight junctionsZO-1Vascular inflammationReciprocal Multifaceted Interaction Between HDL (High-Density Lipoprotein) and Myocardial Infarction
Sposito A, de Lima-Junior J, Moura F, Barreto J, Bonilha I, Santana M, Virginio V, Sun L, Carvalho L, Soares A, Nadruz W, Feinstein S, Nofer J, Zanotti I, Kontush A, Remaley A. Reciprocal Multifaceted Interaction Between HDL (High-Density Lipoprotein) and Myocardial Infarction. Arteriosclerosis Thrombosis And Vascular Biology 2019, 39: 1550-1564. PMID: 31189429, DOI: 10.1161/atvbaha.119.312880.Peer-Reviewed Original ResearchConceptsMyocardial infarctionHigh-density lipoproteinSphingosine-1-PhosphateSpectrum of signaling pathwaysEndothelin-1Cardiac functionCardioprotective benefitsTherapeutic advancesClinical studiesIschemia/reperfusion injuryProinflammatory moleculesAnimal modelsInsulin sensitivityHDLInfarctionMitochondrial channelsFunctional changesOxidative stressSignaling pathwayAndrogens drive microvascular endothelial dysfunction in women with polycystic ovary syndrome: role of the endothelin B receptor
Usselman CW, Yarovinsky T, Steele FE, Leone CA, Taylor HS, Bender JR, Stachenfeld NS. Androgens drive microvascular endothelial dysfunction in women with polycystic ovary syndrome: role of the endothelin B receptor. The Journal Of Physiology 2019, 597: 2853-2865. PMID: 30847930, DOI: 10.1113/jp277756.Peer-Reviewed Original ResearchMeSH KeywordsAdultAndrogensCardiovascular DiseasesDihydrotestosteroneEndothelin-1Endothelium, VascularEstrogensEthinyl EstradiolFemaleGlucose Tolerance TestHumansMicrovesselsNitric OxideObesityPolycystic Ovary SyndromeReceptor, Endothelin BSkinVascular Endothelial Growth Factor AVasodilationYoung AdultConceptsPolycystic ovary syndromeCardiovascular dysfunctionEndothelial dysfunctionOvary syndromeEndothelin-1Endothelial functionNO productionAndrogen receptor-dependent mannerEndothelin-B receptor subtypeCardiovascular risk factorsMicrovascular endothelial dysfunctionMicrovascular endothelial functionCutaneous vascular conductanceB receptor subtypesEndothelin B receptorLaser Doppler flowmetryNitric oxide inhibitionReceptor-dependent mannerEndothelial cell NO productionDose-response curveVasodilating responsePCOS subjectsLean womenObese womenVascular conductance
2018
Endothelins in inflammatory neurological diseases
D'Orléans-Juste P, Akide Ndunge O, Desbiens L, Tanowitz HB, Desruisseaux MS. Endothelins in inflammatory neurological diseases. Pharmacology & Therapeutics 2018, 194: 145-160. PMID: 30291906, PMCID: PMC6348026, DOI: 10.1016/j.pharmthera.2018.10.001.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsCentral nervous systemNeuroinflammatory processesCentral nervous system vasculitisNon-infectious inflammatory processesBlood-brain barrier levelEndothelin-1 antagonistsSynthesis of endothelinInflammatory neurological diseasesMediator/modulatorProgression of neurodegenerationPotent vasoactive compoundsNeuroinflammatory diseasesEndothelin pathwayEndothelin-1Inflammatory processClinical trialsVasoactive compoundsCardiovascular propertiesNervous systemAmino acid peptideNeurological diseasesEndothelial integrityEndothelinAlzheimer's diseaseNeurodegenerative disordersImaging the Effects of &bgr;-Hydroxybutyrate on Peri-Infarct Neurovascular Function and Metabolism
