2020
Residual endotoxin induces primary graft dysfunction through ischemia-reperfusion-primed alveolar macrophages
Akbarpour M, Lecuona E, Chiu S, Wu Q, Querrey M, Fernandez R, Nunez-Santana F, Sun H, Ravi S, Kurihara C, Walter JM, Joshi N, Ren Z, Roberts SC, Hauser A, Kreisel D, Li W, Chandel N, Misharin AV, Mohanakumar T, Budinger GRS, Bharat A. Residual endotoxin induces primary graft dysfunction through ischemia-reperfusion-primed alveolar macrophages. Journal Of Clinical Investigation 2020, 130: 4456-4469. PMID: 32692317, PMCID: PMC7410086, DOI: 10.1172/jci135838.Peer-Reviewed Original ResearchConceptsTissue-resident alveolar macrophagesPrimary graft dysfunctionHuman donor lungsNeutrophil recruitmentGraft dysfunctionDonor lungsBacterial pneumoniaAlveolar macrophagesBone marrow chimeric miceDonor lung injuryActivation of TLR4Blockade of TLR4MyD88-dependent mannerResidual endotoxinCoreceptor CD14Lung transplantationLung injuryNeutrophil infiltrationFatal syndromeSuccessful treatmentMouse modelChimeric miceBacterial endotoxinTLR4Endotoxin
2018
p204 Is Required for Canonical Lipopolysaccharide-induced TLR4 Signaling in Mice
Yi Y, Jian J, Gonzalez-Gugel E, Shi Y, Tian Q, Fu W, Hettinghouse A, Song W, Liu R, He M, Qi H, Yang J, Du X, Xiao G, Chen L, Liu C. p204 Is Required for Canonical Lipopolysaccharide-induced TLR4 Signaling in Mice. EBioMedicine 2018, 29: 78-91. PMID: 29472103, PMCID: PMC5925582, DOI: 10.1016/j.ebiom.2018.02.012.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCells, CulturedCytokinesGenotypeImmunity, InnateInflammasomesInflammation MediatorsInterferon Regulatory Factor-3Interferon-betaLipopolysaccharidesMacrophage ActivationMacrophagesMiceMice, KnockoutModels, BiologicalNF-kappa BNuclear ProteinsPhosphoproteinsProtein BindingProtein MultimerizationRAW 264.7 CellsShock, SepticSignal TransductionToll-Like Receptor 4ConceptsPro-inflammatory cytokinesLPS challengeIRF-3 pathwayDimerization of TLR4Serum levelsLPS-TLR4TLR4 signalingNF-ĸBAnimal modelsPyrin domainInnate immunityExtracellular LPSInterferon-inducible p200 familyInfectious diseasesLPSMicePotential targetTLR4IFNCytokinesMacrophagesBacterial DNASignificant defectsDramatic reductionPathway
2015
An endothelial TLR4‐VEGFR2 pathway mediates lung protection against oxidant‐induced injury
Takyar S, Zhang Y, Haslip M, Jin L, Shan P, Zhang X, Lee PJ. An endothelial TLR4‐VEGFR2 pathway mediates lung protection against oxidant‐induced injury. The FASEB Journal 2015, 30: 1317-1327. PMID: 26655705, PMCID: PMC4750407, DOI: 10.1096/fj.15-275024.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsApoptosisEndothelial CellsHydrogen PeroxideHyperoxiaLungLung InjuryMAP Kinase Signaling SystemMiceMice, Inbred C57BLMice, TransgenicOxidantsOxygenProto-Oncogene Proteins c-aktSignal TransductionToll-Like Receptor 4Vascular Endothelial Growth Factor AVascular Endothelial Growth Factor Receptor-2ConceptsVEGF receptor 2Primary endothelial cellsLung protectionEndothelial cellsC57/BL6 miceEffect of TLR4VEGF transgenic miceRole of TLR4Bone marrow chimerasLung cell apoptosisTLR4 knockdownTLR4 deficiencyLung injuryTLR4 expressionBL6 miceProtective effectLung compartmentsReceptor 2TLR4Transgenic miceHuman TLR4LDH releaseTransgenic modelingCell apoptosisInjuryPharmacological modulation of the AKT/microRNA-199a-5p/CAV1 pathway ameliorates cystic fibrosis lung hyper-inflammation
Zhang PX, Cheng J, Zou S, D'Souza AD, Koff JL, Lu J, Lee PJ, Krause DS, Egan ME, Bruscia EM. Pharmacological modulation of the AKT/microRNA-199a-5p/CAV1 pathway ameliorates cystic fibrosis lung hyper-inflammation. Nature Communications 2015, 6: 6221. PMID: 25665524, PMCID: PMC4324503, DOI: 10.1038/ncomms7221.Peer-Reviewed Original ResearchConceptsCF macrophagesMiR-199aMicroRNA-199aHyper-inflammatory responseCFTR-deficient miceCystic fibrosis patientsCystic fibrosis lungLung destructionDisease morbidityPharmacological modulationCF miceCF lungFibrosis patientsInnate immunityLungMacrophagesCAV1 expressionDrug celecoxibReduced levelsTLR4CelecoxibMiceCav1PathwayMorbidity
2013
Therapeutic inhibition of gut antigen trafficking through scavenger receptor A (P5027)