Bazzigaluppi P, Lake EM, Beckett TL, Koletar MM, Weisspapir I, Heinen S, Mester J, Lai A, Janik R, Dorr A, McLaurin J, Stanisz GJ, Carlen PL, Stefanovic B. Imaging the Effects of &bgr;-Hydroxybutyrate on Peri-Infarct Neurovascular Function and Metabolism. Stroke 2018, 49: 2173-2181. PMID: 30354983, DOI: 10.1161/strokeaha.118.020586.Peer-Reviewed Original ResearchMeSH Keywords3-Hydroxybutyric AcidAcetoacetatesAnimalsAstrocytesBlood GlucoseBrainBrain IschemiaCell DeathCerebrovascular CirculationDisease Models, AnimalElectrophysiological PhenomenaEndothelin-1HemodynamicsMagnetic Resonance ImagingMagnetic Resonance SpectroscopyMicroinjectionsNeuronsRatsReactive Oxygen SpeciesSensorimotor CortexConceptsBody β-hydroxybutyrateFunctional recoveryMagnetic resonance imagingIschemic insultNeuronal deathResonance imagingFocal cortical strokeVehicle-administered animalsNeurological deficit scoresKetone body β-hydroxybutyrateNeuronal glucose uptakeContinuous arterial spinReduced oxidative stressPurpose Recent evidenceReactive oxygen species productionCortical microinjectionsCortical strokePostischemic hyperglycemiaDeficit scoresNeurovascular functionAcute phaseCerebrovascular reactivitySensorimotor cortexCerebral hemodynamicsEndothelin-1Acid Stimulation of the Citrate Transporter NaDC-1 Requires Pyk2 and ERK1/2 Signaling Pathways
Zacchia M, Tian X, Zona E, Alpern RJ, Preisig PA. Acid Stimulation of the Citrate Transporter NaDC-1 Requires Pyk2 and ERK1/2 Signaling Pathways. Journal Of The American Society Of Nephrology 2018, 29: 1720-1730. PMID: 29678998, PMCID: PMC6054333, DOI: 10.1681/asn.2017121268.Peer-Reviewed Original ResearchMeSH KeywordsAcidsAmmonium ChlorideAnimalsCells, CulturedCitric AcidCSK Tyrosine-Protein KinaseDicarboxylic Acid TransportersEndothelin-1Epithelial CellsFocal Adhesion Kinase 2Kidney Tubules, ProximalMAP Kinase Signaling SystemMiceMice, KnockoutMitogen-Activated Protein Kinase 1Mitogen-Activated Protein Kinase 3OpossumsOrganic Anion Transporters, Sodium-DependentPhosphorylationProto-Oncogene Proteins c-rafReceptor, Endothelin BRibosomal Protein S6 Kinases, 90-kDasrc-Family KinasesTransfectionConceptsET-1/ETEndothelin-1Proximal tubulesCultured opossum kidney cellsAcid stimulationInhibition of Pyk2ET-1 stimulationRenal proximal tubulesNaDC-1Opossum kidney cellsCl loadingC-SrcPhosphorylation of Raf1Urine citratePyk2 knockdownEnd pointAcid loadApical NaERK1/2 pathwayStimulationMiceKidney cellsKidneyPyk2ERK1/2
2016
Neurovascular unit remodelling in the subacute stage of stroke recovery
Lake EMR, Bazzigaluppi P, Mester J, Thomason LAM, Janik R, Brown M, McLaurin J, Carlen PL, Corbett D, Stanisz GJ, Stefanovic B. Neurovascular unit remodelling in the subacute stage of stroke recovery. NeuroImage 2016, 146: 869-882. PMID: 27664828, DOI: 10.1016/j.neuroimage.2016.09.016.Peer-Reviewed Original ResearchConceptsPeri-lesional cortexVascular reactivityNeuronal lossSubacute stageEndothelin-1LFP activityLong-term functional outcomeLocal field potential responsesPeripheral somatosensory stimulationActivation of microgliaET-1 injectionFocal ischemic strokeFocal cerebral ischaemiaPeri-infarct zoneSensori-motor cortexSpontaneous neuronal activityAdult Sprague-DawleyField potential responsesExtended temporal windowDynamic functional changesIschemic strokeAstrocytic activationCerebral ischaemiaNeurovascular unitIschemic insultEndothelin-1 Treatment Induces an Experimental Cerebral Malaria–Like Syndrome in C57BL/6 Mice Infected with Plasmodium berghei NK65
Martins YC, Freeman BD, Ndunge O, Weiss LM, Tanowitz HB, Desruisseaux MS. Endothelin-1 Treatment Induces an Experimental Cerebral Malaria–Like Syndrome in C57BL/6 Mice Infected with Plasmodium berghei NK65. American Journal Of Pathology 2016, 186: 2957-2969. PMID: 27640146, PMCID: PMC5222963, DOI: 10.1016/j.ajpath.2016.07.020.Peer-Reviewed Original ResearchConceptsExperimental cerebral malariaEndothelin-1ET-1 treatmentC57BL/6 miceBerghei NK65Pathogenesis of ECMBlood-brain barrier leakagePlasmodium berghei ANKA infectionBlood-brain barrier permeabilitySevere malarial diseasePlasmodium berghei ANKABerghei ANKA infectionP. berghei NK65Plasmodium berghei NK65Functional capillary densityEndothelin-1 treatmentCerebral malariaMicrovascular alterationsANKA infectionBerghei ANKARed blood cellsVascular dysfunctionCerebral microvasculatureNeurological signsBarrier leakageEndothelin-1 Gene Polymorphism and Its Level Predict the Risk of Venous Thromboembolism in Male Indian Population
Kumari B, Prabhakar A, Sahu A, Chatterjee T, Tyagi T, Gupta N, Nair V, Ashraf M. Endothelin-1 Gene Polymorphism and Its Level Predict the Risk of Venous Thromboembolism in Male Indian Population. Clinical And Applied Thrombosis/Hemostasis 2016, 23: 429-437. PMID: 27481876, DOI: 10.1177/1076029616661416.Peer-Reviewed Original ResearchConceptsVenous thromboembolismGene polymorphismsEndothelin-1Plasma levelsHealthy controlsG polymorphismOccurrence of VTEEnzyme (ACE) I/DEndothelial nitric oxide synthaseIndian populationEndothelin-1 gene polymorphismsLogistic regression model analysisEnzyme-linked immunoassay kitNitric oxide synthaseRegression model analysisEndothelial functionClinical progressionVascular functionOxide synthaseG alleleSignificant associationIndividual susceptibilityImmunoassay kitPatientsThromboembolismEndothelin-1 Mediates Brain Microvascular Dysfunction Leading to Long-Term Cognitive Impairment in a Model of Experimental Cerebral Malaria
Freeman BD, Martins YC, Akide-Ndunge OB, Bruno FP, Wang H, Tanowitz HB, Spray DC, Desruisseaux MS. Endothelin-1 Mediates Brain Microvascular Dysfunction Leading to Long-Term Cognitive Impairment in a Model of Experimental Cerebral Malaria. PLOS Pathogens 2016, 12: e1005477. PMID: 27031954, PMCID: PMC4816336, DOI: 10.1371/journal.ppat.1005477.Peer-Reviewed Original ResearchConceptsExperimental cerebral malariaCerebral malariaEndothelin-1Cognitive impairmentExperimental cerebral malaria modelBlood-brain barrier disruptionLong-term cognitive impairmentCerebral malaria modelEndothelin-1 administrationLife-threatening encephalopathyBerghei ANKA infectionPlasmodium falciparum infectionCerebral malaria pathogenesisBrain microvascular dysfunctionMicrovascular congestionCerebral vasoconstrictionAdjunctive therapyANKA infectionBerghei ANKAMicrovascular dysfunctionFalciparum infectionImproved survivalEndothelial activationBarrier disruptionReceptor antagonistChapter 14 Trypanosoma cruzi and Chagas Disease: Innate Immunity, ROS, and Cardiovascular System