Raycroft M, Mamula M. Therapeutic inhibition of gut antigen trafficking through scavenger receptor A (P5027). The Journal Of Immunology 2013, 190: 110.14-110.14. DOI: 10.4049/jimmunol.190.supp.110.14.Peer-Reviewed Original ResearchScavenger receptor ADendritic cellsAutoantibody productionPeyer's patchesAntigen traffickingReceptor AB cellsLupus-prone miceGut immune responseB cell receptorLupus pathologyAutoimmune diseasesImmune responseTherapeutic inhibitionGut antigensHuman immunitySpecific antigenTherapeutic interventionsMice exhibitCell receptorHuman macrophagesInhibition altersMiceAutoimmunityTLR4
2012
HCC Is promoted by bacterial translocation and TLR‐4 signaling: A new paradigm for chemoprevention and management
Toffanin S, Cornella H, Harrington A, Llovet J, Groszmann R, Iwakiri Y, Taddei T. HCC Is promoted by bacterial translocation and TLR‐4 signaling: A new paradigm for chemoprevention and management. Hepatology 2012, 56: 1998-2000. PMID: 23115011, DOI: 10.1002/hep.26080.Peer-Reviewed Original ResearchHepatocellular carcinomaToll-like receptorsIntestinal microbiotaLiver diseaseTranslocation of intestinal bacteriaResident liver cellsAdvanced liver diseaseChronically injured liverHepatocellular carcinoma preventionConsequence of chronic liver injuryTLR-4 signalingChronic liver diseaseChronic liver injuryHepatocellular carcinoma initiationHCC promotionPrevention of apoptosisBacterial translocationTLR-4Liver injuryHepatic inflammationTLR4 activationIncreased proliferationLong-term consequencesTherapeutic targetTLR4
2010
TLR4-mediated activation of mouse macrophages by Korean mistletoe lectin-C (KML-C)
Park H, Hong J, Kwon H, Kim Y, Lee K, Kim J, Song S. TLR4-mediated activation of mouse macrophages by Korean mistletoe lectin-C (KML-C). Biochemical And Biophysical Research Communications 2010, 396: 721-725. PMID: 20450885, DOI: 10.1016/j.bbrc.2010.04.169.Peer-Reviewed Original ResearchConceptsInterleukin-1 receptor-associated kinase 1TNF-alpha productionKorean mistletoe lectinTNF-alphaTLR4 moleculesMouse macrophagesReceptor-associated kinase 1Mucosal immune cellsTNF-alpha secretionMistletoe lectinMouse peritoneal macrophagesImmune cellsMacrophage activationTLR4Immunomodulatory activityPeritoneal macrophagesMacrophagesCancer cellsUnderlying mechanismKinase 1ActivationDownstream eventsCellsCytokinesAdjuvant
2009
ORIGINAL ARTICLE: Regulation of Nod1 and Nod2 in First Trimester Trophoblast Cells
Mulla MJ, Yu AG, Cardenas I, Guller S, Panda B, Abrahams VM. ORIGINAL ARTICLE: Regulation of Nod1 and Nod2 in First Trimester Trophoblast Cells. American Journal Of Reproductive Immunology 2009, 61: 294-302. PMID: 19260860, DOI: 10.1111/j.1600-0897.2009.00694.x.Peer-Reviewed Original ResearchMeSH KeywordsApoptosisBenzamidesCells, CulturedCytokinesDiaminopimelic AcidFemaleGene Expression Regulation, DevelopmentalHumansLipopolysaccharidesNF-kappa BNod1 Signaling Adaptor ProteinNod2 Signaling Adaptor ProteinPregnancyPregnancy Trimester, FirstSequence DeletionSignal TransductionThiazolesToll-Like Receptor 4TransgenesTrophoblastsConceptsFirst trimester trophoblast cellsTrophoblast cellsExpression of NOD1Cytoplasmic pattern recognition receptorsProduction of cytokinesNOD2 mRNA expressionPattern recognition receptorsNOD2 expressionCytokine responsesInflammatory responseNOD2 activationNOD1 activationNFkappaB inhibitorRecognition receptorsNOD1Nod1 stimulationNOD2Bacterial lipopolysaccharideMRNA expressionTLR4LipopolysaccharideNFkappaB pathwayRT-PCRBacterial peptidesTrophoblast
2007
The role of the Toll receptor pathway in susceptibility to inflammatory bowel diseases
De Jager PL, Franchimont D, Waliszewska A, Bitton A, Cohen A, Langelier D, Belaiche J, Vermeire S, Farwell L, Goris A, Libioulle C, Jani N, Dassopoulos T, Bromfield GP, Dubois B, Cho JH, Brant SR, Duerr RH, Yang H, Rotter JI, Silverberg MS, Steinhart AH, Daly MJ, Podolsky DK, Louis E, Hafler DA, Rioux JD. The role of the Toll receptor pathway in susceptibility to inflammatory bowel diseases. Genes & Immunity 2007, 8: 387-397. PMID: 17538633, DOI: 10.1038/sj.gene.6364398.Peer-Reviewed Original ResearchConceptsInflammatory bowel diseaseCases of IBDRisk of IBDToll-like receptorsBowel diseaseIBD risk allelesUlcerative colitisCrohn's diseaseTLR4 pathwayIBD pathophysiologyIntestinal floraTLR pathwayTLR4 allelesHost defenseReceptor pathwayRisk allelesTLR genesDiseaseTLR4Modest effectHost/pathogen interactionsTIRAPAssociationReplication studyRisk
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