Tanowitz H, Wen J, Machado F, Desruisseaux M, Robello C, Garg N. Chapter 14 Trypanosoma cruzi and Chagas Disease: Innate Immunity, ROS, and Cardiovascular System. 2016, 183-193. DOI: 10.1016/b978-0-12-801078-5.00014-5.ChaptersChagas diseaseThromboxane A2Innate immunityAnti-inflammatory factorsContribution of cytokinesTrypanosoma cruziSignificant morbidityVasoconstrictive actionEndothelin-1Nonendemic areasEndemic areasEicosanoid pathwayCardiovascular systemDiseaseNatural transmissionImmunityOxygen speciesCruziMorbidityChemokinesA2CytokinesPathogenesisLipoxinsMortality
2015
The Effects of Delayed Reduction of Tonic Inhibition on Ischemic Lesion and Sensorimotor Function
Lake E, Chaudhuri J, Thomason L, Janik R, Ganguly M, Brown M, McLaurin J, Corbett D, Stanisz GJ, Stefanovic B. The Effects of Delayed Reduction of Tonic Inhibition on Ischemic Lesion and Sensorimotor Function. Cerebrovascular And Brain Metabolism Reviews 2015, 35: 1601-1609. PMID: 25966952, PMCID: PMC4640317, DOI: 10.1038/jcbfm.2015.86.Peer-Reviewed Original ResearchConceptsIschemic lesionsFocal ischemiaEndothelin-1Rat modelMontoya staircase testWeeks of treatmentTotal stroke volumeCortical microinjectionsIschemic strokeChronic stageSensorimotor deficitsStroke recoveryTonic inhibitionSensorimotor functionStroke volumeGABAA antagonismGABA antagonismStaircase testPerilesional regionsDelayed reductionInverse agonistNecrotic coreBrain structuresBeneficial effectsStroke
2014
Endothelin-1 and its role in the pathogenesis of infectious diseases
Freeman BD, Machado FS, Tanowitz HB, Desruisseaux MS. Endothelin-1 and its role in the pathogenesis of infectious diseases. Life Sciences 2014, 118: 110-119. PMID: 24780317, PMCID: PMC4538933, DOI: 10.1016/j.lfs.2014.04.021.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsEndothelin-1Isoforms of endothelinRole of endothelinRickettsia conorii infectionPathogenesis of sepsisPro-inflammatory cytokinesVascular smooth muscle cellsLeukocyte adhesion moleculesSmooth muscle cellsSevere malariaVascular dysfunctionBacterial pneumoniaInflammatory mediatorsVascular tonePotent vasoconstrictorImmunomodulatory propertiesInfectious processAlveolar macrophagesPlatelet aggregationInfectious diseasesMuscle cellsEndothelinAdhesion moleculesPathogenesisChagas diseaseThe angiotensin type 2 receptor agonist Compound 21 elicits cerebroprotection in endothelin-1 induced ischemic stroke
Joseph JP, Mecca AP, Regenhardt RW, Bennion DM, Rodríguez V, Desland F, Patel NA, Pioquinto DJ, Unger T, Katovich MJ, Steckelings UM, Sumners C. The angiotensin type 2 receptor agonist Compound 21 elicits cerebroprotection in endothelin-1 induced ischemic stroke. Neuropharmacology 2014, 81: 134-141. PMID: 24508710, PMCID: PMC7472595, DOI: 10.1016/j.neuropharm.2014.01.044.Peer-Reviewed Original ResearchMeSH KeywordsAngiotensin II Type 2 Receptor BlockersAnimalsBrain InfarctionBrain IschemiaCD11b AntigenCerebrovascular CirculationCytokinesDisease Models, AnimalDose-Response Relationship, DrugEndothelin-1Glial Fibrillary Acidic ProteinImidazolesMaleNitric Oxide Synthase Type IIPeroxidasePyridinesRatsRats, Sprague-DawleyStrokeSulfonamidesThiophenesTime FactorsConceptsMiddle cerebral artery occlusionPost-stroke administrationEndothelin-1Neurological deficitsIschemic strokeCerebroprotective actionCerebral damageCerebral ischemiaAT2R agonistChemokine (C-C) motif ligand 2Inducible nitric oxide synthaseBeneficial effectsCerebral infarct sizeMCAO-induced increaseCerebral artery occlusionAnti-inflammatory effectsCerebral blood flowNitric oxide synthaseSelective AT2R agonistPotential therapeutic valueType 2 mRNAAT2R inhibitorArtery occlusionPeripheral administrationHemorrhagic stroke
2013
Anti-inflammatory effects of angiotensin-(1-7) in ischemic stroke
Regenhardt RW, Desland F, Mecca AP, Pioquinto DJ, Afzal A, Mocco J, Sumners C. Anti-inflammatory effects of angiotensin-(1-7) in ischemic stroke. Neuropharmacology 2013, 71: 154-163. PMID: 23583926, PMCID: PMC3664115, DOI: 10.1016/j.neuropharm.2013.03.025.Peer-Reviewed Original ResearchMeSH KeywordsAngiotensin IAnimalsAnti-Inflammatory Agents, Non-SteroidalBrain IschemiaCells, CulturedCerebral CortexDisease Models, AnimalGene Expression RegulationMaleMiceMice, Inbred StrainsMice, KnockoutMicrogliaNerve Tissue ProteinsNeuroprotective AgentsNitric OxideNitric Oxide Synthase Type IIPeptide FragmentsProto-Oncogene MasProto-Oncogene ProteinsRatsRats, Sprague-DawleyReceptors, G-Protein-CoupledSpecific Pathogen-Free OrganismsStrokeConceptsInducible nitric oxide synthaseAnti-inflammatory effectsIschemic strokeEndothelin-1Cerebral cortexMiddle cerebral artery occlusionCerebral infarct sizeDifferentiation molecule 11bIntracerebral inflammatory responseCerebral artery occlusionAnti-inflammatory actionLipopolysaccharide-induced increasePro-inflammatory cytokinesCerebral blood flowINOS protein expressionNitric oxide synthaseNitric oxide productionNitric oxide generationExpression of mRNAAng-(1-7) treatmentSignificant cerebroprotectionCerebral vasoconstrictionArtery occlusionCerebroprotective actionReceptor MasUtilizing a cranial window to visualize the middle cerebral artery during endothelin-1 induced middle cerebral artery occlusion.
Regenhardt RW, Ansari S, Azari H, Caldwell KJ, Mecca AP. Utilizing a cranial window to visualize the middle cerebral artery during endothelin-1 induced middle cerebral artery occlusion. Journal Of Visualized Experiments 2013, e50015. PMID: 23463164, PMCID: PMC3605805, DOI: 10.3791/50015.Peer-Reviewed Original ResearchConceptsCranial windowEndothelin-1Cerebral arteryBrain parenchymaMiddle cerebral artery occlusion modelMiddle cerebral artery occlusionCerebral artery occlusionArtery occlusion modelMiddle cerebral arteryArtery occlusionIschemic strokeVasoconstricting peptideOcclusion modelVisualized vesselsLateral aspectTemporal boneArteryProximal portionRat cerebrumDuraVessel diameterCortical surfaceMCAOParietal boneParenchymaEndothelin-1 induced middle cerebral artery occlusion model for ischemic stroke with laser Doppler flowmetry guidance in rat.
Ansari S, Azari H, Caldwell KJ, Regenhardt RW, Hedna VS, Waters MF, Hoh BL, Mecca AP. Endothelin-1 induced middle cerebral artery occlusion model for ischemic stroke with laser Doppler flowmetry guidance in rat. Journal Of Visualized Experiments 2013 PMID: 23438950, PMCID: PMC3601209, DOI: 10.3791/50014.Peer-Reviewed Original ResearchConceptsEndothelin-1Laser Doppler flowmetryCerebral ischemiaIschemic strokeHuman strokeMiddle cerebral artery occlusion modelMiddle cerebral artery areaET-1 modelArtery occlusion modelET-1 infusionFocal cerebral ischemiaCause of deathDuration of occlusionNumber one causeArtery constrictionPartial reperfusionReperfusion ratesIschemic damageMCAO modelStereotaxic injectionArtery areaStroke volumeDoppler flowmetryExtracranial vesselsOcclusion model
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